Streptomyces cyaneochromogenes: EJ357_15145
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Entry
EJ357_15145 CDS
T06811
Symbol
leuA
Name
(GenBank) 2-isopropylmalate synthase
KO
K01649
2-isopropylmalate synthase [EC:
2.3.3.13
]
Organism
scya
Streptomyces cyaneochromogenes
Pathway
scya00290
Valine, leucine and isoleucine biosynthesis
scya00620
Pyruvate metabolism
scya01100
Metabolic pathways
scya01110
Biosynthesis of secondary metabolites
scya01210
2-Oxocarboxylic acid metabolism
scya01230
Biosynthesis of amino acids
Module
scya_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
scya00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
EJ357_15145 (leuA)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
EJ357_15145 (leuA)
Enzymes [BR:
scya01000
]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
EJ357_15145 (leuA)
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Gene cluster
GFIT
Motif
Pfam:
HMGL-like
IPMS_D2
LeuA_dimer
Motif
Other DBs
NCBI-ProteinID:
AZQ34649
UniProt:
A0A3S9M658
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All DBs
Position
complement(3392679..3394400)
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AA seq
573 aa
AA seq
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MANRQQPSSMPIHKYGRYEQVDIPDRTWPDNRVTVAPRWLSTDLRDGNQALIDPMSPERK
RRMFDQLVKMGYKEIEVGFPASGQTDFDFVRSIIEEPGAIPDDVTISVLTQAREDLIERT
VESLKGAKRATVHLYNATAPVFRRVVFRGSKDDIKQIAVDGTRLVMEYAEKLLGPETEFG
YQYSPEIFTDTELDFALEVCEAVMDVYQPGPGREIILNLPATVERSTPSTHADRFEWMSR
NISRREHVVISVHPHNDRGTAVAAAELALMAGADRVEGCLFGQGERTGNVDLVTLGMNLF
SQGVDPQIDFSDIDEIRRTWEYCNQMEVHPRHPYVGDLVYTSFSGSHQDAIKKGFDAMEA
DAAAKGVTVDDIEWAVPYLPIDPKDVGRSYEAVIRVNSQSGKGGIAYVLKNDHKLDLPRR
MQIEFSKIIQAKTDAEGGEVTGGDIWATFQDEYLPNPENPWGRIQVKNGQSTTDTDGVDT
LKVEATVDGVDTVLSGTGNGPISAFFDALDAVGVDARLLDYQEHTMSEGASAQAASYIEC
AIDGKVLWGIGIDANTTRASLKAVVSAVNRAAR
NT seq
1722 nt
NT seq
+upstream
nt +downstream
nt
atggcgaaccgccagcagcccagttccatgccgatccacaagtacggccgctacgagcag
gtcgacatcccggaccgcacctggccggacaaccgcgtcaccgtcgccccccgctggctc
tccaccgacctgcgtgacggcaaccaggccctgatcgacccgatgtcgcccgagcgcaag
cgccggatgttcgaccagctggtcaagatgggctacaaggagatcgaggtcggcttcccg
gcgtcgggccagacggacttcgacttcgtacggtcgatcatcgaggagccgggcgcgatc
cccgacgacgtcaccatctccgtactgacccaggcccgcgaggacctgatcgagcggacc
gtcgaatcgctgaagggcgccaagcgggcgaccgtccacctgtacaacgccaccgcgccg
gtcttccgccgggtcgtcttccgtggctccaaggacgacatcaagcagatcgccgtcgac
ggcacgcgcctggtcatggagtacgccgagaagctgctgggcccggagaccgagttcggc
taccagtacagccccgagatcttcaccgacaccgagctggacttcgcgctggaggtctgc
gaggcggtgatggacgtctaccagcccggtccgggccgcgagatcatcctcaacctgccc
gccacggtggagcgttcgaccccctcgacgcacgcggaccgcttcgagtggatgagccgc
aacatctcccgccgcgagcacgtcgtcatctccgtccacccgcacaacgaccgcggtacg
gccgtcgccgccgccgagctggcgctgatggccggcgccgaccgcgtcgagggctgtctg
ttcgggcagggcgagcgcaccggcaacgtcgacctggtcaccctgggcatgaacctgttc
tcgcagggcgtcgacccgcagatcgacttctccgacatcgacgagatccgtcgtacgtgg
gagtactgcaaccagatggaggtccacccgcgccacccgtacgtgggcgacctggtctac
acgtccttctccggctcccaccaggacgccatcaagaagggcttcgacgccatggaggcc
gacgcggccgccaagggcgtcacggtcgacgacatcgagtgggccgttccctacctgccg
atcgaccccaaggacgtcggccgctcctacgaggcggtcatccgcgtcaactcgcagtcc
ggcaagggcggtatcgcgtacgtcctgaagaacgaccacaagctggacctgccgcgccgg
atgcagatcgagttctccaagatcatccaggcgaagacggacgccgagggcggcgaggtc
accggcggcgacatctgggcgaccttccaggacgagtacctgccgaacccggagaacccg
tggggtcgtatccaggtcaagaacggccagtcgacgacggacacggacggcgtggacacg
ctgaaggtggaggcgacggtcgacggcgtcgacaccgtcctgtccggtaccggcaacggt
ccgatctcggccttcttcgacgcgctggacgccgtgggtgtggacgcgcggctgctggac
taccaggagcacacgatgagcgagggcgcgtccgcgcaggccgcgtcgtacatcgagtgt
gcgatcgacggcaaggtgctgtgggggatcggcattgacgccaatacgacgcgggcgtcg
ctgaaggcggttgtgtcggccgtcaacagggcggctcgttga
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