Serinus canaria (common canary): 103818574 Help Entry 103818574         CDS       T05755                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism scan  Serinus canaria (common canary) Pathway scan04020   Calcium signaling pathway scan04260   Cardiac muscle contraction scan04261   Adrenergic signaling in cardiomyocytes scan04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:scan00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     103818574 (RYR2)    04020 Calcium signaling pathway     103818574 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     103818574 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     103818574 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:scan04040]     103818574 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:scan04990]     103818574 (RYR2) Ion channels [BR:scan04040]  Voltage-gated cation channels   Ryanodine receptor    103818574 (RYR2) Domain-containing proteins not elsewhere classified [BR:scan04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    103818574 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  103818574 NCBI-ProteinID:  XP_030092321 LinkDB All DBs Position Unknown AA seq 4948 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGKFMMKSAQGGGHRTLLYGHAILLRHSYSG MYLCCLSTSRSSMDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVS SERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEVAQGYLIGGDVLRLLHGHMDECLTV PSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHITTGKYLS LLDDKSLLLTDKEKADVKSTAFCFRSSKEKLDIGTRKEVDGMGAPEIKYGDSICFIQHVD TGLWLTYQSADAKSVRMGSLQRKAIMHHEGHMDDGLTLSRSQNEESRTARVIRSTVFLFN RFIRGLDSLSKKVKSSTIDLPIESVSLSLQDLIGYFHPPDEHLEHENKQNRLRALKNRQN LFQEEGMINLVLECIDRLNVYSSAAHFADVAGKEAGEAWKSILNSLYELLAALIRGNRKN CAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICLLDKHGRN HKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGISEGS AQYRKWYYELMVDHLEPFVTAESTHLRVGWASTEGYSPYPGGGAEWGGNGVGDDLYSYGF DGLHLWSGCVARSVNSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGL FFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCFEAVLPKEKLKVENSREYKQDRSYT RDLLGPTVSLSQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPV RDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADERAEEKVKKMKLP KNYQLLSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNR RNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHATRLDVCSGIMEKFRI FRTEKTYAVKAGKWYFEFEAVTAGDMRVGWTRPGCLPDQELGSDEEAFVFDGFKAQRWHQ GNEHFGRSWLAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFEVADGFLPVCSL GPSQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITIWLSKRLPQFLPVPQNHEH IEVMRIDGTIDSCPCLKVTQKSFGSQNSKTDVMFFRLSMPIECAEVFSRSAAGGLPGSGL FGPKNDLEDYDADSDFEVLMKTAHGHLVPDRTEREKDATKPELNNHKDYVQEKPSRLKQR FMLRRTKPDYSMSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPANVWVGWIT SDFHQYDTSFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESLSPGQGRNNNGLEI GCLVDAASGLLTFTANGKELGTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLS AGLFKSEHKNPVSQCPPRLHVQFLTHVLWSRVPNHFLKVDVSRISERQGWMIQCLNPLQF MALHIPEENRTIDILELTEQEELLKFHYHTLRLYSAVCALGNNRVAHALCSHVDESQLLY AIENKYMPGLLRAGYYDLLIDIHLNTYATARLMMNNEFIVPMTDETKSITLFPDENKKHG