Seriola dumerili (greater amberjack): 111231221 Help Entry 111231221         CDS       T05606                                  Symbol obscn Name (RefSeq) obscurin   KO K17531   obscurin-RhoGEF [EC:2.7.11.1] Organism sdu  Seriola dumerili (greater amberjack) Pathway sdu04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:sdu00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     111231221 (obscn)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:sdu01001]     111231221 (obscn)   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:sdu04131]     111231221 (obscn) Enzymes [BR:sdu01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      111231221 (obscn) Protein kinases [BR:sdu01001]  Serine/threonine kinases: CAMK group   Trio family [OT]    111231221 (obscn) Membrane trafficking [BR:sdu04131]  Others   Rho GTPase associated proteins    Rho guanine nucleotide exchange factors (GEFs)     111231221 (obscn) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  I-set Ig_3 ig Ig_2 V-set Ig_5 Ig_4 Ig_6 Izumo-Ig V-set_CD47 SOS1_NGEF_PH fn3 RhoGEF C1-set FN3_DSCAM-DSCAML_C C2-set_2 Receptor_2B4 PH IQ CDC48_2 WW_FCH_linker RHG20_PH Motif Other DBs NCBI-GeneID:  111231221 NCBI-ProteinID:  XP_022613979 LinkDB All DBs Position Unknown AA seq 6557 aa AA seqDB search MDPNLFGGAPRFLTRPKAFAVCVGKDATLSCTIVGTPTPLITWEKEKLKLTSGGRFKTVE DGDVYRLTIYDLTLEDSGQYMCRAKNSVGEAYAAVTLKVALPTEMAQRAPVFLVKPTSAR VGLGGDVVFHCRVVAYPEANFDWEKDGRYLGETNRIKIVSDSDSSTLKIQSVRNLDSGTY TCRAQNTVGRAHTAAALVVDAQDSRHLTADKNTSLLSHLQKRKEEMKKDISIYRTEESSS LPKGVFTRTCTVTEGKHAKLSCLVTGHPKPHIIWRRDGSNISEGRRHIIYEDQAENFILK ILFCKQSDNGLYTCNATNMAGQTYSAVLVTVKEPNVPFRRKLQDVEVQEKTAATLMCEVP LSATHANWFMEETRLEQSTKYRMEEEGTLRRLTIHNVTTNDDGVYICEMKEGSRTVAELT VLGNITKKLPRRTVVPVSDTVIFCVELEHPCPDVYWTRNGEKLKEDSRISIACVLRQYTL TIRDCQADDSGEVAFVAGDCKTSTRFSVTAARKHPPDPPVDAVVQNKTDSSITIQWSPPD SDRPVPIKGYHVERRKVGSQTWQRCNAGETIVSTEITIRNFTEEASYQFRISATNDFGQS PYLEVPGSFYLEPTAEIRKGLMNSSAISGEEFSLSLELSAVCSGFWSLSGRLLRSGADYL ITRSKNTHTLLIRVVTMEMNGAEVKFVGGGSQSSCILSVKVPAVRFTNKSGQMEMMTCSA QASAQLTAEVSDYDAQVVWMKNGREVKMGKKYEYVNTDRKRILMVHNVTEEDVGIYECVL ADDKMSLQLTLKDEPAKFLNKARGPMGLSSSLKGDLELSCEVSLASAAVVWRKDQVEITE DQRTNIISKGTQRKLVIKNAKKSDEGHYSCETAADKVTFHVKIKESQTQAQAAFSNKESV QKEVKASLSQKATLSCNVSDSKTEVKWYKDGKLLVSSRTIYSEAKGSSRQLVIEKVEKSD AGEYTCEAGGDKLVFKISVSEALSAFFNKESVQKEVKATLSQKAILSCEVADTKTEVKWY KDGKLLTSSKTIHAESKAKSRQLVIDSVEKRDAGEYICEAGTEKLAFKIQVAEPQSAFFN KESVQREVKATLSQKATLSCEVSDSKTEVKWYKDGKLLTSSKTIHAESKGKSRQLVIDIL EKEDAGEYICEAGSEKLVFKLHVADTHVQSAFSNKESVQKDVKATLSQKATLSCEVADTK TEVKWFKDGKLLTSSKTIHAESKAKSRQLVIDSVEKKDAGEYICEAGTEKLTFKVHVEEI RAKSAFLNKESVQKEVKATLSQKATLSCEVVDTKTEVKWYKDGKLLSPSRTVHSESKGKT RQLVMDSIEKKDAGEYICEVGTEKLAFKVLVTEIQLKSAFSNKESIQKEVKATLSQKAIL SCEVADTKTEVKWYKDGKLLTSSKTIHAESKAKSRQLVIDSVEKRDAGEYICEAGTEKLT FKIQVAETLAGFSNKESVQKEVKATLSQKATLSCEVSDSKTEVKWYKDGKLLTSSKAVHM ESKGKSRELVIEKMEKKDAGEYTCEAGTEKLVFKLQMTEAAVKFQKKSIKDTYTVQASEN IVLTILLTTESGSVKWFRDGVEVKESSKYEMKKDGRSRTLIVKSTEAKDSGTYSCQTAND KLEFKVQVKELALKFVVPLKSVDVELGGTISLMCELNQASGDVVWHHDGREIKPGGRFCV RTDGAKRVLTVTGMSKEDEGEYSCECRNDKTSAKVSSKAPRLVRLTTKLNNVVAMEGKDA IFKCAATPADVSIKWFHKNIPITAGPKYKIEHGGNTHSLTISAVTQKDAGEISVDAEGKS CKATLQVQHEPVTFKKKLENLTVEEQSEVKLEVELSQASDEVRWMKNSVVLQPAGNLEIR VDGVKQTLVFRSVTSADRGIYSCETLDDKTQAKLSVEMKKIQVIKGLTETKAHETETVTL EVELSQADVEGSWTRDGAKLKSGATCRITALAKKHALTLSNLKREDAGTIAFQADGVHTS GKLIVTEPPAMISKPIMDISVPEKEKVTFECEVSRTNADVKWFKNDVELKPGKNFSIHSL GRKRTLVISKCTPDDTGTYICRTTDDNTSAKLAVHARDIKIIKKLEDVEVMEKESATFVC EISHDEVDCQWYKGSTKLKVVGNIKMRQEGRTYVLLFKSVSPEDMGEIKFTAEKASSTAK