Sorex araneus (European shrew): 101555992
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Entry
101555992 CDS
T07854
Symbol
LAMA2
Name
(RefSeq) laminin subunit alpha-2
KO
K05637
laminin, alpha 1/2
Organism
sara
Sorex araneus (European shrew)
Pathway
sara04151
PI3K-Akt signaling pathway
sara04510
Focal adhesion
sara04512
ECM-receptor interaction
sara04820
Cytoskeleton in muscle cells
sara05145
Toxoplasmosis
sara05146
Amoebiasis
sara05165
Human papillomavirus infection
sara05200
Pathways in cancer
sara05222
Small cell lung cancer
sara05410
Hypertrophic cardiomyopathy
sara05412
Arrhythmogenic right ventricular cardiomyopathy
sara05414
Dilated cardiomyopathy
sara05416
Viral myocarditis
Brite
KEGG Orthology (KO) [BR:
sara00001
]
09130 Environmental Information Processing
09132 Signal transduction
04151 PI3K-Akt signaling pathway
101555992 (LAMA2)
09133 Signaling molecules and interaction
04512 ECM-receptor interaction
101555992 (LAMA2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
101555992 (LAMA2)
09142 Cell motility
04820 Cytoskeleton in muscle cells
101555992 (LAMA2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
101555992 (LAMA2)
09162 Cancer: specific types
05222 Small cell lung cancer
101555992 (LAMA2)
09172 Infectious disease: viral
05165 Human papillomavirus infection
101555992 (LAMA2)
09174 Infectious disease: parasitic
05146 Amoebiasis
101555992 (LAMA2)
05145 Toxoplasmosis
101555992 (LAMA2)
09166 Cardiovascular disease
05410 Hypertrophic cardiomyopathy
101555992 (LAMA2)
05412 Arrhythmogenic right ventricular cardiomyopathy
101555992 (LAMA2)
05414 Dilated cardiomyopathy
101555992 (LAMA2)
05416 Viral myocarditis
101555992 (LAMA2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Laminin_G_1
Laminin_G_2
Laminin_EGF
Laminin_B
Laminin_I
Laminin_N
Laminin_II
Laminin_G_3
Motif
Other DBs
NCBI-GeneID:
101555992
NCBI-ProteinID:
XP_012788306
LinkDB
All DBs
Position
Unknown
AA seq
3119 aa
AA seq
DB search
MPGAAGVLLALLLSGGLGGGEAQHRRQSQAHQQRGLFPAVLNLASNALITTNATCGEKEP
EMYCKLVEHVPGKPVRDPQCRICNQSSSDPKQRHPITNAIDGKNTWWQSPSIKNGIEYHY
VTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDVEYKPWQYHAVTDSECLVLYNIQ
PRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLINGRPSADDPSPELLEFTSARYIRL
RFQRIRTLNADLMMLAHKDPREIDPIVTRRYYYSVKDISVGGMCICYGHARACPLDPATN
KSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKSECEACNCHGKTKECYYDENVARRN
LSLNIHGKYIGGGVCINCTENTSGINCETCIDGFFRPKGVSPNDAKPCQPCNCDSIGSLN
EVCVKDIKHAKHGLPPGSCHCKPGFGGVSCERCARGYKGYPDCKPCNCSGEGSTNEDPCV
