Serinus canaria (common canary): 103824361 Help Entry 103824361         CDS       T05755                                  Symbol UBR4 Name (RefSeq) E3 ubiquitin-protein ligase UBR4   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism scan  Serinus canaria (common canary) Brite KEGG Orthology (KO) [BR:scan00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:scan04121]     103824361 (UBR4) Enzymes [BR:scan01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      103824361 (UBR4) Ubiquitin system [BR:scan04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     103824361 (UBR4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  E3_UBR4_N E3_UbLigase_R4 UBR4 zf-UBR Motif Other DBs NCBI-GeneID:  103824361 NCBI-ProteinID:  XP_030088751 LinkDB All DBs Position Unknown AA seq 5143 aa AA seqDB search MKELPQLLASVIESESEILDHDKQYEPFYSSFIALSTHYITTVCGLIPRNQLQSVAAACK VLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVK TLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRVSSSPSITTETQVEGEGEDQA ATDQTSATKTKSIFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDAVSANSFFIM PATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLTPTRLQDVTVLALSCLYAGVSVAT CMAILHVGSTQQVRTGSTSSKEEDYENDAATIVQKCLEIYEMIGQAISNSRRAGGEHYQN FQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDIIARTKEGVGSPKLGPGKG HQGFGVLSVVLANHAIKLLSSLFQDLQVEALHKGWESDGPPAVLDIMAQSTSIQRIQRLI DSVPLTNLLLTLLSTSYRKACVLQRQRKGSMSSDASASTDSNTYYEDDFSSTEEDSSQDD DSEPILGQWFEETISPSKEKVAPPPPPPPPPLESSPRVKSPNKQSAGENGNILASRKDPE LFLSLASNILNFITSSMLNSRNNFIRNYLSVSLSEQHMATLASIIKEVDKDGLKGTSDEE FAAALYHFNHSLVTSDLQSPALQNTLLQQLGVAPFSEGPWPLYIHPQSLSVLSRLLLIWQ HKATAQGDPDVPECLKVWERFVGTLKQNALQGTLPSDTEDLNVEHLQLLLLIFHNFSERG RRSIMMLCIQTIVELTANMETQQCSVPLIVARLLLVFDYLLHQYSKAPVYLFEQVQYNLL TPPIGWVSGSQDSSRRTSVPLYHGFKEVEENWTKHCSSDSAPQPRFYCILSPEASEDDLN RLDSTVCEVLFSRTTKYDELYTALTSLLAAGSQFDTLRRRENKNVTALEACALQYYFLIL WRILGILPPSRSYMHHLAMNTPEMSDCDLLHTLRWSSRLQIPSYVVWIKDHLIKQGMKAE HAAPLIELTSSKCISVKYDVEIAEEYFARQISSFCAVDCTTILQLHEVPSLQSIYTLDAA ISKIQVSLDEHFSKSAAETDPHKSSEITKNLLPATLQLIDTYATFTRSYLLRSLSEEASS DSRASEEKLRGYAAVLAIGSGRCKPNTLGPTLVQNLPSAVQTLCESWNNIHTNEFPNIGS WRNAFANDTIPAESYISAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIIWSDDPN PPQVIHSLLPLLLETSTESVAEISSNSLERILGPADSDEFLARVYEKLIMGCYNILARHS DPNSGLDESILEECLQHLEKQLESSQARKAMEEFFSESGELVQIMMATANENLSAKFCNR VLKFFTKLFQLTEKSPNPSLLRLCGSLAQLACVEPVRLQAWLTRMTMSPPKDSDQLDVVQ ENRQLLQLLTTYIVRENSQVGEGVCTVLLSTLIPMATEMLANGDGTGFPELMVVMATLAS AGQGAGHLQLHGAAVDWLGRCKKYLSQKNVVEKMNANVMQGKHVTILECTCHIVSYLADV TNALSQSSGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTI TQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLA LVKRTPSSGMSSTMKESAFQSEPRVPESVIRHASTSPAEKAKVTISEGKGPDEEKPKKSS LCRNVEGCREELQSQANFSFAPLVLEMLNFLMDAIQVNFQQASAMGSSSRAQQALSELHT LDKSVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMCVLSSPHG RRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLTGNPCKEDYL AVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELAIVTADFVKIYD LSVDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAGYIYTQLMEEASSAQHGPFY VTNVLEVNHEDLKDSNGQVAGGGVSVYYSHVLQMLFFSYCQGKSFAATISRASLEVQRLF PINIKSSNGSSKTSPALCQWSEVMNHPGLVCCVQQTTGVPLVVMVKPDTFLIQEIKTLPA KAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIYMANVENTSYWLQPSLQPSSVISIMK PVRKRKAAAITTRTSSQVNFPIDFFEHNQQLTDVEFGGNDLLQVYNAQQIKHRLNSTGMY VANTKPGGFTIEVTNNNSTMVMTGMRIQIGTQAIERAPSYLEIFGRTMQLNMTRARWFDF PFTREEALQADKKLTIFIGASVDPAGVTMMDSIKIYGKTKEQFGWPDEPPEDFPSASVSN VCPPNLNQGNGTGDTESAAPAAASGTVLESSDTESLTTLDRLVVSSLEALESCFAVGPVN EKEKNKIAAQELATVLLSMPAPSSVQQQTKSLLASLHTSRSAYHNHKDQALLSKAIQYLT SSTKEGKDLDPEVFQRLVITARSIAIMRPNNLVHYTESKLPQLETESEEGQEAQKHVEGE GCTFITQLVNHFWKLHASKPKNAFLAPACLPGLTHVEATVNALVDIIHGYCTCELDCIHT ASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTPMGDKDDDDDDDA EDKLQSSGIANGEHIRQESQEQSEVDHGDFEMVSESMVLETSENVNNGNPSPLEALLAGA EGFPPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGLQSLGLSGQAPSSSSLDAGT LSDTTASAPASDDEGSTAATDGSTLRTSPAEHGGSVGSESGGSAVDSVAGEHSVSGRSSA YGDTTAEGHPAGPGSVSSSTGAISTTTGQQEGEGSEGEGEAEGDVHTSNRLHMVRLMLLE RLLQNLPQLRNVGGVRAIPYMQVILMLTTDLDGDDEKDKGALDNLLSQLIAELGMDKKDV SKKNERSPVNEVHLVVMRLLSVFMSRTKSGSKTSICESSSLISSATAAALLSSGAVDYCL HVLKSLLEYWKSQQNDEEPVATSQLLKPHTSSSPPDMSPFFLRQYVKGHAADVFEAYTQL LTEMVLRLPYQIKKIADTNSRIPPPIFDHSWFYFLSEYLMIQQTPFVRRQVRKLLLFICG SKDKYRQLRDLHTLDSHVRGIKKLLEEQGIFLRASVVTASSGSALQYDTLISLMEHLKAC AEIATQRTVNWQKFCIKDDSVLYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVLSVASSS GASSTSSTSAPAASGSGQAAAQSKSSTKKSKKEEKEKEREGEGSGSQEDQLCTALVNQLN KFADKETLIQFLRCFLLESNSSSVRWQAHCLALHIYRNSSKSQQELLLDLMWSIWPELPA YGRKAAQFVDLLGYFSLKTQQTEKKLKEYSQKAVEILRTQNHILTNHPNSNIYNTLSGLV EFDGYYLESDPCLVCNNPEVPFCYIKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGD LKRTKMVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNL MIEFADFYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLC NACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVTNINTLLDKADRVYHQLMGHRPQL ENLLCKVNEAAPEKPQDESGSSGGISSTSASVNRYILQLAQEYCGDCKNSFDELSKIIQK VFASRKELLEYDLQQREAATKSSRSSALPTFTASQYRALSVLGCGHTSSTKCYGCASAVT EHCITLLRALATNGAIRHILVAQGLIRELFDYNLRRGAAAMREEVRQLMCLLTRDNPEAT QQMNDLIIGKVSAALKGHWANPDLASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMA VNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPMDALTTVKPYSNEIHAQAQLWL KRDPKASYEAWKKCLPARGADANGKTPSKAELHQLYLSEKYVWKWKQFMSRRGKRTCPLD LKLGHNNWLRQVLFTPATQAARQAACTIVEALATIPSRKQQVLDLLTSYLDELSIAGECA AEYLALYQKLIKPAHWKVYLAARGVLPYIGSLITKEIARLLALEEATLSTDLQQGYALKS LTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTT GTESETKAFMAVCIETAKRYSLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQE DFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLP VAEVYKKVWCPTNEGEPMRIIYRMRGLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVMA PCGGLECMLNRLTGIKDFKQGRHLLTVLLKLFSYCVKVKINRQQLVKPEMNTLNVMLGTL NLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGDKDQLVMLLDQ INSTFVRSNLSVLQGLLRIIPYLSFGEMEKMQILVDRFKPYCNFDKYDEEHSGDDKVFLD CFCKIAAGIKNNSNGHQLKDLILQKGITQNALDYMKKHIPSAKNLDADIWKRFLSRPALP FILRLLRGLATQHPATQVLIGTDSISNLHKLEQVSSDEGIGTLAENLLEALREHPEVNKK IDAARKETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCI CREGYKFQPTKVLGIYTFTKRVALEEFENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARG REEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNVHD IKLLFLRFAMEQSFSIDTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQSFLEQ PREKWVESAFEVDGPHYYTVLALHVCPPERWRAIRGDILRRLLVTAHARVVSPGGASRLA DKAVKEYATYRSGLLFWALVDLIYNMFKKVPTSNTEGGWSFSLAEFIRHNDMPIHEAADK ALKTFQEEFMPVETFSEFLDVAGLLAEINDPDSFLKDLLNSIP NT seq 15432 nt NT seq  +upstreamnt  +downstreamnt atgaaggagctgccgcagctgctcgcctcggtcatcgagagtgaatctgaaatcctggac catgacaagcagtacgagcctttctactcctccttcattgcactttccacacactacatc actactgtgtgtggtctcatacccagaaaccagttgcagtcagtggcagctgcctgtaaa gtcctgattgaattctccctgctgcggcttgagaacccagatgaagcatgtgctgtttca cagaaacacctcatcctgctgatcaaggggctttgcacgggctgcagccgcctggaccgc acagaaatcatcaccttcacagcgatgatgaaatcagccaagttgcctcagactgtcaaa accctctctgatgttgaggaccagaaggaattggcctccccggtgagcccagagctgaga cagaaggaagtgcagatgaacttcctcaaccaattgacatcagtctttaaccccagagtc tcgtcatcaccatcaatcacaacagagacacaggtggaaggagagggcgaggatcaagct gccacagatcaaacctctgcaacaaagaccaagagcatattcattgctcagaatgtggcc agcctgcaagaacttggtggctccgagaagctgctgcgcgtgtgcctgaacctgccgtac ttcctgcgctacatcaaccgcttccaggacgccgtgtccgccaactccttcttcatcatg ccagccaccgtggccgacgccacggccgtgcgcaacgggttccactcgctggtgatcgat gtcaccatggctctggatactctgtccctgcccgtgctggagcccctgacacccacgcgt cttcaggatgtgactgttcttgctcttagctgtctctatgcaggtgtgagcgtggccacc tgcatggccatcctgcatgtgggcagcacccagcaggtacgaaccgggtcaacgagctcc aaagaagaagattatgaaaacgatgctgctactattgtacagaaatgtcttgaaatctat gaaatgataggacaagccatcagcaattcacgccgtgcagggggggagcattatcagaac ttccagctgctcggggcttggtgtttgctgaacagcctcttcctcatcttgaacctcagc cccacggccttggctgataaggggaaggagaaggatcccttggctgctcttcgcgtcaga gacatcattgctcgcactaaggagggcgtggggtctcccaaactgggacctgggaaaggg catcaagggtttggggtgctgtcagtggtgctggcaaatcatgccatcaaattgctgtca tctcttttccaagatctgcaggtggaggcattgcacaagggctgggagagtgacggccct ccagcagtgctggatatcatggctcagagcacatccatccagaggatccagcggctcata gactctgtgccactcactaatctgctgctgactctgctctccacttcctacagaaaggcc tgtgtcctgcagcgccagaggaagggctccatgagcagtgatgccagtgcctccactgac tccaacacctactacgaggatgacttcagcagcactgaggaggacagcagccaagatgac gacagtgagccaatcctggggcaatggtttgaagagacaatctctcccagcaaggagaaa gtggctccaccaccaccccctccaccccctcctctggagagctcaccgagggtgaagagc cccaacaagcagagtgctggggagaacgggaacatcttggccagccgcaaggaccccgag