Seriola dumerili (greater amberjack): 111237061 Help Entry 111237061         CDS       T05606                                  Symbol ryr2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism sdu  Seriola dumerili (greater amberjack) Pathway sdu04020   Calcium signaling pathway sdu04260   Cardiac muscle contraction sdu04261   Adrenergic signaling in cardiomyocytes sdu04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:sdu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     111237061 (ryr2)    04020 Calcium signaling pathway     111237061 (ryr2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     111237061 (ryr2)    04261 Adrenergic signaling in cardiomyocytes     111237061 (ryr2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:sdu04040]     111237061 (ryr2)    04990 Domain-containing proteins not elsewhere classified [BR:sdu04990]     111237061 (ryr2) Ion channels [BR:sdu04040]  Voltage-gated cation channels   Ryanodine receptor    111237061 (ryr2) Domain-containing proteins not elsewhere classified [BR:sdu04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    111237061 (ryr2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  111237061 NCBI-ProteinID:  XP_022621736 LinkDB All DBs Position Unknown AA seq 4980 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCSATIHKEQQKLCLAAEGFGNRLCFLESISNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGHVDVEIWTAQGGGHRTLLYGHAVLLRHSY SGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVS VSSERYLHLSYGNGSLHVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGHMDECL TVPSGEHGDEQRRTAHYEGGAVSSHARSLWRLETLRVVWSGSHIRWGQPFRLRHVTTGKY LSLIEDKSLLLMDKEKADVKSTAFCFRSSKEKLDPGLKKEVDGMGVPDIKYGDSVCYIQH VDTCLWLTYQAVDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFL FNLFIRGLDTLRKKGKSSTLDLPIDSVSLSLQDLIGYFQPPGDHLEHEDKQNRLRALKNR QNLFQEEGMISLVLECIDRLHVYSSAAHFAEVVGREAAEAWSSILNSLYQLLAALIRGNR KNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHG RNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLINHVSSMRPNIFLGVSD GSAQYRKWYYELIVDQVLPFVTAEATHLRVGWASTSGYAPYPSGGEGWGGNGVGDDLYSY GFDGLHLWSGCIARTVSSPNQHLLRSEDVVSCCLDLSVPSISFRINGQPVQGMFENFNSD GLFFPVASFSAGVKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPREKLKLEASQDQTAATD LLGPTVTLSQAAFTPTPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWTYGAVRD DNKRQHPCLVEFCRLPEQERSYNLQMSLETLKTLLALGCHVGLADERAVEKVKSMKLSST YELSSGYKPAPLDLSHIKLTSTQEAMVDKLAENAHNVWARDRIHQGWTYGIQQDVKSRRN PRLVPYTLLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAAQSDLNNMSAERFRIFR AEKTYCVNAGKWYFELEVLTAGEMRVGWARPGCLPDQELGSDDQAFVFDGFKVQRWHQGN EHFGRAWQMGDVVGCMVDLNEHTMMFTLNGEVLLDDSGSELTFKDFEAGEGFIPVCSLGV CQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNMNRDVTMWLSKRLPQFVPVPHSHQHIE VTRIDGTVESCPCLKVTQRSFGSQNSYTDITFYRLSMPIECAESFSRSRSNGSLFSPNRE