GPCNCKENVEGGDCSRCKSGFFNLQEDNPKGCDECFCSGVSNQCQSSYWTYENIQDMSDW
YLTDLTGHIKVTPEQDDAIPLQEISISSSEAQKALPESYFWSAPAPYLGNKLTAAGGHLT
FTTSYDFEDEEEDTEHRLQFIIILEGNGLRISTVQDEVYLQPSEELTNVFPFKEELFTIH
GTNSPVSRKEFMTVLANLKRLLIQITYSLGMDAIFRLGSVGLESAVTHPVQFPNGRTAVA
VEVCQCPAGYTGTSCESCWPRHRRVNGTIFGGICEACQCFGHAESCDDVTAECLNCKDHT
GGPYCNQCLSGFYGDPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDECPAGYS
GPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCEL
CADGYFGDAVDAKNCQPCRCNANGSFSDICNTKTGQCECRPNVQGWRCDECKPKTFGLQS
GRGCVPCNCNSFGSKSFDCEENGQCWCQPGVTGKKCDRCAHGYFKFQEGGCTACDCAHLG
NNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSIITGCKACNCSTEGSLDFQCNVNTGQCN
CHPKFSGAKCSECSRGHWNFPHCTPCDCFLPGTDDSTCDSETKRCFCSDKVGQCTCKVNV
EGVHCDKCRPGKFGLDAKNPLGCSSCYCFGVTTQCSEAKGLIRTWVTLTPEQTILPLVDE
ALQHTTTKGIAFQHPEIVAQMNLVKQDLHLEPFYWKLPEQFEGKKLMAYGGKLKYTIYFE
ARDETGFSTYNPQVIIRGGTRTHARVIVRHMAAPLNGQLTRHEIEMTEKEWKYYGDDPRM
SRTVTREHFLDTLYDIHYILIKATYGNVMRQSRISEISMEVAEPGQISAVTPAAHMIEKC
DCPTGYSGFSCESCMQGFYRSHSELGGHTAGPTLGTCVPCQCNGHSNMCDPETSICQNCQ
HNTAGDFCDRCAPGYYGIVKGFPNDCRQCACPLISSSNNFSPSCVLEGLDDYRCTECPRG
YEGQYCERCAPGYTGSPRSPGGSCQECECDPHGSLPVPCDPVTGFCTCRPGATGKKCDGC
EHLHAREGTECIFCGDECTGLLLTDLARLEQMATSINLTGPLPAPYKILYGLENTTQELK
HLLSPQRAPERLIQLAEGNLNTLVTEMNELLTRATKVTADGEQTGQDAERSNTRANALGE
FIKELIRDAEAVNEKAIKLNETLGTQDKAFERNIQELQKEIDQMMSELRRKNLDSQKEVA
EDELVAAEGLLKKVKKLFGESRGKNEEMEKNLREKLTDYQNKVDDAQDLLREATDKLRET
NRLSAANKQNMTILEAKKEAILSGKQEIENTLKDGNNLLDEANRLADEINSVIDYVEDIQ
TKLPSMSDELKDKIDDLSQKIKDQKLAEKVSQAESHAAQLKDSSAILDRILDEAKNISFN
ATAAFNAYSNIKNYIDEAEKLAMEAKDLANEATKLATGPQGLLKEDAKTSLQKSFGILNE
ARKLTNDVKENDHHLNGLTTRLENADARNGNLLRALNDTLGKLSAIPSDTADKLQAVKDK
ARQANDTAKSVLAQIRDLHQNLDGLKKNYKQLADSVAKTNAVVKDPLKNKIIEDADATVK
NLEQEADKLIDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGDCIRTYKP
EIKKGSYNNIVVNVKTPVADNLLFYLGSAKFVDFLAIEMRKGKVSFLWDVGSGVGRVEYP
DLTIDDSYWYRIEASRTGRNGTISVRALDGPKASILPSVYHSASPPGYTILDVDANAMLF
VGGLTGKIKKADAVRVITFTGCMGETYFDNKPIGLWNFREIEGDCKGCTISPQVEDSEGT
IQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSNALILYLATRDLRDFMSVELADGHIKV
SYDLGSGMASVVSNQNHNDGKWKSFTMSRTQKQANISIIDIDTNQEENIVTSSPGNNFGL
DLKADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLRDIEISRTPYNILSSPDYVGITKG
CSLENIYTVSFPKPGFVELSPVAIDVGTEINLSFSTRNESGLILLGSGGTFKRKRRQTGQ
AYYAIFLNKGRLEVHLSTGARTMRKIVIKPEPSLFHDGREHSVHVERTRGVLIVQVDEDR
RHMQDLTTEQAVEVKKLFVGGAPSEFQPFPLRNIPPFEGCIWNLVINSVPMDFAQPVSFK
NADIGRCTHQRPGEDEEGVGPAEAVIEPQPVPTPGFPTHIPFLVHGPCAAESEPALLIGS
KQFGLSKNSHIAIAFDDTKVKNRLTIEFEVRTEAESGLLFYMARINHADFATVQLRNGLP