ctgtttttgagcctagcttcaaacattttgaactttatcacttcttctatgctgaactcc aggaataacttcattcgcaactacctgagcgtgtccctgtcggagcagcacatggccacg ctggcgagcatcatcaaggaggtggacaaggatggcctgaagggcacatcagatgaggag tttgctgctgctctgtatcacttcaaccattccttggtgacctcagatcttcagtcccct gccctgcagaacacacttctccagcagctgggagttgcccctttttctgaaggtccgtgg cctctctacatccaccctcaaagtctgtctgtgctgtcccgactcctcctgatttggcag cataaagccactgcccagggagatcctgacgttccagagtgccttaaagtctgggaaagg tttgtgggcaccctgaagcaaaacgccttgcaggggactctccccagtgacacagaagat ctgaacgtggagcatctccagctgctgctgctcattttccacaatttctcagagaggggc cgcagatccatcatgatgctctgtatccagaccattgtggagctgacagcaaacatggag acccagcagtgttctgtgcccctcatcgtggcacggctgctgctggtgtttgactacctg ctccaccagtattccaaggcccctgtgtacctgttcgaacaggtacaatataatttgctg actccacccattggctgggtgagtggatcccaggacagcagcagacggacatctgtccca ctttatcatggctttaaagaagtggaagaaaactggaccaaacactgttcatcagactct gctccacagcccaggttctactgcatcctgtctccagaggcttctgaggatgatctgaac cgtctggatagcacggtgtgtgaggtccttttctccaggactacaaagtacgacgagctc tacacagccctcacctcattactggctgctggctcccagtttgatacactcaggaggagg gagaacaaaaatgtcactgcactggaagcctgtgcccttcagtactacttcctgatcctg tggcggatcctggggattttgcctccctccagaagctacatgcaccatttggccatgaac acccctgagatgagtgactgtgacctcctgcacaccctgcgctggtcctcccgcctgcag atcccgtcctacgttgtgtggatcaaggatcaccttatcaagcagggcatgaaggctgag catgctgctcctctcattgaactgacctccagcaagtgcatctctgtgaagtacgacgtg gaaatagcagaggaatactttgctcgacagatctcttctttctgtgctgtcgactgcaca accattctccagctgcatgaagtccccagtttacaatccatttacacccttgatgctgcc atctccaagatccaggtttctctagatgagcacttttccaagtcagctgcagaaactgat ccccacaagtcctcagagataaccaagaacctcctccctgctacgctgcagctcattgac acttatgctacttttaccaggtcctacctgctgcggagcctctcggaggaggcgtcctcg gacagcagagcctccgaggagaagctgcggggctacgccgccgtcctggccatcggctcc ggccgctgcaagcccaacactctgggtccaacccttgtccagaacttgccatcagctgtg cagaccctgtgtgaatcctggaacaacatccacaccaacgagttccccaacatcggttca tggcgcaacgcctttgccaacgacaccatccctgcagaaagctacatcagtgccgtgcag gctgcccacttgggcaccctctgcagccagagcctgcccctggcagcctccctcaagcac accctgctgtccctggtcaggctcactggggatctcatcatctggtcagatgatcccaac ccgccccaggtgatccattccctgctgcccctccttctggagaccagcacagagagtgtg gcagaaatcagcagcaactccctggagaggatcttgggcccggcggactcggatgagttc ctagcacgtgtttatgagaagttgatcatggggtgctataacatactggcccgtcactct gacccaaacagtggcctggatgagtccatcttggaggagtgtttgcagcatctggagaaa cagctggagagcagccaggccagaaaagccatggaggaattcttttcagaaagtggagaa ctggtgcagatcatgatggcgacggccaatgagaacctctcggccaagttctgtaacagg gtgctgaaattcttcaccaagctcttccagctgactgagaagagccccaaccccagcctg ctgcgcctctgtggctccctggcccagctggcctgtgtggagcccgtgaggctgcaggcc tggctgaccaggatgaccatgtccccacccaaggattcggaccagctggacgtggtgcag gagaacaggcagctgctgcagctcctgaccacttacattgttcgggagaacagccaagtg ggggaaggcgtgtgcactgttctgctcagcactctgataccaatggcaacggagatgttg gccaatggggatggcacgggctttcctgagctgatggtcgtcatggcaactttggccagt gcaggacaaggggcgggacacctccagcttcatggtgctgctgtggactggctgggcaga