LEDFETVSDFEVLMKSSHGHNGPNGPERDEFNNHKDYNQEKPSKLKQRFMLKRNKPDNSC PSSARLSEEVMADDRDEYEFLMQASTHYYSVRIFPGQEPSSVWVGWVTSDFHQYDPGFEL HKVRTVTVTLGDEKGKVHESIKRSNCYMVWAGESSSPGQGRNNNGLEIGCLVDTTNGLLT FTANGKELSTYYQVEPSTKLFPAVFAKATSPNVFQFELGRIKNVMPLSAGLFKSERKNMV PQCPPRLHVQFLTPVLWSRVPNHFLKVSASRVNDRHGWLVQCSEPLQFMSLHIPEENRSV DILELSEQRDLLKFHYHTLRLYSAICALGNNRVAHALCSHVDEAQLLQAIENKYMPGLLR AGYYDLLIDIHLSSYATARLMMNNEYIVPMTDETKSITLFPDEKKKHGLPGIGLSTSLRP RMHFSSPSFVCGTGSLYRNNGNSGSGSGDCFQYSPEFPLDILKVKTIEMLTEAVREGSMH VRDPIGGSTEFLFVPLIKLFYTMLIMGVFQNGDLKNILRLIEPSVFSERREGQEEIHMEL EMVKEVETEVGGEDRGRTMPKEGLLQMKLPEPVKLQMCHVLQYLCDCQVRHRIEAVVAFS DDFVACLQDNQRFRYNEVMLALNMSAALTAKKTKEFRSPPQEQINMLLNFKDEKQECPCP EYIREQLLDFHEDLMRHCGIELDEDRSIDGDSDFTIRGRLMSLVEKVAYLKKKMANLPKE KKDRKPSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGQVRALPKTYTIN SVSIEDTINLLAALGQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHE TVMEVMVNVLSGGDSKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGL ASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCVMLVRKGYPDIG WNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGDGLLAAMEE AIKISQDSSRDGPSPTSESSRTLDMLEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHL IHAGKGEAIRIRAILRSLIPIEDLVGVISIPFSMPNLAKDGVVVEPDMSAGFCPDHKAAM VLFLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTVALSATDMALALNRYLCTAVLPLL TKCAPLFAGTEPFASLIDSLLHTIYRLSKGCCLTKAQRDAIEECLLAVCGKLRPSMMQHL LRRLVFDVPLLNEHTKMPLKLLTNHYERCWKYYCLAGGWGNFGAASDEELHLSRKLFWGI FDALSYKRYDQELFKLALPCLSAVAGALPPDYMESNYMAMMEKQSSMDSEGNFTPQPADT TNVTVPEKLDYFITRYAEHNHEKWCIEKFSNGWSYGEQICEISKSHPLLKPYKGLSEKDK ESYCWSVRESLKTMQSWGWSIERIREGDPASLHNKSRRISQASQLSFEGAPAFSPRPIDM SNVTLSRDMQSMAELLAENYHNVWARKKKMELEAKGGGNHPLLVPYDTLTAKEKSRDREK AQEILKFLQINGYTVSRGVKSQELDTPAIEKRFAYTFLQQLITYVDQAHQHMMEFDQGTR QKGDKVPHEQQMKFFGKVVLPLVDQYFKNHRLYFLSTAIHPISSGGHASNKEKEMVTSLF CKLGVLVRHRISSFGNNATSIVNCLQILGQSLDARTVMKTGLESVKAALRSYFESAAEDL EKTQENLKLGQFTHSREQPRGVTQIINYTTFALLPVLSSLFEHIGQNMFGEDLILDDVQV SCYRILNSLYFLGTNKSIYVERQRPALGKCLAAFSAAFPVAFLEPHINKFNSFSIYNIKG TKDRGALGLPGHVGEVCPVIPNLEKSLEEIMELAESGMRYTQMPHVMEVVLPMLCSYMSH WWEHGPESNTDKADSCCTSVTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIIS KAKAELLKTHFLPLMEKLKKKAAVVLMDEEHSKAEGRGEMSETELLIMDQFTILVRDLYA FYPLLIRFVDYNRARWLKESNPEAEELFRMVAEVFIFWAKSHNFKREEQNFVVQNEINNM SFLITDTKCKMSKGIVSDQERKKMKRKGDRYSMQTSLIVATLKRLLPVGLNICAPGEQEL IALAKNRFTQKDTEDEVREIIRNNLHLQGKLEDPAIRWQMALYRDLPNHYEDTSDPEKTV ERVLDIAHVLFHLDQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLF LQGYEKSWIEAEEHYFEDKLIEDLAKPGDQEPSEEEEGVKHIDPLHQLIQLFSRTALTEK CKLDEDNLYMAYADIMAKSCHDEEDEDGEEVKSFEVGGQSLCEKEMEKQKLLYQQARLHD RGAAEMVLQTISASKGEMGPMVASTLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSL AGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDLFRFLQLLCEGHNSD FQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAINVA KQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMD LQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFK EYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENELLDYEEFVERFHEPAKD IGFNVAVLLTNLSEHMPHDTRLQTFLELAESVLNYFQPYLGRIEIMGSAKRIERVYFEIS ESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQMSDAGERS AVKEESEREKPDEDNPEMGFFSVTTVCMALLALRYNVMLLIKVLSMKSLKKQMKRIKNMT VKDMVTTLVSLYWSLLLGFLHVAFSVTRGFCRIFYNTFMGGSLVEGAKTIKVSELLANMP DPTQDEVRGEGEDREKRLSDRSSPKEDLADLAVNTSETELLSDIFGLDLRREGGQYKITP HNPNASLTELLNSPVPSPNPPTPPTAPPPELRQRHQSSSSEAKEATPETASEPEKTLGAG HIEQLEKQQKNEKMKQKVRRHHTSKSDEPDLQESAFLKKIIAYQRKLLNYFARNFYNMRM LALFVAFAINFILLFYKVSTSSSVVEEREVIYTSSQPDSSVHWDGLSGEAMETKEEVMDE TGELLKPVTVRFVLEESSGYMEPMLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVA RKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRIS ELLGMDKAALDFSDAHKKRKPRRDSSLAAVLNSIDVKYQIWKLGVVFTDNSFLYLAWYMT MSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFN FFRKFYNKSEDGELPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFD ITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFET HTLQEHNLANYLFFVMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14943 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggaggagaaggcgaggatgaaatccagtttctgcggactgatgatgaggta gtcctgcagtgctcagctacgatccataaggagcaacagaaactctgtctggctgctgaa ggcttcggaaacagactctgcttccttgaatccatctccaactccaagaatgtgcctcca gatctgtccatctgcacctttgtcttggagcagtcactatcagtacgagcccttcaggaa atgctggccaacacagaggagaaagctgaggggcatgtagatgtggaaatatggacggcc cagggcggtgggcatcgcaccttactgtatggacacgctgtcctgctacgacactcatac agtggaatgtacctatgctgtctgtcaacctcccgctcatccacagacaaactggctttt gatgtgggactacaggaagataccacaggcgaggcttgctggtggaccatccatccagca tccaagcagcgttcagagggagagaaggttagagtgggagatgatctcatcctggtcagc gtctcctctgaaagatatctgcatctgtcctatggcaatggcagtctccatgtagatgca gctttccagcagactctgtggagcgtggctcccatctgttctggcagtgaagtagcacaa ggtttcctgataggaggggatgtcctgcgtctccttcatggtcacatggacgagtgtcta actgttccatctggggaacatggagacgagcagaggaggacagctcactatgagggtgga gcagtgtccagtcatgccaggtccctgtggaggctggagacacttcgagttgtgtggagt gggagtcatatccgatggggtcaaccgttcagactgagacatgtgaccacagggaagtat ctgagtctgatagaagacaaatctctgctgctgatggacaaagagaaagctgatgtcaag tctacagccttctgcttcaggtcatctaaggaaaagttggatcccggtttgaagaaggag gtggatgggatgggtgttcctgacattaaatatggcgactctgtgtgttacatccaacat gttgacacctgtctatggctcacataccaagctgttgatgccaagtgtgcacgcatgggt ggcgtacagagaaaggccatcatgcaccatgagggtcacatggatgacgggctaacgctg tctcggtcccaacatgaggagagtcgcactgccagggtcatccgtagcactgtctttctg ttcaacctgttcatcaggggtctggacacactaaggaaaaaggggaagagctctacttta gatctaccaatcgattcagtcagtctgagtctgcaggatctgattggctacttccagcca cctggagatcatctggaacatgaagacaagcagaaccgactaagggctctgaagaaccga cagaacctctttcaggaggaggggatgatcagcctggtcctagagtgtattgatcggctt