Seriola dumerili (greater amberjack): 111225977 Help Entry 111225977         CDS       T05606                                  Name (RefSeq) ryanodine receptor 3-like   KO K04963   ryanodine receptor 3 Organism sdu  Seriola dumerili (greater amberjack) Pathway sdu04020   Calcium signaling pathway sdu04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:sdu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     111225977    04020 Calcium signaling pathway     111225977  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:sdu04040]     111225977 Ion channels [BR:sdu04040]  Voltage-gated cation channels   Ryanodine receptor    111225977 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  111225977 NCBI-ProteinID:  XP_022606767 LinkDB All DBs Position Unknown AA seq 4856 aa AA seqDB search MGVSVWDDEVVLQCVACIQKENRKFCLAAEGLGNRLCYLEPTSEAKYVPPDLCICTFVLE QSLSVRALQEMLAKSGQNSEGAAQSGGHKTLLYGHAILLRHSFSSMYLACLKTSRSQTDK LSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLHLSISNGNIQ VDASFMQTLWNVHPICSGSNIEEGYLLGGHVMRLFHGHDEVVTIPGSDQSEEQQRIVNYE TGNAGAKARSLWRLEPLRISWSGSHIRWGQPFRLRHLTTGHYLALTEDRGLVLQDREKSD TVATAFCFRVSKEKLEQSPKRDIEGMGVAEIKYGDSLCFITHVATGLWLSYQAPDVKSAR LGPLKRRACLHSEGHMDDGLTLQRCQHEESRAARIIRNTTLLFNRFIRDLDCLGLKNRAL VALPVEEVLQTLNDLITYFQLPDAELEHEERQIKLRSLKNRQNLFKQEGMLTLVSNCIDR LNVYNSAAHFGECAGSEAGAAWKDILNLLYELLAALIRGNRNNCTQFSNNLDWLVSKLER LESSSGILEVLHCILIESPEALNIIQRGHIKSIISLLYKHGRNHKILDVLCSLCVCNGVA VRTNQNLICDHLLPKRDLLLQTQLVNDVQSMRPNIFLGVSEGSAQYKKWYYELMIDQVDH FVTSEPSHLRVGWANAKGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSGRIPRAVASM NQHILTSEDVVSCCLDLGAPSISFRINGQPVQGMFENFNTDGLFFPVVSFSAGVKVRFLL GGRHGDFKFLPPSSYAPCYEALLPKEKMKVEPVKEYKRDMEGVRDLLGTTQFMSQASFIP TPVETSQIVMPPHLEKVRDKLAENIHELWGMNKIELGWSYGKIRDDNKRQHPCLVDFSKL PETEKNYNLQMSTETLKTLLALGCRVVHVNPNAEDSLKKIKLPKNYMMSNGYKPSPLDLS DIKLTPGQELLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSKRNPRLVPYVLLDERTKK SNRDSLREAIRTLIGYGYNIEPSDQEGGQVAERLSIDKIRFFRVERTYSVKTGKWYFEFE SVTGGDMRVGWARPGCKPDVELGTDELAFVFDGYRGHCLNMGSRLFGRCWHAGDVVGCMI NMEDKSMIFTLNGEILITTKGSELCFTDFETEDGFIPVCSLGLSQVGRMNLGKDASTFKY YTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFVNVPKDHNHIAVTRIDGTIDSPPCLKVT HKTFGTQNSNADMVFCRLSMPVEFHSFFKSCPVVDMNGVHEEDTLKVKHRCSPPQNHEYY HSVRVFAGQDPAGVWVGWVTPDYHYHSNNFNLSKNRTVTVTLGDERGRVHESVKRSNCYM VWGGDVTNAAHTSSRSNVDLEIGCLIDLATGLVTFTVNGKEISTSYQVEPNTKLFPAVFV RPTSPNLFQFELAKIKNAMPLSSAIFKSEHKNPVPQCPPRLDVQTINAVLWSRMPNTFLK VETARVNDRHGWVVQCVEPLQMLAVHIPEENRCVDIMELSEQEDMRKFHYHTLKLYCALC ALGNTRVAHALCSHLDQSQLLYTIDNQYLSGMLREGFYNVLISIHLETAKEARLMMKDEF IIPVTAETRSIRLFNDASKKHLPPGVGLSTSLKPRLNFAPLCFISNKREQYLYSPQIPLD