tgcaagaaatacctgtctcaaaagaacgtggtagagaaaatgaatgccaacgtcatgcaa gggaagcacgtgacaatcctggagtgcacgtgccacatcgtgtcctacctggccgatgtc accaacgcactgagccagagcagtgggcagggccccagccacctgtctgtggacggcgag gagcgcgccatcgaggtggactcggactgggtggaggagctggccgtggaggaggaggac tctcaggctgaggattcggatgaagattctctctgtaataaactttgtaccttcaccatc acacagaaagaattcatgaatcaacactggtaccactgtcacacttgcaagatggttgat ggggttggtgtttgcacagtttgtgctaaagtttgtcacaaggatcatgagatttcttac gccaagtacggatccttcttctgtgactgtggagccaaggaggatggcagctgcctggca ctggtgaagagaactcccagcagtgggatgagctctaccatgaaggaatcagccttccag agcgagccccgcgtgcccgagagcgtcatccgccacgcgagcacgtccccggctgagaaa gccaaggtcaccatcagtgagggcaagggccccgatgaggaaaagcccaagaagagcagc ctgtgcagaaacgtggagggctgtcgagaggagctgcagtcccaggccaacttctccttt gcaccgttggtgctggagatgctgaatttcctgatggatgccatccaggtcaacttccag caagcttcagccatggggagcagcagccgtgcccagcaggctctcagcgagctccacact ttggacaaatcagtagaaatgacggatcagctgatggttcccaccctgggctcacaggaa ggcgcctttgagaacgtgcgcatgaactacagcggggaccagggccagaccatccggcag ctgatcagcgcgcacgtgctgcgccgcgtggccatgtgcgtgctgtcctcgccccatggc cgccgccagcacctggctgtcagccacgagaagggcaagatcacagtgctccagctctca gccctgctgaaacaagccgactccagcaaaaggaaactgaccctcacccgcctggcatcg gcgcccgtcccgttcactgtgctgagcctgactgggaatccctgcaaggaggactacctg gctgtgtgtgggctgaaggattgccatgtgttaacattcagcagctctggatcagtctct gatcatttggtgcttcatccccaactggccactgggaatttcatcatcaaagccgtgtgg ctgccaggatcccaaacagagctggccattgtcactgcagacttcgtgaagatttacgac ctctcagtagacgccttgagtccaactttctacttcctcctaccgagttccaaaatcagg gatgtcactttcctgttcaacgaggaggggaagaacatcattgtgatcatgtcttctgct ggctacatctacacacagctcatggaggaggccagcagtgcccagcacgggcccttctat gtcaccaatgtgcttgaagtcaaccatgaggacctgaaggacagcaatggccaggtggca ggagggggagtgtcagtctattactcccacgtgctgcagatgttgttcttcagctactgc caaggcaaatccttcgcagccaccatcagccgggccagcctggaagtgcagcggctcttc ccaattaacatcaagagttccaatggtagcagtaagacttctccagccctgtgtcagtgg tctgaggtgatgaaccaccctggcctggtgtgctgtgtccagcagaccacgggtgtccca ctggtggtgatggtgaagccagacaccttcctcatccaggagattaagaccttgccagcc aaagcaaagatccaggacatggtggccatccgtcacacggcctgcaacgagcagcagagg accaccatgatcctgctgtgtgaggatggcagcctgaggatctacatggccaacgtggag aacacgtcctactggctgcagccctctctgcagcccagcagcgtcatcagcatcatgaaa cccgtgcgcaagcgcaaggcagccgccatcacaactcgcacatccagccaggtgaacttc cccattgacttctttgagcacaaccagcagctcacagatgtggagttcgggggcaatgac ctgctgcaggtctacaatgcccagcagataaagcaccgcctcaattccacaggcatgtac gtggccaacacaaagcctgggggtttcaccatcgaagtgaccaacaacaacagcacgatg gtgatgacgggcatgcgcatccagatcggcacgcaggccatcgagcgcgcgccctcctac ctggagatcttcggccgcaccatgcagctcaacatgacccgcgcccgctggttcgacttc cccttcacccgcgaagaggccctgcaggctgacaagaaactcactatcttcattggggct tctgtggatcctgctggagtcaccatgatggactccataaaaatttatggcaaaaccaaa gagcagtttggctggcctgatgagcctcccgaggacttcccgtctgcttccgtgagcaac gtttgtcccccaaacctcaaccaagggaatggcactggggacaccgagtcagctgcccct gctgctgccagtgggactgttctggagagttctgacactgagtccctaaccaccctggac