Sorex araneus (European shrew): 101554880 Help Entry 101554880         CDS       T07854                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism sara  Sorex araneus (European shrew) Pathway sara04020   Calcium signaling pathway sara04024   cAMP signaling pathway sara04260   Cardiac muscle contraction sara04261   Adrenergic signaling in cardiomyocytes sara04371   Apelin signaling pathway sara04713   Circadian entrainment sara04911   Insulin secretion sara04921   Oxytocin signaling pathway sara04972   Pancreatic secretion sara05020   Prion disease sara05022   Pathways of neurodegeneration - multiple diseases sara05410   Hypertrophic cardiomyopathy sara05412   Arrhythmogenic right ventricular cardiomyopathy sara05414   Dilated cardiomyopathy sara05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:sara00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     101554880 (RYR2)    04020 Calcium signaling pathway     101554880 (RYR2)    04024 cAMP signaling pathway     101554880 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     101554880 (RYR2)    04921 Oxytocin signaling pathway     101554880 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     101554880 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     101554880 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     101554880 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     101554880 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     101554880 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     101554880 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     101554880 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     101554880 (RYR2)    05414 Dilated cardiomyopathy     101554880 (RYR2)    05415 Diabetic cardiomyopathy     101554880 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:sara04040]     101554880 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:sara04990]     101554880 (RYR2) Ion channels [BR:sara04040]  Voltage-gated cation channels   Ryanodine receptor    101554880 (RYR2) Domain-containing proteins not elsewhere classified [BR:sara04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    101554880 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RR_TM4-6 RyR SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  101554880 NCBI-ProteinID:  XP_004619413 LinkDB All DBs Position Unknown AA seq 4814 aa AA seqDB search MLKIALQAHVDCGISFNTLIMAIRVDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLES TSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTMEKSEGQVDVEKWKFMMKTAQGSGHR TLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSE GEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQAVIYPI KMCDKLLFQRLLFLFLDLNDRITVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFR LRHVTTGKYLSLLEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGMRKEVDGMGTSEIKY GDSVCYIQHVNTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTA RVIRSTVFLFNRFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPDEQLEHEDKQ NRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYEL LAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKS IISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMR