Streptomyces argyrophylli: HKX69_25510
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Entry
HKX69_25510 CDS
T09378
Name
(GenBank) UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
sarg
Streptomyces argyrophylli
Pathway
sarg00300
Lysine biosynthesis
sarg00550
Peptidoglycan biosynthesis
sarg01100
Metabolic pathways
sarg01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
sarg00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
HKX69_25510
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
HKX69_25510
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
HKX69_25510
Enzymes [BR:
sarg01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
HKX69_25510
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
DUF561
DUF2126
Motif
Other DBs
NCBI-ProteinID:
QJS12427
UniProt:
A0A6M4PP46
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All DBs
Position
5693881..5695296
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AA seq
471 aa
AA seq
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MIALSLAEIAAVVGGQTHDIPDPSVQVTGPVVRDSREVVPGSLFAAFVGERVDGHDYARA
VTEAGAVAVLASRPVGVPAIVVEDVQTALGALARHVVRRLGATLVALTGSAGKTSTKDLI
AQVLRRKAPTVFTPGSLNNEIGLPLTALSATEETRFLVLEMGARGIGHIRYLTGLTPPRI
GLVLNVGSAHIGEFGGREQIAQAKGELVEALPPAEEGGVAVLNADDPLVRAMASRTKAKV
VLFGESAEADVRAENVRLTDSGQPSFRLHTPSGASDLTMRLYGEHHVSNALAAAAVAHEL
GMSAEEIATALSEAGSLSRWRMEVTERPDGVTIVNDAYNANPESMRAALRALAAMGKGRR
TWAVLGKMAELGDEALAEHDAVGRLAVRLNVSKLVAVGGIEASWLQLGAYNEGSWGEESV
HVSDAQAAIDLLRSELRPGDVVLVKASRSVGLESVAQALVETGAEGEVAAR
NT seq
1416 nt
NT seq
+upstream
nt +downstream
nt
gtgatcgccctctccctcgccgagatcgcagcagtcgtcggcgggcagacgcacgacata
ccggatccgtccgtacaggtcacgggaccggtcgtccgggactcccgcgaggtggtgccc
ggcagcctgttcgccgccttcgtcggcgagcgcgtggacggccacgactacgcccgcgcg
gtgaccgaggccggcgcggtcgccgtgctggcctcccgcccggtcggcgttcccgcgatc
gtcgtcgaggacgtccagacggccctcggcgccctcgcccggcacgtcgtacgccggctc
ggcgcgaccctcgtcgccctgaccggctcggccggcaagaccagcaccaaggacctcatc
gcccaggtgctccggcgcaaggcgccgacggtgttcacgccgggctcgctcaacaacgag
atcgggctgccgctgaccgccctgtccgccaccgaggaaacccgcttcctcgtactggag
atgggcgcccggggcatcgggcacatccgctacctcaccggcctcaccccgccgaggatc
ggcctggtgctcaacgtcggcagcgcccacatcggcgagttcggcggacgtgagcagatc
gcccaggccaagggcgaactcgtggaggcgcttcccccggccgaggagggcggcgtcgcg
gtcctcaacgccgacgacccgctggtgcgcgccatggcctcccgtaccaaggcgaaggtg
gtccttttcggagagtcggccgaagcggacgtacgggccgagaacgtacgactcacggac
agcggacagccctccttcaggcttcacacaccctccggtgcaagtgatctgacgatgcgc
ctgtacggtgagcaccacgtgtcgaacgcgctcgccgcggccgccgtcgcccatgagctg
ggcatgtccgcggaagagatcgccaccgcgctctccgaggcgggctccctctcccgctgg
cgcatggaggtcaccgagcgcccggacggcgtgaccatcgtcaacgacgcctacaacgcc
aaccccgagtccatgcgggccgccctcagggcgctcgcggccatgggcaaggggcgccgc
acgtgggcggtgctcggcaagatggccgagctgggggacgaggcgctcgccgagcacgac
gccgtcggacggctcgccgtccggctcaacgtcagcaagctcgtcgccgtcggggggatt
gaggcctcctggctgcaattgggcgcatataacgagggttcgtggggtgaggagtcggtg
cacgtgtccgacgcacaggcggcgatcgacctgctgcgcagcgagttgcgcccgggggac
gtcgtgctcgtgaaggcgtcccgttcggtgggtctggagagcgtcgcccaggcgctcgtc
gagaccggtgccgagggtgaggttgccgcccgatga
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