LKVKELPVKFVKRLRDKIAMYKHRGHLECQVSRASAMVKWYKNKMEIKPSKKYEIKSEDV YRKLTINEVESGDEDTYTCDASDDKTSCKLLVEEQSISIVRELSSVEVTEPFAAVFEVEI SMELVKPPVWTLNGVAVQESADAEMEKEGTMHRLTFKKTKESMTGPVQFTAGKSKSLAQL TVKERPLEIAEPMKDVKAKEKSSAILSCKFSASPKEVKWFKGQEPLAASDKYNMKQDATR AQLTIQKLTGEDSGEYRCQSGPAETKGTLTVEVREIKFTKHLADTEVDEDSDAVFTCEIN YADEEAQWLLNDKVLFTNEVNTITHEGKVHKLMLKNLAPKDGGTITFQVRKVKESVTLKV KEKRAVFLKSLDDVIGEEKGMITLACEASKPRVTPTWRKEGKVLKAGPKYELLHTGKSLG LIIKDVTKDDAGEYSCDLGTEVSKAKVTVREIGIGITKWLKSAEVNEGETCSFECILSRE STDECSWTVNGQTISKGGRFEVTSKGRKYILTIKDVTPADAGEVVFNIKDLSSKATLTVE GKASSVSKALQNVSAVQGEDAVFTCEVTQASSTVKWAKEGKAIRKSQRYDISQEDKVMKL IIHNVSAQDSGEYSCEVVGGATTKAQLEIKEPVHKFTEALKDSQADEKSSVTLQCATAQT PSTVIWLKGHTELKAGGRYEMSQKERVLTLTIKHLEEKDTDIYTCDVGTAKTIAKVTIKA LPASFKEKLKNQDRKEGESVTLSCALSKPAANVQWKKGSEILEGGEKYEMKQKDTCLELQ IKDLKVEDSGEYSCVCGDQKTAATVKVNALPPTFTQKLKSQEAEEGVSITLQCELSKPGV PVEWKKGTQVLKSGEKYQMKQKASVNELLINKVVPEDSGDYSCVCGDQKTTASLKINAQP VTFKHKMESQEAEEGAGVTLQCELSKPGVPVEWKKGTQVLKSGEKYQMKQKASVNELLIN KVVPEDSGDYSCVCGDQKTTASLKINAQPVTFKHKLGSQEAEEGAGVTLQCELSKPGVPV EWKKGAQVLKSGEKYQMKQKASVNELLINKVVPEDSGDYSCVCGDQKTTASLKINAQPVT FKHKLESQEAEEGAGVTLQCELSKPGVPVEWKKGTQVLKSGEKYQMKQKASVNELLINKV VPEDSGDYSCVCGDQKTTASLKINAQPVTFKHKMESQEAEEGAGVTLQCELSKPGVPVEW KKGTQVLKSGEKYQMKQKASVNELLINKVVPEDSGDYSCVCGDQKTTASLKINAQPVTFQ HKLESQEAEEGAGVYSASCELSKLESQVVPEDSGDYSCVCGDQKTTASLKIKAQPVTFKH KLESQEAEEGAGVTLQCELSKPGVPVEWKKGAQVLKSGEKYQMKQKASVNELLINKVVPE DSGDYSCVCGDQKTTASLKINAQPVTFKHKMESQEAEEGAGVTLQCELSKPGVPVEWKKG TQVLKSGEKYQMKQKASVNELLINKVVPEDSGDYSCVCGDQKTTASLKINAVKLSAPPSA AVLESKRQETKGTMEAKTPEASSIAAKDKHNRQEIYETVEAVTLPTTGQTPEQQLLKQET QRDSQQLKVGGEVKKTDPGISVKQDTQKQGTKGPKEVLPVIVIRDLESQEAEEGGSVTLQ CELSKPGLAVEWKKGTQVLSFGEKYQMRQTGFSYKLQIHDLTPGDTGNYSCSSEDTISSA SLAVNAAPVIFTKELESLTANEGDSVTLHSQPVLFKTQLQNLERQAGETASLRCETTKPG ASVVWRCGDSVLESSSRYQLKQEGTVVELVIYKLQAADSGEYSCDTGSQRTSAVLTVQEV EVNILKFLESCVVYEGEDVRFECLVSHEEAPLAQWKLQDVPLQNNEMNLIKTEGQVHSLT LRGVTTADSGTVTFTVGNNTSTASLTVRAAAPVLFKKELESQEATEGGKATLSCETSSPD CKVTWRKGSTVLTHGEKYTMEQRATTHTLVIHKLNVEDSGEYSSDTGDKRSTAALTVKGA PVFFQKELKNQDAIEGDDITLCCELSKPSVRVEWRKGGMVLQAGKKYEMRQERCIQELCI RNLEPEDSGYYTCDAGDQLTTASLAVQVKEVFIVSGLKTIDVFVGEWATFSCQLSGRTPG KVQWWLDGTLLENSPFSEIGLSQSHIYTLTLKNLATDDSGTVTFKAGSLTSTAKLLVKDP TVEVVSEMEDLRVVENQPAEFICQYSRPVKAQWKKDGQPLQPDGRRVVVEQDWNVARLYI SCVSAEDRGTYSCEAQGTCVVASLHVEGKPINIVQGLENMETFDGGEALFECALSRPENK DCSWLLDGKPVKDSPNAEIVSFESGLRHLLLLKELRVKDSCTVTFKAGTASSSAQLSVKG WQLDVVKGLEDKVAAVGEKVEFCVQLTEPVPVTEIAWYANGVELKPSDLWAMRADGCSYR LVLRQAPLLPQQEITFAARDALSLAKLSIITVPDPPEDAEVLSKTEQSVSLSWFTPLHDG GSPILGYRVEMRLVDSALWLPCHSEPVCNTEFVVENLTPGGGYRFRVAAINRAGTGEPVE LPQTLQLEAPVQSLICQGTEAKQGEELGQPSLPPEAADEGDVHELWEASAKKRRMSREPT LDSITEQPEEDGKNKSREKELKSSEKAEIKSEEKEQAIVSKKQTNLCISSEDESVSGGQT LVSYLKKSSKSTVTEAKQKTVQQTEVKTTTTQETDKTQVSTEETDIVEISKEDEPELRDA AIKIQAAFKGYKARKDMRPVFKDVFKDQTKEPNGTIHLECVAEGKPDKVRWLKDGEPLTD GKHHHIDIYNDGTCSLVITAITTKDTGVYTCEVTNKFGVTSHSGKVTVGTVRESSGRRPL TVGYSADSEPESSSGSEMDESLRMASRRLRRLLRTRLPPDVAEEPFVSADEGDLPPPDPH SYREDDSYIYIRFESRTEAEVASKRFQEMFTIHGVPVETAILEAGLHKVELRIRKMGYIQ DGTQTPTQDRQPPAFMTGAPAAPVFLTELQSQDVPDGYPVSFDCVVIGKPPPTVRWFKDG KLLEENDHYMINEDLEGCHQLIITTVLPTDMGVYRCTAENSSGIAATKAELRVDMSCSSD YDTAADATETSSYVSAKGYMSRETETFESVAEDDQLPQVVEELHDVHVSPGSPIAKMQVR VKGFPKPRVYWFKDGHPLRPSERILLLTERDVHGLEILGVKKDDMGEYSAYISNAAGSAY SSARLIVLHPKEPLVPPRFLERFSNRKVKQGASITLSVKVEGSPTPMVSWLKEESLEDVL WIKPDTKGYKIASSGRQHSLILMDVGTEYTGAYTCIATNRAGQSICTAHLEVDDTPQPKK ETKPLEVLGITVSPPEDETSTGKEGKIPYLGEVGTEEFLMKLTSQITEMVSAKITQASLR VPGVDSDDETKTPSPSPHHGRSRPPSLIADSSSESDEGDARGEMFDIYVATADYNPTVAS KESISLKEGQYVEVLDSAHPLKWLVRTKPTKTTPSRQGWVSPAYLDKKLKLSAETGDLPE