cacgtctacagcagtgcagctcattttgctgaggtagtaggaagggaggcagcagaggcc tggagctctatcctcaactccctctaccaacttctggctgcgctgatcaggggaaacagg aagaactgtgcccagttctctggttcgctggactggctgattagcagactagagcggctg gaggcctcttctggtatactagaggtgcttcactgtgtgctggtggagagtcctgaggca ctgaacatcatcaaagagggacacatcaaatctattatatctctgctggacaagcatgga cgcaaccacaaggttctagatgtgttgtgttcgctgtgtgtgtgtcacggtgtagcagta cgctccaaccagcacctgatctgtgacaatctgctgccaggaagagatctgctactgcag acccgtttgatcaaccacgtaagcagcatgcgtccaaacatcttcctgggtgtcagtgat ggctctgctcagtacaggaagtggtactatgaactgatcgtggatcaggtgttgccattt gtcacagcagaggccactcacctcagggtgggctgggccagtaccagtggctatgcaccc taccccagtgggggggaggggtggggaggcaacggggtgggtgatgacctctactcgtat ggctttgatggactccatctttggtcaggctgcattgcacggactgttagctcccccaat cagcatctgctgaggtcagaggatgtggtgagctgctgcctggacctcagcgtacccagt atttccttcaggatcaacggccagccggttcagggcatgtttgagaacttcaactcagat ggcctcttcttccctgttgccagcttctctgctggggtcaaggtgcgtttcctccttggg ggtcgtcatggggagtttaagttcctccctcctccaggttatgctccttgttatgaggca gtgttgccaagggagaaactgaagctggaagccagtcaggaccagacagcagccacagac ctcctgggacccaccgtcaccttgagccaggctgcattcacccctacacctgtggacacc agccagattgtgctgcctcctcacttggagaggatcagggagaagcttgcagaaaacatc catgaactgtgggtgatgaacaagatagaactgggctggacctatggtgcagtgcgagat gataacaagcggcagcacccttgtctagtggagttctgcaggcttcctgaacaggagcga agctacaacctccagatgtctctggaaactctcaaaactctcctggctttgggttgccat gttggcttagcagatgaacgcgctgtagagaaagtcaagagcatgaaactgtcctcaacc tatgagttgtccagtggttataaacctgctcctctggacctgagtcacatcaaactgacc tccacccaggaagccatggtggacaaactggctgagaacgctcacaatgtctgggcaaga gaccgcatccatcagggctggacctacggcatccaacaggatgtgaagagtcgtagaaac cctcgtctggtcccctacactctgctggatgagagaaccaagaagtcaaacaaagacagt ctgagagaggctgtcaggactctgctgggatatggatacaacctggaagctcctgaccag gaccatgcagctcaatctgacctcaacaacatgtctgctgagaggtttcgcattttcaga gcagagaaaacctactgtgttaatgctgggaagtggtactttgaactggaggtgctgaca gcaggagagatgagggtgggctgggccaggccaggatgcctcccagaccaagagttggga tctgatgaccaggcctttgtctttgatggcttcaaggtccagcgctggcaccagggcaac gagcacttcgggcgtgcctggcagatgggggatgtggtgggatgcatggtggatctgaat gaacacaccatgatgtttacactcaatggagaagtgctgctggatgattctggctcagag ctaaccttcaaggactttgaagctggcgaaggttttatccccgtgtgcagtctgggtgtg tgtcaggtggggaggatgaactttggtaaagacgtaagcactctgaagtacttcaccatc tgtggccttcaggaaggctacgagccgtttgctgtcaacatgaaccgagacgttaccatg tggctcagcaagaggctgcctcagtttgtacctgtccctcacagtcaccagcacatagag gtgacaaggatagatgggacagtggagtcttgtccatgcctgaaggtcacccagaggtca tttggctcacagaacagttacactgacattaccttctacagactgagcatgcccatcgag tgtgcagaatccttctctagatcccggtctaacggcagcctcttctcgccgaatagggag ctggaggactttgaaacggtatcagactttgaggtcctgatgaagtcgtctcacggtcac aatggtcccaatggacctgagagagacgaattcaacaaccacaaagattataaccaggag aagccatccaagctcaaacaacggttcatgttgaagagaaacaaaccagacaacagctgc ccctcatctgctagactgtcagaggaagtgatggctgatgacagagatgagtacgaattc