Streptomyces cyaneochromogenes: EJ357_12250
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Entry
EJ357_12250 CDS
T06811
Symbol
murF
Name
(GenBank) UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
scya
Streptomyces cyaneochromogenes
Pathway
scya00300
Lysine biosynthesis
scya00550
Peptidoglycan biosynthesis
scya01100
Metabolic pathways
scya01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
scya00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
EJ357_12250 (murF)
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
EJ357_12250 (murF)
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
EJ357_12250 (murF)
Enzymes [BR:
scya01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
EJ357_12250 (murF)
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
DUF561
DUF2126
Motif
Other DBs
NCBI-ProteinID:
AZQ34155
UniProt:
A0A3Q9ERX2
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All DBs
Position
complement(2756480..2757895)
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AA seq
471 aa
AA seq
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MIALSLAEIAEVVGGQTHDIPDPTVEVTGSVVRDSREVGPGSLFVAFVGERVDGHDYAAA
VVEAGAAAVLACRPVGVPAIVVEDVQTALGALARHVVRRLGATLVALTGSAGKTSTKDLI
AQVLQRKAPTVWTPGSLNNEIGLPLTALSATEETRFLVLEMGARGIGHIRYLADLTPPRI
GLVLNVGTAHIGEFGGREQIAQAKGELVEGLPSAEDGGAAILNADDPFVRAMATRTKAKV
ILFGESGEADVRAENVRLTDSGQPAFTLHTPSGASDVTMRLYGEHHVSNALAAAAVAHEL
GMSASEIATALSEAGSLSRWRMEVTERPDGVTVVNDAYNANPESMRAALRALAAMGQGRR
TWAVLGKMAELGDEALAEHDAVGRLAVRLNVGKLVAVGGREASWLQLGAYNEGSWGEESV
HVSDAQAAVDLLRSELRPGDVVLVKASRSVGLESVAEALLAGGAEGEVAAR
NT seq
1416 nt
NT seq
+upstream
nt +downstream
nt
gtgatcgccctctctctcgccgagatcgcagaagtcgtcggcgggcagacgcacgacata
ccggatccgaccgtggaggtcaccggatccgtcgtccgggactcccgtgaagtggggccg
ggcagcctcttcgtcgccttcgtcggggagcgcgtggacggccacgactacgccgccgcg
gtcgtcgaagcgggcgccgccgccgttctggcgtgccgccccgtcggcgtacccgccatc
gtcgtggaggacgtccagacggcactcggcgccctcgcccgtcatgtcgtacgacgactc
ggcgccaccctcgtcgccctgaccggctcggcgggcaagaccagcaccaaggacctgatc
gcccaggtgctccagcgcaaggcgcccactgtgtggacgccgggctcgctcaacaacgag
atcgggctgccgctcaccgccctcagcgccaccgaggagacgaggttcctcgtcctggag
atgggcgcccgcgggatcggccacatccgctacctcgccgacctgacgcccccgaggatc
ggcctcgtcctcaacgtcggcaccgcccacatcggcgagttcggcggccgcgagcagatc
gcgcaggccaagggcgagctcgtcgagggcctgccgtcggcagaggacggcggcgccgcg
atcctcaacgccgacgatcccttcgtacgggccatggcgacccgtacgaaggcgaaggtg
atccttttcggagagtcaggcgaagcggacgtacgcgccgagaacgtgagactcacggac
agcggacagcctgctttcactctccacacaccctccggtgcaagcgatgtgaccatgcgc
ctgtacggtgagcaccacgtgtcgaacgcgctcgccgcggccgccgtcgcccatgagctg
ggcatgtccgcaagtgagatcgccaccgcgctctccgaggcgggctccctctcccgctgg
cgtatggaggtcactgagcgcccggacggcgtgaccgtcgtcaacgacgcctacaacgcg
aaccccgagtccatgcgggccgccctcagggcgctggcggccatgggccaggggcggcgg
acctgggcggtgctcggcaagatggccgagctcggggacgaggcgctcgccgagcacgac
gcggtcggacggctcgccgtccggctcaatgtcggcaagctcgtcgcggtcgggggcagg
gaagcgtcctggctgcaactgggcgcatataacgagggttcgtggggtgaggagtcggtg
cacgtgtccgacgcacaggcggcggtcgacctgttgcgcagcgagttgcgcccgggggac
gtcgtcctcgtgaaggcgtcccgttcggtcggtctggagagcgtcgccgaggcgctgctc
gcgggcggtgccgagggtgaggttgccgcccgatga
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