KEGG   Streptomyces durmitorensis: M4V62_39040
Entry
M4V62_39040       CDS       T08503                                 
Name
(GenBank) amino acid adenylation domain-containing protein
  KO
K16428  nonribosomal peptide synthetase CepA
Organism
sdur  Streptomyces durmitorensis
Pathway
sdur01055  Biosynthesis of vancomycin group antibiotics
Brite
KEGG Orthology (KO) [BR:sdur00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01055 Biosynthesis of vancomycin group antibiotics
    M4V62_39040
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins [BR:sdur01008]
    M4V62_39040
Polyketide biosynthesis proteins [BR:sdur01008]
 Nonribosomal peptide synthetase (NRPS)
  Linear NRPS
   Vancomycin synthetase
    M4V62_39040
SSDB
Motif
Pfam: AMP-binding Condensation PP-binding AMP-binding_C
Other DBs
NCBI-ProteinID: UQT60589
LinkDB
Position
8724287..8730919
AA seq 2210 aa
MESSVVAELIAARVESSPGAVAVEGEQTLSYGELWARSGQWAAHLAGLGVGRGDRVAVVM
ERSPELVTVLLGVWRAGAAYVPVDAGSPPERIAFVVEDSAPAVVLCTSDRRGVVPESAAV
QVVDDPRVRAAVAARDGGDVRAPVDGRDVAYVMYTSGSTGVPKGVAVPHGSVAALVGEEG
WAIGPDDAALMHAPHAFDVTLFEMWVPLAAGGRVVIAEPGAVDGQKVRRHVKNGVSAVHV
TAGSFRVMAEESPDCFTGVREVLTGGDVVPPGSVARVREACPDVAVRHLYGPTEVTLCAT
WHVLRPGDKTDSVLPIGRALPRRRTFVLDAALRPLPAGTVGELYVAGPSLARGYWNSPGP
TADRFVACPYASGERMYRTGDLVRETEDGELLFVGRADSQVKVRGFRVELGEVEAALAAH
PAVAQAVVVAREDRHGERRLAGYVVPQEPEGLDPRLVRDAVARTLPEYMVPTAVLALASL
PVTRNGKVDRDALPAPDFAAKVTGHAPRTEDEAVLCALMAELLGLERVGVEDSFFELGGD
SIMSMQLAARARRAHLFFRAEDVFEHATPAALAAVARSGQGAGERSGVPGGPGERQETTG
RDRSAASLMDDLREDETDRLRAAVPGLVDVWPLSPLQEGMLFHATFDDEGPDVYASQRTL
ALDGPLDVARLRTSWHTLLARHAVLRASFHQRDSGQTVQVITTDAELPWREADLSELPEG
DVPAEVARLAAAERAEKLDLRAAPLLRLLLIRLGAGRHRQIVTVHHSLVDGWSTDVVFAE
LSELYAAGGDGRTLPTTTSYGTYLAWIDRQDKEAARDAWRAEFAGADEPTLLVPDEPVGP
QVVPEPVPFELTEELTRGVAELARSQGVTVNTVVQGAWAQVLARLVGRTDVVFGTPVAGR
PAELPGVESAVGLFLNTLPVRVSLAADQSVAGLLADLRERQVGLMSRQHLGLREIHRIAG
PGAVFDTLVVFENLPRTPDGTGAAAELAIRPVGEPEDRGHYPLALIVVPDTRLRGLVVHR
PDVVGRDRAQAVISSLVRVIEQMVADPSSPVGRLDILTETERALVAREQERQRGERNASA
RAAVPDVTAPDLFAEQAAATPAAVAVVDGRRSLTYGELAARAGRLARCLTDRGVGPETRV