ctcatgcaagcctccactcactactactcagttcggatcttccctggtcaggagcccagc agtgtgtgggtaggctgggtgacctctgacttccatcagtatgacccaggcttcgaactg cacaaggtccgaacggtcactgttaccctgggagacgagaaaggcaaagttcacgagagt ataaagcgcagtaactgttacatggtgtgggctggagagagcagcagtcctggtcagggg aggaacaacaatggcttagagataggctgtctagttgacacaacaaatggactattgacc ttcactgccaacggcaaagaactcagcacatattaccaggtggagcccagtactaagctg ttccccgcagtctttgccaaggcgaccagccccaatgtcttccagtttgaactggggaga ataaagaatgtgatgcctctgtcagctggtctgtttaagagtgagaggaagaacatggtt cctcagtgtcctccacggcttcatgtccagtttcttactcctgttttatggagtcgtgtt cccaaccacttccttaaggtgtcagcatccagagtgaatgacagacatggctggctggtc cagtgtagtgaacccctgcagttcatgtctctgcacatacctgaggagaacaggtcggtc gatatcctggagctgtcagagcagagggacttattaaagtttcactaccataccctcaga ctgtactctgcaatctgtgctctgggaaacaaccgggtggcacatgccctctgctcccat gtggacgaagcacagctgctgcaggctatagagaataagtacatgccaggtttgcttcgt gctggctattacgacctccttatcgatatccacctgagcagctacgccacagctcgcctc atgatgaacaatgagtacattgttcccatgacagatgaaacaaagagcatcaccctgttt cctgacgagaagaagaaacatggcctgccaggcattggcctcagcacttccctgagaccc agaatgcacttctcatctccaagctttgtctgcgggaccggatcgttgtatcgaaacaac ggaaacagcggatcaggatcaggagactgtttccagtacagccctgaattccctttagat atactgaaagtcaaaacaattgagatgctgacagaggctgtgcgggagggaagcatgcac gtacgggatccaataggaggcagcactgagtttctctttgttccccttatcaagctcttc tacaccatgctcatcatgggagttttccaaaatggagatctgaagaacatcctccgactg attgagccatctgtgttctctgaaaggcgagaagggcaggaggagattcacatggagctg gagatggtgaaggaggtggagactgaggttggaggggaggatagagggaggaccatgcca aaagaaggactgttgcagatgaagctgccagagcctgtaaaactccagatgtgccatgtg ctacagtatctgtgtgactgtcaggtgcgtcatcgtatcgaggcagtggtggccttctct gatgattttgtggcctgtctccaagacaaccagcgattccgctacaacgaggtgatgctg gcactcaacatgtctgcagctctcactgccaagaaaaccaaagagttcagatcacctcca caggaacagatcaacatgttgctgaactttaaggatgagaagcaggagtgtccctgtcct gaatacatcagagaacagctgctcgactttcatgaagatctgatgagacactgtggtata gaattggatgaggacagaagcatagatggtgacagtgacttcaccatccgaggtcgactc atgtcactggtggagaaagtggcttatctgaagaagaagatggccaacttgccgaaggag aagaaggacaggaaacccagtacgttacagcaactgatctcagacacgatggtccgctgg gctcaggagtcggttattgaggatccagagctggtcagagccatgtttgtcctgctgcac cgccagtatgatggcatcggaggacaggtgcgggctcttcctaagacctacactataaat tcagtttccattgaggacaccatcaacctgttggctgctctgggtcagatcagatctcta ctgagtgtccgcatgggaagagaggaggagaaactaatgatccgagggctaggtgacatc atgaacaacaaggtcttttaccagcatcctaacctgatgagagctctggggatgcatgag actgtcatggaggtgatggtgaacgtgctcagtgggggagactcaaaggaaataaccttt cctaagatggtggccaactgttgtcgctttctctgttatttctgtcggatcagtcgtcag aaccagaaggccatgtttgaccatctcagctaccttctggagaacagcagtgttggcctc gcttctccatccatgcgaggctccactcctcttgatgtggctgcagcatcagtcatggat aataatgagttggctctggcgttgagagagccagacctggagaaggtggtgcagtacctg gccggctgtgggttgcagagctgtgtgatgctggtgcgtaagggataccccgacatcggc tggaaccctgtggagggcgaacgctacctcgacttcctgcgctttgctgtcttctgcaat