Squalius cephalus (European chub): 307168299 Help Entry 307168299         CDS       T11930                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3 isoform 1   KO K04963   ryanodine receptor 3 Organism scep  Squalius cephalus (European chub) Pathway scep04020   Calcium signaling pathway scep04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:scep00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     307168299 (ryr3)    04020 Calcium signaling pathway     307168299 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:scep04040]     307168299 (ryr3) Ion channels [BR:scep04040]  Voltage-gated cation channels   Ryanodine receptor    307168299 (ryr3) SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Ago_Mid Motif Other DBs NCBI-GeneID:  307168299 NCBI-ProteinID:  XP_079744207 LinkDB All DBs Position 12:6286088..6380761 Genome browser AA seq 4865 aa AA seqDB search MAEGGEGEDEVQFLRTEDEVVLQCVAAIQKENRKFCLSAEGLGNRLCYLEPTSEAKYFPP DLCICNFVLEQSLSVRALQEMLAGQNGEGNPDHERWAAQGGGHRTLLYGHAILFRHSFSG MYLTCLKTSRSLTDKLSFDVGLEEDSIGEACWWTIHPASKQRSEGEKVRIGDDLILVSVS SERFLHLSISNGSIQVDASFMQTLWNVQPTCSRSNVAVGFLLGGQVMRLFHGHDESLTIP GSEQSEAQQRVVNYETGKGGSKARSLWRLEPLRISWSGSHIRWGQPFRLRHLSTGHYLGQ TEDHGLILIDREKSDTTATAFCFRASKEKIDSGPKRDIDGMGVAEIKYGDSFCFIMHVST GLWLSYQAPDAKSSRLGPLKRRAVLSLEGHMDDGLTLQLCQHEESRAARIIRNTTHLFTQ FIRGLDGLNGEKATEVTLPVCEVLQTLNDLIVYFQQPDSELEHEEKQRQLRSLIKRQDLF KEEGMLTLVSICIDRLNVYNSAAEFEELAGEEAGEAWKDILNLLYELLAALIRGNRTNCT QFSRKLDWLVSKLERLESSSGILEVLHCVLIESPESLNIIQKAHIKSIISLLYKHGRNHK ILDVLCSLCVCNGVAVRANQNFICDHLLPKRDLLLQTRLVNDVQSMRPNIFLGMSEGSAQ YKKWYFELIIDQVDHYVTSEPTHLRVGWATTKGYAPYPGGGEGWGGNGVGDDLYSYSFDG LHLWSGRIPRAVASINQHLLNSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNVDGFFF PVVSFSAGVKVRFLLGGRHGDFKFLPPAGYAPCYEALLPKEKMRVEPVKEYKRDLEGVRD LLGTTEFLSQASFIPVPVDTSQIVLPPYLENVRDKLAENIHELWGMNKIELGWMYGKVRD DNKRQHPCLVDFSKLPETEKNYNLQMSTETLKTLLALGCHVAQVNIDAEEDLKKMKLPKN YMMANGYKPTPLDLSEVKLTPGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNRRN PRLVPYALLDERTKKSNRDSLREAIRTLVGYGYFIDPPDQESAHHGEDGIESIRLFRVEK TYAVKTGKWYFEFEALTGGDMRVGWARPGCRPDKELGLDDQAFIFDGYRGRRVHMGSHFF GRSWNKGDVVGCMINMEDKSMIFTLNGELLITNKGSELCFADFETEDGFIPVCSLGLSQI GRMNLGKDANTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFVNVPEEHPHIEVTR IDGSVDTPPCLKVTHKTFGTQASNDDMVCCRLSMPVDFHSGPRKITDINEVIADAQRAKK DDGGKIDYGSITKYFYSVRVFAGQDPSSVWVGWVTPDYHYYSKHFSLNTVRTVTVTLGDE RGRVHESVRRSNCYMVCAGDIVSQSTGRSNTDLEIGCSIDLASGLVSFTANGRELPNAYQ VEPNTKLFPAVFVKPTSPNLFQFEFPKIPDAMPLSSAIFKSLQKNPEPQCPPRLDVQTIV SVLWSRMPNTFLSVETARVSERHGWVVQCLEPLQMMGVHIPEENRCIDIMELSENEGLRQ FHYHTLKLFCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLTGQLREGFYNVLISIHLE