KEGG   Saimiri boliviensis boliviensis (Bolivian squirrel monkey): 101040361
Entry
101040361         CDS       T04350                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
sbq  Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Pathway
sbq01521  EGFR tyrosine kinase inhibitor resistance
sbq01522  Endocrine resistance
sbq04010  MAPK signaling pathway
sbq04012  ErbB signaling pathway
sbq04014  Ras signaling pathway
sbq04015  Rap1 signaling pathway
sbq04022  cGMP-PKG signaling pathway
sbq04024  cAMP signaling pathway
sbq04062  Chemokine signaling pathway
sbq04066  HIF-1 signaling pathway
sbq04068  FoxO signaling pathway
sbq04071  Sphingolipid signaling pathway
sbq04072  Phospholipase D signaling pathway
sbq04114  Oocyte meiosis
sbq04140  Autophagy - animal
sbq04148  Efferocytosis
sbq04150  mTOR signaling pathway
sbq04151  PI3K-Akt signaling pathway
sbq04210  Apoptosis
sbq04218  Cellular senescence
sbq04270  Vascular smooth muscle contraction
sbq04370  VEGF signaling pathway
sbq04371  Apelin signaling pathway
sbq04380  Osteoclast differentiation
sbq04510  Focal adhesion
sbq04517  IgSF CAM signaling
sbq04540  Gap junction
sbq04550  Signaling pathways regulating pluripotency of stem cells
sbq04613  Neutrophil extracellular trap formation
sbq04620  Toll-like receptor signaling pathway
sbq04650  Natural killer cell mediated cytotoxicity
sbq04660  T cell receptor signaling pathway
sbq04662  B cell receptor signaling pathway
sbq04664  Fc epsilon RI signaling pathway
sbq04666  Fc gamma R-mediated phagocytosis
sbq04668  TNF signaling pathway
sbq04720  Long-term potentiation
sbq04722  Neurotrophin signaling pathway
sbq04725  Cholinergic synapse
sbq04726  Serotonergic synapse
sbq04730  Long-term depression
sbq04810  Regulation of actin cytoskeleton
sbq04910  Insulin signaling pathway
sbq04912  GnRH signaling pathway
sbq04914  Progesterone-mediated oocyte maturation
sbq04915  Estrogen signaling pathway
sbq04916  Melanogenesis
sbq04917  Prolactin signaling pathway
sbq04919  Thyroid hormone signaling pathway
sbq04921  Oxytocin signaling pathway
sbq04926  Relaxin signaling pathway
sbq04928  Parathyroid hormone synthesis, secretion and action
sbq04929  GnRH secretion
sbq04934  Cushing syndrome
sbq04935  Growth hormone synthesis, secretion and action
sbq05010  Alzheimer disease
sbq05022  Pathways of neurodegeneration - multiple diseases
sbq05034  Alcoholism
sbq05132  Salmonella infection
sbq05135  Yersinia infection
sbq05160  Hepatitis C
sbq05161  Hepatitis B
sbq05163  Human cytomegalovirus infection
sbq05164  Influenza A
sbq05165  Human papillomavirus infection
sbq05166  Human T-cell leukemia virus 1 infection
sbq05167  Kaposi sarcoma-associated herpesvirus infection
sbq05170  Human immunodeficiency virus 1 infection
sbq05200  Pathways in cancer
sbq05205  Proteoglycans in cancer
sbq05206  MicroRNAs in cancer
sbq05207  Chemical carcinogenesis - receptor activation
sbq05208  Chemical carcinogenesis - reactive oxygen species
sbq05210  Colorectal cancer
sbq05211  Renal cell carcinoma
sbq05212  Pancreatic cancer
sbq05213  Endometrial cancer
sbq05214  Glioma
sbq05215  Prostate cancer
sbq05216  Thyroid cancer
sbq05218  Melanoma
sbq05219  Bladder cancer
sbq05220  Chronic myeloid leukemia
sbq05221  Acute myeloid leukemia
sbq05223  Non-small cell lung cancer
sbq05224  Breast cancer
sbq05225  Hepatocellular carcinoma
sbq05226  Gastric cancer
sbq05230  Central carbon metabolism in cancer
sbq05231  Choline metabolism in cancer
sbq05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:sbq00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101040361 (MAP2K1)
   04012 ErbB signaling pathway
    101040361 (MAP2K1)
   04014 Ras signaling pathway
    101040361 (MAP2K1)
   04015 Rap1 signaling pathway
    101040361 (MAP2K1)
   04370 VEGF signaling pathway
    101040361 (MAP2K1)
   04371 Apelin signaling pathway
    101040361 (MAP2K1)
   04668 TNF signaling pathway
    101040361 (MAP2K1)
   04066 HIF-1 signaling pathway
    101040361 (MAP2K1)
   04068 FoxO signaling pathway
    101040361 (MAP2K1)
   04072 Phospholipase D signaling pathway
    101040361 (MAP2K1)
   04071 Sphingolipid signaling pathway
    101040361 (MAP2K1)
   04024 cAMP signaling pathway
    101040361 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    101040361 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    101040361 (MAP2K1)
   04150 mTOR signaling pathway
    101040361 (MAP2K1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    101040361 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101040361 (MAP2K1)
   04148 Efferocytosis
    101040361 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    101040361 (MAP2K1)
   04210 Apoptosis
    101040361 (MAP2K1)
   04218 Cellular senescence
    101040361 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101040361 (MAP2K1)
   04540 Gap junction
    101040361 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    101040361 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101040361 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    101040361 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    101040361 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    101040361 (MAP2K1)