ggtgaaagtgttgaggagaatgccaatgttgtggtgaggcttctgattcgccgaccagaa tgttttggccctgctcttcggggtgagggtggtgatgggttgttggcagcaatggaggaa gccattaagatctctcaggattcttccagggatggtccctctcctacatctgagagcagc agaacacttgacatgctggaagaagaggaagatgataccatccacatgggaaatgccatc atgaccttctatgctgctctcattgatctgctaggtcgctgtgctccagagatgcattta atccatgctggtaaaggtgaagcaatccgtatcagagccattctgaggtctctcattcct attgaagacctggtgggagtaatcagtattccattttccatgcccaacctggctaaagat ggggtggtggtggagccagacatgtcagctggtttctgtccagaccataaggcagccatg gtgctgttcctggacagggtctatggtatagaagaccagaatttcctgctccacctgctg gaagtcggattcttaccagacctgagagctgctgcctcgctggacactgttgctctcagt gccacagacatggcactcgctctcaacaggtatctgtgtacggctgtgctgcctctcctg actaaatgtgcaccactgtttgcggggacagagccgtttgcttcactgattgactccctc ctccacaccatttaccgcctgtcaaaaggctgctgtctcaccaaggcccagagggacgcc atagaggagtgtctgctggctgtttgtggaaagctgagaccctcaatgatgcagcatctc ctgaggaggctggtgtttgacgttcctctgcttaatgaacacaccaagatgcctctgaag ctgttgaccaatcactatgagcgttgttggaagtattactgcctggctggaggctggggc aactttggagctgcatcagatgaagaacttcacctctccaggaaactgttttggggaata tttgatgctctgtcatacaagcggtatgaccaggagctgtttaagctggcattgccatgt ctcagtgctgtggcgggagctcttcctccagactacatggagtctaactacatggccatg atggagaaacagtcatccatggactcagagggaaacttcactccacaacctgcagacacc accaatgtgactgtcccagagaaactggactatttcataaccagatatgcagaacacaac catgaaaagtggtgtatagagaagttttccaatggctggtcatatggggaacagatatgt gaaatcagcaagagccaccctttactgaaaccatacaaaggcctctctgaaaaggataag gagtcgtactgctggtcagtcagagagtctctgaagaccatgcagtcgtggggctggagc atcgaaaggatcagagagggagaccccgccagcctccacaacaagtccaggaggatatca caggctagccagctgtcttttgaaggcgctccagctttcagcccgagacccattgatatg agcaatgttacactgtccagagacatgcagtctatggcagagctgctcgcagagaattat cataatgtctgggcgaggaaaaagaaaatggagctggaagccaaaggtggaggaaaccat ccccttctggttccttatgacacactgactgccaaagagaaatccagagacagagagaaa gcacaggagattctcaagttcctccagatcaacggttacactgtgtccagaggtgtgaag tcacaggagctggacactccagctatagagaaacgattcgcctacactttcctccagcag ctcatcacatacgtagaccaggcccaccaacacatgatggagtttgaccagggaacgaga cagaagggagacaaggttcctcatgaacagcagatgaagttctttggaaaggttgtcttg ccattggtggatcagtactttaaaaaccataggctctacttcctgtccacagccatccat ccaattagcagtggtggccacgcctccaacaaggagaaagagatggtgaccagtcttttc tgcaaactgggagttcttgtcagacataggatatcctcttttggtaacaatgccacatcc atagtcaactgtctgcagatactgggacaaagcctggatgccaggacagtgatgaagact ggtctggagtcagtgaaggctgctctgcgatcatactttgagagtgcagcagaggacctg gagaagacacaggagaacctgaagctcggtcagttcacccacagcagagagcagccgcga ggtgtcactcagatcatcaactacaccaccttcgccctgctgcctgtcctctcctcccta tttgaacacatcggacagaacatgtttggagaagacctcatattggatgatgtccaggta tcctgctatagaatcctcaacagcctttattttctgggaaccaacaaaagtatctatgta gaaagacagcgtccagcattaggaaaatgtctagctgctttctcagcagccttccctgtg gcctttcttgagcctcacatcaacaagttcaacagcttctccatctacaacatcaaagga actaaagacagaggggctctaggtcttccaggacacgttggagaggtttgtcctgtgatc