ASVEEVSEGEYKRKLFQMLQDLINGESEFVKEIDFFTSHHLKHADSSDVPPDVSTQKETI FRNIDDIKSFHSKAFLPKLNDCDTDDDVAMCFLKNKEGFEKYLQYLVGQSQAESAVSDKT VHHFFKEYTEKAQASADPADPPVRSINAYLQQPLDRIQKYKAFLKELIRNKARNGQNCCL LEEAYAMVSALPQRSENTHHVSMIENYPATLEVLGEPIRQGPFQVWEGAPGIRTSSRGHH RHVFLFKNYCIICKPKRDSNTDTQTYVFKSMMKLNNIDVNETVEGDDRAFEIWHEREDSV RKYTLQARTITIKNSWLRDFRELQQRYVTPAWSPPDFEEILANCTAELGQTVKLACKVTG VPKPVVTWYKDGRTVEADPHHIIIEDPDGSCTLILDNMTADDSGQYMCFATSSAGNASTL GKITVQVPPRFVNKMRNAVFIAGEDAQFTCVIQSAPSPKIRWFKDGRLLTDQEKYQTYSE LRSGVLVLVIKNLTERDFGHYECELSNRLGSAKCAADLVLPSAVARTGEQAITIEVTEQE TKIPRKTIIIEETITTVVKNPRMRRHRSPGLTVAGAHRSETSTPEPATARLRRMPTPRKT AIPTLYVTEPEGAEARAMESKPRWVEVEEVIEYKVNKSPRLPRRRGISPAASDRAATPSR PKRSPPENPNANNSNNKLVEQAQAQLPGDVSSQPLSWEEEEGNAPSGSATVEPHELSTVL TPAGEDNDDLDDQQTVIFEPDDEDNDHDLFRKQEPKILKQGDRVLTLEDLEDYVPEEGET YGSSNVITEKPCEISVLQREIGGSTVGQPVLLNVGRPVVAPRQRSSFFSRFKEHLSSSLF SSTVPQAGGARSSTERHVPIQVSHAKLEVKPSYCSEVQRVEGGQQSFKTKVSTQTYGYTS VGNPVTLQIRDNLYQNQ NT seq 19674 nt NT seq  +upstreamnt  +downstreamnt atggatccaaacttgtttggaggagcccccaggtttctcactcgtccaaaggcgtttgcg gtgtgtgtgggcaaagatgccacactcagctgcactattgtgggcactccaaccccgctg atcacttgggagaaggaaaagctgaagctgacatctgggggccgcttcaagaccgtggag gatggagatgtgtaccgcttgaccatctatgacttaacactggaggatagtggacagtac atgtgccgggccaagaacagtgttggggaagcttatgctgctgtaaccctaaaagtggcg ctgccaacagagatggctcagagggcccccgttttcttggtgaagcctacatctgcacgt gtaggtttgggaggcgatgttgttttccactgccgggttgtagcttaccctgaggccaac tttgactgggaaaaggatgggcgctacctgggggagacaaaccgcatcaagattgtttct gacagcgacagcagcaccttaaagatccaaagtgtgcgtaacctggacagcggtacctac acctgcagggctcagaacactgttggccgagcacacactgcagcagctcttgtcgtagat gcgcaggactcccgccacctgactgcagataagaacacctccctcctctctcacttacaa aagcgcaaagaggaaatgaagaaggacatttccatctatcgcactgaagaaagctcctca ctgcccaaaggtgtgttcacccgtacctgcactgtgactgagggcaaacacgccaaactc agctgccttgtgacgggtcaccctaaaccccacattatttggagaagggatggatcgaac atcagtgagggccgtaggcatatcatttatgaggaccaggctgagaacttcatcctcaag atcctgttctgcaagcagagtgataatggtctctacacctgcaatgcaaccaatatggcc gggcagacctacagtgctgtattggtaacagtcaaagagccgaacgtgccgttcaggagg aagctgcaggatgtggaggtccaagagaaaacggcggccacattgatgtgtgaggtgcct ctcagtgccacccatgccaactggttcatggaggaaacaaggctggagcaaagcaccaaa tatcgcatggaggaggagggcaccctgcgacgtctcaccattcacaatgtcaccacaaac gatgatggtgtttacatctgtgagatgaaagagggcagtcgcactgtggctgagctcact gtcctgggcaacattaccaagaagcttccacggaggacagtagttcctgtcagtgacact gtcatcttctgtgtggagctggagcatccctgcccagatgtctattggacccgcaatggg gagaagctgaaggaagattcccgtatttccattgcctgcgtgctaagacagtacacactc accattagagattgccaggcagatgactcaggagaagtggcctttgtggctggagactgc aagacctccactcgattctctgtcactgctgcaaggaagcatcctcctgatcccccagtc gatgctgtggtgcagaacaagactgactcatccatcaccattcagtggtctcctcctgac agcgatcgccctgtgcccatcaagggttaccatgtggagaggaggaaggttggcagtcag acatggcagaggtgcaatgctggagaaaccattgtttcaacagagattaccatcagaaac ttcactgaagaagccagctaccagttccgtatctctgctacgaatgactttggccagagt ccctacctggaggtgcctggaagcttctaccttgagcccactgcagaaatcaggaaaggc ctgatgaacagcagtgcaatatctggcgaggagttctctctctctctggagctttctgct gtttgttctggcttctggtctctgagtggacgcctcctccgcagtggagctgactacctc atcaccaggtccaagaacacacacacactgctcatccgtgtcgtgaccatggaaatgaac ggagctgaagtcaagtttgtgggcggaggctcacaaagcagttgcatcctatctgtgaag gtccccgctgttaggttcactaacaagtcaggtcagatggagatgatgacctgcagtgcc caagccagtgctcagctgactgctgaggtgtcggattacgatgcacaggtggtttggatg aagaatgggcgggaggtgaaaatgggcaagaagtatgaatatgtcaacactgaccgcaag aggatcctgatggtacacaatgttacagaggaagatgtgggcatctacgagtgtgtttta gctgatgacaagatgtccctgcaactcactcttaaagatgaacctgccaagtttctgaac aaggccagaggtcccatgggactatcatcgtcccttaaaggagatcttgagctcagctgt