LPGIGLSTSLRPRMQFSSPSFVSISSECFQFSPEFPLEILKAKTIEMLTEAVQEGSLHVR DPVGGSTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPRVFKEAMSQEDEIDFSEKE FSSDELKSEEEEETRGEQMPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRIEAIVAFS DDFVAKLQENQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKNDCPCP EEIRDQLLDFHEDLMTHCGIELDEDGTLDGNSDSTIRGRLLYLMEKVTYLKKKQDEKTVD EEDKTSSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTIN SVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHE TVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGL ASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPLLICKGYPDIG WNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEE AIQISEDRTRDGPSPSNGSSKTLEIEEQEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLI HAGKGEAIRIRSILRSLIPLEDLVGVISIAFHMPTIAKDGTVVEPDMSAGFCPDHKAAMV LFLDRVYGIEDQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLT RCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEECLLSICGQLRPSMMQHLL RRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPSGWGNFGAASEEELHLSRKLFWGIF DALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVNMMEKQSSMDSDGNFNPQPVDTS NITIPEKLEYFINKYAEHAHDKWSMEKFANGWTYGETFSESAKVQPLMKQYKLLSEKEKE IYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQISVDTAHGYTPRAIDMS NVTLSRDLHAMAEMMAENYHNIWAKKKKLELEAKVGGGNHPLLVPYDTLTAKEKAKDREK AQDILKFLQINGYVVSRGLKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSR GKGEQFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSSASRPLSSGGHASNKEKEMVTSLF CKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVRMALRAFLDNAAEDL EKTMENLKQGQFTHSRNQPKGVTQIINYTTVALLPVLSSLFEHIGQHQFGEDLILEDVQV SCYRILASLYALGTSKSIYVERQRSALGECLAAFSGAFPVAFLETHLNKHNIYSIYNTKN ARDRAVLNLPTSVEEVCPNIPSLMKLMEEIVELAESGIRYTQMPHIMEVILPMLCSYMSH WWEHGPENNPDKAEMCCTALTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIIS KAKPQLLKTHFLPLMDKLKKKAAVVVSDEEHLRAEGRGDMSEAELLILDEFTTLARDLYA FYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNM SFLISDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQEL IALAKNRFSMKDTEDEVRDVIRSNLHLQGKLEDPAIRWQMALYKDLPNRTDDSSDPEKTV ERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLF LQGYDKSWIETEEHYFEDKLIEDLAKPGEEPPEEDESLKRVDPLHQLILLFSRTALTEKC KLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMV LQTISASKGEMGPMVAATLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSC SVLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRT QTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTL TEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVV MLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGK GIISKRDFHRAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAV LLTNLSEHMPHDTRLQTFLELSESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQW EKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKEE NEKDNPEEEDPRMGFFSLVTMKSALVALKYNLMTLMKMLSMKSLKKQMKKVKKMTMKDMV MALFSSYWSILVGLLHFACSVVRGFFRIICSLLLGGSLVEGAKKIKVAELLANMPDPTQD EVRGEEEEGERKPTEAALPAEDLTDLQTLTEESDLLSDIFGLDLKREGGQYKLIPHNPNA GLSDLLSTPSLAPMPEVQEKIQEKVKEDEKEEKEETKSEPEKAEGEDGEKEEKTKEDKGK QKLRQMHTHRYGEPEVQESVFWKNIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLF YKVSTSAVTEEKELPLVSDGESNKLNILESDDERVIAVHYVLEESSGYMEPTLRILAILH TVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQS FPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSFSAVLN SIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSS VTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDMPDMKCDDMLTCYMFHMYV GVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQ VKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESY VWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14847 nt NT seq  +upstreamnt  +downstreamnt atggccgaggggggcgagggcgaggacgagatccagttcctgcgaactgatgatgaagtg gttttgcagtgcactgcaactgttcacaaggagcaacagaaactgtgtcttgctgcagaa ggatttggcaacaggctttgctttttggaatccacatctaattctaagaatgttccacct gatttgtccatctgcacctttgtgctggagcagtctctgtcagtacgggccctccaggaa atgctggctaacacagaagaaaaggcagaagggaaatttatgatgaagtctgcacaaggt ggtggacatcgaacactgctctacgggcatgcaatcttgctgcgccattcctacagcggc atgtacctatgctgtctctctacatctcgatcgtcaatggataagctggcatttgatgta ggattgcaagaagacacaacaggtgaggcttgctggtggaccatacatcctgcctccaaa caacgatcagaaggagaaaaagtgcgcgttggagatgatctgattttagtcagtgtctct tcagaaaggtatttgcatctctcttatggcaatggtagcctacatgttgatgcagccttc cagcagacgctttggagtgtagcaccaatcagttcaggaagtgaagtagcccaaggatat ctgataggaggggatgttctgaggttattgcacggtcacatggatgaatgtttgacagtg ccttcgggtgaacatggagaagagcaaagaagaactgtccattatgaaggcggtgctgtg tccattcatgctcgttccctttggcgactagagactctaagagttgcgtggagtggaagc cacattagatggggacagccattccggctaagacatataacaacaggaaaatatttaagc ctcctggatgacaagagtcttcttcttacagacaaagagaaggcagatgtaaaatctaca gcattctgttttcggtcttccaaggaaaagttggacattgggacaagaaaggaggtggat ggaatgggagcacctgaaataaagtatggggattcaatatgcttcatacaacatgtagat acaggcttgtggctcacgtatcagtctgctgatgcaaagtctgtaaggatgggttctctg cagcggaaggcaataatgcaccatgaagggcacatggatgatggtttaacactgtccaga tctcagaatgaagaatcccgaacagcacgtgtcatccgtagtacagtcttccttttcaac aggttcataaggggccttgattctctcagcaagaaagtgaagtcttccaccattgatttg ccaatcgagtcagtcagtctgagccttcaggacttgattggctactttcacccccctgat gaacatttggagcatgaaaacaaacaaaacaggctccgagcactgaagaatcgccagaac ctcttccaagaagagggtatgatcaaccttgttcttgaatgtattgatcgcttgaatgta tacagcagtgcagctcactttgcagatgtagctgggaaggaggctggagaagcatggaaa tctattctaaattctttgtatgaattactagcggctctgattcgaggaaatcgtaaaaac tgtgctcagttttctggatctcttgattggttgatcagcagattagaaagactggaagct tcttctggaattctagaggttttacactgtgtgttggtagaaagcccagaagctctcaac attattaaggaaggacatattaaatcaatcatctgtcttttggacaagcatggaagaaac cataaggttttggatgttttgtgttccctctgtgtttgtcatggagtagctgtgcggtct aatcaacatctaatttgtgataatctcctgccaggaagagatctgctcttacagacacgc cttgtcaaccatgtgagcagcatgagacccaacatcttcttggggattagtgaaggctca gcccagtacagaaaatggtactatgaacttatggtggatcatctagagccctttgtgact gcagaatcaactcacctacgagtgggctgggcttccacagaaggctactcaccctaccct gggggaggagcggaatggggaggaaatggtgttggtgatgacctatattcctacggcttt gatggtctacatctgtggtcaggttgtgtagcacgatcagtaaattctcccaaccaacat ctattaagaactgatgatgttattagctgctgtttggacctgagtgcccccagcatctct ttccgaataaatggtcagccagttcaaggaatgtttgaaaacttcaacatagatggcctc ttcttcccagttgtcagcttctctgcaggaataaaggttcgtttcttgcttggaggtcgc catggggagttcaagttccttcctccacctggatatgctccatgctttgaagctgtcctg ccaaaagagaagctgaaagtggagaacagccgagagtacaaacaagatcgtagctacaca agagacctgttgggccccactgtctctctctcacaagcagctttcactccagttcctgta gatactagccagattgtattgcctcctcacctggaaaggattagagaaaaattagcagag