TAKEAHLMMNNEFIIPVTDETRSIRLFPDDSKRHCLPGVGLSTSLTTRLNFSPPCFITTK RYQPLYSPEIPLGILKEKAISMLTEAVQGGGTHIRDPVGGSVEYQFVPILKLIGTLLIMG ALTSEEVRIILLLVDPSVFGDGKEEEKQTAVAEQGAEKEEATSNEEKAVEAGEEESKEAK QLPKGLLEKSLPESVKRQMCELLHYFCDCELKQRIEAIVAFSDDFVSKLQYNQKFRYNEL MLAFNMSAAVTAKKTREFRSPPQEQINMLLNFSAGDDCTCPEELQEELQGFHDDLRLHCG IPMEEEEEEQDTSLKGRLMSVVYKIKGRPQKTEEEPTEQEQAAPTNLKELISQTMVSWAQ ECKILDPELVRSMFSLLRRQYDGVGELLRALRKSYTISAKSVADAINLLASLGQIRSLLS VRMGEEEGQLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKNKEIAFPK MVASCCRFLCYFCRISRQNQKSMFDHLSYLLENSSVGLACPTMRGSTPLDVAASSVMDNN SLALALEEPDLEKVVTYLAGCGLQNCPMLIARGYPDIGWNPIEGERYLSFLRFAVFVNGE SVEENANVVVKLLIRRPECFGPALRGEGGQGLLAAMKEAIKISEDPALDLPNLPEGVAPT VGKDEEEEEEVAHMGNSIMSFYSALIDLLGRCAPEMHLINKGKGEALRIRAILRSLVPTK DLVGIISIPLKMPVVNKDGTVTEPDMNASFCPEHKAPMVLFLDRVYGIDDQSFLLHLLEV GFLPDLRASASLDSEVLRTTETALAMNRYVGSAVLPLLTRCAHLFTHTEHHAMLVDSTLH TIYRLSKGRSLTKAQRDAIDECLMAICMHLRPSMLQQLLRRLVFDVPQLTEYCKMPINLL TNHYEQNWKYYCLPMGLGSYGMASEEELHLTKKLFWGLFDSLSQKKYDAELFKMAMPCLS AIASALPPDYVDSSPGSTLVKQASVDAQGNFDPQPVSTANISLPEKLDYIASKFAEHTHE KWSSEKIALGWSAGDKLDDKAKTHPLLKPYKALSEKERETYRYPVKETLKSMLAMGWNIE RTREGEARSQQKETEKQRKVSESSQGEFNPAPQDLENVILSRELQAMVETVAENYHNIWA KKKKKELDSKGGGNHPLLVPYDTLTAKEKYRDREKAQELFKFVQVNGYAISRGLKDLEQD SSSMEKRIAYKFLKRLLSYVDSAQEFIAHLEAMASSGKTDKSPHDQEIKFFAKVLLPLID QYFKNHCMYFLSTPNINLSSSGYASNKEKEMITSLFCKLAALVRHRISLFGSDSTTMVSC LHILSRSLDFRTVMKSGSELVKAGIRTFFENAAEDLEKTLENLKLGKLGQSRSQMKGVTQ IINYTTVALLPILTVVFQHITQHQFGAELLLDDIQLSCYRILTSLYSLGSGKNIYVEKQL PSLGECLSTLVGAMPVAFLEPHLNMHNPQSVFNTKTPRERAILSMPDTVDEMCHEMPHLD GLMKDIGEISETGARYTEMPQVIEVILPMLCNYLSYWWEKGPDNSPVDANCCTTVTSEHL SLILGNILKILNNNLGIDNAPWMKRLAVYTQPIISRASADLLRAHFLPTLEKLKKKTVKI VTEEELLKAESRIDTQEAELQILDEFAVLCRDLYAFYPMLIRYVDNNRSTWLKEPHSDST ELFKMVSEIFILWCKSHNFKREEQNFVVQNEINNLAFLTGDSKTKMSKSGGQDQERRGKK RKGELYSIQTSLIVAAHKKMLPIGLNMCTPGDQELISLAKIRYSLKDTDDEVKDYLRKNL HLQEKSADPAVQWQLNLYKDVVVKSEGAPDPEQNVERVQAISAAVYHLEQVELPLRNKKM VFQKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLSGYQRLWIETEEYSFEERLVQDLA KTPMAVVEEEEEEEAEVQPDPLHQLILHFSHNALTERSFLEEDPLFIAYADMMAKSCAEN EEEEEEEGKEKTFEEKEMEKQKILYQQARLHARGAAEMVLQMISASKGRLGPMVTGTLKL GISILNGGNVLVQQKMLDYLKDKRDAGFFKSLSGLMMSCSVLDLNAFERQNKAESLGMMT EEGSSNMRERGSKVLQNDDFTKDLFRFLQLLCEGHNNDFQNFLRTQTGNTTTVNIIISTV DYLLRLQESISDFYWYYSGKDVMDEAGQLNFSKALAVAKQIFNSLTEYIQGPCIGNQQSL AHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELMDLQKDMVVMMLSLLEGNVVNGTI GKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTSDNFKEYDPDCKGVISKKEFQKSMESQ KQYTQSEIEFLLSCVEADENDVFNYEEFVERFHEPAKDIGFNVVVLLTNLSEHMPHDSRL ATFLDLAESVLNYFEPYLGRIEIMGGAKRIERVYFEISESSRTQWEKPQVKESKRQFIFD VVNEGGESEKMELFVNFCEDTIFEMQLASQISEPDAAERPEEEEDEELHSLLEGLSEEED