gaggtatccctagctagcgcggctgttgtgtggagaaaagatcaggttgagatcactgag gaccaaagaactaacatcatctccaaagggactcaaaggaaactagtcatcaagaatgcc aagaaaagtgatgaaggacattactcctgtgagacggcagcagacaaagtcacattccat gtcaagataaaagaaagtcaaactcaagcccaagctgccttctctaacaaggagtcagtc cagaaggaggtgaaagcctctctgtcccagaaagcaactcttagttgtaatgtgtctgat agcaagacagaggtgaaatggtataaagatggcaagctgttggtatccagtaggaccata tactcagaagcaaaaggcagttctcgccagctggtgattgaaaaggtggagaagagtgat gctggagaatatacttgtgaagctggaggggataagctggtcttcaagatatctgtgtca gaggccctgtcagctttcttcaacaaggagtcagtccagaaggaggtgaaagccactctc tcccagaaagccattttaagctgtgaggtagctgataccaagacagaggtgaaatggtac aaggatggcaaactgttgacttccagtaagacaatccatgcagagtcaaaggccaagagt cggcagctggtgatagacagcgtggagaagagggatgctggagagtacatctgtgaggct gggactgagaagttggcctttaagatacaggtggcagagccccagtcagctttcttcaac aaggagtcagttcaaagggaggtgaaagctactctctcccagaaagccactctgagctgt gaggtttctgattctaagactgaggtgaaatggtacaaggatggcaagctgctgacttca agcaagacaatccatgcagagtcgaagggcaaaagtcgccagctggtgattgacattctg gagaaggaggatgccggagagtacatctgtgaggctgggtctgagaagttggtctttaaa ctccatgtggcagacacacatgtccagtctgcattctctaataaggagtcagtccagaag gatgtgaaagccactctctcccagaaagccactctgagctgtgaggtagctgataccaag acagaggtgaaatggttcaaggatggcaagctgctgacttccagcaagacaatccatgca gagtcaaaggccaagagtcgccagctggtgatcgacagcgttgagaagaaggatgctgga gagtacatctgtgaggctgggactgagaagttgacctttaaagtacatgtggaagaaatc cgggctaaatctgctttcctcaacaaggagtcagtccagaaggaagtgaaagccactctc tcccagaaagccactctgagctgtgaggtagttgataccaagacagaggtgaaatggtac aaagatggcaagctgctgagtcccagcagaacagttcactcggaatcaaagggcaaaact cgtcaactggtgatggacagcatagagaagaaagatgcaggggagtacatctgtgaagtc ggaacagaaaaactggcatttaaagtactagtgacagagattcagctgaagtcggccttc tctaacaaggagtctatccaaaaggaggtgaaagccactctctcccagaaagccatttta agctgtgaggtagctgataccaagacagaggtgaaatggtacaaggatggcaaactgttg acttccagtaagacaatccatgcagagtcaaaggccaagagtcggcagctggtgatagac agcgtggagaagagggatgctggagagtacatctgtgaggctgggactgagaagttgacc ttcaagatacaggtggcagaaaccctagctggcttctcgaataaggagtcagtccagaag gaggtgaaagccacactctcccagaaagccactttgagctgtgaggtttctgattccaag acagaggtgaaatggtacaaggatggcaagctgctgacttccagcaaagcagttcacatg gagtcaaagggcaagagtcgtgagttggtgattgaaaaaatggagaaaaaagatgctgga gaatacacctgtgaggctggaacagagaagctggtatttaagctgcaaatgacagaagca gctgtcaagttccagaagaagtccatcaaggacacatatactgttcaagcaagtgaaaac attgttttgaccattttgctgaccacagagagtggtagtgtgaagtggtttagagatggt gtggaggtcaaggagagcagcaagtatgaaatgaaaaaagatggccgttctcgtaccctg atagtaaaatccaccgaagccaaagacagtggaacatactcctgtcaaactgctaatgac aaactggagttcaaagttcaggttaaagaattagctttgaagtttgttgtacccttgaaa tctgttgatgtggagttgggaggtacaattagcctgatgtgtgaactaaatcaagcctca ggggatgttgtctggcaccatgatggtcgtgagattaaacctggaggcaggttttgtgtc aggacagatggtgctaagcgggttctcactgtgactggcatgtctaaggaagatgaagga gaatacagctgtgaatgtcgaaatgataagacctctgctaaagtttcctccaaagcaccc agactagtgaggctgaccaccaaactcaacaatgtggttgcaatggagggaaaagacgca attttcaagtgcgctgccaccccagcagacgtcagcattaagtggttccacaagaatata cccatcactgctgggcctaagtataagattgagcatggtggcaacactcactcactcacc atcagcgctgtcacccaaaaagatgctggagagattagtgttgatgcagaaggcaaaagc tgcaaagctaccttacaagtgcaacatgagccagtgacattcaagaaaaagctagaaaac ctgacagtggaggagcagagtgaagtgaagctggaggtggagctcagtcaggcatccgat gaagtcaggtggatgaagaacagcgtagtgctgcagcctgcgggaaacctggagattcgg gtagatggagtcaagcagactctggtcttcaggagtgtgacctctgctgaccgtgggatc tactcctgtgaaactctggatgacaagacccaggccaaactcagtgttgagatgaagaag atccaggtaattaagggcctaacagaaaccaaggcacatgagacagagacagtaacactt gaggtagaactcagccaggctgatgtcgaaggctcctggaccagggatggagccaagtta aagtcaggggcgacctgtcgtatcacagctctggcaaagaagcacgcccttacattgtcc aatctcaagagggaggatgcaggaactattgcattccaggcagatggtgtccatacttct