Sorex araneus (European shrew): 101556525 Help Entry 101556525         CDS       T07854                                  Symbol JAK1 Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism sara  Sorex araneus (European shrew) Pathway sara01521   EGFR tyrosine kinase inhibitor resistance sara04151   PI3K-Akt signaling pathway sara04217   Necroptosis sara04380   Osteoclast differentiation sara04550   Signaling pathways regulating pluripotency of stem cells sara04620   Toll-like receptor signaling pathway sara04621   NOD-like receptor signaling pathway sara04630   JAK-STAT signaling pathway sara04658   Th1 and Th2 cell differentiation sara04659   Th17 cell differentiation sara05140   Leishmaniasis sara05145   Toxoplasmosis sara05152   Tuberculosis sara05160   Hepatitis C sara05161   Hepatitis B sara05162   Measles sara05163   Human cytomegalovirus infection sara05164   Influenza A sara05165   Human papillomavirus infection sara05166   Human T-cell leukemia virus 1 infection sara05167   Kaposi sarcoma-associated herpesvirus infection sara05168   Herpes simplex virus 1 infection sara05169   Epstein-Barr virus infection sara05171   Coronavirus disease sara05200   Pathways in cancer sara05203   Viral carcinogenesis sara05212   Pancreatic cancer sara05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:sara00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     101556525 (JAK1)    04151 PI3K-Akt signaling pathway     101556525 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     101556525 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     101556525 (JAK1)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     101556525 (JAK1)    04621 NOD-like receptor signaling pathway     101556525 (JAK1)    04658 Th1 and Th2 cell differentiation     101556525 (JAK1)    04659 Th17 cell differentiation     101556525 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     101556525 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101556525 (JAK1)    05203 Viral carcinogenesis     101556525 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     101556525 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     101556525 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     101556525 (JAK1)    05161 Hepatitis B     101556525 (JAK1)    05160 Hepatitis C     101556525 (JAK1)    05171 Coronavirus disease     101556525 (JAK1)    05164 Influenza A     101556525 (JAK1)    05162 Measles     101556525 (JAK1)    05168 Herpes simplex virus 1 infection     101556525 (JAK1)    05163 Human cytomegalovirus infection     101556525 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     101556525 (JAK1)    05169 Epstein-Barr virus infection     101556525 (JAK1)    05165 Human papillomavirus infection     101556525 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     101556525 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     101556525 (JAK1)    05140 Leishmaniasis     101556525 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     101556525 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:sara01001]     101556525 (JAK1) Enzymes [BR:sara01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      101556525 (JAK1) Protein kinases [BR:sara01001]  Non-receptor tyrosine kinases   JAK family [OT]    101556525 (JAK1) SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 SH2_1 FERM_F1 ABC1 RIO1 SH2 DUF5710 FERM_C_FAK1 Motif Other DBs NCBI-GeneID:  101556525 NCBI-ProteinID:  XP_004607152 LinkDB All DBs Position Unknown AA seq 1141 aa AA seqDB search MAFCAKMRSSKKTEVSLEAPEPGVEVFFYLPDREPLRLRSGEYTAEELCIKAAQTCSISP LCHNLFALYDDNTKLWYAPNHTITVDDKTWLPLHYRMRFYFTNWHGTNDNEQSVWRHSPK KQKNGYEKKKVPEATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGM AVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFN NKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISAENEMNRFHPNDGGIVLC YEVMVTGNLGIQWRQKQNVVPVEKEKNKLKRKKLDSKHKKDEEKSKIREEWNNFCYFPEI THIVIKESLVSINKQDNRKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLI VHNIENGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEVLGSQK QFKNFQIEVKKGCYSLHGSESSFPSLGELMGHLKKQILRTDNISFVLKRCCQPKPREISN LLVATKKAQEWQHCSCMSQLSFDRILKKDIVQGEHLGRGTRTHIYSGTLVDYRDDEGTAE EKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDLENIMVEEFVEGG PLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGP FIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIP LKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNP DIVSEKKPAAEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPE SGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKN KINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKE YYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIG PTHGQMTVTRLVNTLKEGKRLPCPRNCPDEVYQLMRKCWEFRPSSRTTFQNLIEGFEALL K NT seq 3426 nt NT seq  +upstreamnt  +downstreamnt atggcgttctgtgcgaaaatgaggagctccaagaagacggaggtgagcctggaggcgccc gagcccggggtggaggtgttcttctacctgcccgaccgggagcccctccggctgcgcagc ggcgagtacacggccgaggaactgtgcatcaaggcggcgcagacgtgcagtatttctcct ctgtgtcacaacctcttcgctttgtacgatgacaacacgaagctctggtatgccccaaat cacaccatcactgtcgacgacaaaacgtggcttccgctgcactaccggatgaggttttat ttcaccaactggcacggcaccaacgacaacgagcagtcagtctggcgacactctccaaag aagcagaagaacggctacgagaagaaaaaagtccccgaggccacccctctgctggacgcc agctccctggagtacctgtttgcccagggacagtacgatctggtcaagtgcctggctccc atccgcgaccctaagactgagcaggatggacatgacatcgagaacgagtgtctgggaatg gccgtcctggccatctcccactacgccatgatgaagaagatgcagctgccagagctgccc aaggacatcagctacaagaggtatatcccggagacactgaacaagtccatcagacagagg aacctgctcaccaggatgcggataaataatgtcttcaaggatttcctaaaggaatttaac aacaagaccatctgcgacagcagcgtgtccacacatgacctgaaggtgaagtacctggcc accctggagacgctaacgaagcattacggagcggaaatatttgagacttccatgttactg atctcagctgaaaatgagatgaatcggtttcatccaaacgacggtgggattgttctctgc tatgaagtgatggtgacaggcaatcttggcatccagtggaggcagaaacaaaacgtggtt cctgtcgaaaaggaaaaaaataaactgaaacggaaaaaactggacagtaaacacaagaag gatgaggagaaaagcaagatccgggaggagtggaacaacttctgctatttccctgagatc acccacattgtcatcaaggagtccctggtcagcatcaataagcaggacaacagaaaaatg gagctgaagctgtcttcccacgaggaggccttgtccttcgtgtccctggtggatggctac ttccggctcacggcagacgcccaccattacctgtgcaccgacgtggcccccccgctgatc gtgcacaacatcgagaacggctgccacggccccatctgcacggagtacgccatcaacaag ctgcgccaggagggcagcgaggagggcatgtacgtgctgcgctggagctgcacagacttc gacaacatcctcatgaccgtcacgtgcttcgagaagtccgaggtgctgggcagccagaag cagttcaagaactttcagattgaggtgaagaagggctgctacagcctgcacggctcggag agcagcttccccagcctgggcgagctcatgggccacctcaagaagcagatcctgcgcacg gacaacatcagcttcgtgctgaagcgctgctgccagcccaagccccgagaaatctccaac ctgctggtggccaccaagaaagcgcaggagtggcagcactgctcctgcatgagccagctg agcttcgaccggatcctcaagaaggacattgtgcagggtgagcacctgggccgaggcacg cgcacgcacatctactcgggcacgctggtggactaccgggacgacgagggcacggccgag gagaagaggatcaaagtgatcctcaaagtcctggaccccagccacagggacatctctctg gccttctttgaggcggccagcatgatgcgccaggtctcccacaagcacatcgtgtacctc tatggcgtctgcgtccgggacttggagaacatcatggtggaggagttcgtggagggcggc cccctggacctcttcatgcaccggaagagcgacgtcctcaccacgccatggaagttcaaa gtggccaagcagctggccagtgccctgagttacttggaggacaaggacctcgtccacggg aacgtgtgcaccaagaacctcctcctggcccgggagggcatcgacagcgagtgcggcccc ttcatcaagctcagcgaccccggcatccccatcacggtgctgtccaggcaagagtgtata gagcggatcccgtggattgctcccgagtgcgtggaggactccaagaacttgagcgtggct gccgataagtggagctttggcaccaccctctgggaaatctgctacaacggcgagatcccc ctgaaggacaagaccctgatcgagaaggaaagattctacgagagccggtgcaggcccgtg accccgtcttgcaaggagctggctgacctcatgacccgctgcatgaactacgaccccaac cagcggcccttcttccgggccatcatgcgagacatcaacaagctggaggagcagaacccc gacatcgtttccgagaaaaagccagccgccgaggtggatcccacgcactttgagaagcgg ttcctaaagcggatccgggacctgggagagggccactttgggaaggtggagctctgcagg tacgaccctgagggtgacaacaccggggagcaggtggctgtgaagtccctgaagcccgag agcggcggcaaccacatcgccgacctcaagaaggagatcgagatcctccggaacctctac cacgagaacatcgtcaagtacaagggcatctgcacagaggacgggggcaatggaatcaag ctcatcatggagtttctgccttctggaagccttaaggagtatcttccgaagaacaagaac aaaatcaacctcaagcaacagctaaaatacgccgtgcagatctgtaagggcatggactac ctgggctcccggcagtacgtgcaccgggacctggcggccaggaacgtgctggtggagagt gagcaccaggtgaagatcggagacttcgggctgacgaaagccatcgagaccgacaaggag tattacacggtcaaggatgaccgagacagccctgtgttctggtacgccccggagtgtctg atccagtgcaagttctacatcgcctctgacgtgtggtccttcggcgtgacgctgcacgag ctgctcacctactgtgactcggactccagccccatggcgttgttcctgaaaatgatcggc ccgactcacggccagatgacagtgacgagacttgtgaatacactgaaagagggaaagcgc ttgccctgcccacggaactgccctgatgaggtctatcagctcatgagaaaatgctgggag ttccggccatctagtcggaccacctttcagaacctcattgaaggatttgaagcactttta aaataa

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