SLKEKAILMLTEAVQGGGHHIRDPVGGGVEYQFVPILKLISTLLTMGVLGSEDVHKILLL IDPNVFRETHEEGAAGATDKEGLTGTEEKAVEAGEEEAAKEAKQPMKGLLEKRLPEPVKR QMCELLHYFCDCELKHRIEAIVSFSDNFVSKLQYNQKFRYNELMLALNMSAAVTAKKTKE FRSPPQEQINMLLTFSMGEDCPCPTDIQEELYIFHNQLQLHCGIPMEEDEDEQDTSIKGR LLMLVSKIKGQSHKAEEPTEKEQAAPSNLKELISQTMVSWAQECHIQDPELVRKMFSLLR RQYDSIGELLRAMRKTYTISAASVQDTINLLASLGQIRSLLSVRMGKEEEKLMIDGLGDI MNNKVFYQHPNLMRILGMHETVMEVMVNVLGGDKSQEIAFPKMVASCCRFLCYFCRISRQ NQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAASSVMDNNGLALALEEPDLDKVVTYL AGCGLQSCPMLLAKGYPDIGWNPIEGERYLSFLRFAVFVNGESVEENSSVVVKLLIRRPE CFGPALRGEGGNGLLAAMKEAIKISETPALDLPGSVQGVYSDVSGDGDDEEEVVHMGNAI MSFYSALIDLLGRCAPEMHIINKGKGEALRIRAILRSLVPTEDLVGIISIPLKMPIINKD GSMTEPDMSASFCPDHKAPMVLFLDRVYGIEDQSFLLHLLEVGFLPDLRAATSLDTEGLC TTETALAMNRYIGSAMLPLLTRCAPLFAGTEHYASLIDSTLHTIYRLSKGRSLTKAQRDA IEECLLSVCKHLRPSMLQQLLRRLVFDVPLLTEYCKMPLRLLTNHYEQNWKFYCLPSGWG SYGTASEDELLLTKKIFWGVFDSLSQRKYDAELFKMAMPCLSAIAGALPPDYVDASISTA VEKPVSVDAQGNFDPKPINTANIALPEKLEHFANKYAEHSHEKWSAEKVLLGWKYGDCVD EKAKTHPQLRTYKALTEKEKEIYRWPIRESLKSMLAMGWSIDRTKDGESMSQQRENEKMR KISQTSQANGFNPSPIDMSNVVLSRELQGMVEVVAENYHNIWAKKKKSDLGSRGGGTHPL LVPYDTLTAKEKARDREKAQDLFRFLQINGYSITRGLKDLEQDSSSMEKRFAYKFLKKLL KYVDSAQEFITHLEAMAASGKTDRSPHEQEIKFFAKVLLPLIDQYFKNHSLYFLSSPNKN LSSSGYASNKEKEMVTSLFCKLAALVRHRISLFGSDSTTMVSCLHILAHTLDTRTVMKSG SEMVRVGLRTFFENAAEDLEKTFENLKLGKFTHSRSQMKGVSQNINYTTVALLPILTALF EHITQHHFGVDLLLDDVQVSCYRILTSLYALGTGKNIYVERQLPALGQCLATLAGAMPVA FLEPLLNTYNPCSVFNTKSARERAILGIPDSVEEVCPGMPRLDGLMKDINDMAESGARYT EMPHVIEVVLPMLCNYLSYWWERGPENQPASGGSVCCTTVTSEHLSLILGNILKILNNNL GIDEASWMKRIAVYVQPIISKARADLLKSHFLPTLEKLKKKTVKVVAEEELLKADSKGDT QEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSRWLKEPDADSNDLFRMVAEIFILWCK SHNFKREEQNFVVQNEINNLSFLTGDNKTKMSKSGGQDQERKHKKRRGEFYSIQTSLIVA ALKKMLPIGLNMCTPGDQELISLSKTRYLLKDTDDEVKDHIRQNLHLREKSEDPAVRWQL NLYKDIVMRSEWPPDPDRVVDRIQRISAAVFNLEQVEQPLRSKKCVWQKLLSKQRKRAVV ACFRMAPLYNLPRHRSINLFLLAYQRIWIETEEYSFEEKLVQDLATQPKVEEEEEEEVRK QPDPLHQLILHFSHNALTECSSLEEDPLYIAYADMMAKSCAEGEEEEDEEGKEKTFEEKE MEKQKMLYQQARLHDRGAAEMVLQMISASKGRLAAMVTFTLKLGISILNGGNTLVQQKML DYLKEKRDVGFFKSLSGLMMSCSVLDLNAFERQNKAEGLGMVTEEGSINVSERGSKVLQN DEFTKDLFRFLQLLCEGHNNDFQNFLRTQTGNTTTVNIIISTVDYLLRLQESISDFYWYY SGKDIIDEAGQRNFSKALAVAKQVFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFA NMQMKLSQDSSQIELLKELLDLQKDMIVMMLSLLEGNVVNGTIGKQMVDTLVESSSNVEM ILKFFDMFLKLKDLTTSDSFREYDSESKGIISKKDFQKSMENQKQYSQSEIEFLLSCAEA DENDMFNYEQFVERFHEPAKDIGFNVAVLLTNLSEHMPHDARLSTFLDLAESVLSYFEPF LGRIEIMGGAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGESEKMELFVNF CEDTIFEMQLASQISEPDPVERPEEEEDDNQSVVENQEEAEEESMMLESSSAFTIACVSL RKSLCHFRQMLTLKSMRRQYRKFRKMSVKEMVRGFFSFFWVIITGLFHFVYSLIWGFFHI