YFSYDLGSGDTNTLIPTKINDGQWHKIKITRVKQEGILYVDDASNRTISPKKADILDVVG
MLYVGGLPINYTTRRIGPVTYSIDGCIRNLQMAEAPVDLEQPTSSFNVGTCFANAQKGTY
FDGTGFAKAVGAFKVGLELLVEFEFRTTRTTGVLLGISSQKMDGMGIEMIDEKLMVHVDN
GAGRFTAVYDAGIPGHLCDGKWHKVTASKIKHHIKLTVDGNQVEAKSPNPASTSADTNDP
VFVGGFPDGLKQFGLTTSVRFRGCIRSLRLTKGTGKPMEVNFTKALELRGVQPVSCPVN
NT seq
9360 nt
NT seq
+upstream
nt +downstream
nt
atgccaggggcggccggggtcctcctggccttgctcctgagcggaggcctcgggggcggc
gaggcgcagcatcggcggcagtcccaggcgcatcagcaaagaggtctattccctgctgtt
ctaaatcttgcttctaatgctctcattactacaaatgcgacgtgtggagaaaaagaaccc
gaaatgtattgcaaactggtcgagcatgtccctgggaagcctgtgagagacccccagtgt
cgaatctgcaatcaaagcagcagcgatcctaaacagagacacccaattacgaacgctatt
gacggcaagaacacttggtggcagagtcccagtatcaagaatggaattgaatatcattat
gtgacaatcacactggacttacagcaggtgttccagattgcatacgtgattgtaaaagca
gctaactctcctcggcctggaaactggattttagaacgttcacttgacgatgttgaatac
aagccgtggcaatatcatgcggtgacagattcagaatgcctagtcctctacaatatacag
ccccgcactggaccaccctcctatgccaaagatgatgaggtcatctgcacttcattttat
tccaagatacatcccttagaaaatggagagattcacatctctttgatcaatggaagacca
agtgctgatgatccttctcctgaactgctggaatttacttctgctcgctacattcgtctg
agatttcagaggatccgcaccttgaatgcagatttgatgatgttggctcacaaagaccca
agagagattgaccccattgtcacacggaggtattactactctgtcaaggatatttcggtt
ggagggatgtgcatctgctatggtcatgccagggcttgtccacttgatccagcgacaaat
aaatcccgctgtgagtgtgagcataatacgtgtggagacagctgtgatcagtgctgtcca
ggattccatcaaaaaccttggcgagctgggactttcctaacgaaatccgaatgtgaagcg
tgcaattgtcatgggaaaactaaagaatgctattatgatgaaaatgttgccagaagaaat
ctgagtttaaatatacatggaaaatacattggaggtggtgtgtgcatcaattgtaccgaa
aatacttcgggtataaactgcgaaacatgcattgatggtttcttcagacctaaaggggta
tctccaaatgatgcaaaaccttgccagccatgcaattgtgattcaattggttccttaaat
gaagtctgtgttaaggacataaagcatgctaaacacggtctgccccctgggtcctgccat
tgcaaacctggctttggaggagtgagctgtgaacggtgtgccagaggctacaagggctac
ccagattgcaaaccgtgcaactgcagcggtgaaggaagcacaaatgaagacccttgtgtt
ggaccctgtaattgcaaggaaaatgtggaaggaggagactgcagtcgctgcaaatctggc
ttctttaacttgcaagaggataatcctaaaggttgtgatgagtgtttttgttcaggagtt
tcaaaccaatgtcagagttcctactggacctatgagaatatacaagacatgagtgactgg
tacctgactgacctcacaggccacattaaagtgactccggagcaggatgatgccattcca
cttcaggagatcagcatcagtagtagtgaggcccagaaagccctgccagagagctacttc
tggagtgcaccagctccgtatttaggaaacaaactcacagcagctggaggacatttgaca
tttactacatcatatgacttcgaagatgaggaagaagacacagaacacagactccagttt
ataattatcctagagggaaatggcttgagaatcagcacagtccaagatgaggtatacctg
caaccatcggaagaacttactaatgtgtttccatttaaagaagaattatttactattcat
ggtacaaattccccagtcagtagaaaagagtttatgactgtgcttgcaaatttaaagagg
ctcctcatacaaatcacatacagccttgggatggatgccatcttcaggttgggttctgtt