ggcaaactgattgtcacagaaccgcctgctatgatctccaagcccattatggatatcagt gttcctgagaaggagaaggttacttttgaatgtgaagtgtccagaacaaatgcagatgtt aaatggttcaagaatgatgtggaactgaaaccagggaaaaactttagcatccattccttg ggccgaaagcgcactttggtcatcagcaagtgcacccctgacgatacaggcacttacatc tgccgcactactgatgataacacctctgccaagctcgctgttcatgccagagatatcaag atcattaagaaactggaagatgtggaggtgatggagaaggaaagtgctacatttgtctgt gaaatttcacatgatgaagtggactgtcagtggtacaaaggaagtactaaactcaaagtc gttggcaatatcaagatgagacaagagggccgaacatatgtactgctgtttaagtccgtt tccccagaggatatgggcgagattaaattcacagctgagaaggcctcttcaactgcaaaa cttaaagtgaaagagctgcctgtcaagtttgtgaagcgactcagggataagatagcgatg tataagcatcgtggtcatcttgaatgccaagtgtcacgtgccagtgcgatggtgaagtgg tacaagaacaagatggagatcaaacccagcaagaagtacgagatcaaaagtgaggatgtg taccgaaaactcaccatcaatgaggtcgagtccggggacgaagacacatatacctgtgac gcctctgatgacaagacatcctgtaaactgcttgtagaagagcagtccatcagcattgtg cgggagcttagttcagtagaagtgacagaaccctttgcagctgtttttgaagttgaaatc agtatggaactggtgaaacctcctgtatggactctgaatggagttgctgtgcaggagagt gctgatgctgaaatggagaaagagggcactatgcaccgtctcactttcaaaaagaccaaa gaatcgatgacaggacctgtgcagtttacagctgggaagagcaaatctcttgcccagctc acagtcaaagagcgtccgcttgagattgcagagcccatgaaagatgtgaaggcgaaggag aaaagctcagccatactctcgtgcaagttctccgcatcacccaaagaggttaaatggttt aaaggtcaggaacctctggcagcatcagacaagtataacatgaagcaagacgctacgagg gctcaactaaccattcaaaagttaactggggaagacagcggagagtaccgctgtcaatct ggacctgctgagaccaaaggcacacttactgttgaagtgcgtgaaattaaattcaccaag catttggctgacacggaggttgatgaagacagcgatgcagtgttcacatgtgagataaac tatgcagacgaagaggcacagtggcttctaaatgacaaggtgctcttcactaatgaagtc aacaccatcactcatgaggggaaggttcacaagctcatgctgaagaacttggcacctaag gatggggggactatcacctttcaagtacgcaaggtgaaagagtctgttacgcttaaagtt aaagagaagcgtgctgtgttcctcaagtctttagatgatgtcattggagaggagaaaggc atgataactttggcgtgtgaggcgtccaagcccagggttactcccacatggagaaaagaa ggtaaagtcttgaaggccggaccaaagtatgagctccttcacacaggcaagtctttggga ctgatcatcaaggacgtcaccaaagatgatgctggggagtacagttgtgatcttggaact gaggtttcaaaagcaaaagtcactgtgagagagatcggcattggaattaccaaatggctg aagtcagctgaggtgaatgagggagagacatgcagctttgagtgcatcctgtcccgtgag agcacagatgagtgctcatggactgttaatggccaaaccatttcaaaaggaggccgtttt gaagtcaccagcaaaggccgcaagtacatactaaccattaaggatgtcacacctgctgat gctggtgaggtagtcttcaacattaaagacctgagctctaaagcaacattaacagttgaa ggcaaagcttcatctgtgtccaaagcactgcagaacgttagtgctgttcaaggggaggat gcagtatttacctgtgaggtgacacaggctagttccactgtaaagtgggccaaggaaggc aaagccattagaaagagccagaggtatgacatcagccaagaggataaggtcatgaagctc atcatccataatgtctctgctcaagactctggagagtacagctgtgaagttgttggaggt gcaaccaccaaagcccaacttgaaataaaggagccagtccataagttcactgaagcactg aaggacagccaagcagatgagaagagctctgtgaccctgcagtgtgcaacggctcaaacc ccatccaccgtgatatggctgaaaggtcacacagagctcaaggctggaggtcgatatgag atgtcccagaaagagagggtcttaactctcaccatcaaacacttggaggagaaagacacc gatatctacacttgtgacgtgggcactgctaagaccatagcaaaggtgacaattaaagcc ctgccagccagtttcaaagaaaaactcaagaaccaggatagaaaagaaggggagagtgtg acactgtcttgcgcgttatcaaaacctgcggctaacgttcagtggaagaaaggctctgaa atcctcgaaggtggagagaagtatgagatgaagcagaaggacacctgtttggaacttcaa attaaggatttgaaggttgaagatagtggagagtactcttgtgtctgtggagaccagaag acagctgcaactgtgaaagtcaatgcattaccgccgaccttcacacagaaactgaagagc caggaggccgaagagggagtcagcattactctgcagtgtgagctctctaaacccggagtc ccagtggagtggaagaagggaacacaggtcctgaagtctggagaaaaataccagatgaag cagaaagcctctgtgaatgaactcctgatcaacaaggtggtgccagaagacagcggagac tacagctgtgtgtgtggagaccagaagaccacagccagcctcaagatcaatgcccaacca gtgaccttcaaacacaagatggagagtcaggaagccgaggagggagccggcgttactctg cagtgtgagctctctaaacctggagtcccagtggagtggaagaagggaacacaggtcctg aagtctggagaaaaataccagatgaagcagaaagcctctgtgaatgaactcctgatcaac