KEGG   Sorex araneus (European shrew): 101559009
Entry
101559009         CDS       T07854                                 
Symbol
AKT2
Name
(RefSeq) RAC-beta serine/threonine-protein kinase isoform X2
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
sara  Sorex araneus (European shrew)
Pathway
sara01521  EGFR tyrosine kinase inhibitor resistance
sara01522  Endocrine resistance
sara01524  Platinum drug resistance
sara04010  MAPK signaling pathway
sara04012  ErbB signaling pathway
sara04014  Ras signaling pathway
sara04015  Rap1 signaling pathway
sara04022  cGMP-PKG signaling pathway
sara04024  cAMP signaling pathway
sara04062  Chemokine signaling pathway
sara04066  HIF-1 signaling pathway
sara04068  FoxO signaling pathway
sara04071  Sphingolipid signaling pathway
sara04072  Phospholipase D signaling pathway
sara04140  Autophagy - animal
sara04150  mTOR signaling pathway
sara04151  PI3K-Akt signaling pathway
sara04152  AMPK signaling pathway
sara04210  Apoptosis
sara04211  Longevity regulating pathway
sara04213  Longevity regulating pathway - multiple species
sara04218  Cellular senescence
sara04261  Adrenergic signaling in cardiomyocytes
sara04370  VEGF signaling pathway
sara04371  Apelin signaling pathway
sara04380  Osteoclast differentiation
sara04510  Focal adhesion
sara04550  Signaling pathways regulating pluripotency of stem cells
sara04611  Platelet activation
sara04613  Neutrophil extracellular trap formation
sara04620  Toll-like receptor signaling pathway
sara04625  C-type lectin receptor signaling pathway
sara04630  JAK-STAT signaling pathway
sara04660  T cell receptor signaling pathway
sara04662  B cell receptor signaling pathway
sara04664  Fc epsilon RI signaling pathway
sara04666  Fc gamma R-mediated phagocytosis
sara04668  TNF signaling pathway
sara04722  Neurotrophin signaling pathway
sara04725  Cholinergic synapse
sara04728  Dopaminergic synapse
sara04810  Regulation of actin cytoskeleton
sara04910  Insulin signaling pathway
sara04914  Progesterone-mediated oocyte maturation
sara04915  Estrogen signaling pathway
sara04917  Prolactin signaling pathway
sara04919  Thyroid hormone signaling pathway
sara04920  Adipocytokine signaling pathway
sara04922  Glucagon signaling pathway
sara04923  Regulation of lipolysis in adipocytes
sara04926  Relaxin signaling pathway
sara04929  GnRH secretion
sara04931  Insulin resistance
sara04932  Non-alcoholic fatty liver disease
sara04933  AGE-RAGE signaling pathway in diabetic complications
sara04935  Growth hormone synthesis, secretion and action
sara04936  Alcoholic liver disease
sara04973  Carbohydrate digestion and absorption
sara05010  Alzheimer disease
sara05017  Spinocerebellar ataxia
sara05132  Salmonella infection
sara05135  Yersinia infection
sara05142  Chagas disease
sara05145  Toxoplasmosis
sara05152  Tuberculosis
sara05160  Hepatitis C
sara05161  Hepatitis B
sara05162  Measles
sara05163  Human cytomegalovirus infection
sara05164  Influenza A
sara05165  Human papillomavirus infection
sara05166  Human T-cell leukemia virus 1 infection
sara05167  Kaposi sarcoma-associated herpesvirus infection
sara05168  Herpes simplex virus 1 infection
sara05169  Epstein-Barr virus infection
sara05170  Human immunodeficiency virus 1 infection
sara05200  Pathways in cancer
sara05205  Proteoglycans in cancer
sara05207  Chemical carcinogenesis - receptor activation
sara05208  Chemical carcinogenesis - reactive oxygen species
sara05210  Colorectal cancer
sara05211  Renal cell carcinoma
sara05212  Pancreatic cancer
sara05213  Endometrial cancer
sara05214  Glioma
sara05215  Prostate cancer
sara05218  Melanoma
sara05220  Chronic myeloid leukemia
sara05221  Acute myeloid leukemia
sara05222  Small cell lung cancer
sara05223  Non-small cell lung cancer
sara05224  Breast cancer
sara05225  Hepatocellular carcinoma
sara05226  Gastric cancer
sara05230  Central carbon metabolism in cancer
sara05231  Choline metabolism in cancer
sara05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
sara05415  Diabetic cardiomyopathy
sara05417  Lipid and atherosclerosis
sara05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:sara00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101559009 (AKT2)