aacatccatgaactttgggtcatgaataagattgaacttggctggcagtatggaccagtt agagacgacaataaaagacaacacccatgcttagtggagttctcaaaattgccggagcag gaaagaaattataacttgcaaatgtcacttgaaacactgaaaaccctgctggcattaggc tgccatgttggaattgctgatgaacgtgctgaagaaaaagtgaaaaaaatgaaacttcct aagaactatcagttattgagtggatataagccagcacccatggatctaagttttatcaaa ctgaccccttctcaagaagctatggtggataaactagcagagaatgctcacaatgtgtgg gcaagggaccggataaggcaaggctggacatatggcatccagcaggatgtgaaaaaccga cggaaccctcgcctcgttccgtacgctcttttggatgatcgaacaaagaagtccaacaaa gacagtcttcgggaagccgtccgcacccttctaggctatggttacaatttggaagctcct gatcaagatcatgcaacaagactggatgtgtgcagtggaataatggaaaagttcaggatc ttccgtacagaaaagacctatgcagtgaaggctgggaagtggtactttgagtttgaggca gttactgcaggagacatgagagttggctggaccaggcctggttgtctgccagatcaggaa cttggctcggatgaagaagcttttgtttttgatggctttaaggcgcagcggtggcatcaa ggtaatgagcattttggccgctcttggttggcaggagatgttgttggctgtatggttgac atgaatgagcacaccatgatgttcaccttaaatggtgaaatcctgcttgatgactcaggc tcagaacttgcattcaaggactttgaggttgctgacggatttctacctgtgtgcagcctg ggcccatctcaagtgggaagaatgaactttggaaaagatgtcagcactctaaaatatttc acgatatgtggcttacaggaagggtatgaaccctttgctgttaatacaaacagagacatc accatatggctgagtaaaaggcttcctcagtttctaccagtgccacaaaaccatgaacat attgaggtgatgagaattgatggcaccatagacagctgcccctgtctgaaggtcacccag aagtcctttggttcacagaacagtaaaacagatgtcatgttttttcgattgagcatgccc attgaatgtgctgaggtgttctccagatcagctgcaggagggttacctggctctggtctt tttggcccaaaaaatgacttggaagattatgatgctgattctgattttgaggttctaatg aaaactgctcatggtcatctagttcctgaccgaacagaaagagaaaaagatgccacaaaa ccagagctgaataaccataaagattatgttcaagaaaagccctcacgtcttaaacaaaga tttatgctcaggaggacaaagccagattatagcatgagtcactctgcacggcttactgag gatgtgctagcagatgatagggatgactatgattatttgatgcagacttccacgtactat tactctgtgagaatatttcctggtcaagaacctgctaatgtctgggtgggctggattaca tcagactttcaccagtatgacacaagctttgacttggacagagtgcgtaccgtcacagtt accctgggagacgaaaaagggaaggttcatgagagtataaaacgcagcaactgctatatg gtgtgcgcaggagagagcctgagccctggacaaggacgtaataataatgggctggagatt ggctgcttggttgatgctgccagtggcctgctgaccttcacagctaatggcaaggagctg ggcacatactatcaggttgaaccaagtacaaagttgtttcctgctgtatttgctcaagct acaagccccaatgttttccagtttgaattgggaagaataaagaatgtaatgccattatct gctggattattcaaaagtgaacacaaaaacccagtctctcaatgtcccccacgtctccat gtccagtttctgactcatgtgctttggagcagagtgccaaaccacttcttgaaggtggat gtgtctcggatcagtgaacgtcaaggctggatgatacagtgcctgaatcctttgcagttc atggcccttcatattcctgaggaaaacagaaccattgatattttagagctgacagaacaa gaggaattgctgaagtttcactaccacaccctccgattgtattcagccgtttgtgcttta ggcaacaaccgagtggcccatgctctgtgcagccatgtggatgagtctcagctcctctat gccattgagaataaatacatgccaggattactacgggcaggatattacgacttgctcatt gacatccatctcaatacctatgcaactgccaggctgatgatgaataatgaatttatagtt ccaatgacagatgagaccaagagtattactttgtttcctgatgaaaacaaaaagcacggc cttcccggtataggactcagcacttcattaaggccaagaatgcagttttcctctccaagt tttgtaagcattagcagtgaatgctttcagttcagtcctgaattccctctggaaattttg aaggccaaaaccattgagatgctgactgaagctgtccaggagggaagcctccatgtcaga gatccagttggaggttctacagaatttctgtttgttcctctcatcaagctcttttatacc ctcctaattatgggaatcttccacaatgaggatctgaaacacatcttgcagttgattgag ccccgagttttcaaagaagcaatgagccaggaggatgaaattgatttctcagagaaggag ttcagttcagatgagctcaagtcagaagaagaagaagaaaccagaggggagcaaatgcca aaggaaggactccttcagatgaaacttccagaacctgttaaattacagatgtgtcacctg