LWTTMFGGGLVEGAKNMKVTDILGNMPDPTQFGIHGDVLETEKLEASEASALAEMGQMAQ GEAAEADLMAELLNIQPKKEGKHAAEPGLGDVSEVVVGDAPSIASAVKQKKAQLAAKKRA ANGDYKSDSEKGDSEDGEKKDHDKAKDEAPPEHAAEEKKAPKKRLGQKKEPPEAFMASFF AGLEVYQTKMLNYLARNFYNLRFLALFVAFAINFILLFYKVTGDYSDDEDPWNGRGRAGE EEDEGALEYFVLQESTGYMAPTLRCLAILHTIISFLCVVGYYYLKVPLVVFKREKEIARK LEFAGLYITEQPSDDDIKGQWDRLVINTPSFPNNYWDKFVKRKVIKKYGDLYGAERIAEL LGLDKSALDFNPTEETVAKEASLVSWLSSIDTKYHVWKMGVVFTDNSFLYLVWYTTMSIL GHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRK FYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYELYRILFDITFF FFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTTPHGFETHTLQ EHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14571 nt NT seq  +upstreamnt  +downstreamnt atgggcgtgagcgtgtgggatgatgaagtggtgctccagtgcgtggcctgcatccagaag gagaatcgcaagttctgcctggctgctgagggtctggggaaccggctgtgttacctggag cccacatctgaggcgaagtatgttcctccagacctgtgcatctgcacctttgtgctggag cagtctctgtcggtacgggccctgcaggagatgctggctaagagcggacagaacagtgaa ggggcagcgcagagcggcggacacaagactcttctgtacggacacgccatcctcctgcgg cattccttcagctctatgtacctggcctgtttgaagacatcaaggtcacagacagataag ctgtcctttgatgtcggcctgcaggaggactcaacaggtgaggcctgttggtggaccatc caccctgcctccaaacagagatcggaaggagagaaagtgcgcatcggtgatgacctcatc ctcgtcagtgtgtcctcagagcgataccttcacttatccatctccaatggcaatatccag gtggatgcttccttcatgcaaaccctgtggaatgtccatcccatctgctctggtagcaac atagaggaaggctacctgctgggcggtcatgtgatgcggctgttccatggacacgatgag gtagtgaccatcccgggatcagaccagagtgaagagcagcagaggatagtcaactatgag acgggtaatgccggcgccaaggccaggtccttgtggaggctggagccactcagaatcagc tggagtgggagccacatccgctggggccagcctttccgactgcgccacctgaccactggt cactacctggccctgaccgaggaccgggggttggtgctgcaggaccgagagaagtccgac accgtcgccacagccttctgcttcagagtctctaaggagaagctggagcagagccccaag cgggacatcgagggcatgggggtggcggagattaaatacggggactcactctgcttcatc acgcacgtggccacgggactctggctctcctatcaggcacctgatgtcaaatctgcccgt ctgggtcccctcaagagacgagcgtgtctacattctgaaggtcacatggatgacgggttg accctgcagcgctgtcaacacgaagagtcccgcgcagcacgcattatccgcaacaccacc ctgctcttcaacagattcatcagagacctagactgtctgggtcttaagaacagggcactg gtcgccctgcctgtcgaggaggtgctccaaactctcaatgacctcatcacctatttccag ctccctgacgctgagctggagcacgaagagaggcagatcaaactgcgctcgctcaagaac cgacagaatctattcaaacaggaaggcatgctgactctggtttccaactgtatcgaccgt ctgaacgtgtacaacagtgcggcccactttggagagtgtgccgggtctgaagccggagca gcctggaaagatattctcaatctgctgtacgagctgctggcggcgttaatccgagggaac aggaacaactgcacgcagttctccaacaacttggactggctggtgagcaagctggagaga ctggagtcttcttcaggcatcctggaagttctgcactgcattctaattgagagccccgag gccctcaacatcatccagagaggacacattaagtccatcatatccctgctctacaagcac ggacgcaaccacaagattctggatgtgctttgctcgctgtgtgtgtgtaatggtgtagct