   04012 ErbB signaling pathway
    101559009 (AKT2)
   04014 Ras signaling pathway
    101559009 (AKT2)
   04015 Rap1 signaling pathway
    101559009 (AKT2)
   04370 VEGF signaling pathway
    101559009 (AKT2)
   04371 Apelin signaling pathway
    101559009 (AKT2)
   04630 JAK-STAT signaling pathway
    101559009 (AKT2)
   04668 TNF signaling pathway
    101559009 (AKT2)
   04066 HIF-1 signaling pathway
    101559009 (AKT2)
   04068 FoxO signaling pathway
    101559009 (AKT2)
   04072 Phospholipase D signaling pathway
    101559009 (AKT2)
   04071 Sphingolipid signaling pathway
    101559009 (AKT2)
   04024 cAMP signaling pathway
    101559009 (AKT2)
   04022 cGMP-PKG signaling pathway
    101559009 (AKT2)
   04151 PI3K-Akt signaling pathway
    101559009 (AKT2)
   04152 AMPK signaling pathway
    101559009 (AKT2)
   04150 mTOR signaling pathway
    101559009 (AKT2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101559009 (AKT2)
  09143 Cell growth and death
   04210 Apoptosis
    101559009 (AKT2)
   04218 Cellular senescence
    101559009 (AKT2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101559009 (AKT2)
   04550 Signaling pathways regulating pluripotency of stem cells
    101559009 (AKT2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101559009 (AKT2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101559009 (AKT2)
   04613 Neutrophil extracellular trap formation
    101559009 (AKT2)
   04620 Toll-like receptor signaling pathway
    101559009 (AKT2)
   04625 C-type lectin receptor signaling pathway
    101559009 (AKT2)
   04660 T cell receptor signaling pathway
    101559009 (AKT2)
   04662 B cell receptor signaling pathway
    101559009 (AKT2)
   04664 Fc epsilon RI signaling pathway
    101559009 (AKT2)
   04666 Fc gamma R-mediated phagocytosis
    101559009 (AKT2)
   04062 Chemokine signaling pathway
    101559009 (AKT2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101559009 (AKT2)
   04922 Glucagon signaling pathway
    101559009 (AKT2)
   04923 Regulation of lipolysis in adipocytes
    101559009 (AKT2)
   04920 Adipocytokine signaling pathway
    101559009 (AKT2)
   04929 GnRH secretion
    101559009 (AKT2)
   04915 Estrogen signaling pathway
    101559009 (AKT2)
   04914 Progesterone-mediated oocyte maturation
    101559009 (AKT2)
   04917 Prolactin signaling pathway
    101559009 (AKT2)
   04926 Relaxin signaling pathway
    101559009 (AKT2)
   04935 Growth hormone synthesis, secretion and action
    101559009 (AKT2)
   04919 Thyroid hormone signaling pathway
    101559009 (AKT2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101559009 (AKT2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101559009 (AKT2)
  09156 Nervous system
   04725 Cholinergic synapse
    101559009 (AKT2)
   04728 Dopaminergic synapse
    101559009 (AKT2)
   04722 Neurotrophin signaling pathway
    101559009 (AKT2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101559009 (AKT2)
  09149 Aging
   04211 Longevity regulating pathway
    101559009 (AKT2)
   04213 Longevity regulating pathway - multiple species
    101559009 (AKT2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101559009 (AKT2)
   05205 Proteoglycans in cancer
    101559009 (AKT2)
   05207 Chemical carcinogenesis - receptor activation
    101559009 (AKT2)
   05208 Chemical carcinogenesis - reactive oxygen species
    101559009 (AKT2)
   05230 Central carbon metabolism in cancer
    101559009 (AKT2)
   05231 Choline metabolism in cancer
    101559009 (AKT2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101559009 (AKT2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101559009 (AKT2)
   05212 Pancreatic cancer
    101559009 (AKT2)
   05225 Hepatocellular carcinoma
    101559009 (AKT2)
   05226 Gastric cancer
    101559009 (AKT2)
   05214 Glioma
    101559009 (AKT2)
   05221 Acute myeloid leukemia
    101559009 (AKT2)
   05220 Chronic myeloid leukemia
    101559009 (AKT2)
   05218 Melanoma
    101559009 (AKT2)
   05211 Renal cell carcinoma
    101559009 (AKT2)
   05215 Prostate cancer
    101559009 (AKT2)
   05213 Endometrial cancer