aaggtggtgccagaagacagtggagactacagctgtgtgtgtggagaccagaagaccaca gccagcctcaagatcaatgcccaaccagtgaccttcaaacacaagttggggagtcaggaa gccgaggagggagccggcgttactctgcagtgtgagctctctaaacctggagtcccagtg gagtggaagaagggagcacaggtcctgaagtctggagaaaaatatcagatgaagcagaaa gcctctgtgaatgaactcctgatcaacaaggtggtgccagaagacagtggagactacagc tgtgtgtgtggagaccagaagaccacagccagcctcaagatcaatgcccaaccagtgacc ttcaaacacaagttggagagtcaggaagccgaggagggagccggcgttactctgcagtgt gagctctctaaacctggagtcccagtggagtggaagaagggaacacaggtcctgaagtct ggagaaaaataccagatgaagcagaaagcctctgtgaatgaactcctgatcaacaaggtg gtgccagaagacagtggagactacagctgtgtgtgtggagaccagaagaccacagccagc ctcaagatcaatgcccaaccagtgaccttcaaacacaagatggagagtcaggaagccgag gagggagccggcgttactctgcagtgtgagctctctaaacctggagtcccagtggagtgg aagaagggaacacaggtcctgaagtctggagaaaaatatcagatgaagcagaaagcctct gtgaatgaactcctgatcaacaaggtggtgccagaagacagtggagactacagctgtgtg tgtggagaccagaagaccacagccagcctcaagatcaatgcccaaccagtgaccttccaa cacaagttggagagtcaggaagccgaggagggagccggcgtttactctgctagttgtgag ctctctaaactggagtcccaagtggtgccagaagacagtggagactacagctgtgtgtgt ggagaccagaagaccacagccagcctcaagatcaaggcccaaccagtgaccttcaaacac aagttggagagtcaggaagctgaggagggagccggcgttactctgcagtgtgagctctct aaacctggagtcccagtggagtggaagaagggagcacaggtcctgaagtctggagaaaaa taccagatgaagcagaaagcctctgtgaatgaactcctgatcaacaaggtggtgccagaa gacagtggagactacagctgtgtgtgtggagaccagaagaccacagccagcctcaagatc aatgcccaaccagtgaccttcaaacacaagatggagagtcaggaagccgaggagggagcc ggcgttactctgcagtgtgagctctctaaacctggagtcccagtggagtggaagaaggga acacaggtcctgaagtctggagaaaaatatcagatgaagcagaaagcctctgtgaatgaa ctcctgatcaacaaggtggtgccagaagacagtggagactacagctgtgtgtgtggagac cagaagaccacagccagcctcaagatcaatgctgtgaagctgtcagctcctccttcagct gctgtactggaatctaaaaggcaggagaccaagggaacaatggaagccaagacccctgaa gcttcatccatagctgctaaagacaagcacaacaggcaggagatatatgaaacagtagaa gctgtaactctgccaaccactggacagactcctgaacagcagctcctcaaacaggagact cagagagattcgcaacagctgaaagtgggaggtgaagttaagaagactgatcctggaata tctgtcaaacaagacacccagaagcaggggaccaaagggccgaaagaagttcttccggtc atagtcattcgagacctagagagccaggaggctgaggagggaggtagtgttactctgcaa tgtgagctttctaaacctggacttgctgtcgaatggaagaagggaactcaagtcctgagt tttggagaaaagtaccagatgagacaaacaggattcagttataaactccagatccacgat ttgacacctggagacacaggaaactactcatgctcttcagaggacacaataagctcagcc tctcttgcagtaaatgctgccccagtcatatttacaaaagagctggaaagcctaacggct aacgagggggacagtgtcaccctgcactcccagcctgtccttttcaaaacccagctgcag aaccttgaaagacaggcaggggagactgctagtcttcgctgtgagaccacaaaaccagga gccagcgtggtctggaggtgtggtgacagtgtgcttgaatccagcagcaggtatcaactg aaacaggaagggactgtagtcgagcttgtcatctacaaactgcaggcagctgactcagga gaatactcctgtgatactggcagccagaggacttcagctgtcctcactgtgcaggaggtc gaggtgaacatactgaaattcttggagagctgcgttgtgtatgagggtgaagatgtccgc tttgagtgtctggtttctcatgaggaggcaccactggcccagtggaaactccaggacgtc ccactgcagaataatgaaatgaatctaatcaagactgagggtcaagtgcatagcctcaca ctcagaggtgtcaccacagctgactcaggaacagtcactttcacagtgggaaacaatact tccactgcttctctaacagtcagagcagctgcaccagtgttattcaagaaggagctggaa agccaagaggccaccgaaggaggcaaagccaccctgtcctgcgagacatccagccctgac tgcaaggtgacctggcggaagggctcaactgtgctcacccatggcgagaagtacaccatg gagcagagagctaccactcacaccctggttatacacaagctgaatgtggaggatagtgga gaatatagcagtgatacaggcgacaagagaagcactgctgcactgactgtgaaaggtgct ccagtgttcttccagaaagagctaaagaaccaagacgcaatagagggtgatgatatcacc ctgtgctgtgagctgtctaagccaagtgttcgtgttgagtggaggaaaggaggcatggtc ctccaggccggtaagaagtatgagatgaggcaggaaaggtgcattcaagagctgtgtata cggaacctggagcctgaggacagtggctactacacctgtgacgcaggagaccagctcact acagcttctttggcagtgcaagtgaaagaagtcttcattgtttctggtcttaagaccatc gacgtctttgttggggaatgggcaaccttctcctgtcagctgtctggtaggacacctggc aaggtgcagtggtggctggatggtaccttgctggagaacagcccttttagtgagataggg