gtgcgaaccaatcagaaccttatctgtgatcacttgctgcccaagagagatctgctgctg cagacccagctggtcaatgatgtgcagagtatgagaccgaatatcttccttggggtgagc gagggctcagctcagtataagaagtggtactatgagctgatgatcgaccaggtggaccat tttgtgaccagcgagccctcccacctgagagtgggctgggccaacgctaaaggatacgct ccctaccctggaggaggagagggctgggggggcaatggagttggagatgacctctactct tatggttttgatggactccacctctggtcaggtcgtatcccgcgggcggttgcgtccatg aaccagcacatcctgacctcagaggatgtagtgagctgttgtctggacctgggagcaccc agcatctctttcaggatcaatggacagcctgtccagggcatgttcgaaaatttcaacaca gacggcctcttcttccctgttgtcagcttctctgcaggggtcaaggtgcgattccttttg ggtggtcgacacggcgactttaagttcctgcctccgtcaagctacgctccatgttatgag gctctgctgccgaaagagaagatgaaggtcgagccggtgaaagagtacaagagggatatg gagggagtcagagatctgctgggcaccacccagttcatgtcacaggcctccttcatcccc acacctgtggaaaccagccagattgtgatgccacctcatttggagaaggttcgggacaag ctggctgagaacattcatgaactgtggggcatgaataagattgagctgggctggtcgtac ggcaagataagggatgataataagcggcagcatccatgcctggtggatttctccaagctg ccagaaacagaaaagaactacaatctgcagatgtcaacagaaactctgaagaccctgctg gcattgggctgtcgtgtagttcacgtgaatccaaatgctgaggactccctcaagaagata aaactccctaagaactacatgatgtccaatggctataagccatctccgctggacctgtct gacataaaactgactccgggtcaggagctgctggtggacaaactggcagagaatgcgcac aatgtgtgggccaaggaccgtatcaaacagggatggacctacggcatccagcaggatctg aagagtaagcgcaaccctcgcctggttccttatgttctgctggatgagcgcaccaagaag tcgaacagggacagcctccgggaggctatccgcaccctgattggctatggatacaacatt gagccctcggaccaagaaggcggacaagtggctgagcggctcagcatcgacaagatccgc ttcttcagagtagagaggacgtactcggtgaagaccgggaaatggtactttgaatttgag tctgtgacgggaggagacatgagagtgggctgggccaggcctggatgtaagccagatgtg gaacttggcacagatgagctggctttcgtcttcgatggatacaggggccattgtctgaac atgggcagccgtttgttcgggcggtgctggcatgctggggacgtggtgggctgtatgatc aacatggaagacaagtccatgatcttcacccttaatggagagatcctcatcaccaccaag ggctcggaactctgcttcaccgactttgaaactgaggatggattcatcccagtgtgcagt ctcggcctgtctcaggtgggtcggatgaatctggggaaagatgcgagcaccttcaagtac tacaccatgtgcggccttcaggaagggtttgagcccttcgctgtcaacatgaacagagag gtcaccatgtggttcagcaagcgtctgcctacttttgtcaacgtgccgaaggaccacaac cacatcgcagtgaccaggattgacggcaccatcgacagccccccgtgtcttaaagtgacc cataagacgtttggcacccagaacagtaacgccgacatggtgttttgccgtctcagcatg cctgtggagttccactccttcttcaagtcctgtccagttgtggacatgaacggagtgcat gaggaagacacccttaaagtcaaacacaggtgctcacctccccagaatcatgaatactat cattcagtgagggttttcgcgggtcaggaccctgccggcgtgtgggttggatgggttacc cccgactaccattaccatagcaacaatttcaacctcagcaaaaacagaacggtgactgta accctgggcgatgagcgaggacgagtccacgagagtgtgaagaggagtaactgctacatg gtgtggggtggtgacgtgaccaacgctgctcacacctccagtcgcagcaacgtggacttg gagattggctgtctgatagacctggccaccggcctggtgacattcactgtcaatggcaaa gagatatccacctcttaccaggtggaaccgaacaccaagctcttccctgctgtgtttgtg cgacccaccagcccgaacctcttccagtttgagctggctaaaataaagaacgccatgcca