ASLESTSAFTAACVSVKKSISNFRQMLTFKSMKKQFKKFKKLTIREMITGFFSFFWMLFT GFFKGIFGIIFGFFHIIWSSMFGGGFVEGAKNMKVTDILGNMPDPTQFGIHGDVLEAEKT ESSELVVSADMVQMTGAGAEKLEPDTIMDLLNTGVKKEGKHGAEPGLGDVCEVLTEASAP AEKKKSQKVAAEKPESEPEKADTENQEKEDKVKEETPEEPAAEKPAPKAKRGSSKDKAPA FMATFFAVLEVYKTKTLNYLARNFYNLRFLALFVAFAINFILLFYKVTGGFDDEEEEEGS WGGEEEEEGDEDDEGMEYFILQESTGYMAPTLTFLAITHTIISLLCVFGYYYLKVPLVVF KREKEIARKLEFDGLYITEQPSDDDIKGQWDRLVIATPSFPNNYWDKFVKRKVINKYGDL YGAERIAELLGLDKSALDFDPTEEAVVKEASLLSWLSSIDTKYHIWKMGVVMTDNSYLYL IWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYT VVAFNFFRKFYNKSEDEDAPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIVDPAGDPYELY RILFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDRIP HGFETHTLQEHNLANYLFFLMYLINKDETEYTGQESYVWKMYQERCWDFFPAGDCFRKQY EDLLG NT seq 14598 nt NT seq  +upstreamnt  +downstreamnt atggccgaaggtggtgaaggggaagatgaggtccagttcttacgaactgaagatgaggtg gtgctgcagtgtgtcgccgccattcagaaggagaatcgcaaattctgcctttcagcagag ggactcggcaaccgcctgtgttatctagagcccacatcagaggcgaagtattttcctcct gacctatgcatctgtaactttgtgctggagcagtcgctctcagtgcgggccctacaggag atgctcgccgggcagaacggtgaaggaaatcctgatcatgagcgatgggcagcacaagga ggtggacatcggacactgctctacggtcacgctatcctctttaggcattccttcagtgga atgtatctgacatgtctgaagacttccaggtctctaacagacaaactgtcttttgatgtt ggcctagaagaggattcaattggggaagcttgttggtggacaattcacccggcatccaag cagaggtcagagggtgagaaagtgcgtattggggatgacctcatcttggtcagtgtgtct tctgagaggttcctgcacctctctatctccaatggaagtattcaagtggatgcttctttc atgcaaacactgtggaatgttcagcctacctgctccagaagcaacgtggcagtgggattt cttctgggtgggcaagtgatgcgcttgttccatgggcacgacgagagtctcactatacca ggatccgaacaaagtgaagcacaacagagagtggtgaactatgagactggtaaaggaggg tccaaggccaggtctttatggagattggagcctcttcggataagctggagtgggagccac atcagatggggtcaacccttccgcctgcgccatctctccaccggtcactacctgggccag acagaggaccatggcctgatactgatagacagagagaagtctgacaccactgcaactgcc ttctgtttccgggcaagcaaggaaaagattgactctggcccaaagcgtgatattgatggt atgggggttgcagagatcaaatatggtgattcgttctgcttcattatgcatgtgtccacg ggcctgtggctgtcctaccaagcgcctgatgcaaaatcttctcgcctgggaccactgaag agaagggctgtcctgtctcttgagggccatatggatgacgggctgactctgcagctctgc cagcacgaggagtccagggcggctcgcatcattcgtaataccacccacctcttcactcag ttcatcaggggtctggatggtttgaatggagaaaaggctacagaggtgactctgcctgtg tgtgaagtgctgcagaccctcaacgacctcattgtgtacttccaacagccagactctgag ctcgaacatgaggaaaaacagaggcagcttcgatctctcattaagcgccaagatctcttc aaagaggagggaatgctaaccttggtctcaatctgcatcgatcggctaaacgtgtacaac agtgccgctgagtttgaggagctagctggcgaggaggccggagaggcatggaaggacatt ctcaacctcctctatgagcttctggccgctctgattcgaggcaacagaaccaactgcaca cagttctctcgcaagctggattggctagtcagcaagctagagcgattggagtcctcatca ggcattttagaggtgcttcattgtgtcctaatcgagagtccagaatctctgaacatcatc