cggctagtagtgagttctttagaagcgctggaaagctgctttgctgtgggaccagtcaac gagaaggagaagaataagattgcagctcaggaactggctactgtgctgctgtccatgcca gccccttccagcgtgcagcagcagactaagagcctgctggccagcttgcacaccagccgt tcagcctaccacaaccacaaggatcaagcactgctaagcaaagccattcagtatttgact tcctccaccaaagaaggaaaggacctggatcctgaggtattccagaggctggtcatcact gctcgctccattgctattatgagacccaacaatctggtccactacacagaatcaaagctg ccacagctggaaacagagagtgaagaagggcaggaggcccagaaacacgtggaaggagag ggctgcaccttcattacccagctggtgaaccacttctggaagctccatgcatcaaaaccc aaaaatgccttcctggcccctgcctgcctgccaggtctcactcacgttgaagccacagtc aatgctttggtggatattatccatggatactgcacgtgtgagctggactgtatccatact gcatccaagatctacatgcagatgttactttgcccagacccagcagtaagcttttcctgc aagcaagctttgatcagggtgctgagaccccggaacaagcgacgacacgtgaccctgcca tcgtccccccgcagcaacacccccatgggagataaggatgatgatgatgacgacgatgca gaagacaagctgcagagttctgggatagcaaatggagagcacatccgacaggagagccag gagcagagtgaggtggatcacggggactttgagatggtgtccgaatccatggttctggag acttctgagaacgtgaataatgggaatccttctcctctggaggctctcctggctggagca gagggattccctccgatgctggatatccctccagatgcagatgatgagacaatggtggag ttggctattgccctgagccttcaacaagatcagcaagggagcagcagcagtgcccttggg ctgcagagcttgggactgtccggccaggctcccagctcctcctctctggacgctggaaca ctctcggacacaacagcatcagctccagcctctgacgacgagggcagcacagcggccacg gatggctccacgctgcggacatcgcccgcggagcacggcggcagcgtgggctcggagagt ggcggcagcgccgtggactcggtggccggggagcacagcgtgtccggccggagcagcgcc tacggggacaccacggccgagggccacccggcggggccgggcagcgtcagctccagcacc ggagccatcagcaccaccacgggccagcaggagggagagggctccgagggggaaggggag gcagagggggacgtccacaccagcaacaggctgcacatggtcaggctgatgctgctggag aggctgctgcagaatctcccacagctgaggaatgtggggggggtccgggccatcccttac atgcaggttattctgatgctcacaacagacctagatggagatgatgagaaagacaaggga gctttggataaccttctgtcccagctgattgcagagctgggcatggacaaaaaggatgtg tccaagaaaaacgagcgctcccctgtgaacgaggtgcacttggtggtgatgaggctgctc agtgtcttcatgtcaaggaccaagtcaggatccaagacttccatttgtgagtcttcctcc ctgatctccagtgccacagcagctgccttgctgagctctggtgctgttgattactgtctg cacgtgctcaagtccctgctggagtactggaagagccagcagaatgacgaggagcctgtg gccaccagccagctgctgaagcctcacacctcttcctctccccctgacatgagccccttt ttcctccgccagtatgtgaagggtcatgctgcagatgtttttgaggcctacactcagctc ctgacagagatggtgctgcgcctgccctaccagatcaagaagattgcagacaccaactcc cgcatccccccgcccatctttgatcactcctggttctactttttgtctgagtacctgatg atccagcagacgccgttcgtgcgccgccaggtgcgcaagctgctgctgttcatctgcggc tccaaggacaagtaccggcagctgcgggacctgcacacgctggactcgcatgtgaggggc atcaagaagctcctggaggagcagggcatcttcttgagggccagcgtggtgacagccagc tcaggctctgccctgcagtatgacaccctgatctccctgatggaacatttgaaggcttgt gcagagattgccacgcagagaacagtgaattggcagaaattctgcatcaaggatgactcg gttctctatttcctgctccaagtcagcttcctggtagacgaaggagtgtccccagttctc ctgcagctgttgtcttgtgctctgtgtggcagcaaagtgctgtctgtggcttcatcctct ggagcttccagcacctcttccacctctgctcctgcagcatcaggctccgggcaggcggca gcgcagagcaaatcctccaccaaaaagagcaagaaggaggaaaaggagaaggagcgagag