ctgtcgtcagccatctttaagagtgaacataagaacccggtgccacagtgtccgccgcgt ctagacgtccagaccatcaatgcagtgctgtggagccgcatgcccaacacctttctgaag gtggaaacagccagggtcaatgacagacacggctgggtggtgcagtgcgtggagcccctg cagatgttggctgtacacatacctgaggagaacagatgtgtcgacatcatggagctgtct gaacaggaggacatgaggaagttccattaccacaccctgaagctctactgcgccctctgc gctctgggcaacacccgtgtggcccacgccctctgcagccacctcgaccaatcccagctc ttatacaccatcgacaatcagtacctgtcgggcatgttacgcgagggcttctacaacgtt ctgatcagcatccacctggagactgccaaggaggcacggctcatgatgaaagacgagttc atcatccccgtcacggccgagacacgctccatccgtctctttaacgacgcttccaaaaag cacctcccgccaggggtggggctcagcacctccctcaaaccacgcctcaactttgctccg ctctgtttcatcagcaacaaacgggagcaatatctgtacagtccccaaatcccgctggat tcactgaaggagaaagcgattttgatgttgacggaagccgttcaaggtggagggcaccac atccgagatcctgtgggaggaggtgtggagtaccagtttgtgccgatcctgaagctcatc agcaccttgctgactatgggtgtattagggagtgaggatgttcacaagatcctactgctc atcgacccgaatgtgttcagagaaacacacgaggagggggctgcaggggccacagacaaa gaaggactcacagggacagaggagaaggcagtggaagctggagaagaggaggcagcgaaa gaggctaaacagccaatgaaaggactgctggagaagaggctgccggagcctgtgaaacga cagatgtgcgagctgctccactatttctgcgactgtgagctgaagcaccgcatcgaggcc atcgtgtcgttctccgacaacttcgtctccaagctgcagtacaaccagaagttccgctac aatgagttgatgctggccctcaacatgtctgccgctgtaacggcaaagaagaccaaagag ttcagatcgcctcctcaagaacagatcaacatgctgctgaccttcagtatgggcgaggat tgtccgtgtccgacggacatccaggaggaactctacatttttcacaaccagctgcagctc cactgtggaatccctatggaggaagacgaagacgagcaagacacatctatcaaaggtcgc ctcctaatgctggtgagcaagatcaaaggccagtctcacaaagcagaggagcccacagag aaggagcaggccgcaccatccaatctgaaggagctgatctctcagaccatggtcagctgg gcccaggagtgtcacatccaggacccagagctggtccgtaagatgttcagcctgctgagg aggcagtatgacagcatcggggagctgctccgggccatgaggaagacttacaccatcagt gccgcctcggtgcaggacaccatcaacctcctggcctccctgggtcagatcagatctctg ctgtctgtccgcatggggaaagaggaagagaagctcatgattgatggacttggcgatatc atgaacaacaaggttttctaccagcacccaaacctaatgaggatactgggcatgcatgag actgtcatggaggtcatggtgaatgtgcttggaggagacaaatcccaggaaatcgccttc cccaagatggtggccagctgctgtcgcttcctgtgctacttctgccggatcagccgtcag aaccagaaagccatgttcgaccacctcagttacctgctggagaacagcagcgtgggtcta gcttcaccggctatgaggggctctactcctctagatgtggctgcttcctcagtgatggac aacaacggcctggctctggcactggaagaacctgatctggacaaggtggtcacctacctg gcaggatgtggtctccagagctgtccaatgcttctggctaaaggttatccagacattggc tggaaccccatcgaaggggaacgatacctttccttcttgcggtttgccgtcttcgtcaat ggtgagagtgtggaagagaactccagcgttgtggtgaagctgctcatccgtcgcccggag tgtttcggaccggccctgaggggagagggagggaacggcctgctggctgccatgaaggaa gccattaaaatctccgagacacctgctttggacctgccgggctccgtccagggagtctac tccgacgtgtctggtgatggtgatgacgaagaggaggtggttcacatgggcaatgccatt atgtccttctattctgcgctcattgaccttttgggacgttgtgccccagagatgcatatc atcaacaaggggaaaggtgaagctctgcgtattcgtgccatcttgcgctctctggtgccg