cagaaggcccacatcaaatccattatttctctgctgtacaagcatgggcgcaaccataag attctagatgttctctgttccctgtgtgtctgcaatggtgtggctgtgagagccaatcag aatttcatctgtgatcacctgcttcccaagagagacctgctgctccagacacgtctggtc aatgatgtccaaagtatgagacccaacatcttcctgggcatgagtgagggctctgcgcag tataagaaatggtactttgagctgatcatcgatcaagtagaccactatgtaaccagtgag cccacccaccttcgagttggctgggccaccactaaaggatatgccccctatcctgggggt ggagagggttggggaggaaatggtgtgggtgacgatctttactcctacagttttgatgga cttcatctgtggtcagggcgaatcccacgggccgtggcctctattaaccagcacttgctg aattcagatgatgtggtgagctgctgtctggatctcggagcccctagcatgtctttccga attaacggtcagcccgttcaaggcatgtttgaagacttcaacgtagatggcttcttcttt cccgtcgtcagtttctctgcaggggtcaaggtccgtttcttgttgggtggtcgccatgga gactttaagttccttcctcctgcgggctatgcaccatgttatgaagccctgctccccaaa gaaaagatgcgtgtggagcctgtgaaggagtataaaagagacctggaaggagtgagagat ctgctgggcaccacagagttcctgtcccaggcttccttcattcctgttcctgtcgacacc agccagattgtcctgcctccatatcttgaaaatgtgcgggacaagttggctgagaacatc catgagctctggggcatgaacaaaatagagcttggttggatgtacggcaaggttcgtgat gacaacaagagacagcacccttgtcttgtcgacttttctaaactgccagaaacagaaaag aattataacctgcaaatgtcaactgaaactttgaagaccctacttgctttgggctgccat gttgctcaagtcaatatagatgctgaggaagacttgaaaaagatgaaactccccaagaac tacatgatggcaaatggttataaacctacaccactagacctttctgaagtgaaactgaca cctggtcaagaggttctagttgataaactggctgaaaatgctcataatgtttgggccaaa gaccgcataaaacaaggatggacctatggtattcagcaggatttgaaaaaccgtcgtaat ccacggttggtgccatatgctttattagatgaacgcactaagaaatcgaacagagacagt cttcgtgaggccatccgtactctggttggatatggatatttcattgatccacctgatcaa gagtctgctcaccatggagaggatggcattgaatccattcgtctcttccgtgtggagaag acctacgctgtgaagacagggaagtggtattttgagtttgaggcgctcactggaggtgac atgcgggttggctgggcacggcccggatgcagacctgataaggaactgggactcgatgac caagccttcatctttgatggctacaggggccgccgggtgcatatgggcagtcatttcttt gggcggtcatggaataaaggagatgtggtgggctgcatgatcaacatggaggacaaatcc atgatattcaccctgaatggagagctcttaatcaccaacaagggctctgagctctgcttt gctgactttgaaactgaagatgggttcattccagtgtgcagcctgggtctttcccaaatt ggtcgcatgaacttggggaaagatgctaatacttttaagtactacactatgtgtggcctt caggagggctttgaaccctttgctgtcaacatgaatcgagaggtcaccatgtggttcagc aaacgcctgccaacatttgtgaatgtgccagaggagcacccccatattgaggtcactaga atagatgggtctgtggacacacctccatgtctaaaggtgacacacaagacatttggcacc caggccagcaatgacgatatggtctgttgtcgtctgagcatgcctgttgatttccactct ggccctcggaagatcactgatatcaatgaggtgattgctgatgcccaaagagccaagaag gacgatggaggcaagattgattatggcagcattacaaagtacttttactctgtgagagtg tttgccggacaagatccatcatcagtttgggtgggctgggtaacaccagactaccattac tacagcaaacatttcagccttaacacagttcgcaccgtcacagtaacactgggagacgag cggggacgtgttcatgagagtgtgaggagaagtaactgttacatggtctgtgctggcgac attgtcagccagtccacaggccgtagtaacactgatctggagattggctgctccatagat cttgcctcaggcttggtctcattcactgccaatggcagagagctgcctaacgcataccag