Spermophilus citellus (European ground squirrel): 308656271
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Entry
308656271 CDS
T11988
Symbol
PDE8B
Name
(RefSeq) high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 1
KO
K18437
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:
3.1.4.53
]
Organism
scil Spermophilus citellus (European ground squirrel)
Pathway
scil00230
Purine metabolism
scil01100
Metabolic pathways
scil04927
Cortisol synthesis and secretion
scil04934
Cushing syndrome
scil05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
scil00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
308656271 (PDE8B)
09150 Organismal Systems
09152 Endocrine system
04927 Cortisol synthesis and secretion
308656271 (PDE8B)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
308656271 (PDE8B)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
308656271 (PDE8B)
Enzymes [BR:
scil01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.53 3',5'-cyclic-AMP phosphodiesterase
308656271 (PDE8B)
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Paralog
GFIT
Motif
Pfam:
PDEase_I
PDE8A_N
PDE8
PAS_9
PAS
PAS_3
PDE8_3rd
PAS_4
PAS_8
JetB
Motif
Other DBs
NCBI-GeneID:
308656271
NCBI-ProteinID:
XP_081163297
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All DBs
Position
1:complement(225146400..225361425)
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AA seq
885 aa
AA seq
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MGCAPSIHVSQSGVIYCRDSEESNSPRQTTSVSQGSAAPLHGLFVQTDAADAIPPSRASG
PLGAIRVRRARAELGSGSSAGSAAPAATTCRGRRRHCCSSAEAETQTSYTSVKQVSSAEV
RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII
VIDHRQTRSFDAESVCRSIRATNPSEHTVILAVVSQASDDHEEASVLPLLHAGFNRRFME
NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFER
MMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVK
ITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDV
KSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLE
ILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITI
NDVPPSIAQLLDNEESWDFNIFELEAVTHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAW
LQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHP
GRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAI
IDMVLATEMTKHFEHVNKFVNSINKPMAAETEGSDCECNSTGKNFPENQILIKRMMIKCA
DVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYF
ITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS
NT seq
2658 nt
NT seq
+upstream
nt +downstream
nt
atgggctgcgcccctagtatccatgtctcgcagagcggcgtgatctactgccgggactcg
gaggagtccaactcgcctcgccagaccaccagtgtgtcgcagggctccgcggcccccctg
cacggcctcttcgtccagaccgacgccgccgacgccattcccccgagccgggcgtcggga
cccctgggcgctatccgcgtccgcagggcccgggctgagctgggcagcggtagcagcgcg
ggctccgcagccccagccgcgaccacctgcaggggccggaggcgtcactgctgcagcagc
gccgaggcggagacccagaccagctacaccagcgtcaagcaggtgtcttctgcggaggta
cgcattgggcccatgagactgacgcaggaccctatccaggttttgctaatctttgcaaag
gaagatagccagagtgatggcttctggtgggcctgtgacagagccggttacagatgcaac
attgctcggactccagagtcagcccttgaatgctttctagataagcatcatgagattatt
gtgattgatcacagacaaactcggagctttgatgcagaatcagtgtgcaggtcgatccgg
gccacgaatccctcggagcacacagtgatccttgccgtggtttcacaagcatctgatgac
catgaagaggcctcggtccttcctctcctccatgcaggcttcaacaggagatttatggag
aatagcagcataattgcttgctataatgaactgattcaaatagaacatggggaagttcgc
tcacagttcaaattacgggcctgtaattcagtgtttacagcattagaccactgtcatgaa
gccatagaaataacaagcgatgaccatgtgattcagtatgtcaacccagcctttgaacga
atgatgggctatcacaaaggggagctcctggggaaggaacttgccgacctgcccaagagt
gataagaaccgtgcagaccttctcgacaccatcaacacgtgcatcaagaagggaaaggag
tggcagggggtttactatgccagacggaaatccggggacagcatccaacagcatgtgaag
atcaccccagtgattggccaaggagggaaaattaggcattttgtctccctcaagaagctg
tgttgtaccactgacaataacaagcagattcacaagattcatcgtgattcaggagacaat
tctcagacagaacctcattcattcagatataagaacagaaggaaagagtccattgatgtg
aaatccatatcatctcgaggcagtgatgcaccaagcttgcagaatcgtcgctacccatcc
atggcaaggatccactccatgaccattgaggctcccatcaccaaggttataaatataatc
aacgcagcccaagaaaacagtccagtcacagtagcagaagccttggacagagttctagaa
attttacggaccacagaattatattcgcctcagctgggtaccaaagatgaagatcctcat
accagtgatcttgttggaggcctaatgactgatggcttgagaaggttgtcaggaaatgag
tacgtgtttacaaagaatgtgcaccagagtcacagtcaccttgcaatgccaataaccatc
aatgacgttcccccttctattgcccaattacttgataatgaggaaagttgggacttcaac
atctttgaattggaagcggttacacacaaaaggccattggtttacctgggcttaaaggtc
ttctctcggtttggagtatgtgaatttttaaactgttctgaaaccactcttcgggcctgg
ctccaagtgattgaagccaactatcactcctccaatgcctaccacaactccacccatgcc
gccgacgtcctgcatgccaccgctttcttccttggaaaggaaagagtaaagggaagcctg
gaccagctggatgaggtggcagccctgattgctgccacagttcatgacgtggatcacccg
ggaaggaccaactctttcctgtgcaacgcgggcagtgagctcgctgtgctctacaatgac
actgcagtcttggagagtcaccacacagccctggccttccagctcacagtcaaggacacc
aagtgcaacattttcaagaacattgacaggaaccattatcgaacgctgcgccaggctatt
attgacatggttttggcaacagagatgacaaaacactttgaacatgtgaataaatttgtg
aacagcatcaacaagccaatggcagctgagactgagggcagcgactgtgaatgtaactct
actgggaagaactttccagaaaatcaaatcctgatcaagcgcatgatgattaagtgtgct
gatgtggccaacccatgtcgccccttggacctgtgcatcgaatgggccgggaggatctcc
gaggagtattttgcacagacggatgaagagaagagacaggggctaccagtggtgatgcca
gtgtttgaccggaatacctgcagcatccccaagtcccagatctccttcattgactacttc
ataacagatatgtttgatgcgtgggatgcctttgcacatctgccagccctgatgcagcac
ttggcggataactacaaacactggaagacattagatgacctaaagtgcaaaagtctgagg
cttccatctgacagctaa
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