ctccagtacctgtgtgactgccaagtgcggcaccgaatagaagccattgtcgcgttttct gatgatttcgtggccaagctccaggagaatcagcgctttcggtacaatgaagtgatgcag gccttgaacatgtctgctgccctgacagctaggaaaacaaaagagtttcgatcccctcct caagagcagattaacatgctgctgaactttaaagatgataaaaatgattgtccttgccct gaagaaattcgggatcaactcttggatttccatgaagacctaatgacacactgtggaatt gaactagatgaagatggaactttggatggcaacagtgattcaaccattaggggtcgcctc ctatacctcatggaaaaagttacatatctgaagaagaaacaagatgagaagacagttgat gaggaggataagacatcctctactctccagcagctgatttcagacacgatggtgcgctgg gcccaggagtcagtgatagaagacccagagttagtgagggccatgtttgtgctgctgcat cgccagtatgatggaattggtggtctggttcgagccctgccaaagacctacaccataaat agtgtgtctgtggaagacaccatcaatcttctggcatcccttggccaaatccgttccttg ctaagtgtcagaatggggaaggaagaggagaagcttatgattcgtggattaggagacatc atgaataataaagtattttaccaacatccaaatctcatgagagctttaggcatgcatgaa actgtaatggaagtgatggtgaatgtgcttggtggaggagaatccaaggaaatcactttc ccaaagatggtggcaaactgctgtcgttttctgtgttatttttgccgcatcagcaggcag aatcaaaaagctatgtttgatcatcttagctatttattggaaaacagcagtgttggcctt gcctctccttctatgcgagggtcaactcctttagatgttgctgcagcgtctgtaatggat aacaatgagcttgctctggctttaagggagcctgatctggagaaggtggttcgctacttg gctggatgtgggttgcagagttgtcctttgttgatttgtaaaggctacccagacattgga tggaatccagttgaaggagaacgatatttggattttcttcgttttgctgttttttgcaat ggagagagtgtggaggaaaatgctaatgttgtagtcagactgcttattcgccgccctgag tgttttggtcctgctctgagaggagaaggaggcaatgggttgcttgcagccatggaggag gcaatacaaatatcagaagatcgaacaagagatggaccttccccaagtaatggatctagt aaaacccttgaaatagaagaacaagaagatgacactattcacatgggaaatgcaataatg accttttatgctgccttgattgatctcttaggacgttgtgcccctgaaatgcatctaatt catgctggtaaaggggaagccattagaatcagatcaattctacggtctttgattccactt gaagatttggtgggagtaatcagtattgctttccacatgccaaccatagcaaaagatggt actgtggtggaacctgacatgtctgcggggttttgcccagatcacaaggcagccatggtt ttgttccttgacagggtctatggaattgaggaccaggattttcttctacaccttcttgaa gttggctttctgccagaccttcgtgctgctgcctcattagatacggctgctttgagtgct acagatatggctttggctctgaatcgatacctttgcacagcagtgttgcctctcttgacc agatgtgctcccctgtttgctggcacggagcaccatgcctccctcattgattccttattg cacactgtgtacagactctcaaagggatgctctcttaccaaagctcagcgagattccatt gaagagtgtttgctgtccatctgcgggcagttgcggccttccatgatgcagcacttgctg aggagattagtatttgatgtacctctgttaaatgaacatgcaaagatgcctctcaagtta ctgacaaatcattatgaaagatgctggaagtattactgtttgccaagtggatggggtaac tttggtgctgcctcagaagaagaacttcatttatccagaaagttgttctggggtattttt gatgctttgtctcaaaagaagtatgaacaagagctcttcaaactggctttgccctgtctg agcgcagttgcaggggccttacctccagactatatggaatccaattatgtcaatatgatg gaaaagcagtcttcaatggattcagatgggaactttaatcctcagcctgttgatacctca aacattacaatccctgaaaagctagaatattttattaacaaatatgcagaacatgctcat gacaaatggtcaatggaaaagtttgccaatggatggacctatggtgaaacattttctgaa tctgcaaaagtgcaaccattaatgaaacaatataagttactgtctgagaaggagaaagaa atttatcgatggccaatcaaagaatcactcaaaaccatgctggcatggggatggcgaatc gaaagaacacgggaaggagattccatggcgctgtataatcggacgcgtcgcatatctcag accagccaaatctctgtagatacagcccatggttacactcctcgagcaattgacatgagc aacgtcaccctctccagagacttacatgctatggctgagatgatggctgaaaactaccat aatatatgggcaaagaaaaagaaactggagcttgaagcaaaagtaggaggaggcaaccat ccccttcttgtcccttatgatacactcacagccaaagaaaaagccaaggacagagaaaaa gcacaggatattctgaaatttctacagattaatggatatgttgtctccagaggacttaag gacctggaattagacacgccctccattgagaaacgctttgcctatagtttccttcagcag