   04660 T cell receptor signaling pathway
    101040361 (MAP2K1)
   04662 B cell receptor signaling pathway
    101040361 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    101040361 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    101040361 (MAP2K1)
   04062 Chemokine signaling pathway
    101040361 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101040361 (MAP2K1)
   04929 GnRH secretion
    101040361 (MAP2K1)
   04912 GnRH signaling pathway
    101040361 (MAP2K1)
   04915 Estrogen signaling pathway
    101040361 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    101040361 (MAP2K1)
   04917 Prolactin signaling pathway
    101040361 (MAP2K1)
   04921 Oxytocin signaling pathway
    101040361 (MAP2K1)
   04926 Relaxin signaling pathway
    101040361 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    101040361 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    101040361 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    101040361 (MAP2K1)
   04916 Melanogenesis
    101040361 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    101040361 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    101040361 (MAP2K1)
   04726 Serotonergic synapse
    101040361 (MAP2K1)
   04720 Long-term potentiation
    101040361 (MAP2K1)
   04730 Long-term depression
    101040361 (MAP2K1)
   04722 Neurotrophin signaling pathway
    101040361 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101040361 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101040361 (MAP2K1)
   05206 MicroRNAs in cancer
    101040361 (MAP2K1)
   05205 Proteoglycans in cancer
    101040361 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    101040361 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    101040361 (MAP2K1)
   05230 Central carbon metabolism in cancer
    101040361 (MAP2K1)
   05231 Choline metabolism in cancer
    101040361 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101040361 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101040361 (MAP2K1)
   05212 Pancreatic cancer
    101040361 (MAP2K1)
   05225 Hepatocellular carcinoma
    101040361 (MAP2K1)
   05226 Gastric cancer
    101040361 (MAP2K1)
   05214 Glioma
    101040361 (MAP2K1)
   05216 Thyroid cancer
    101040361 (MAP2K1)
   05221 Acute myeloid leukemia
    101040361 (MAP2K1)
   05220 Chronic myeloid leukemia
    101040361 (MAP2K1)
   05218 Melanoma
    101040361 (MAP2K1)
   05211 Renal cell carcinoma
    101040361 (MAP2K1)
   05219 Bladder cancer
    101040361 (MAP2K1)
   05215 Prostate cancer
    101040361 (MAP2K1)
   05213 Endometrial cancer
    101040361 (MAP2K1)
   05224 Breast cancer
    101040361 (MAP2K1)
   05223 Non-small cell lung cancer
    101040361 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101040361 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    101040361 (MAP2K1)
   05161 Hepatitis B
    101040361 (MAP2K1)
   05160 Hepatitis C
    101040361 (MAP2K1)
   05164 Influenza A
    101040361 (MAP2K1)
   05163 Human cytomegalovirus infection
    101040361 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101040361 (MAP2K1)
   05165 Human papillomavirus infection
    101040361 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101040361 (MAP2K1)
   05135 Yersinia infection
    101040361 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101040361 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    101040361 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    101040361 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    101040361 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101040361 (MAP2K1)
   01522 Endocrine resistance
    101040361 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:sbq01001]
    101040361 (MAP2K1)
Enzymes [BR:sbq01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     101040361 (MAP2K1)
Protein kinases [BR:sbq01001]
 Serine/threonine kinases: STE group
  STE7 family
   101040361 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 101040361
NCBI-ProteinID: XP_003929750
UniProt: A0A2K6SZ10
LinkDB
Position
Unknown
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctccgcggtt
aacgggaccagctctgcggagaccaacctggaggccttgcaaaagaagctggaggagcta
gagcttgacgagcagcagcgaaagcgccttgaggcctttcttacccagaagcagaaggtg
ggagaactgaaggatgatgactttgagaagatcagtgagctgggggctggcaatggtggt
gtggtgttcaaggtctcccacaagccttctggcctggtcatggctagaaagctaattcat
ctggagatcaaacctgcaatccggaaccagatcataagggagctgcaggttctgcatgag
tgcaactctccgtacatcgtgggcttctacggtgcattctacagcgatggcgagatcagt
atctgcatggagcacatggatgggggttccctggatcaagttctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaattaagggcctgacatatctg
cgggagaagcacaagatcatgcacagagatgtcaagccctccaacatcctagtcaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tctgtgcagtcggacatctggagcatgggactctctctggtagagatggcggttgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcagctgagaccccacccaggccaaggacccctgggaggccccttagctcatat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaatgag
cctcctccaaaactgcccagtggagtattcagcctggaatttcaagattttgtgaataaa
tgcttaattaaaaacccggcagagagagcagatttgaaacaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccattggc
cttaaccagcccagcacaccaacccatgctgctggcgtctaa

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