PNIFLGVSEGSAQYKKWYYELMVDHTQPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGN GVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQ GMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEH SREYKQERTYTRDLLGPTVPLTQAAFTPVPVDTSQIVLPPHLERIRERLAENIHELWVMN KIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEH AEERVKKMKLPKNHKNLLKFAAARAEVCSSTGERFRIFRAEKTYAVKTGRWYFEFEAVTA GDMRVGWSRPGCQPDQELGSDDRAFAFDGFKAQRWNQGHEHYGRSWQAGDVVGCMVDMTE HTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTIC GLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEHIEVTRIDGTIDSSPCLKITQKSF GSQNSSTDIMFYRLSMPIECAEVFSKTGLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGH LVPDRVDKDKEATKPEFNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADD RDDYDYLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEK GKVHESIKRSNCYMVCAGESMSPGQGRNNNGLEIGCVVDAASGLLTFTANGKELSTYYQV EPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSH VLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLKF HYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRTGYYDLLIDIHLSS YATARLMMNNEFIVPMTEETKSITLFPDENKKHGLPGIGLSTSLRPRMQFSSPSFVSINN ECYQYSPEFPLDILKAKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGV FHNEDLKHILQLIEPSVFKEAASPEEESESLEKDLGTEDSKQEGTMEEEARAGNGPKEGL LQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNM SAALTARKTKEFRSPPQEQINMLLNFKDDKNECPCPEEIRDQLLEFHEDLMAHCGIELDE DGSLDGNSDLTIRGRLLSLVEKVTYLKKKQAEKPVESDSQKSSTLQQLISDTMVRWAQES VIEDPELVRAMFMLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVR MGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMV ANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNEL ALALREPDLEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNEVTE SINDTEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPL ADLVGVISIAFQMPTIAKDGNVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLE VGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLL HTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKL LTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCL SAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHSH DKWSMDKLATGWIYGEVFSDSSKVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRI ERTREGDSMALYNRTRRISQTSQVSVDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYH NIWAKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFKD LELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSRTKGEHFPYEQEIKFFAKVVLP LIDQYFKNHRLYFLSAASRPLCTGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSI VNCLHILGQTLDARTVMKTGLESVKSALRAFLDNAAEDLEKTMENLKQGQFTHTRNQPKG VTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVE RQRSALGECLAAFAGAFPVAYLETHLNKHNIYSIYNTKTSRERAALNLPANVEDVCPNIP SLEKLMEEIVDLAESGIRYTQMPHVMEVILPMLCSYMSRWWEHGPENNLERAEMCCTALS SEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKK AAMVVSEEDHLKAEARGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPN PEAEDLFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAVSDQER KKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQELIALAKMRFSMKDTEDEVRDII RSNIHLQGKLEDPAIRWQMALYKDLPNRTEDTSDPEKTIERVLDIANVLFHLEQVEHPQR SKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLI EDLAKPGVEPSEEDEGNKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHD EEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGP MVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNK AEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIIS TVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQ SLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNG TIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAME SHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDISFNVAVLLTNLSEHMPNDT RLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFI FDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSTNKEESEKEKPEEQGPRM GFFSILTVKSALFALRYNILTLMRMLSLKSLKKQMKKVKKMTMKDMVTAFFSSYWSIFLG LLHFVASVFRGFFRIICSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDGEEGERKP LEAPLPSEDLTDLKELTEESDLLSDIFGLDLRREGGQYKLIPHNPNAGLSDLMSNPVPLP EVQEKFQEQKAKEEEKEEKEEIKSEPEKAEGEDGEKEEKVKDDKGKQKLRQLHAHRYGES EVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKEL PTRSLSENAKVSTVDSDSNRIIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCL KVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKV MDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVV FTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGL LAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIED PAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGI GNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFP AGDCFRKQYEDQLN NT seq 14445 nt NT seq  +upstreamnt  +downstreamnt atgctaaagattgctcttcaagcacacgttgactgtggcatcagttttaacacactcatc atggctattagagttgatgatgaagtggttttgcagtgtaccgcaaccatccacaaagaa caacagaagttatgcttggcagcagaaggatttggcaacagactttgtttcttggagtcc acttcaaattccaagaatgttcccccagacctttccatctgtacctttgtcctggaacag tctctctcagtccgggccctgcaggagatgctggccaacacgatggagaaatcagaaggg caagttgatgtggaaaaatggaaattcatgatgaagacggctcagggtagtggtcatcga acactcctctatggacatgccatattgctacgtcattcctacagtggcatgtatctatgc tgtttgtccacttctcgatcttcaacagacaagctggcttttgatgttggcttgcaagag gatacaactggggaggcttgttggtggactattcatccagcttctaaacaacggtccgaa ggagaaaaagtacgagttggagatgatctcattttagtcagtgtttcctctgagagatac ctgcacttgtcgtacggcaatggcagtttgcatgtggatgctgctttccagcagactctc tggagtgtggccccaatcagctcaggaagtgaagcagcccaagctgtaatatatcctatc aaaatgtgtgacaagctgcttttccaaagacttctttttcttttccttgacttgaatgat agaataactgttcattatgaaggtggtgctgtatctgttcatgcccgttccctttggaga ctagagacactaagagttgcgtggagtggaagccacatacgatggggccaacctttccga ctacgtcatgtcacgacaggaaaatacttgagtctcctggaagacaaaaatcttctactg atggacaaagaaaaagctgatgtgaaatcaacagcctttacctttcgatcatccaaggaa aaattggatgtcggcatgagaaaagaagttgatggcatgggaacatctgaaataaaatat ggagactcagtatgttatatccaacatgtaaatacaggcctgtggcttacttaccagtct gtggatgtgaaatctgtgagaatgggatccatacaacgtaaggctattatgcatcatgaa ggccatatggatgatggcttaaatttatctaggtctcagcatgaagaatcacggacagca cgcgtaatccggagcacagttttccttttcaatagattcataaggggccttgatgcactc agcaaaaaagcaaaggcctccacagtggacttaccgatagagtctgtcagtctaagtctg caggacctgattgggtacttccacccgccagatgagcagttagagcatgaagacaagcag aacaggttgcgagctctaaagaatcgtcagaacctcttccaggaagagggcatgatcaac ctggtgctggagtgcatagacagacttcatgtctacagcagcgcagcgcacttcgctgat gtggctgggagagaagcaggggaatcttggaaatcaattctcaattctctgtatgaattg ctagcggctctaattagaggaaatcgtaaaaattgtgctcaattttctggctcccttgac tggttgattagccgattggaaagactggaagcttcttcgggtattcttgaagttttacac tgtgtattagtagaaagcccagaagctctaaatattattaaagaaggacatattaaatcc attatttcacttttagacaagcatggaagaaatcataaggttctagacgtgctgtgctcc