ggtgagggttcaggcagccaggaggaccagctgtgcacagccctggtcaaccagctgaac aagtttgctgacaaggagaccctcatccagttcctgcgctgcttcctgctggaatccaac tcctcctcagtgaggtggcaggcccactgcctggccctgcacatctacaggaactccagc aagtcccagcaggagttactgctggatctcatgtggtccatctggccagagctcccggcc tatggaagaaaggctgcccagtttgtagatctcctgggatatttctccctgaaaacacaa cagactgagaaaaagctgaaggaatattcccaaaaggccgtggagatcctccggactcaa aaccacattctcaccaaccaccccaactccaacatctacaacacattgtctgggctcgtg gaatttgatggctactacctggagagtgatccttgtcttgtctgcaacaaccccgaggtg cctttctgttacatcaagctctcgtccatcaaagtggacacgcgctacacgaccacacag caggtggtgaagctcattggcagccacaccatcagcaaggtgacagtgaagattggggac ctgaaacgaaccaagatggtgagaaccatcaacctctactacaacaacaggactgtgcag gccatcgtggagctgaagaacaagcccgcacgctggcacaaggccaagaaggtgcagctg acaccggggcagacggaggtgaagatcgatctgcccctgcccatcgtggcctccaacctg atgattgagttcgccgacttctacgagaactaccaggcgtccaccgagaccctgcagtgc ccgcgctgcagcgcctccgtgcccgccaaccccggcgtgtgcggcaactgcggcgagaac gtctaccagtgccacaagtgcaggtccatcaattatgacgagaaggatcccttcctgtgc aatgcctgtggcttctgcaaatacgcccgcttcgacttcatgctctacgccaagccctgc tgcgccgtggaccccatcgagaacgaggaggatcgcaagaaggcagtgacaaacatcaac accctgctagacaaggctgacagggtgtatcaccagctgatgggacaccgaccacagctg gagaacctcctgtgcaaagtgaacgaggcagcccctgagaagccccaggatgagtctggc agcagtggagggatcagttctacctcagccagtgtgaacaggtacatcctgcagttagcc caggagtactgtggggactgcaagaactccttcgatgaactttccaaaatcatccagaaa gtgtttgcctcccggaaggagctgctggagtacgacctgcagcagcgcgaggcggccacc aagtcctcgcggagctcggcgctgcccacgttcacggccagccagtaccgggcgctgtcc gtgctgggctgcggccacacctcctccaccaagtgctacggctgcgcctcggccgtcacc gagcactgcatcaccctgctgcgggccctggccaccaacggcgccatccgccacatcctg gtggcccaggggctcatccgggagctctttgactacaacctgcgccggggcgcggccgcc atgcgcgaggaagtgcggcagctcatgtgcctcctgaccagggacaatccagaggccaca cagcaaatgaatgatttaatcattgggaaggtttctgcagctctgaagggacactgggca aatccggacttggcgagcagcctccagtacgagatgctgctgctgacagactccatctcc aaggaggacagctgctgggagctgcgcctacgctgcgctctcagcctcttcctgatggca gtgaacatcaagactccagtggttgttgaaaacatcaccctcatgtgcctgcgcatcctc cagaagctcatcaagccacctgctccaaccagcaagaaaaacaaggatgtgcccatggat gctctcaccactgtgaagccttacagcaatgaaattcatgcacaggctcagctgtggctc aagagggaccccaaggcatcatatgaagcttggaagaagtgcctccctgccagaggtgca gatgccaatgggaaaactcccagcaaagctgagcttcaccagctctacttgtcagaaaaa tacgtctggaagtggaagcaattcatgagtcgccgtgggaagagaacttgtcctctggat ctcaagctgggacacaacaattggctgagacaggtgctgttcactcctgccacccaggct gccaggcaggctgcctgcaccatcgtggaggccctggccaccatccccagcaggaagcag caggtcctcgatctcctcaccagctacctggatgagctgagcattgctggtgaatgtgct gctgagtacctggccctgtatcagaaactcatcaaacctgcccactggaaggtctacctg gcagccagaggggttctgccctacattggcagtctcatcactaaggaaatagctcgtttg ctggccttggaggaagcaacactcagcacggatttgcagcagggatatgccctgaagagc ctcacaggtcttctctcttccttcgtggaggtggagtccatcaaaaggcacttcaagagc cggctggtgggcacggtgctcaacggctacctgtgcctgaggaagctggtggtgcagagg acaaaactgattgatgagacccaggacatgctgctggagatgctggaggatatgacaaca