ccaaacttagaaaagtctctggaggagatcatggagttggcagagtctggcatgagatac actcagatgccccatgtcatggaggtggtgttgcccatgttatgtagctatatgtctcac tggtgggaacatggacctgagagcaacacagacaaagctgacagctgctgcacctccgtg acctctgaacacatgaacactctgctggggaacattctcaagatcatctacaacaacctt ggaatagatgagggggcctggatgaaaagactagctgttttctctcagccaatcatcagc aaggccaaagctgagctgctgaagacccacttcctgcctctgatggagaaactgaaaaaa aaagctgcagttgtgttgatggatgaagaacacagcaaggcagaggggaggggtgagatg tcagagacggagcttctcatcatggaccagttcaccatattggtcagagacctgtacgct ttctaccctctcctcatccgatttgttgactacaacagggccagatggctgaaggagtcc aacccagaggctgaggagctgttccgcatggtggctgaggttttcatcttctgggccaag tctcataacttcaagagggaagagcagaactttgtggttcagaatgaaatcaacaacatg tccttcctcatcactgacaccaagtgtaagatgtcaaagggaatagtttcagaccaggag aggaagaagatgaagaggaagggagatcgatactcaatgcagacaagtctgatcgttgct actctaaagcgtctactgcctgtcggactcaacatctgtgcccctggagaacaagagctc atcgcactggctaagaaccgtttcacccagaaagatacagaggacgaagtccgagagatc atcaggaataatctccatttacaagggaagctggaggacccagctattcgttggcagatg gcgttgtacagggacctccctaatcactatgaggacacctcagacccagagaaaactgta gagagagtcctggacattgctcatgttctcttccatctggatcaggttgagcaccctcag cgcagtaagaaggcagtttggcacaaacttctgtccaaacagaggaagagagcagtggtt gcttgcttcaggatggcaccgctctacaacctgcccaggcaccgggctgtcaacctgttc ctgcagggctatgagaagtcctggatcgaggcagaggaacactactttgaagataaactc atcgaggacctcgctaaaccaggtgaccaagagccatccgaagaagaggaaggggtgaag cacattgatccactgcatcagctcattcagctgttcagtagaacagccctcacagagaag tgtaaactggatgaggataatctttacatggcctatgctgacatcatggctaagagttgc catgatgaagaggatgaagacggggaggaagtgaagagttttgaagtaggtggtcagtca ctctgtgagaaggagatggagaagcagaagctgttgtatcagcaggctcggctacatgac cgaggagctgctgagatggtgcttcaaaccatcagcgctagtaaaggtgagatgggtccc atggtggcctctactctgaagctgggcatagctattctcaatggaggaaactctactgtg cagcagaaaatgttggattatctgaaagacaagaaggatgtgggcttttttcagagtctg gctgggctgatgcagtcatgcagtgttctggatcttaatgcatttgagaggcagaacaaa gcagaaggactgggaatggtgacagaggagggctcaggtgagaaggtcatgcaggacgat gagttcacctgtgaccttttccgcttcctgcagctgctctgtgaaggacacaactcagac ttccagaactacttaaggacacaaactgggaacaatacgactgtcaacatcatcatctct actgttgactatctactaagagtccaggagtctatcagtgatttctactggtattattct gggaaagatgttatcgacgagcagggccagaggaatttctccaaggcgataaatgtggcc aagcaggttttcaatacactaactgagtacatccagggtccgtgcactggcaaccagcag agcttggcccatagccgtttgtgggacgctgtggttggttttctccatgtctttgctcat atgcagatgaaactttctcaggactccagtcagattgagttactgaaggagttgatggac ctacagaaagacatggtggtcatgctgctgtctatgctggagggtaatgtagtcaatggg actatcgggaagcagatggtggacatgttggtggagtcctccaacaatgtggagatgatc ctcaagttctttgatatgttcctcaaactgaaagacctgacctcctccgatgccttcaag gagtatgaccctgacggaaaaggtgtcatctccaagagggacttccataaggccatggag agccacaaacactacacccagtctgagacggagttcctgctgtcctgtgctgagactgat gagaatgaactcttggactatgaagaatttgtggagcgctttcatgagccagccaaggat attggcttcaatgtggcggttttgctgaccaacctgtcggagcacatgcctcatgacacc