ggcttggaatctgctgtcacccatccagtccagtttcctaacggaagaactgcagtggct
gtggaagtctgtcagtgcccagcagggtatacaggaacttcctgtgaatcttgttggcct
agacacagaagagtgaatggcactatttttggtggcatctgtgaagcctgtcagtgcttt
ggtcatgcggagtcctgtgatgatgtcactgctgaatgcctgaactgcaaggatcacaca
ggtggcccatattgcaatcagtgtctttctggtttctatggcgatcctactaaaggaacc
tctgaagactgtcagccctgtgcttgtccactcaatatcccatccaataactttagcccg
acgtgtcatttagaccgcagtctcggattgatctgtgatgaatgccctgccgggtacagc
ggaccgcgctgtgagaggtgtgcagaaggctattttggacaaccttctgtacctggagga
tcatgtcagccttgccaatgcaacgacaaccttgacttttccatccctggcagctgtgac
agcttgtctggctcctgtctgatatgtaagccaggtacaacaggccgctactgtgagctc
tgtgctgatggatattttggagacgctgttgatgcaaagaactgtcagccttgtcgctgt
aatgccaacggctctttctctgatatttgcaacactaagacaggacaatgcgaatgcaga
cccaatgtgcaggggtggcgttgtgatgagtgtaagcctaaaacctttggcctgcagtca
ggaaggggttgtgttccttgtaactgcaattcctttgggtctaaatcatttgattgtgaa
gagaatgggcagtgttggtgccagcctggagtcacaggaaagaagtgtgaccgctgtgct
cacggctacttcaagttccaagaaggagggtgcacagcttgtgactgtgctcatctgggt
aataattgtgatccaaaaactggtcgatgcatctgtcctcccaataccattggagagaaa
tgttcaaaatgtgcacctaatacctggggtcacagtattatcactggttgtaaggcttgc
aactgcagcacagagggctctctggattttcagtgtaatgtaaacactggccagtgcaac
tgtcatccaaaattctcaggagcaaaatgttcggagtgtagccgaggtcactggaacttc
ccacattgcaccccatgtgattgcttccttcccggcacggatgactccacctgcgattca
gaaacgaaacggtgcttctgtagcgacaaagttgggcagtgcacttgtaaggtgaatgtg
gaaggtgtccattgtgacaagtgtcggccaggcaaattcggactcgatgccaagaatcct
cttggctgcagcagctgctactgcttcggtgttactactcagtgctctgaagcaaaagga
ctgatccgcacatgggttaccctgacacctgagcagaccattctcccactggtggatgag
gcattgcagcacacaaccaccaaaggcattgcttttcaacacccagagattgttgcacag
atgaatctcgtgaaacaagatctccatttggagcctttttattggaaacttccagaacaa
tttgaaggaaagaagttgatggcttacggtggcaaactcaagtacacaatctactttgaa
gctcgagatgagacaggcttctctacttacaacccgcaagtgatcattcgaggcgggact
cgtactcatgctagagttatcgtcaggcatatggctgctcctctgaatggccaattgaca
aggcatgaaattgaaatgacagagaaagaatggaaatactatggggatgatccgcggatg
agtagaactgtgacccgtgaacacttcttggatactctatatgatattcactatattctt
atcaaggctacttatggaaatgtcatgcgacaaagcaggatttctgaaatctccatggag
gtggctgaaccaggacagatatcagcagtgactccagcagctcacatgatagaaaaatgc
gattgtcccacaggttactctggcttttcctgcgagagctgcatgcagggattttatcga
agtcactctgagcttggaggtcacacggctggaccaaccctgggtacctgtgttccttgt
cagtgtaatggacacagcaatatgtgtgatcctgaaacttccatatgccagaattgccaa
cacaacactgcaggtgacttctgtgaccgatgtgctcctggatactatggaattgtgaaa
ggatttccaaatgactgtcggcagtgtgcttgccctctgatttcttccagcaacaatttc
agtccttcatgtgtcttggaaggcctggatgattaccggtgcacagaatgccccagagga