gttgagcctaacactaagctattccctgctgtgtttgttaaacccacgagtcccaacctc ttccagtttgagtttccaaaaatcccagatgcaatgcccctgtcttcagccatcttcaag agtttacaaaaaaacccagagccccagtgtcctcctcggctggatgtccagacaattgtg tccgtgctgtggagcagaatgcccaacaccttcctgtcggtggagacggcccgtgtgagt gagaggcatggctgggtggtgcaatgtctggaacccctgcagatgatgggcgtgcatatc ccagaggagaacagatgtatcgacatcatggagctgtcggaaaatgaaggtctacggcag ttccactatcacactttaaagcttttttgcgccctttgtgccctgggcaacactcgtgta gctcacgccctctgcagccatctcgaccaatcgcagctcctgtacaccattgataaccaa tacctgactggtcagctacgtgaaggcttttacaatgtcctcattagcattcacctggag acagccaaagaggcccatctaatgatgaacaacgagtttataatcccagtgacggacgag acaaggagcatccgcctcttccctgatgactcaaagcgccactgtcttcctggagtgggc ctgagcacctcacttaccactcgcctcaacttctcccctccgtgtttcattaccaccaag cgttatcagcctctctatagccccgagatccctctgggtatcctgaaggagaaagccatc agtatgctgacggaagctgtgcagggcggaggcacccacattcgagatcctgtgggcgga agcgtcgagtatcagtttgttccgattctcaagttgattggcacactgctgataatgggg gcgttgaccagcgaggaggtgagaatcattctgctcctcgtcgaccccagtgtgtttggg gacggtaaggaggaggagaaacagacagcagttgcagaacaaggagccgagaaagaggag gccaccagtaatgaagagaaggctgtggaggcgggagaggaagagagtaaagaagccaag cagcttcccaaaggtcttctggagaagagcttgcctgaatcggtcaaacgccagatgtgt gagctactgcactatttctgtgactgtgagctgaagcagcgcattgaggctatcgtggcc ttctcagatgattttgtatccaagctgcagtacaatcagaagttccgctacaacgagttg atgctagccttcaacatgtcagctgctgtcactgccaagaagactagagagttccgctca cctccccaagagcagataaacatgctgttgaacttcagcgctggtgatgattgcacctgc cccgaggagcttcaagaggaacttcaaggcttccatgatgaccttcgactacattgtggc atccctatggaagaggaggaggaggaacaagacacatctcttaaaggccgcctgatgtcc gtggtttacaagattaaaggtcgtcctcaaaaaactgaggaagaaccaactgagcaagag caggctgctcctaccaacctgaaggagctgatatctcagactatggtcagctgggctcag gagtgcaaaatcctagacccggaactggttcgcagcatgttcagccttttgaggaggcag tatgatggcgtcggtgagctgctcagagctttgaggaagagctacaccatcagtgccaag tctgtagcggacgcgatcaacctgctggcctcactgggccagatccgttcactactcagc gtccgcatgggcgaagaggagggccagctcatgattgacggcctgggggacatcatgaac aacaaagtgttttaccagcatccaaatctgatgcgtgttcttggcatgcacgagaccgta atggaggtcatggtcaatgtgctgggtggagacaagaataaggagattgccttccccaag atggtggccagctgttgtcgctttctgtgctacttctgtcgcatcagccgtcagaaccag aagtctatgtttgaccacctgagctacctcctggagaacagcagcgtggggctggcttgt ccaaccatgagaggctccacacctttagacgtagctgcgtcctctgtgatggacaacaac agtttggctctggcactagaggaacctgatcttgagaaggtggttacatatctggcaggc tgtgggttacagaactgcccaatgctcattgccaggggatacccagacattggctggaac ccaatagaaggagaacgctatttgtccttcctacggtttgctgtttttgtcaatggtgaa agtgttgaagagaacgctaatgtcgttgtgaagcttttgatcaggcgtccggagtgcttt ggacctgctcttagaggagagggaggtcaaggtttactcgctgccatgaaggaagccatc aagatctcagaagatcctgctttagacctgcccaacttacctgaaggggttgcaccaacg gttgggaaggatgaagaggaggaggaggaggttgcccacatgggcaactctattatgtcc