Streptomyces broussonetiae: GQF42_25120
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Entry
GQF42_25120 CDS
T07359
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
sbro
Streptomyces broussonetiae
Pathway
sbro00860
Porphyrin metabolism
sbro01100
Metabolic pathways
sbro01110
Biosynthesis of secondary metabolites
sbro01120
Microbial metabolism in diverse environments
sbro01240
Biosynthesis of cofactors
Module
sbro_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
sbro_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
sbro00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
GQF42_25120
Enzymes [BR:
sbro01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
GQF42_25120
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
GQF42_25120
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Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
QHA06131
UniProt:
A0A6I6N6R2
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Position
5417565..5419274
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AA seq
569 aa
AA seq
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MSPTTLPAGLEHGHVTFLGAGPGDPGLLTLRAVEALSHADVLIAEHEVLDVIRTHARQGV
SVVWTDADPSSVSPPGTGTPQLTVVDGTSTTAAVPSPARDAAHLVMEAARSGRRVVRAVS
GDPGLDTYAAEEMLACAAAGVPFEVVPGVAAAVGVPAYAGVPLRDAQGADVRFVDARTAS
DRCWTEVGASDGTVVVSTTLDSVAAAAGELVSAGRKPDTPLTVTVAGTTTRQRTWTATLG
TIAQTLKQAKVLPSPDGGRPVIAVVGERSAAAQRDQLSWFESKPLFGWKVLVPRTKEQAA
SLSDQLRSYGAVPHEVPTIAVEPPRTPQQMERAVKGLVTGRYEWIAFTSVNAVKAVREKF
EEYGLDARAFAGIKVAAVGEQTARALVAFGVKPDLVPSGEQSAAGLLEDWPPYDPVFDPI
DRVFLPRADIATETLVAGLIELGWEVDDVTAYRTVRASPPPADTREAIKGGGFDAVLFTS
SSTVRNLVGIAGKPHNVTVIACIGPATAKTAEEHGLRVDVMAPEPSVHKLAEALADFGLK
RRAAALEAGDPVTRPSERRPGARRRRSTT
NT seq
1710 nt
NT seq
+upstream
nt +downstream
nt
gtgagccccaccacccttcccgccggcctcgaacacgggcacgtcaccttcctcggtgcc
ggacccggggatccgggactgctgactctgcgcgccgtggaggcgctgtcgcacgcggac
gtcctgatcgccgagcacgaggtgctcgacgtgatccggacgcacgcgcggcagggcgtc
tccgtcgtgtggacggacgccgacccctcctcggtgtcgccaccgggcacgggcacaccg
cagctcacggtcgttgacggcacgtcaacaaccgccgctgtcccgtcccctgcccgggat
gccgctcatcttgtcatggaggccgcgcgctccggcaggcgggtcgtccgtgcggtgtcc
ggggacccgggacttgatacgtacgcggccgaggaaatgctcgcctgcgccgccgccggt
gtgcccttcgaggtcgtgccgggtgtggcggccgcggtcggcgtgccggcgtacgccggt
gtgccgctgcgcgacgcgcagggcgcggacgtccggttcgtggacgcccggaccgcctcc
gaccgctgctggacggaggtgggtgcctccgacggcacggtggtcgtctccacgaccctc
gactcggtggccgcggcggccggcgaactggtctccgccggccgcaagccggacaccccg
ctgacggtcaccgtcgccggtacgacgacccgccagcgcacctggaccgccaccctcggc
acgatcgcgcagacgctgaagcaggcgaaggtgctgccgtcgccggacggcggccggccg
gtgatagccgtggtcggtgagcgttccgccgccgcccagcgcgaccagttgtcgtggttc
gagtccaagccgctgttcggctggaaggtgctcgtgccgcgcacgaaggagcaggcggct
tcgctctccgaccagctgcggtcctacggcgcggtgccgcacgaggtcccgacgatcgcg
gtggaaccgccgcgcaccccgcagcagatggagcgggcggtcaagggcctggtgacgggc
cgctacgagtggatcgcgttcacgtcggtcaacgcggtgaaggcggtccgggagaagttc
gaggagtacggcctcgacgcgcgtgccttcgcgggcatcaaggtggccgcggtgggcgag
cagaccgccagggcgctggtcgccttcggtgtgaagccggacctggtgccgagcggtgag
cagtcggccgccggtctgctggaggactggccgccgtacgacccggtcttcgacccgatc
gaccgcgtcttcctgccgcgggccgacatcgccacggagaccctggtcgccgggctgatc
gagctgggctgggaggtcgacgacgtcacggcctaccggaccgtgcgggcctcgccgccg
ccggcggacacacgggaggcgatcaagggcggcggcttcgacgccgtgctcttcacgtcc
tcgtccaccgtgcggaacctggtgggcatcgcgggcaagccgcacaacgtgacggtgatc
gcctgcatcggcccggcgaccgccaagaccgccgaggagcacgggctgcgggtcgacgtc
atggctccggagccgtcggtgcacaagctggcggaggcgctggccgacttcggcctcaag
cggcgcgctgccgcgctggaggccggggacccggtgacgcggcccagcgagcggcggccg
ggggcgcgcaggcgccggtccacgacgtga
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