actgaggaccttgtgggaataatcagcataccactcaaaatgcccatcatcaacaaagat gggtcaatgacagagccggacatgtcagccagcttttgtccagaccacaaggcccccatg gtgctgtttctggacagggtgtacggtattgaggaccagagctttctgcttcacctgctg gaagtgggctttctgcctgatctgagggctgccacctctctggatacggagggtctgtgt acgacagagacagccctggccatgaaccgctacatcggctcagccatgctccccctcctc acccgctgcgcccctctctttgcgggcaccgagcactacgccagcctcatcgactccact cttcacaccatctaccgcctttccaagggccggtccctcaccaaggcccagagagatgcc atagaggagtgtctgctgtctgtctgcaaacaccttcgtccctccatgctgcagcagctc ctgcgccgccttgtctttgatgtgcccttgctgactgaatactgcaagatgcctctcagg ctgctaaccaaccactatgagcagaactggaagttctactgcctcccgtcgggctggggc agctacggcacagcatctgaggatgaactactgctcaccaagaaaatcttctggggagtg tttgattctctgtcccagaggaaatatgatgcagagctattcaagatggccatgccttgc ctcagtgctatagctggagctttgccacctgactatgtggacgcctctattagtaccgct gtggaaaagcctgtttctgtagatgctcagggcaactttgacccaaaacccatcaatact gctaacattgccctcccagagaagcttgagcactttgccaacaaatatgccgaacattcc catgagaaatggtctgcagagaaggtgctgctgggatggaaatacggagactgtgtggat gagaaggccaagactcaccctcagctcaggacctacaaagccctaacagagaaggagaag gagatttacagatggccaataagagagtccctgaagagcatgctggcaatggggtggagc atcgataggaccaaggatggagagagcatgtctcaacagagggagaatgagaaaatgaga aagatatctcagacctcacaggcaaatgggttcaatccgagcccgatagatatgagcaac gtggttctatccagggagctgcaggggatggtggaggtggtggcggaaaattaccataac atctgggccaagaagaaaaaaagtgaccttggaagcagaggggggggaacacacccactg ctggttccctacgacacgctgacagccaaggagaaggcccgtgatcgagagaaggcccag gacctttttcgcttcctgcaaatcaatggctacagcatcacaagaggtttgaaggacttg gagcaggattcttcttccatggagaagaggtttgcctataagtttctcaagaagctgctc aagtatgtggactcagctcaggagttcatcacccacctggaggccatggccgccagtgga aaaacagaccggtcccctcatgagcaagaaatcaagtttttcgccaaagttcttctccct ctcatcgaccagtacttcaagaaccactctctctacttcctctcctcccccaacaagaac ctgagcagcagcggttacgcctccaacaaggagaaggagatggtcaccagcctgttttgt aaactggcagctcttgtcagacataggatttcactctttgggagtgactccaccaccatg gtgagctgtctgcacatcctggcgcacactctggacaccaggacggtgatgaagtcgggc tcagagatggtgcgggtggggctgcggacgttcttcgagaacgccgcagaggacctggag aagacgttcgagaacctgaagctggggaagttcactcactcccgctcgcagatgaaaggg gtgtcgcagaatatcaactacaccactgtagctctgctccccatcttaaccgctctgttt gaacacatcactcagcaccactttggagtcgacctgctgctggatgatgtccaagtgtcc tgctatcgaatcctgaccagcctctatgcactgggcactggaaaaaacatctacgtagaa agacagctgccagctctgggccagtgtctggccacccttgccggggccatgcctgtggcc ttcttggagccattgctcaacacgtacaacccctgctcggtttttaataccaagagtgcc cgagaacgagccatcctcggcataccagactcagtggaggaggtgtgtcccgggatgccg cggctggatggcctgatgaaggacatcaatgacatggctgagtctggagcgcggtacaca gagatgccgcacgttatagaggtggtgttgcctatgctgtgcaactatctgtcctactgg tgggagagggggcctgagaaccagccagccagcgggggcagcgtctgctgcaccaccgtc