tatgaaggccagtactgtgaaaggtgtgcccctggctacactggtagcccacgcagcccc
ggaggctcctgccaagaatgtgagtgtgaccctcatggctcactgcctgtcccctgtgac
cctgtcacaggattctgcacgtgcagacccggagccacggggaagaagtgtgacggctgc
gaacacttgcatgcacgcgagggcacggagtgtattttttgtggcgatgaatgtacaggc
cttctcctcactgacctggctcgcctagagcagatggccacgagcatcaacctcactggc
cctctgcctgctccatacaaaatactctacggtcttgaaaatacgacccaggaattgaag
catttgctctcaccccagcgagccccggagagactaattcagttggcagagggcaatctg
aacactcttgtgacagagatgaatgagcttctgaccagggctaccaaagtgacagcagat
ggcgaacaaactggacaggatgctgagaggagcaacacgagagcaaatgctctaggagaa
ttcattaaggagcttatccgggatgcagaagctgtaaatgagaaagctataaaattaaat
gaaactctaggaactcaagacaaggcctttgagagaaatattcaagagctccaaaaagag
attgaccagatgatgtcagaactgaggaggaaaaatctagattcacagaaggaagttgct
gaggacgagttggtagctgccgaaggtcttctgaagaaagtgaagaagctgtttggagag
tctcgaggcaaaaatgaagaaatggagaagaacctgagggagaaactgactgactaccaa
aacaaagttgatgatgctcaggacttgttgagagaagccacagacaaacttagagaaact
aatcgcttgtcagcagcaaacaaacaaaacatgactattctcgaggcaaagaaggaggct
atattaagtggcaaacaagaaattgagaatactttaaaagacggtaataacctccttgat
gaagccaaccgtcttgcagatgaaatcaactcagtcatagattatgttgaagacattcaa
actaaattgccatccatgtctgatgaacttaaagataaaatagacgacctctcccaaaaa
ataaaggaccagaaacttgctgagaaggtttcccaagctgagagccatgcagctcaattg
aaggactcatctgctatccttgacagaatccttgatgaggctaaaaacatctccttcaat
gcaactgcagccttcaatgcttacagcaatattaagaactatattgatgaagctgagaaa
cttgccatggaagccaaagatcttgcaaatgaagctacaaaactggcaacaggtcctcag
ggtttattaaaggaagatgccaaaacctctctccagaaaagctttgggattcttaatgaa
gccagaaagttaacaaatgatgtgaaagaaaatgaccatcatctgaatggcttgacaact
agattagaaaatgccgatgctagaaatggaaatctcttaagagctctgaatgacactttg
gggaagttatccgccattccaagtgacacagcagacaaactgcaagctgtgaaggacaag
gcgagacaagctaatgatacagccaaaagtgtactggcacagataagagaccttcaccag
aatctggatggcctgaagaaaaattacaaacaactagccgacagcgtagccaaaacaaat
gctgtggtcaaagatcctttgaagaacaaaatcattgaagatgcagatgccactgtgaaa
aatctagaacaagaggctgataaactgatagataaactcaagcccatcaaagaacttgag
gataatctgaagaaaaacatttctgaaataaaggaattgataaatcaagcacggaagcaa
gccaattctatcaaagtatcggtatcttccggaggtgactgcattcgaacatacaagcct
gaaatcaagaaaggaagctacaataatattgttgtcaatgtaaagacacctgttgctgat
aacctcctgttttatcttgggagtgccaaatttgttgattttctggctatcgaaatgcgt
aagggtaaagtaagctttctctgggatgttggatctggagttggacgtgtagagtatcca
gatttgactattgatgactcatactggtaccgtattgaggcatcaagaactgggagaaat
ggaactatttccgtgagagccctggatggacccaaagccagcatcctgcccagtgtctac
cattcagcatcacctccagggtacactattctagatgtggatgcaaacgcaatgctcttc
gtgggtggcttgactgggaaaataaagaaggcagatgctgtacgtgtgatcacattcact
ggttgcatgggagaaacttactttgacaataaaccaataggattgtggaatttccgagaa