ctctgcgtttgccatggagtggcggtccgttctaaccagcatctcatctgtgacaatctc ctgcccggaagagatctgttactgcagactcgccttgtgaatcacgtcagcagcatgaga cccaatatttttctgggcgtcagtgaaggttctgctcagtataagaaatggtactatgag ttgatggtggaccatacacagccatttgtgacagcagaagcaactcatctacgagtgggc tgggcttccactgaaggttattctccataccctggcggcggtgaggaatggggtggaaat ggtgttggagatgatctcttttcatatggatttgatggtcttcatctttggtcaggttgt attgctcgtactgtaagttcaccaaaccagcatctgttaagaacggatgacgtcatcagc tgctgtttagatctaagtgcccctagtatttcattccgaattaatggacagcctgttcaa ggaatgtttgagaatttcaacattgatggcctcttctttcctgttgtgagtttctctgca ggaataaaggtacgctttctacttggaggaagacatggggaatttaaattccttcctccg cctggttatgcaccatgttatgaagctgttctgccaaaagaaaagttgaaagtggagcac agtcgagagtacaagcaagaaagaacgtatacacgggacctcctgggccctacggtgccc ctgacgcaagctgcctttacgccagtccctgtggacaccagccagatcgtgttgcctcct caccttgagaggataagagaaagactggcagagaatatccatgaactctgggttatgaat aaaattgaacttggctggcagtatggtccggttagagatgacaataagagacagcatccg tgtttggtggagttctccaagctgcctgaacaggaacgcaactacaatttgcagatgtcc cttgagaccctgaagactttactggctttaggatgccatgtgggtatatcagatgaacat gctgaagaaagagtgaaaaaaatgaagctacccaagaatcacaagaatctcttgaaattc gcagctgccagagctgaagtgtgtagcagtaccggggaacggttccgaatcttccgtgct gagaaaacctatgctgtgaagacaggaaggtggtattttgaattcgaggctgtcactgca ggggacatgagagttggctggagcagacccggttgtcagcctgatcaggagctggggtca gatgatcgggcctttgcttttgacggtttcaaggctcagcggtggaaccagggccatgaa cactatggacgctcttggcaagcaggcgatgttgtgggatgtatggtggacatgacagag cataccatgatgtttacactgaatggagaaatccttcttgatgactcaggttcagaactg gctttcaaggactttgatgttggtgatggatttatacctgtatgtagccttggagtggct caagttggaaggatgaactttgggaaggatgtcagcaccctgaaatattttaccatctgt ggtttgcaagagggttatgaaccatttgctgttaatacgaacagggatattaccatgtgg ctaagcaagagacttcctcagtttctccaggttccatcaaaccatgaacatattgaggtg accagaatagatggtaccatagacagttctccgtgtttaaagatcacccagaagtccttc ggttctcagaacagtagtaccgacatcatgttttatcgcctgagcatgcccatcgaatgt gcagaggtcttctccaagacagggcttccgggggcaggtctctttgggcccaagaacgat ttggaagattatgatgcagattctgactttgaggttctaatgaagacagcacatggccac ttagtgcctgaccgagttgacaaagataaagaggctacaaagccagagttcaataaccac aaggattatgctcaggagaagccctctcgcctgaaacaaagatttttacttagaagaaca aaacctgattatagcacaagccattctgcaagacttactgaagatgtccttgcagatgat cgggatgactatgattacctgatgcaaacatccacgtactattattcagtgagaatcttt cctgggcaagagcctgctaatgtgtgggtaggctggattacatcagattttcatcagtac gatacaggctttgacttggacagagtccgtacagtaaccgtcactctaggagatgagaaa ggaaaagtgcatgaaagcatcaaacgcagcaactgctacatggtgtgcgcaggcgagagc atgagccctgggcaaggacgtaacaataacggtctggagattggttgtgtggtggatgcg gccagcgggctgctcacgtttactgctaatggcaaggaactgagcacatactatcaggtt gaaccaagtacaaagttatttcctgcagtttttgcacaagctaccagtcctaatgttttt cagtttgagttgggaagaatcaagaatgtgatgccactttctgcagggttgttcaagagc gaacacaaaaacccagtgccacagtgccccccacgtcttcacgtgcaatttttatcacat gtcttgtggagcagaatgccaaaccaattcttgaaggtggatgtctctcggatcagcgaa cggcaaggctggttggtgcaatgtttggatcccctgcaatttatgtctcttcatatcccg gaagagaacaggtccgttgacatattagaattgacagagcaggaagaactgctgaagttc cactatcacactctccgactctattcagccgtctgtgcccttgggaaccaccgggtggcc catgccttgtgcagccatgtagacgagcctcagctcctctatgccatcgagaacaagtac atgcctggcttgctgcggactggctactatgacctactgatcgacatccaccttagctcc tatgccaccgccaggctcatgatgaacaatgaatttattgtccccatgacagaggagacg aagagcatcaccttgttccccgatgagaacaagaagcacggcctccccgggattggctta agcacctccctgagacctcgaatgcagttttcctcccccagcttcgtaagcattaataac