acctcagagcacctcagcctcattcttggcaacatcctcaagatcctcaacaacaacctg ggcatcgatgaggcgtcctggatgaagaggattgcagtgtacgtgcaacccattatcagc aaggctcgcgctgacctgctgaagagccacttcctgcccacgctggagaagctaaagaag aagacagtgaaggtggtggctgaggaggagctgttgaaggcggacagtaagggagacacc caggaggccgagctgctcatcctggacgagtttgctgtactctgcagggacctgtacgcc ttttaccccatgcttatccgctacgtggacaacaacaggtccaggtggctgaaagaacca gatgctgactccaatgatctcttcagaatggtcgctgagatttttatcctctggtgcaag tcacataatttcaaacgagaggaacagaactttgtggttcaaaatgaaattaacaacctt tccttcttgactggagataataaaaccaagatgtctaagtctggaggacaagaccaggag aggaaacacaagaaaaggcgtggtgagttctactccatccagacctcactgattgtggcc gctctgaagaagatgctgccgattggcctcaacatgtgtacgccaggagatcaggagctc atatctctatccaagactcgctacctcctgaaagacacagatgatgaggtcaaagatcac attcggcagaatctgcatcttagagaaaagtcagaggaccctgcagtgaggtggcagcta aacctgtacaaggacatagtgatgaggagcgagtggcctccagaccctgacagggtggtg gaccgtatccagaggatctctgctgctgtcttcaacctggagcaggtggagcagccactg agatccaaaaaatgtgtttggcagaagttactgtccaagcagaggaagagagcggttgtt gcctgcttccgcatggctccactctataatctacccaggcatcgctctattaacctcttc ctcctggcctatcagagaatatggatagaaacagaggagtactcttttgaggagaagcta gtgcaggatcttgcaacgcagcccaaagtggaggaagaggaggaggaggaggtcagaaaa caaccggacccgcttcaccagctcattctgcatttcagccacaacgctctgactgagtgc agttctttggaagaggatcccctgtacatcgcatatgcagatatgatggcaaaaagttgt gctgaaggtgaagaagaggaagacgaggaagggaaagagaaaacatttgaggaaaaggaa atggagaagcaaaagatgctgtatcagcaagccaggcttcatgaccgaggggctgcagag atggtgctccagatgatcagcgccagcaaaggtcgactcgctgctatggtgacattcacc ctcaaactgggtatctccattctgaacgggggaaacacactggtccagcagaaaatgctg gactatctgaaggagaaaagagatgttggctttttcaaaagtttatctggactgatgatg tcctgcagtgtcctggacttgaacgcgtttgaaaggcaaaacaaagctgaaggtctgggg atggttactgaagagggatcaatcaacgtgagtgagcggggttccaaggtactgcagaat gatgaattcactaaggatctctttaggttcctgcagcttctctgtgagggccacaacaat gattttcagaacttcttgaggactcaaacagggaacacaactacggtcaacatcatcatt agtactgtagactacctactaagactccaggaatccatcagtgatttttactggtactac tctggtaaggacatcattgatgaggccggtcaaaggaacttctccaaagcactggcagtg gccaagcaggtcttcaactctttaactgagtatatacagggtccatgcattgggaatcag cagagtctggctcacagcaggctgtgggatgctgtggtgggattcctgcatgtttttgcc aacatgcagatgaagttatcccaggactccagtcagattgaattactgaaggagctgctg gacctacagaaggacatgatcgttatgatgctctctcttctcgaaggtaatgttgtcaat ggcaccattggcaaacaaatggtggacactttggtggaatcttcaagcaacgtggagatg atcctaaaattctttgacatgttcctcaagttgaaggatttaacgacctcagacagcttc agggaatatgactctgagagcaaagggatcatttcgaagaaggatttccagaagtccatg gagaaccagaaacagtactcccagtctgagattgagtttcttctctcttgtgctgaggcg gatgagaacgacatgttcaactacgagcagtttgtggagagattccacgaacccgccaag gacatcggctttaacgtagccgtgctgctaaccaatctctccgagcatatgccccatgat gctcgcctctcaaccttcctcgacctggctgagagcgttctcagctactttgagcccttt