    101559009 (AKT2)
   05224 Breast cancer
    101559009 (AKT2)
   05222 Small cell lung cancer
    101559009 (AKT2)
   05223 Non-small cell lung cancer
    101559009 (AKT2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101559009 (AKT2)
   05170 Human immunodeficiency virus 1 infection
    101559009 (AKT2)
   05161 Hepatitis B
    101559009 (AKT2)
   05160 Hepatitis C
    101559009 (AKT2)
   05164 Influenza A
    101559009 (AKT2)
   05162 Measles
    101559009 (AKT2)
   05168 Herpes simplex virus 1 infection
    101559009 (AKT2)
   05163 Human cytomegalovirus infection
    101559009 (AKT2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101559009 (AKT2)
   05169 Epstein-Barr virus infection
    101559009 (AKT2)
   05165 Human papillomavirus infection
    101559009 (AKT2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101559009 (AKT2)
   05135 Yersinia infection
    101559009 (AKT2)
   05152 Tuberculosis
    101559009 (AKT2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    101559009 (AKT2)
   05142 Chagas disease
    101559009 (AKT2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101559009 (AKT2)
   05017 Spinocerebellar ataxia
    101559009 (AKT2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101559009 (AKT2)
   05418 Fluid shear stress and atherosclerosis
    101559009 (AKT2)
   05415 Diabetic cardiomyopathy
    101559009 (AKT2)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    101559009 (AKT2)
   04932 Non-alcoholic fatty liver disease
    101559009 (AKT2)
   04931 Insulin resistance
    101559009 (AKT2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101559009 (AKT2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101559009 (AKT2)
   01524 Platinum drug resistance
    101559009 (AKT2)
   01522 Endocrine resistance
    101559009 (AKT2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:sara01001]
    101559009 (AKT2)
Enzymes [BR:sara01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     101559009 (AKT2)
Protein kinases [BR:sara01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   101559009 (AKT2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 PH_11 ABC1 Seadorna_VP7
Other DBs
NCBI-GeneID: 101559009
NCBI-ProteinID: XP_004620799
LinkDB
Position
Unknown
AA seq 481 aa
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRSPGEDPM
DYKCGSPSDSSAAEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMLCGRLPFYNQDHERLFE
LILMEDIRFPRTLSPDAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSVNWQDVVQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGSLELDQRTHFPQFSYSASIR
E
NT seq 1446 nt   +upstreamnt  +downstreamnt
atgaatgaggtgtccgtcatcaaagaaggttggctccataagcgcggtgaatacatcaag
acttggaggccccggtacttcctgctgaagagtgacggctccttcattggctataaggag
cggccggaggcccctgaccagaccttacccccactaaacaacttctccgttgcagaatgc
cagctgatgaagaccgagaggcctcggcccaacacctttgtcatccgctgcctgcagtgg
accacggtcatcgagaggaccttccacgtagactctccagacgagagggaggagtggatg
cgggccatccagatggtcgccaacagccttaagcagcggagccccggggaggaccccatg
gactacaagtgcggctcccctagtgactcttcggctgctgaggaaatggaggtggcagtg
agcaaggcacgggccaaagtgaccatgaatgactttgactatctcaagctcctgggcaag
ggcacctttggcaaagtcatcctggtgcgggagaaggccaccggccgctactatgccatg
aagatcctgcggaaggaggtgatcatcgccaaggatgaagtcgcccacacagtgacggag
agccgagtcctccagaacaccaggcacccgttcctcaccgcgctgaagtacgccttccag
acccacgaccgtctgtgcttcgtgatggagtatgccaacggcggcgagctgtttttccac
ttgtcccgggagcgcgtgttcacggaggagcgggctcgcttctacggtgctgagatcgtc
tcggccctggagtacctgcactcgcgggacgtggtataccgggacatcaagctggagaac
ctcatgctggacaaagacgggcacatcaagatcacggacttcgggctgtgcaaggagggc
atcagcgatggggccaccatgaagaccttctgcgggacccccgagtacctggcccctgag
gtgctggaggacaacgactacggccgggcagtggactggtgggggctgggcgtggtcatg
tacgagatgctgtgtggccgcctgcccttctacaaccaggaccacgagcgcctcttcgag
ctcatccttatggaggacatccgcttcccccgcacactcagccccgatgccaagtccctg
ctggccgggctgctgaagaaggaccccaagcagaggcttggtgggggccccagtgacgcc
aaggaggtgatggagcacaggttcttcctcagtgtcaactggcaggacgtggtccagaag
aagctcctgccacccttcaagcctcaggtcacttctgaggtggacaccaggtactttgac
gacgagttcaccgcccagtccatcacaatcacccccccggaccgctatgacagtctcggc
tcgctggagctggaccagcggacgcacttcccccagttctcctactcggccagcatccgc
gagtga

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