ctgagccagagccacatctacacactcaccttaaagaacctggctacagatgactctggc actgtcacgttcaaagctggaagtttaacatcaactgccaagctcttagtcaaagatccc acagttgaagtggtgagcgagatggaggaccttcgggtggtcgaaaaccaaccggctgag ttcatctgccagtactcaaggccagtcaaggctcagtggaagaaagacgggcagccattg cagcctgatggtcgaagggtggtagtggagcaggactggaatgtggctcggttgtacatt agctgtgtgtccgctgaggacaggggcacatactcctgtgaggcacaggggacctgtgtg gttgcttcacttcatgtggaaggcaagcccattaacattgttcagggcctggagaatatg gaaacctttgatggaggtgaagcactgtttgagtgtgccctctctcgtcctgagaacaaa gattgcagctggcttcttgatggcaaaccagtgaaggactctcctaatgctgagattgtt tcatttgagagtggtcttcgtcatctgctcctgctgaaagagttgcgtgttaaagacagt tgcacagtgaccttcaaagctggcacagcatcctcatctgcccaactctctgtcaaggga tggcagctggatgttgtgaagggtctggaagacaaagtggctgcagtgggagagaaggtt gagttttgtgttcagctgactgagcctgtccctgtgacagaaatagcttggtatgctaat ggagttgagctcaagcccagcgatctctgggctatgcgggctgatggctgttcttatcgc ctcgtcctgagacaggcaccacttttgccccaacaggaaattacatttgctgctagagat gctctctctttggccaagctctccatcatcactgtacctgatcccccagaggacgcagag gtcctcagtaagacggaacagtcagtttccctttcatggttcactccactacatgatgga gggagtcccattctgggctacagggtggagatgcggctggtagacagtgccctctggctt ccatgtcattctgaacctgtgtgtaacacagagtttgtggttgaaaatcttaccccaggg ggcggctacaggtttagagtggcagccatcaacagagcagggactggagagcctgttgag ctgcctcagactctacagcttgaggcacctgtgcagtcactaatttgccaaggtacagag gcaaaacagggggaggaactggggcagcccagtctgcctccagaagctgctgatgaaggt gatgttcatgaactctgggaggcttcagctaagaaacggcgcatgagtcgagagccaact ctggactccatcactgaacaacctgaggaggatggtaaaaacaaatcaagagagaaggag ctgaagtcctcagagaaagcagaaataaaatcagaagagaaggagcaggccattgtgtct aagaagcagaccaatttgtgcatcagctctgaggacgaatctgtttctgggggtcagacg cttgtgtcctacctcaagaagagcagtaaatctaccgtcacagaggccaagcagaaaaca gtgcagcaaactgaagtgaaaacaaccacaactcaggagacagataaaacacaggtgtct acagaggagactgacatagtggagatcagtaaagaagatgagcctgagctccgagatgct gcaattaagattcaagctgcattcaagggctacaaggcccgcaaggacatgcgtcctgtc ttcaaagatgtcttcaaagaccagaccaaagaacctaatggcaccatacatctggaatgt gtggcagaagggaaacctgataaggtgcgttggctgaaggatggagaaccactgacagat ggcaagcaccaccatatcgatatctacaatgatggtacttgctcactggtcatcaccgcc atcaccacaaaggataccggggtttacacttgtgaggtcaccaacaagtttggagttact tctcacagtggtaaggtgacagtaggaacagtgagagaatcatctgggcgacggcccctg acggtgggctacagtgcagacagtgagcccgagagctcctcaggtagtgagatggatgag tcactgaggatggcaagcagacgtctccggcgcctgttgcgcacacgtctcccaccagat gttgcggaagaaccattcgtcagcgcagatgaaggagacctgccccccccagatcctcac tcttatcgtgaggatgacagttacatctacattcgctttgagtcacggacagaggctgaa gttgcctctaagaggttccaggagatgtttacaattcatggcgttcctgtagagactgcc atccttgaggcagggcttcacaaagttgagctgcgaattagaaagatgggctacatacag gatggcacacagacccccacacaagatagacagcctcctgcattcatgacgggagcccca gctgccccagtcttcttgacagagctgcagagccaggacgttccagatggctatccagtc agctttgactgtgttgtgattggcaagccccctccaactgttcgctggtttaaggatggc aaattgctggaggagaatgaccattacatgatcaatgaagacctggagggctgccaccaa ctgatcattaccaccgtgctgcccactgacatgggtgtctatcgctgcacagctgaaaac agcagcggcatcgcagccacgaaggctgaactcagggttgacatgtcttgcagctcagat tatgacactgctgctgatgctactgagacatcttcctatgtcagtgccaagggctacatg tccagggaaactgagacctttgagtctgtggctgaagatgatcagctaccacaagttgtg gaggagcttcatgatgttcatgttagtccaggttcccctattgctaaaatgcaagtcaga gtaaagggcttccccaaacccagagtatactggttcaaagacggccaccctctgcggccc tcggaaaggattctgttactaaccgagagagatgttcacggcttggagattctgggggtg aagaaagacgatatgggagagtactctgcttacatcagcaatgcagctgggtctgcttac tcctctgcccgactgatagttctgcaccccaaggaaccccttgtgccaccacgcttcctt gaaaggttcagcaacaggaaggtgaaacaaggagcaagcatcactctatcggtcaaagta gaagggtcccccactcctatggtctcctggctaaaggaggaatcactggaagatgtcctg tggatcaaacctgataccaagggatacaaaatagcaagctctggacgccagcacagcctc