ttctactcagcccttattgatcttctgggccgatgtgcacctgagatgcatcttataaac aaagggaaaggtgaagcattgcgtatccgtgccatcctccgttccctagtacccactaaa gatttggttggaataatcagtattcctctcaaaatgccggtcgtcaataaagatggtact gtgacggagccagatatgaatgccagcttttgtccagagcacaaggcgcccatggtgctt ttcctggaccgtgtctatggcattgacgaccaaagcttcttgttgcacctgcttgaggtt ggcttcctgccagacctgcgagcttcagcctccctggactcggaggtgctcaggactacc gagacagccctggccatgaaccgctacgttggatccgcagtgcttcctctgctgacccgc tgtgctcatctgttcactcacactgagcaccatgcaatgctcgttgactctacgcttcac accatctatcgcctctcaaagggccgatcactcaccaaggcacagagagatgctattgat gaatgtctaatggccatctgcatgcatctgcggccgtcaatgctacagcaacttttgcgt cgtcttgtgtttgatgtcccacagcttacagagtactgtaagatgcccattaatcttttg acgaatcactatgagcagaattggaagtactactgtctgccaatgggcctgggcagctat ggaatggcatcagaggaggaactccacctcaccaagaaactcttctggggactttttgac tctctgtctcaaaagaaatatgatgcagagcttttcaaaatggccatgccgtgtctgagt gccatagccagtgcattaccacctgactacgtggactccagcccaggttccacattagtt aagcaggcctctgtggatgcgcaaggcaacttcgacccccagcctgttagcactgctaat atctcgctccctgaaaaactagattacattgcaagcaagtttgcggagcatactcatgag aaatggtcctctgagaagatcgctcttggctggtctgcgggtgataaattagatgacaaa gctaaaactcatccgcttctgaaaccatacaaagcacttagtgaaaaggaaagggagact tatcgctaccctgtgaaagagactctaaagagcatgttggcaatgggatggaacattgag aggactagagaaggagaggccaggtcgcagcaaaaggaaacagaaaaacaacgcaaagta tcagagtcctcacagggtgagtttaatccagccccacaagatttggaaaatgttattcta tcaagggaactacaggcaatggttgaaacagttgcagaaaattaccacaacatttgggca aagaagaagaagaaggaacttgacagtaaaggaggaggaaatcatccattgttggtaccg tacgacacgctgacagcgaaggagaagtacagagacagagagaaggcccaggagctcttt aaatttgttcaggtcaatggatatgccatcagcagaggtctgaaggacctggagcaagat tcctcttctatggaaaaaaggattgcctataagttcctcaagaggctcttgagttatgtt gattctgcacaggagtttatcgcccatcttgaggctatggcttccagtgggaagacggac aaatctccccatgatcaagagatcaagttttttgctaaggttctgctgcccctcatagac cagtacttcaagaaccactgcatgtacttcctgtcaacccccaacatcaaccttagcagc agtggctacgcatccaacaaagagaaggagatgatcaccagtcttttctgtaagctggca gcccttgtcagacataggatttcactctttggaagtgactccaccaccatggtgagctgc ttacacatcctgtcacgctcactggacttcaggactgtgatgaagtctggctcagagctg gtgaaggctggtatcaggactttcttcgagaatgcagcggaagacctggagaagactctg gagaacttgaagctagggaagttgggtcagtcacgctctcagatgaagggcgttacccag atcatcaactacaccacagtggccctgctgcccatcctgacggttgtctttcagcatatc acccaacaccagtttggagcagagctgctattggatgacattcagctgtcctgctaccgc atcctgaccagcctgtactcattgggcagtggcaagaacatctatgtggaaaaacagctg ccctctctgggtgaatgtttatctaccctggttggagccatgcctgttgctttcctggaa ccccacctaaatatgcacaatccccaatctgtcttcaacaccaagacaccaagagaacga gctattttgagcatgccagacaccgtggatgagatgtgtcatgagatgcctcatctagac ggcctaatgaaggacattggggagatttctgaaactggagcacgctatacagagatgcca caggtcatcgaggtcatccttcccatgttgtgtaactacctgtcttactggtgggaaaaa