KEGG   Sorex araneus (European shrew): 101554406
Entry
101554406         CDS       T07854                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
sara  Sorex araneus (European shrew)
Pathway
sara01521  EGFR tyrosine kinase inhibitor resistance
sara01522  Endocrine resistance
sara04010  MAPK signaling pathway
sara04012  ErbB signaling pathway
sara04068  FoxO signaling pathway
sara04270  Vascular smooth muscle contraction
sara04650  Natural killer cell mediated cytotoxicity
sara04720  Long-term potentiation
sara04726  Serotonergic synapse
sara04730  Long-term depression
sara04810  Regulation of actin cytoskeleton
sara04910  Insulin signaling pathway
sara04914  Progesterone-mediated oocyte maturation
sara04928  Parathyroid hormone synthesis, secretion and action
sara05010  Alzheimer disease
sara05022  Pathways of neurodegeneration - multiple diseases
sara05034  Alcoholism
sara05160  Hepatitis C
sara05161  Hepatitis B
sara05200  Pathways in cancer
sara05205  Proteoglycans in cancer
sara05208  Chemical carcinogenesis - reactive oxygen species
sara05210  Colorectal cancer
sara05211  Renal cell carcinoma
sara05212  Pancreatic cancer
sara05213  Endometrial cancer
sara05214  Glioma
sara05215  Prostate cancer
sara05218  Melanoma
sara05219  Bladder cancer
sara05220  Chronic myeloid leukemia
sara05221  Acute myeloid leukemia
sara05223  Non-small cell lung cancer
sara05224  Breast cancer
sara05225  Hepatocellular carcinoma
sara05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:sara00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101554406 (ARAF)
   04012 ErbB signaling pathway
    101554406 (ARAF)
   04068 FoxO signaling pathway
    101554406 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101554406 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    101554406 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101554406 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    101554406 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    101554406 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    101554406 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    101554406 (ARAF)
   04720 Long-term potentiation
    101554406 (ARAF)
   04730 Long-term depression
    101554406 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101554406 (ARAF)
   05205 Proteoglycans in cancer
    101554406 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    101554406 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101554406 (ARAF)
   05212 Pancreatic cancer
    101554406 (ARAF)
   05225 Hepatocellular carcinoma
    101554406 (ARAF)
   05226 Gastric cancer
    101554406 (ARAF)
   05214 Glioma
    101554406 (ARAF)
   05221 Acute myeloid leukemia
    101554406 (ARAF)
   05220 Chronic myeloid leukemia
    101554406 (ARAF)
   05218 Melanoma
    101554406 (ARAF)
   05211 Renal cell carcinoma
    101554406 (ARAF)
   05219 Bladder cancer
    101554406 (ARAF)
   05215 Prostate cancer
    101554406 (ARAF)
   05213 Endometrial cancer
    101554406 (ARAF)
   05224 Breast cancer
    101554406 (ARAF)
   05223 Non-small cell lung cancer
    101554406 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    101554406 (ARAF)
   05160 Hepatitis C
    101554406 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101554406 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    101554406 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    101554406 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101554406 (ARAF)
   01522 Endocrine resistance
    101554406 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:sara01001]
    101554406 (ARAF)
Enzymes [BR:sara01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     101554406 (ARAF)
Protein kinases [BR:sara01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   101554406 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 Pkinase_fungal TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 101554406
NCBI-ProteinID: XP_004612939
LinkDB
Position
Unknown
AA seq 606 aa
MEPPRGLPANGAEPSRTVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYNSVHDLSGGSRHHEAPLNRPLNEPL
SPQGPSSCTQNHSPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSSLLQFTAQNFS
TDAVGGRGGGDGAPRVSPSLANVSSGRKSPHSKSPSEQRERKSLADEKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFKREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt   +upstreamnt  +downstreamnt
atggagcctccacggggcctccctgccaatggggctgagccgtcccggacagtgggcacg
gtcaaagtatacttacccaacaagcaacgcacggtggtaactgtccgggatggcatgagt
gtctacgactctctagacaaggccctcaaggtgagaggtctcaatcaggattgctgtgtg
gtttaccggctcatcaaggggagaaagacagtcactgcctgggacacagccattgcccct
ttggatggtgaagagctcattgtggaggttcttgaggatgtcccactgaccatgcataat
tttgtacggaagactttcttcagcctggcattctgtgacttctgccttaagtttctgttc
catggtttccgctgccaaacctgtggctacaagttccaccagcattgttcctccaaggtg
cccacagtctgtgtcgacatgagcaccaaccgccaacagttctacaacagtgtccatgat
ttgtctggaggctccagacaccacgaggctcccttgaatcgccccttgaatgagccacta
agtcctcagggtcccagctcctgcacccagaaccacagccctgagcacttccccttccct
gctccagccaatgctcccctccagcgcatccgatccacatccacccccaatgtccatatg
gtcagcaccacagcccccatggactctagcctcctccagttcactgcccagaatttcagc
actgatgcagttggtggtagaggtggtggtgatggagccccccgagtgagccccagccta
gccaatgtgtcctcggggaggaagtctccacattccaagtccccatcagaacagcgggag
cggaagtccttggctgatgagaagaagaaagtgaagaatctggggtaccgggactcgggc
tattactgggaggtgccacccagtgaggtgcagctgctgaagaggatcgggacaggctcg
tttggcactgtgtttcgcgggcggtggcatggtgatgtggccgtgaaggtgctcaaggtc
gcccaacccacagccgaacaggctcaggccttcaagaacgagatgcaggtgctcaggaaa
actcgacacgtcaacatcttgctgttcatgggcttcatgacccgaccaggatttgctatc
atcacacagtggtgtgaaggctccagcctctaccaccacctgcatgtggccgacacacgc
ttcgacatggtccagctcattgatgtggctcggcagactgcccagggcatggactacctc
cacgccaagaacatcatccatcgagatctcaagtctaacaatatcttcctacatgagggg
ctcacggtgaagattggtgatttcggcctggccacggtgaagacgcggtggagtggggcc
cagcctttggagcagccttcaggctctgtgctgtggatggcggctgaggtgattcgaatg
caggacccgaacccgtacagcttccagtcagatgtctatgcctacggggttgtgctgtac
gagctgatgaccggttcactgccttatagccacattggtagccgtgaccagattatcttt
atggttggccgtggctatctatccccggacctcagcaaaatctccagcaactgccccaaa
gccatgcggcgcctgctgtctgactgcctcaagttcaagagggaagagcggcctctcttc
ccccagatcctggccacgattgagctgctgcagcggtcactccccaagattgagcggagt
gcctccgaaccctccttgcaccgcacccaggctgatgagttgcctgcctgcctactcagc
gcagcccgcctagtgccttag

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