Streptomyces calvus: CD934_22230
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Entry
CD934_22230 CDS
T06819
Name
(GenBank) dihydrofolate synthase
KO
K11754
dihydrofolate synthase / folylpolyglutamate synthase [EC:
6.3.2.12
6.3.2.17
]
Organism
sast
Streptomyces calvus
Pathway
sast00790
Folate biosynthesis
sast01100
Metabolic pathways
sast01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
sast00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
CD934_22230
Enzymes [BR:
sast01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.12 dihydrofolate synthase
CD934_22230
6.3.2.17 tetrahydrofolate synthase
CD934_22230
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_C
Mur_ligase_M
Motif
Other DBs
NCBI-ProteinID:
QDI71096
UniProt:
A0A514JUM5
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Position
5170810..5172330
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AA seq
506 aa
AA seq
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MSERPESAGPDPDDTFDEFAELVEEETRRDPDLAVIEAGSRTLRTQGGPPQADVPARPED
PEVDKALREVEAELATRWGETKLEPSVSRIAALMDVLGEPQRSYPAIHITGTNGKTSTAR
MIEALLGAFELRTGRYTSPHVQSITERISLDGAPIGAERFIETYRDIAPYVEMVDAQQEY
RLSFFEVLTGMAYAAFADAPVDVAVVEVGMGGSWDATNVIDGSVAVVTPIDLDHTDRLGS
TPGEIAGEKAGIIKRDATVIMAQQPVDAAQVLLKKAVEVDATVAREGLEFGVVARQVAVG
GQLVTLRGLGGEYEEVFLPLHGAHQAHNAAVALAAVEAFFGVGAQRAERLDIDTVRKAFA
AVASPGRLEVVRRSPTVVLDAAHNPAGARAAAEAIGEAFQFSRLVGVVGASGDKNVRGLL
EAFEPVFAEVVVTQNSSHRAMDADELAAIAVEVFGEDRVQVEPRLPDALEAAITLAEEEG
EFAGGGVLVTGSVITVGEARLLLGKG
NT seq
1521 nt
NT seq
+upstream
nt +downstream
nt
gtgagcgagcgcccagaatcagcaggtcccgacccggacgacaccttcgacgagttcgcc
gagctcgtcgaggaggagacccgccgcgaccccgacctcgccgtgatcgaggccggcagc
cgcaccctgcgcacgcagggcggcccgccgcaggccgacgtgcccgcacggccggaggac
cccgaggtcgacaaggccctgcgcgaggtcgaggcggagctcgcgacccgctggggcgag
accaagctggagccgtcggtcagccgcatcgccgcgctgatggacgtgctgggcgagccg
cagcggtcgtaccccgccatccacatcaccggcaccaacggcaagacctccaccgcccgc
atgatcgaggcgctgctcggtgccttcgagctgcgcaccggccggtacacctccccgcac
gtccagtcgatcaccgagcggatcagcctcgacggggcgccgatcggtgccgagcggttc
atcgagacgtaccgggacatcgcgccgtacgtcgagatggtcgacgcgcagcaggagtac
cggctgtccttcttcgaggtgctcaccggcatggcgtacgcggccttcgccgacgccccc
gtggacgtggccgtcgtcgaggtcggcatgggcggcagttgggacgcgaccaatgtgatc
gacgggagcgtcgccgtggtgacgcccatcgacctcgaccacaccgaccggctcggcagc
acgcccggcgagatcgccggtgagaaggccggcatcatcaagcgggacgccaccgtgatc
atggcgcagcagccggtggacgcggcgcaggtgctgctgaagaaggccgtcgaggtggac
gccaccgtggcccgggagggcctggagttcggtgtggttgcccggcaggtcgccgtcggc
ggccagctggtgacgctgcgcgggctcggcggcgagtacgaggaggtgttcctcccgctg
cacggcgcccaccaggcgcacaacgcggccgtggcgctcgccgccgtggaggcgttcttc
ggcgtcggcgcccagcgcgccgaacggctcgacatcgacaccgtgcgcaaggcgttcgcc
gccgtcgcctccccgggccggctggaggtcgtgcgccgctcgccgaccgtcgtcctggac
gccgcccacaacccggcgggcgcccgggccgcggccgaggcgatcggtgaggcgttccag
ttcagccggctcgtcggtgtcgtcggcgcgagcggcgacaagaacgtgcgcgggctgctg
gaggcgttcgagccggtcttcgccgaggtcgtcgtcacgcagaactccagccaccgcgcg
atggacgccgacgaactggcggcgatcgccgtcgaggtgttcggcgaggaccgcgtgcag
gtcgagccgcggctgccggacgcgctggaggccgcgatcacgctggccgaggaggagggc
gagttcgccggcggcggcgtgctcgtcaccggttccgtcatcaccgtcggcgaggcccga
ctgcttctggggaagggctga
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