atagaaggtgactgcaaaggatgtaccattagtcctcaggttgaagacagtgaagggaca
attcagtttgacggagaaggttatgctttggtcagccgacccattcgctggtaccctaac
atctccacagtcatgttcaagttcagaacattttcttcaaatgccctgatattatatctt
gccacacgagacctgagggatttcatgagtgtggagctcgctgatgggcacataaaagtc
agctatgatctgggttcaggaatggcttctgttgtcagcaatcaaaaccataatgatggg
aaatggaaatcattcaccatgtcaagaactcaaaaacaagccaacatatcaattatagat
atagatactaaccaggaggagaacattgtaacttcatctcctggaaacaactttggtctg
gacttgaaagcagatgacaaaatatattttggtggcttgccaacactgagaaacttgagt
atgaaagcaagaccagaagtaaatctgaagaaatattctggctgccttagagatattgaa
atttcaagaacaccttataatatactcagtagccctgattatgttggcattaccaaagga
tgttctcttgagaatatttacacagtgagtttcccgaagcctggatttgtggaactctcc
cctgttgcaattgatgtaggaacagaaatcaacttgtctttcagcactaggaatgagtct
ggcctcattctgctggggagtggagggacctttaagagaaaaagaaggcaaacaggacag
gcctattatgcgatattcctgaacaagggccgcctggaagtacatctctccacgggggca
cgaacaatgaggaaaattgtcatcaaaccagagccgagtctgtttcacgacgggagagaa
cattctgttcatgtagagagaaccagaggagtcttgattgttcaagtggatgaagacaga
agacacatgcaagacctgacaacagaacaagcggtggaagttaaaaagctttttgttggg
ggtgccccatctgaatttcagccctttccactcagaaacatccctccttttgaaggctgt
atttggaatcttgtcattaactctgtccccatggactttgcacagcctgtgtccttcaag
aatgcagacattggtcgttgcacccatcagagacccggtgaggatgaagagggagtagga
ccagcggaagcagttattgagcctcaaccagttcccaccccaggcttccctacacacatc
ccatttctggtacatggcccgtgtgctgcagaatcagaaccagcgcttttgatcgggagc
aagcaatttggcctttcaaaaaacagtcacattgcaattgccttcgatgacaccaaagtg
aaaaaccgtctcacaattgagtttgaggtgcgaaccgaagctgaatcaggcttgctgttt
tacatggctcggatcaatcatgctgattttgctacagttcagctgcgaaatggattaccc
tacttcagttatgacttgggaagtggtgacacaaacacccttattcccaccaaaatcaat
gatggccagtggcacaagattaagattacgagagttaagcaagaaggaattctctatgta
gacgatgcttccaaccgaaccatcagtcccaagaaagctgatatcctggatgttgtagga
atgttgtatgttggtgggttacccatcaactacaccacccgaagaattggtccagtgacc
tacagtattgatggctgcatcaggaacctgcagatggctgaggcccctgttgatcttgaa
caaccaacctccagcttcaatgtgggaacgtgttttgcaaatgctcagaaaggaacatat
tttgatggaacaggttttgccaaagcagttggtgcgttcaaagtaggattggaacttctt
gtggaatttgaattccgtacgactagaaccactggagttcttctgggaatcagcagccaa
aaaatggatggaatgggtattgaaatgattgatgaaaagctcatggttcatgtggacaat
ggtgcaggccgcttcactgctgtctatgatgctgggatcccagggcatttgtgtgatgga
aaatggcataaagtcacagccagcaagatcaaacatcacattaaactgacagtagatggt
aaccaggtagaagccaagagtccaaacccagcatcgacatcagctgatacaaatgaccct
gtgtttgttggagggttcccagatggtctcaaacagtttggtctgactaccagtgttcgc
ttccgtggttgcatccggtctctaaggctcaccaaaggcacaggcaagccaatggaggtg
aatttcactaaagccctggaactaaggggtgttcaacctgtatcctgcccagtcaactaa
DBGET
integrated database retrieval system