cttataagatatgtggatgaagcccatcagtacattttggagtttgatggtggcagcaga ggcaaaggagagcaattcccatatgaacaagaaatcaagttttttgccaaagttgtgctc cctttgattgatcagtattttaaaaatcatcgcctatatttcttatcttctgcaagtagg cctctcagcagtggtggccatgcctctaataaagagaaagaaatggtgacaagcctgttc tgcaaacttggagttcttgtcaggcataggatttcactgtttggaaacgatgcaacatca atagtcaactgtcttcacatactgggacagaccttggatgcaaggactgtgatgaaaact ggtctggaatctgttaggatggcattgagagcatttttggacaatgctgctgaggatctg gagaaaacaatggaaaatcttaagcaaggccagtttacacacagcagaaaccagccaaaa ggagttacacaaatcattaattataccacagttgctctcctgccagtgctatcttcatta tttgagcatattggacagcaccagtttggggaagatttgatattggaagatgttcaggtc tcttgttacagaatattggccagtttatatgctctgggaaccagcaagagtatctatgta gagaggcaacgatcagcactaggggagtgcttggctgctttctcaggcgcctttccagtg gcttttttggaaactcatttgaacaaacataatatctactcaatctacaataccaagaat gcgagagatagagcagttctcaatttgccaactagtgtagaagaggtttgcccaaacatt ccttccttgatgaagctgatggaagaaatagtggaactggcagaatccggtattcgttac acacaaatgccacatatcatggaagtcattctgcctatgctgtgtagttacatgtcccac tggtgggagcatgggccagagaacaatcctgacaaggctgaaatgtgttgcacagccttg acgtcagagcacatgaacactctgttgggtaacatattgaaaatcatctataacaacctt ggtattgatgaaggagcctggatgaagagattagcagtgttttcccagcccatcataagt aaagcgaagccacagctcttaaagacacacttccttccactgatggataaactaaagaaa aaggcagcagtggttgtatcggatgaagaacatctaagagcagaaggcagaggtgacatg tcggaggctgaactgctcatcctagatgagttcaccactttggcacgggacctctatgcc ttctaccctttgttgattagatttgtggactataacagggcaaaatggttgaaagagccc aatcctgaagcagaagagctgtttcgcatggtggctgaggttttcatttactggtcaaag tctcataatttcaaaagggaagagcagaactttgtggtacaaaatgaaatcaacaacatg tctttccttatcagtgacaccaaatctaagatgtctaaggcagcggtttctgaccaggaa aggaagaagatgaagagaaaaggtgaccgctactctatgcagacctctctcattgtggca gcactgaagagattgcttccaataggcctaaacatttgtgctcctggagaccaagagcta attgcactggccaaaaatcgttttagcatgaaagacaccgaagatgaagtacgagatgtc atccgcagtaatcttcaccttcagggcaagcttgaggatcctgccattagatggcagatg gcactttacaaagatttgccaaacaggactgacgactcctcagatccagagaagactgtg gaaagggtccttgatatagctaatgtgctgtttcacctggaacaggttgagcatcctcag cggtccaaaaaagcagtgtggcataagctgctgtctaaacagaggaaaagagcagtggtg gcctgctttagaatggcaccactgtataatctgccaagacaccgagccgtcaatctcttt ctgcaaggctatgacaaatcttggattgaaacagaagagcattattttgaagacaaactg atagaagacttagcaaaacctggagaggaaccaccagaagaagatgaaagccttaaaaga gttgatcctttacatcaacttattctgctattcagtcgaacagccttgactgaaaaatgc aaactggaagaagatttcctgtatatggcttatgctgacattatggcaaagagctgccat gatgaagaagatgatgatggtgaagaagaagtgaagagttttgaagaaaaagaaatggaa aagcaaaaacttctgtatcaacaagccagactgcatgatcgtggtgctgctgagatggtt ctgcagacaatcagtgcaagtaaaggtgagatggggccaatggttgcagccaccctaaag ctaggaattgccatcctaaatggaggaaattctactgttcagcagaaaatgcttgactac ctcaaggataaaaaggatgtggggttctttcagagccttgcaggtcttatgcagtcctgt agtgttcttgacctaaatgcatttgaacgtcagaacaaagcagaaggccttggcatggtg actgaagagggatcaggagaaaaggtgatgcaagatgatgagttcacctgtgacctcttc cgcttccttcagttgctttgtgaaggacacaattcagattttcagaactacctgagaact caaactggtaacaacacaactgttaatattataatttctactgtggattacttattgagg gttcaggagtccatcagtgatttctattggtattattctgggaaggatgttattgatgag caaggacaacgaaatttttccaaagccatccaggttgcaaaacaagttttcaatactctc acagagtatatccaggggccatgtactggtaatcagcaaagtctggcacacagcaggctg tgggatgctgtagttggtttccttcatgtgtttgcccacatgcagatgaagctctctcag