ggtccagataactccccagttgatgccaattgctgcacaactgtcacatctgagcatctc agcctcatcctgggcaatatcctcaagattctaaacaacaaccttggcattgataacgcc ccctggatgaaaagacttgcagtatacacccagccgatcattagcagggctagcgcagat ctcctgagagcgcacttcctgccaacgctggagaaactgaagaagaaaacagtgaagata gtgactgaggaggagctgcttaaggctgaaagcaggatagacactcaggaagctgaactg cagattctggatgagtttgctgttctctgcagggatctgtatgccttctatccgatgctc attcgttatgtggacaacaatagatccacatggctgaaggaaccacattcagattcaact gaacttttcaaaatggtgtcggagattttcatcctttggtgtaaatctcataactttaaa agggaagagcaaaattttgtggtgcaaaatgaaattaacaacctggcattccttactgga gacagcaagacgaagatgtcaaagtctggaggtcaggaccaagaaagaagaggaaaaaaa agaaaaggagagttgtactccatccagacgtcccttattgtagctgctcacaagaagatg ctgcctattggcctgaacatgtgcactcctggagaccaggagctcatatccctcgccaag atccggtacagtctgaaagacacagatgatgaggttaaggattacctgaggaagaacctc catcttcaggagaagtcggcagatccagcagtgcagtggcagctgaacctctataaagat gttgtggtgaagagtgagggagctccagacccagagcaaaacgtggagagagttcaggcc atctctgctgctgtctaccaccttgaacaggttgagctgccacttaggaacaagaagatg gtgtttcagaagctgctgtcaaagcaacgaaagcgtgccgtagtggcctgtttccgaatg gcaccactctacaacttaccaaggcatcgctcaattaacctcttcctcagtggctatcag agactttggatagagacagaggagtactcctttgaggagaggctagtgcaggacctggca aaaacgcctatggctgtggtagaagaagaagaggaagaggaagctgaagttcagccagac cctcttcatcagctcatccttcactttagtcacaatgctctgacggagagaagtttccta gaagaggatcctctctttattgcatatgctgacatgatggcaaaaagctgtgctgagaat gaggaagaagaagaagaggaaggaaaagaaaaaacttttgaggaaaaagaaatggagaag cagaagattctgtaccagcaggccagacttcacgcccgtggggctgctgaaatggtccta cagatgatcagtgccagtaaaggccgacttggtcctatggtgactggcacccttaaactg ggtatttctatcctaaacggaggcaacgttcttgtccagcagaaaatgctggattatttg aaggataagcgagatgccggcttctttaaaagtttatctggactgatgatgtcttgcagt gtgctggatttgaatgcatttgaaaggcaaaataaagcagagagtcttggaatgatgact gaagaggggtcaagcaacatgagagagcggggttccaaagtactacaaaatgatgacttt acaaaggatctattcaggtttttgcaacttctgtgcgagggccacaataatgatttccaa aacttcttgcggacccagactggaaacactactacagtcaacatcatcattagcactgtg gactacctattacgtctacaagaatccataagcgatttctactggtattactctgggaaa gacgtcatggatgaggctgggcaacttaacttttccaaagctttggcagtagccaaacaa atctttaactcactcactgagtacattcagggcccttgtatcgggaatcagcagagtttg gcacacagcaggttgtgggatgcagtggttgggttcctgcatgttttcgcaaacatgcaa atgaaactgtcacaggattctagtcaaatagagttattgaaggaactgatggatttgcag aaggatatggtggtcatgatgttatctcttcttgagggtaatgtggtgaatggaactatc ggtaagcagatggtcgacactttagtggagtcctccagcaatgtggaaatgatcctcaag ttcttcgacatgttcctcaaactgaaggacctcactacatctgataacttcaaggagtat gacccagattgcaaaggcgttatatccaagaaggagttccagaagtctatggagagccag aagcaatacacacagtctgaaatcgagtttcttctctcctgtgtggaggcagatgaaaat gacgtattcaactatgaggagtttgtggaacgcttccatgaaccagccaaggacatcggc ttcaacgtggttgtgcttctcactaacctttcagaacacatgcctcacgactcgcgcctg