gaatgttaccagtacagtccggagttcccactggatatcctaaaggccaagacgatacag atgctgacagaagctgttaaagagggaagtcttcatgcccgggacccagttggaggcacc actgaatttctctttgtacctctcatcaaactgttctatacattgctcatcatgggcgtc tttcacaatgaggatttgaagcacatcctacagctgattgaacctagcgtgttcaaggaa gcggccagtccagaggaggagagcgaaagtttggagaaagatctgggcacagaagactca aagcaggaaggcactatggaagaagaagccagagcgggcaacggacccaaggagggcctg ctccaaatgaaactgccagagccagttaaattgcagatgtgtctgctacttcagtacctc tgtgactgccaggtccggcaccggatagaagccattgtggctttttcagatgactttgta gcaaagcttcaagataatcaacgcttccgttataatgaagttatgcaagctttaaatatg tctgctgcgttgacagccaggaaaacaaaagaatttaggtcaccacctcaagaacagatc aatatgcttctcaattttaaggatgacaaaaatgaatgtccatgtcctgaagaaattcga gaccagctcttggaatttcatgaagatttgatggctcattgcgggattgagctggatgaa gatgggtctctggatggaaacagtgatttaacaattagaggacgcctgctgtccctggta gaaaaggtgacatacctgaagaagaaacaagctgaaaagccagttgagagtgactcccag aagtcctctactctacaacagttgatatcagacacgatggtccgatgggctcaagagtct gtcattgaagaccctgagttggtgagggccatgtttatgttgctccatcgacagtatgat ggcatcgggggtctggttcgggctctgccgaagacctacactataaatggtgtttcagtg gaagataccatcaacctgctggcgtctcttggtcaaatccgttctttgttaagtgtgaga atgggcaaagaagaagagaaacttatgattcgtggattaggggatatcatgaataacaaa gtattttaccagcaccctaatctcatgagggctcttggtatgcatgagacagtgatggag gtcatggtgaatgttttgggaggtggagagtccaaggaaatcacttttcctaagatggtg gccaactgttgtcgttttctctgttacttctgtcgtataagtaggcagaatcaaaaagct atgtttgatcatctcagttatttattggaaaacagcagtgttggtctagcctcaccagca atgaggggttctacaccacttgatgtggcagctgcgtcagtgatggataataatgaattg gccttagctttgcgagaaccagatctagaaaaggtagttcgatatttggctggttgcgga ctccagagttgtcagatgctggtgtctaaaggttatcctgatattgggtggaatccagtt gaaggagagcgatatcttgattttctcagatttgctgtcttctgtaatgaagtgacagaa tccatcaatgatacagaagaggaggaagatgatactatccacatggggaatgccatcatg accttttacgcagctttgattgaccttttaggacgctgtgctcctgaaatgcatttgatt catgctgggaaaggagaagccatcagaatcaggtctattctgagatccttaattccattg gcagatttggtgggagtgatcagcatcgcttttcagatgccaacaatagccaaagatggc aatgtggtggagcctgacatgtctgcaggattttgcccagatcacaaggcagccatggtt ttgttccttgacagggtctatggaattgaggttcaagattttctcctccatcttcttgaa gttggctttctgccagatctccgtgctgctgcttctctagatacggctgctttgagtgct acagacatggctttggctctcaatagatacctctgcacagccgtgctgcctttgttaaca agatgtgctcctctttttgctggcacagagcaccatgcttccctcattgattcattgctc cataccgtctatagactttctaagggctgctcacttaccaaagctcaacgagattccata gaagtttgcttactgtctatctgtggccaactgagaccatccatgatgcaacacttactc cgaagattagtatttgatgtcccattattaaatgaacatgcaaagatgcctcttaagctg ctgaccaatcattatgaaagatgctggaaatattactgcttacctggagggtggggaaat tttggagcagcatcagaagaagaacttcacttatcaagaaaactgttctggggaattttt gatgccctgtctcaaaagaaatatgaacaagaacttttcaaactggcactaccttgcctg agtgcagttgcgggagctttgcctccagactacatggagtcaaattatgtcagtatgatg gaaaaacagtcatcaatggattctgaagggaactttaacccacaacctgttgatacctca aatattacaattcctgagaagttggaatacttcattaacaaatatgcagaacattcccat gacaagtggtcaatggacaagttggcaactggatggatttatggggaagtattttcagac tcatctaaagttcaaccattaatgaagccatataaactattatctgaaaaggaaaaagaa atttatcgttggccaatcaaagaatctttaaaaacaatgctggcttggggttggagaatt gaaagaactcgagagggagacagtatggccctctataatcggactcgacgtatttcccag acgagccaggtgtcagtagatgctgcacatgggtatagccctcgagccattgatatgagt aatgtcacactatccagagatcttcacgctatggcagaaatgatggctgaaaactatcat aacatttgggcaaagaaaaagaaaatggaactggaatccaaagggggtggaaaccatcca ctactggtaccctatgatacactgacggccaaagagaaagccaaagacagagagaaagca