cggctgcagaccttcctggagctggcagagagtgttctcaactacttccaaccctacctg ggcaggatcgagatcatgggcagtgccaagcgcattgagagggtttactttgagatcagt gagtccagtcgaacacagtgggagaaacctcaggtcaaagaatccaagcgtcagttcatc tttgatgtggtgaacgagggaggggagaaggagaagatggagctgtttgtgaatttctgt gaggacaccatttttgaaatgcagctggcggctcagatgtctgacgctggtgagcgttca gcagtgaaggaggagagtgagcgggagaaaccagatgaggacaatcctgagatgggcttc ttctctgttaccacagtctgcatggcgctgttggctctgcgatacaatgtcatgctgcta ataaaggtgctgtccatgaagagcttgaagaagcagatgaagaggataaagaacatgaca gtgaaggacatggtgaccaccctggtgtccttatactggtcactgttgctgggctttctc catgtggcgttcagtgtgactcgaggattttgccgtatcttctacaacaccttcatggga ggcagtctggtggagggggccaagaccataaaggtttcagagctgctggccaacatgcct gaccctacccaggatgaggtgcggggtgaaggggaggacagagagaagagactttctgat cgcagctccccaaaggaggacctggctgatctggcagtcaacaccagcgagactgagctg ctgtcagacatttttggtctggacctaagaagggaggggggccagtacaagatcaccccc cataaccccaatgccagcctgaccgaactgctcaactctccggttccctccccaaaccca ccaaccccacccacagcacctccacctgagctcaggcagaggcaccagagctcttcctca gaggcgaaggaagcaacaccagagactgcatctgaacctgagaaaacattaggggctgga catatagagcaactagagaagcaacagaagaatgagaagatgaagcaaaaagttagaagg catcacacctcaaagtctgatgagccagatctgcaggagtctgcgttcttgaagaagatc atagcctaccagaggaagctactgaactactttgccaggaacttctacaacatgaggatg ttggcactgtttgttgcctttgcaatcaacttcatcctcttattctacaaggtgtccaca tcctcatctgtggttgaagaaagggaagttatatacaccagcagccaaccagacagcagt gttcattgggatggattgagtggagaagcaatggagacaaaggaggaggtgatggatgag actggggagctcctgaaacctgtcacagtccgttttgtgctggaagagagcagtggatac atggagcccatgttacggatcctggccatcctgcacactgttatctccttcttctgtatc attggatactactgtctcaaggtgccactggttatctttaagcgtgagaaggaggtggcc aggaagctggaatttgatggcctttatatcacagaacaaccgtctgaagatgacatcaag ggacagtgggacagactggttatcaacacacaatctttcccaaacaactactgggataag tttgtgaagaggaaggtgatggataaatatggggagttttatggccatgaccgcatcagt gagctgctgggaatggacaaggctgcactggacttcagtgatgctcacaaaaagagaaag cccaggagagacagctcactggctgctgtgttgaactccatagatgtcaagtaccagatc tggaagctgggggtggtattcacagacaattccttcctgtatctggcctggtatatgacc atgtccatcctgggtcactataacaacttcttctttgctgcccatctgctcgacatcgcc atggggttcaagacactgcgcaccatcctgtcctcagtgacacacaatggcaaacagctg gtgttaacagttgggctgttagcagtggtggtctacctttacacagtagtggccttcaac ttcttcaggaagttctacaacaagagtgaagatggagaactgccagacatgaagtgtgac gacatgctgacatgctacatgtttcacatgtatgtaggtgtgagagcaggtggggggatc ggtgaccaaattgaagacccagcaggtgacgagtatgagatctatcgcatcatctttgac atcaccttcttcttctttgtcattgtaatcctcctggctatcatccagggtttgatcatt gatgcatttggagagctgagggatcagcaggaacaagtaaaagaagacatggagaccaaa tgttttatctgtggaataggtaacgactactttgacacagtgccacatggctttgaaacg cacacgctacaggagcacaacttagccaactacctattctttgtgatgtatctcattaac aaagatgaaacagagcacacaggccaggagtcttacgtatggaagatgtaccaggagcgc tgctgggagtttttccctgctggtgactgtttccggaaacagtacgaggatcagctcaac tga

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