gccaccttcttagacctggctgaaagtgtgctcaattactttgagccgtacctgggccgt attgagatcatgggtggtgccaagaggatcgagagggtttacttcgagatcagcgagtct agcagaacccagtgggagaagccacaagtcaaagagtccaaacgacagttcatcttcgac gtggtcaacgaaggcggtgagagcgagaagatggagttatttgtaaacttctgtgaggac accatttttgaaatgcagttggcctcacagatctccgagccagatgccgcagaacgacct gaggaggaagaagatgaagagttgcacagcctgcttgaaggcttgtctgaggaggaagac gcatctcttgaatccacctcggccttcacggcagcctgcgtctctgtgaagaagagcata tctaatttccgtcaaatgctgacatttaagagtatgaagaagcagtttaagaaattcaag aagctgaccatcagagaaatgatcacagggttcttctccttcttctggatgctcttcacc gggttcttcaaaggcatttttggcatcatcttcgggttcttccatataatttggtcctcc atgtttggagggggttttgtagagggagctaaaaacatgaaagtgacagatattttgggt aatatgcctgatccaacacagtttgggatccatggcgatgtactggaagcagaaaaaact gagagcagtgagctggtagtgtcggcagatatggtgcagatgaccggtgctggtgctgag aagctggagccggatacgatcatggatctgcttaatactggtgtaaagaaagaaggcaag catggagcagaacccggtctgggcgatgtctgtgaagtcctgactgaagcaagtgcccct gctgagaagaagaaaagccagaaagtagcagcagagaagccagaatctgagccagagaaa gctgacaccgagaatcaggagaaagaagacaaggttaaagaggaaacgcctgaggaacca gcagcagaaaaaccagctccaaaagccaaacgtggctcttccaaagataaagctccagca ttcatggccactttctttgcagtgcttgaagtctacaaaaccaaaacactaaactacctg gctcgtaatttctacaaccttcgttttctggctctgtttgtggccttcgccatcaacttc atcctgctcttctacaaggtgactggaggtttcgatgacgaggaagaggaggagggatcc tggggtggagaagaggaggaggagggtgatgaagatgatgaaggaatggaatacttcatt cttcaggagagcactggctacatggctcccacattgactttcttggctataacacacacg atcatctccttgctctgtgtctttggatattactaccttaaggttcctttagtcgtgttc aagcgggagaaggagatcgctaggaagcttgagtttgatggtttgtatattaccgagcag ccgtctgatgatgacatcaaaggacagtgggatcgtttggtcattgcaactccgtccttc cctaacaattactgggacaaatttgttaagaggaaggtcatcaataaatacggtgacctg tacggggccgagcgcatagctgaactcctgggtctggataagagtgctctggactttgat cccactgaagaggccgtggtgaaggaagcctccctgctgtcctggttgagctcaattgat acaaagtaccacatctggaaaatgggggtggtgatgacggacaactcttacctctacctg atctggtacaccaccatgtcgattctggggcattacaataacttcttctttgccgctcat ttgctggacatagcgatgggcttcaagaccttgaggaccatcctctcttctgtgactcac aatggcaaacagctggtgttgaccgtgggcctcctggctgtcgtggtctacctgtacact gtagtggcttttaacttcttccgcaagttctacaacaagagcgaggatgaggacgcacct gacatgaagtgtgatgatatgatgacttgctacctgttccacatgtacgtgggtgtgagg gctggcggtggcatcggtgatgaaatcgtggacccggccggtgacccttacgagctctac cgcattctgtttgacatcaccttcttcttctttgtcatcgtcattctgctggccatcatt cagggtttgatcattgatgccttcggcgagttgagagaccagcaggagcaggtgaaagag gacatggagacaaaatgcttcatctgtggaatcgggaatgactactttgacagaatcccg catggttttgagacccataccttacaagagcacaatctagccaactatctattcttcctg atgtaccttatcaacaaagatgagactgaatacactggtcaggagtcgtatgtttggaag atgtatcaggagaggtgctgggatttcttccctgctggagactgtttccggaagcaatac gaggacctgctgggctag

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