caggacatcctcaagttcttacagataaatggatatgctgtctccagaggattcaaggac ttggaactggacacaccttctattgagaagcgatttgcctatagttttcttcaacagctc attcgctatgtggatgaagcccatcagtacattcttgagtttgatggtggcagcagaacc aaaggagagcatttcccttatgagcaagaaatcaagttctttgctaaagttgttcttcct ttaattgatcaatatttcaaaaaccatcgtttatacttcttatctgcagcaagcaggcct ctctgtactggaggacatgcatcaaataaagagaaagaaatggtgactagcctattctgc aaacttggagttcttgtcaggcataggatttcactatttggaaatgatgcaacatcaatc gtcaactgtcttcacattttgggtcagactttagatgcaagaactgtgatgaagactggc ctggagagtgtcaaaagtgcactgagagcgttcctggacaatgctgcagaggatctggag aaaacaatggagaatcttaagcaaggccagttcacccacacacgaaaccaaccgaaagga gttactcagattatcaattacaccaccgtggcactgctgccaatgctgtcatcattattt gaacatattggacagcatcagttcggagaagatctaatattggaagatgtccaggtatca tgttatagaattttaactagtttatatgctttgggaaccagcaagagtatttatgtagaa agacaacgttctgctttaggagaatgtctggctgcctttgctggtgcctttcccgtagca tatttggagacccacctcaacaagcataatatttactctatctacaatactaagacttca cgggagagagcagctctcaatttgccagcaaatgtggaagatgtttgtccaaatataccg tctttggagaaacttatggaagaaattgtggacttggcagaatctggcattcgctacact cagatgccacatgtaatggaagtgatactacccatgttgtgtagctacatgtctcggtgg tgggagcacggccccgaaaacaatctggaaagggcagaaatgtgctgtaccgctttgagc tcagagcacatgaacacacttctggggaatatattgaaaatcatatataataacttgggg atcgatgagggagcctggatgaagaggttggcagtattttcccagcctattataaacaaa gtgaaacctcaactcttgaaaactcatttcttgccattaatggaaaaactcaagaaaaag gcagcgatggtggtatctgaagaagaccatctgaaagccgaggccagaggggatatgtcg gaggcagaacttcttattctagatgagtttaccacactggccagagatctctatgccttc taccctctcttaattagatttgtggactataacagggcaaagtggctaaaggaaccaaac ccagaagcagaggatctttttcggatggtggcagaagtatttatctactggtccaaatcc cataatttcaagagggaagagcagaacttcgtggtacagaatgagatcaataatatgtct ttcctcattactgacaccaagtcaaaaatgtctaaggcagctgtttctgatcaggaaagg aagaaaatgaagcgaaaaggagatcgctattccatgcagacctctcttattgtagcagct ttgaagcgtttgctgcccattggattaaacatttgtgcccccggagatcaggagctcatt gctcttgccaaaatgcggttcagtatgaaagacactgaggatgaagtacgagatataatc cgcagcaacattcatttacaaggcaagttggaagatcctgctattagatggcaaatggct ctttacaaagatttaccaaatagaactgaagatacttcagatcctgaaaagacaatagag agagtattggatatagcaaatgtgctttttcatcttgaacaggtggaacatcctcagaga tctaaaaaggcggtctggcacaaactgctgtctaagcagaggaaaagggcggtggtagcc tgcttccgaatggctcctttatataacctgccaaggcatcgggctgtcaatctctttctt cagggatatgaaaagtcttggattgaaacagaagaacattactttgaagataaactgata gaagatttagcgaaacctggagtggagccttccgaagaagatgaaggcaacaaaagagtc gatcctcttcatcagctgatccttctgtttagtcgaacagctttaacagagaaatgcaaa ctggaagaagattttttatatatggcctatgcagatattatggcaaagagttgtcatgat gaggaagatgacgatggtgaagaagaagtgaagagttttgaagtcacaggatcccaacgc agcaaggaaaaagaaatggaaaagcaaaagctactctaccagcaagccaggctccatgat cgaggtgctgctgagatggtgttgcagaccataagtgccagcaaaggtgaaactggaccc atggtagctgctacgttgaaacttggaattgctatcttgaatgggggcaactctacagtg caacagaaaatgcttgactacctcaaggagaaaaaggatgtggggttctttcaaagtctt gctggcctgatgcagtcatgtagcgtccttgacttaaatgcatttgaacggcaaaacaaa gctgaaggactgggaatggtgacagaagaaggatcaggagaaaaggttctacaggatgat gagttcacctgtgacctcttccgcttcctacagctgctttgtgagggacacaattcagat tttcaaaattatctgagaactcagactggcaataatacaactgtcaacataattatttct actgtagactacctgctaagagttcaggaatccataagtgatttctattggtattattct ggaaaagatgttattgatgaacaaggacaacggaatttctctaaagcaatacaagtggca aagcaagtctttaatactctcacagagtatattcagggtccttgcactgggaatcaacag