ttgggtcgtattgagatcatgggtggagccaagcgcatcgagagagtctacttcgagatc agcgagtcgagtcgtacccagtgggaaaagcctcaggtgaaggagtcgaagcggcagttc atcttcgatgttgtcaatgaaggcggagagagcgagaagatggaactgtttgtcaacttc tgtgaggacaccatctttgagatgcagctggcttcccaaatttcagagccagacccggtg gagcgcccggaggaggaggaagacgacaaccagagtgtggtggagaaccaggaggaggca gaggaggaaagcatgatgttggagtcttcctctgctttcacaatcgcctgcgtctcattg agaaaaagcctgtgccacttccgccagatgctgactctcaagagcatgaggcggcagtac aggaagttcaggaagatgagtgtgaaggagatggtgcgaggtttcttctctttcttctgg gtgatcatcacgggactcttccacttcgtctacagcctcatttggggtttcttccacatc ttgtggaccactatgtttggcggcggcctcgttgaaggggctaaaaatatgaaagtgaca gatattttgggaaacatgccagatcccactcagtttggcatccatggagatgtgttggag acggagaagttggaggcgagcgaagcgtcggcgttggcagagatgggtcagatggctcag ggggaagcagcagaggcagacctgatggctgagttgctgaacatacagcccaagaaggag ggaaagcacgcggcagagcctggtttgggggatgtgtctgaggtggtggtgggggacgct ccgtctattgccagtgccgtcaagcagaagaaggcacagctggctgcgaagaagagggct gcgaatggagactacaaatctgattcagagaaaggagattcagaagacggtgagaagaag gaccacgacaaggccaaagacgaagcccctccagagcacgcggcggaggagaaaaaagcc ccgaagaagaggctcggccagaagaaagaaccgccagaggcgttcatggccagcttcttc gccggcctggaagtctaccagactaagatgctgaactacctggccagaaacttttacaac ctccgctttctggcacttttcgttgcctttgccatcaacttcattctgctcttctacaag gtaaccggggattactcggacgatgaagacccctggaatggtcgaggtagagctggggag gaggaagatgaaggggcgcttgagtacttcgtcctgcaggagagcacaggctacatggcg ccaacgcttcgctgtctggcgatactacacactatcatatctttcctgtgtgtagtggga tactattacctgaaggtgccactggtggtgtttaaacgtgagaaggagatagcgaggaag ttagagtttgccggtctctacatcactgagcagccatctgatgatgacatcaaaggacag tgggacagactggtcatcaataccccttctttcccaaacaactactgggataaatttgtc aaacgcaaggtgatcaaaaaatatggagacctgtatggagcggagaggatagcggagctg ctgggcctggataagagtgccctggatttcaaccctacagaggaaactgtcgccaaggag gcttcattggtgtcatggttgagctcaatcgatacaaagtaccacgtctggaaaatggga gtggtgtttacagacaattctttcctgtacctagtgtggtacaccaccatgtccattctg ggccactacaacaacttcttcttcgccgcccatctgctggacatcgccatgggcttcaag accctccgcaccatcctctcctctgtcacacacaacggcaaacagctggtgctgacggtc ggcctgctggcagtcgtggtctatctctacactgtggtggccttcaacttcttcaggaag ttctacaacaagagcgaggatgaggatgagccggacatgaagtgtgatgacatgatgacg tgctacttattccacatgtacgttggggtgagagcaggagggggcatcggggatgagatc gaggacccggctggtgacccgtatgaactctaccgcatcctttttgacattaccttcttc ttctttgtcatcgtcatcctcctggccatcatccagggtttgatcattgatgcctttgga gagctgagagaccagcaggaacaagtcaaagaggacatggagaccaaatgtttcatttgc gggatcggtaatgattacttcgacacaacacctcacggctttgagacccacaccttacaa gagcacaatttggccaactacctgtttttcttgatgtaccttatcaacaaggatgagaca gagcacactggccaggagtcatatgtgtggaagatgtaccaggagcgatgctgggatttc ttcccagctggagattgcttccgcaaacagtatgaagatcagcttggatag

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