atcttgatggatgtgggcacagagtacactggtgcctacacctgtattgctacaaataga gcaggacagtccatctgcactgcccacctcgaggtggatgacacaccacaaccaaagaaa gagaccaaacctttagaggttcttgggattacagttagtcctccagaggatgagactagc actggaaaagagggtaaaataccctatctaggtgaagtaggtacagaggaattcctcatg aaactcacctcccagatcactgaaatggtatcagcaaagatcacccaggcttcattacgc gtacctggtgttgacagtgatgatgagaccaagactccttctccatcacctcatcacggt cgctctcgtcctccttccctcattgctgactcctcctcggagtctgatgagggggatgcc aggggagagatgtttgacatctatgtggcaacggctgactacaaccccactgtggcaagc aaagaatctatctctctgaaggaaggacagtatgttgaggttttggactcagcccatcca ctcaaatggttagtccggaccaaaccgaccaaaaccacaccatcccgccaaggctgggtc tcacctgcctacttggacaagaaactcaaactctcagctgaaacgggtgaccttccagag gcaagtgtagaggaggtgtcagagggtgaatacaagaggaaattattccaaatgttacag gacctgataaatggtgaatcagagtttgtaaaggagatagacttctttacctcccatcac ctgaagcatgcagacagctctgatgtgccgcctgatgtcagcacccaaaaggaaaccatt ttcaggaacattgatgacatcaagtccttccatagcaaggcattcctcccgaagctgaac gactgcgacacagatgatgatgtagccatgtgcttcctgaagaacaaggagggctttgag aagtacctgcagtatcttgttggtcaaagtcaggcagaatctgctgtcagtgacaagact gtccaccacttcttcaaggagtacactgagaaagcacaggctagtgcagaccctgctgat ccccctgtacgcagcatcaatgcctacctccaacaaccactggacaggattcagaagtac aaggctttcctcaaggagctcattcgaaacaaggcgagaaatggtcagaactgctgcctc ctggaagaagcttatgctatggtgtctgcgctccctcaacgctctgagaatactcaccat gtctccatgatcgagaactatcctgccacactggaagtactcggagagccaattagacag ggacctttccaagtgtgggaaggagctcctggaataaggacgtcctctagaggtcaccac cgccacgtcttcctctttaagaactactgcataatctgcaaacctaagagagacagcaac actgatacacaaacatatgtctttaagagcatgatgaagctgaataacattgatgtgaac gagacagttgagggtgatgaccgtgcctttgaaatctggcatgaacgtgaggactctgtg aggaaatacaccttacaggcccgaaccatcaccatcaagaactcatggttgagagatttc agagaactgcagcagcgatatgtcacgcctgcatggagtccccctgactttgaggaaatt ctggcaaactgcacagcagagctgggacagactgttaagctggcctgcaaagtcactgga gtccccaaacctgtggtcacgtggtacaaggatggacgtacagtggaggcagatcctcat cacatcatcatcgaggaccctgatggttcctgcacgctgatcctggacaacatgacagca gatgattctggccagtacatgtgctttgccacaagctcagctggcaatgccagcactctt ggaaagatcacagttcaggtacctcctcgttttgtgaataaaatgaggaatgctgtcttt attgctggtgaggatgcgcagttcacctgtgtcattcagagcgcccccagccccaagatc agatggttcaaagatggcaggctgctgactgaccaggaaaagtatcagacctacagtgag ctccgcagtggggttctggtcttggtaataaaaaacctgacagagagagacttcggacac tacgagtgtgagctgtccaaccgtctgggcagtgccaagtgtgctgctgatctagtccta ccctctgctgtggctcgcactggtgaacaggccatcactattgaagttaccgagcaggag actaaaataccaaggaaaaccatcattatcgaggagactataaccactgtggtgaaaaac cctcgtatgaggaggcacagatcccccggcttgactgttgctggagcccaccgctctgag acttccaccccagagcctgccaccgccaggctcaggaggatgcccactccaagaaagacc gctatccctaccctctatgtcaccgagcccgagggtgctgaggccagggctatggagagc aaacccaggtgggttgaagtagaggaggtcatcgagtacaaggtcaataaatctcccagg ctgcccaggaggagaggcatctcacctgcagcatctgatcgcgcagccactccctccaga cccaaaaggtctccaccggaaaacccaaacgctaacaattctaacaacaagctagtggag caggctcaggcccagctgcctggagacgtcagcagccagccgctctcctgggaagaagag gagggcaatgctccctctggttctgccactgtagagccacatgagctctcaactgtcctc actccagctggagaggacaacgatgacctggatgatcaacaaactgtcatctttgaacct gatgatgaagataatgatcatgatctgttcagaaagcaggaacctaagatcctgaaacaa ggagatcgtgttttgaccctcgaggacttggaggactatgttccagaagaaggagagacc tatggctcctccaacgttatcactgaaaagccttgtgagatctctgtgctccagagggag atcggtgggtccacggtgggacagcctgtgctcctgaacgtggggcggcctgtcgtggcg ccgaggcagaggagcagcttcttcagtcgcttcaaggagcacctctctagcagtcttttc tcatccactgtccctcaagccggcggagcacggtccagtacggagaggcacgtgcccatc caagtgagccacgcaaagctcgaagtgaagccttcctactgctcagaggtgcagagagtt gaaggtgggcagcagagctttaaaaccaaagtgtcaactcagacttacggctacacatca gtgggaaacccagtcactcttcaaattagagataacctttatcagaaccaatag

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