agtttggcacacagtcgtctatgggatgcggtggtgggatttcttcatgtttttgctcac atgcaaatgaagttgtctcaggactccagtcaaattgaactcttaaaagagttaatggat ctccagaaggatatggtggtcatgttgttgtccatgttagaaggtaatgttgtcaatgga accattggcaaacagatggttgatatgcttgtggaatcttccaacaacgtggaaatgatt ctcaaatttttcgacatgttcctaaagttaaaggatttgacatcttctgatacattcaaa gaatatgatcctgacggcaagggagtcatttccaagagggacttccataaagccatggag agccacaagcactacacacaatccgaaaccgagtttctcctgtcgtgcgcagagacagat gaaaatgaaacgctggactatgaagaatttgtcaagcgcttccacgagcctgccaaggac atcagcttcaatgtggccgttcttctgacaaatctttccgaacacatgcccaacgataca cgcttacagacctttctggagttagcagaaagcgtgctgaattacttccagcccttcctt ggccgaattgagatcatgggcagtgccaaacgcattgagagggtttattttgaaatcagt gaatccagccgaactcagtgggagaaaccgcaggtcaaggagtccaaaaggcagttcata tttgatgtggttaatgaagggggagagaaagagaagatggaactcttcgtgaacttctgt gaggataccatatttgagatgcagctggcggcccagatctccgagtctgatttgaacgag aggtcaacaaacaaggaggagagtgagaaggagaagcctgaggagcaggggccgaggatg ggtttcttttccattctgactgtcaagtcggccttgtttgctctcaggtataatatcttg actcttatgcgcatgcttagcctcaagagcctaaagaaacagatgaaaaaggtcaagaag atgaccatgaaggacatggtcacagccttcttttcctcctattggagtatttttctgggc ctcttgcacttcgtggccagtgtgttcagaggctttttccggatcatttgtagcctgctg ctgggaggaagcttagtagaaggtgctaaaaagatcaaagttgccgagctcttggccaac atgccagaccccactcaggatgaggtacgaggagatggagaggaaggcgagaggaagccc ttggaggctcccttgccctccgaagatctaacagacctaaaggagctgacagaggaaagc gaccttctctccgacatatttggcttggatctgaggcgagaaggaggacaatacaagttg attcctcacaatccaaatgccggcctcagtgacctcatgagcaacccagtccccctccct gaagtgcaagaaaagtttcaggaacagaaggcgaaagaggaagaaaaggaagaaaaagaa gaaataaaatctgaaccggaaaaggctgaaggagaagatggagaaaaggaagaaaaagtc aaagatgacaagggtaaacaaaaactacggcagctccacgcacacagatacggtgaatca gaggttcctgagtcagcattctggaagaaaatcatagcctaccaacagaaacttctaaac tattttgctcgcaacttttacaacatgagaatgttagccttatttgtcgcatttgcaatc aatttcatcttgcttttttataaggtctccacttcttctgtggttgaaggaaaagaactc cccactcgtagtttaagtgaaaatgccaaagtcagcactgtggacagcgattcaaatcga atcattgccgttcactacgtcctagaggagagcagtggctacatggagccgacgctgcgt atcctagctatcctccacactgtcatttctttcttctgcatcattggatactactgcttg aaagtcccgttagttatttttaagcgagaaaaggaagtagcacggaaattggaatttgat ggactttatattacagaacagccctcagaagatgatattaaaggccagtgggatagactt gtgatcaacacacagtcttttcccaacaactactgggacaaatttgttaaaagaaaggtt atggataagtatggagaattctatggtcgagatagaatcagtgaattgcttggtatggac aaggctgccctggatttcagtgatgcccgagaaaaaaagaagccaaagaaagacagctcc ctgtcagccgtactgaactctattgatgtgaagtatcagatgtggaaactcggagttgtt tttactgacaattccttcctctacttagcctggtacatgactatgtccgttcttggacac tataacaacttttttttcgctgctcatcttctggacattgctatgggattcaagacctta agaactatcttgtcatcagtaactcacaatggcaaacagcttgtattaactgttggctta ttagctgttgttgtatacctctatactgttgtggcatttaattttttccgaaaattctac aacaaaagtgaagatggtgatacaccagatatgaaatgtgatgatatgctaacatgctat atgttccacatgtacgttggagtacgtgccggcgggggtattggtgatgaaattgaagac ccagctggtgatgagtatgagatttatagaatcatctttgacatcaccttcttcttcttt gtaattgtcattctcttggccatcatacaaggtttgattattgatgcttttggagaacta agagaccaacaggaacaagtcaaagaagacatggagaccaagtgcttcatctgtgggatt ggcaatgattactttgacacagttcctcatggctttgaaacccacactttacaggagcac aacttggccaattacctgttttttctgatgtaccttataaataaagatgaaacagaacac acaggacaggaatcttatgtctggaaaatgtatcaagaacggtgttgggaatttttccca gcaggggattgcttcaggaagcagtatgaagaccagctaaattag

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