ggcacagagtcagagaccaaggcgttcatggccgtgtgcatagagactgccaagcgttac agcctcgatgactacaggaccccagtgttcatctttgagaggctctgcagcatcatctac cctgaggagaatgaagtcactgagttctttgtcactctggagaaagatccccagcaggaa gatttcctgcagggcaggatgccagggaatccctacagcagtaacgagcctggcatcggg cccctcatgagggacatcaagaacaagatctgccaggactgtgacctggtggctctgctg gaggatgacagtgggatggagcttttggtgaacaacaagatcatcagtctggatctgcct gtggctgaggtctacaagaaggtgtggtgtcccacaaatgagggggagcccatgaggatc atttaccgcatgcgggggttactgggagatgccacggaggaattcatcgagtccctagac tccaccactgatgaggaggaggatgaggaagaggtgtataagatggcaggggtgatggcc ccatgtggaggcctggagtgcatgctcaacagactgactggcatcaaggacttcaaacag ggccggcacctcttaactgtgctgttaaaactcttcagttactgtgtgaaggtgaaaata aaccggcagcagctggtcaagccagagatgaacactttgaatgtcatgctggggactctc aacttggctctggtggctgagcaggagagcaaggacagtgggggagcagcagtggcagag caggtgctcagcatcatggagatcattctggatgaatccaatgcagagcctctgagcgag gacaagggcaacctcctcctgacaggggacaaggaccagctggtgatgctgctggaccag atcaacagcacctttgtgcgctccaacctgagcgtgctgcaggggctgctgcgcatcatc ccctacctgtccttcggggagatggagaagatgcagatcctggtggatcgcttcaagccc tactgtaactttgataagtatgatgaggagcacagtggagatgataaagttttcctggat tgcttctgtaaaatagcagcaggaataaagaacaacagcaacggccatcagctgaaagat ctcatcctgcagaaggggattacacagaatgccctggattacatgaaaaagcacattcca agtgcaaagaatttggatgcagacatatggaagaggttcttatctcgacctgcacttcct tttatcctgcgcctgctccgaggcctcgcgacgcagcaccctgcaacacaggtgctaata ggaacagactccatctccaacctgcacaaactggagcaggtgtcgagtgatgaaggcatt gggacgttggcagagaaccttctggaggctctgagggaacaccccgaggtgaacaagaag attgacgccgcgcggaaggagacgcgcgccgagaagaagaggatggccatggccatgagg cagaaggccctgggcaccctgggcatgacgacaaatgagaagggccaggtggtgaccaag actgcgctgcttaaacagatggaggagctcatagaggagccaggactgacctgctgcatc tgccgggagggatacaagttccagcccaccaaggtgctggggatttacacgttcaccaag cgcgtggcgctcgaggagtttgagaacaagccccgcaagcagcagggctacagcaccgtg tcccacttcaacatcgtgcactacgactgccacctggcagctgtcagacttgctcggggc cgcgaggagtgggagagtgcagccctgcaaaatgccaacaccaagtgcaatgggctcctg ccagtgtgggggccccacgtgccagagtctgcttttgccacgtgcttggcacgccacaac acgtacctgcaggagtgcacggggcagagggagcccacgtaccagctcaacgtgcacgac atcaagctgctgttcctgcgcttcgccatggagcagtcgttcagcatcgacaccgggggc ggcggccgcgagagcaacatccacctcatcccctacatcatccacaccgtgctctacgtg ctcaacacgacccgggcgacctcgcgggaggagaagaacctgcagagcttcctggagcag ccccgcgagaagtgggtggagagcgccttcgaggtggacgggccccactactacaccgtg ctggccctgcacgtgtgtcccccggagcggtggcgggccatccgcggggacatcctgcgc cgcctcctcgtcaccgcccacgcccgcgtggtgtccccgggaggggccagcagactggca gacaaggcagtgaaggaatacgccacgtaccgctcggggctgctcttctgggccctcgtg gatctcatctacaacatgttcaagaaggtgcctaccagtaacacagagggaggctggtcc ttctctctggctgagttcatccgacacaacgacatgccaatccacgaggctgcagacaag gccctgaaaaccttccaggaggaattcatgccagtggaaacgttttctgagtttttggat gtggctggactcttggcagaaatcaatgatcccgacagcttcctcaaggacctcctgaac tccatcccctga

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