gattccagtcaaattgaactattgaaggaattaatggatcttcagaaagatatggttgtc atgttgctgtctatgctggaaggtaatgttgtgaatggaactattggaaagcagatggtg gacatgcttgtggaatcgtcaaacaatgtggagatgattctgaagttttttgatatgttc ttaaaattgaaagatttgacttcctctgatgcattcaaagaatatgaccctgatggtaaa gggataatttcaaagagggattttcacagggcaatggaaagccataagcactacactcag tctgaaacagagtttctgctctcatgtgctgaaacagatgagaatgagactttggactat gaggagtttgtgaaacgattccacgagcctgcaaaagacattggtttcaatgttgctgtt ctcctgaccaacctgtcagagcacatgccccatgatacgcgcttgcagactttcctggag ctctcagagagtgtgctgaattactttcagcctttccttggacgtatagaaataatgggc agtgcaaagcgcattgaacgagtttattttgaaataagcgagtcgagtcggactcagtgg gaaaaacctcaggtcaaagagtcaaagagacagtttatatttgatgttgtaaatgaaggt ggggaaaaagaaaagatggagctttttgttaacttctgtgaggataccatctttgaaatg caactggctgcccagatctctgagtcagatctgaacgaaaggtcagctaataaagaggag aatgagaaagataatcctgaggaagaagatcctaggatgggtttcttctctctcgtgacc atgaagtcagctttagtagctctcaagtataatttaatgactcttatgaaaatgctcagc atgaagagtctaaagaaacaaatgaaaaaagtgaagaaaatgaccatgaaggacatggtc atggctttgttttcttcctactggagcattttggtgggcttactacattttgcttgtagt gttgtccggggcttttttcgcatcatatgcagtttgctgcttggaggaagcctagtagaa ggagccaagaaaatcaaggtggctgagctgttggctaatatgccagatcccactcaggat gaagtgcgtggggaagaagaagaaggggagaggaaaccgacggaagctgcattgcctgca gaagacttgacggatctgcagactctgacagaagagagtgatctactctcagatatattt ggtttggatttgaaacgagaaggtggacagtataaattgatccctcacaatccaaatgct ggtttgagcgatttactgagcactccctccttagccccaatgcctgaggtacaggaaaaa atccaggagaaggtgaaagaagatgaaaaggaagagaaagaagaaacaaaatcagaacct gaaaaagctgaaggagaagatggagaaaaagaagagaaaaccaaggaagacaaagggaaa cagaaattaagacaaatgcatacacacagatacggagaaccagaagttcaggaatcagtt ttctggaagaatatcattgcataccagcagaagcttcttaattattttgcgcgaaacttt tacaacatgaggatgttggcgttatttgttgcttttgccatcaacttcatccttcttttc tataaggtctccacatctgctgtgacagaagaaaaggagcttcctttggtatctgatggt gaaagtaacaagttgaacatcctggaaagcgatgatgagagggtcattgcagtgcattat gtcctggaagaaagcagtggctacatggagcccacactgaggattttggccatcctacac acagtcatctcattcttctgcatcatagggtattattgtttgaaagttccactggttatt tttaagagagaaaaggaagtggcaaggaaattggaatttgatgggctatatataacagag cagccatcagaggatgatattaagggacagtgggatagacttgtaatcaacacacagtct tttccaaataactattgggacaagtttgtgaaaagaaaggtaatggataaatatggtgag ttctatggccgtgacaggatcagtgaattactaggaatggacaaagctgctcttgatttt agtgatgctcgagaaaagaagaaaccaaagaaggacagctccttttctgctgtgctaaat tccattgatgttaaatatcagatgtggaaattaggagttgttttcactgataattctttc ctttacctagcgtggtacatgaccatgtcagtccttggccattacaacaattttttcttt gctgctcatctccttgacattgcaatgggattcaagacattacgaactatcctgtcatca gttacccacaatggcaaacagcttgtcctaacagtgggattactggcagtagtggtatac ttgtatacagtagtggcattcaattttttccgcaagttctacaacaagagtgaagacggt gacatgccagacatgaaatgtgatgatatgctgacatgctacatgtttcatatgtacgtt ggagtacgtgcaggaggaggcattggtgatgaaatagaagatccagcaggagacgaatat gaaatctatcggattatctttgacatcactttcttcttctttgtgattgtcatcctgctt gcaattatccaaggtttaattattgatgcttttggtgagttaagagatcagcaagagcaa gttaaggaagacatggagacgaagtgctttatctgtggaataggaaatgactactttgat acagtgcctcatggctttgaaacacacacactacaggagcacaacttggccaattatttg ttttttctgatgtatcttatcaacaaagatgaaactgagcatacaggacaggaatcttat gtttggaaaatgtatcaagaacggtgctgggagtttttccctgctggtgattgcttccgg aaacagtatgaagaccagctcaactaa

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