AVMADRSAELVTALLAVAAAGGVYVPVDPGLPPARLRLLLDDVAPPVLVCAEQTRDAVPQ
EFTGQLMLLDDQLTTGGVAEQAGFADGLMKDAERRTPLTASNAAYVIYTSGSTGTPKGAV
VPHRGLRNLVADRIARYRIDADSAVLQLVSPSFDVSMSDIWPVLCAGGRLVLAPPARRHA
TGEELVHLMRTQRVTHVAMTPTLLAQLPPEELPALRVLVIGGEPVSDELRRQWSVNREIY
SEYGVTEATVASTVSRPLDAHDEPSIGRPVANTSAHVLDAFLRPVPADTVGELYVAGAGL
ARGYLRRTRLTARRFVASPFAHGERMYRTGDLVRRTGTGDLVYAGRADAQVKVRGFRVEL
GEIEAALTGHPAVDRAVVILRQDRQGERRLVGYVVGTDARAEAQAQAGAGAGARAEHRMA
PRPLDMQSVREYAAEALPEYMVPAAVLALDALPVTPNGKVDVPALPAPDFADHVSGRAPE
GEAEKILCALFAEVLGLERVGADDNFFRLGGDSISSMQLVSRARREGALFSAQDVFEHGS
PEGLARVVRLGAGRVAGPDVGEGEVAWTPVMRALGERALGGGFTQWVVMGTPAGLGGEVL
AAGLGAVLDTHDMLRAHAVATDAVATDAVADGDTGPRLVVGERGSVDAARLITRLDTAEV
PTEGLDELAGRAARDAVLRLDPFAGAMVQAVWLDAGPGRVGRLALVVHHLAVDGVSWRIL
APDLRAACEAAAAGREPGLDPVGTSFRRWSRLLVEEATGSDRVAELDAWTTLLGDRATAE
PPLGHRALDPARDTAAGMHHRSWTVPPQQAATLAGSTPALFHCGVHEVLLATLAGAVVQG
RRGTHGTVLIDVEGHGRKPVQDADLLRTVGWFTSVHPIRLDLSGIDTTRAAAGGPDVGSL
LKAVKEQARAVPGDGLGHGLLRHLNPETGPVLAALPGPQVGFNYMGRFPAVGGSADVRPW
QMAGEEAIGSSTAAAMPATHTLEAGATIRDAAEGPELTLSLSWHGAVLDESVAERVGRHW
LDLLAGLAAHTTDPTAGGHTPSDFPLVELAQDEVEQFEAMAAELEGGRSL
NT seq 6633 nt   +upstreamnt  +downstreamnt
gtggagtcgtcggtggtggcggagctgatcgccgcacgggtggagtcgtcgcccggcgcg
gtcgcggtcgagggcgaacagacgctgtcgtacggagagttgtgggcgcggtcgggtcag
tgggcggcgcatctggctgggctcggagtgggccggggcgaccgcgtcgcggtggtgatg
gagcggtcgccggagctggtgacggtgctcctgggcgtgtggcgggcgggcgcggcctac
gtgcccgtcgacgcgggttcaccgcccgagcgcatcgccttcgtcgtcgaggactcggct
cccgcggtggtgctgtgcacgtctgaccgcaggggtgtggtgcccgagagcgccgccgtg
caggtggtggacgacccgcgggtacgggcggcggtggccgcccgcgacggcggcgacgtc
cgcgcgccggtggacgggcgggacgtggcgtacgtgatgtacacgtcgggttcgaccggg
gtgcccaagggcgtcgcggtgccgcacggaagcgtcgcggccctggtcggcgaggaaggc
tgggcgatcggcccggacgacgcggccctgatgcacgccccgcacgccttcgacgtcacg
ctgttcgagatgtgggtgccgctcgccgccggtggccgtgtggtgatcgccgaaccgggc
gcggtggacggccagaaggtgcgccggcacgtcaagaacggcgtgagcgccgtgcacgtg
accgcgggttcgttccgcgtcatggccgaggagtccccggactgcttcacgggggtgcgc
gaggtgctcaccggcggtgacgtggtcccgcccggctccgtggcccgcgtgcgcgaggcc
tgcccggacgtggccgtccggcacctgtacggcccgaccgaggtgaccctgtgcgcgacc
tggcacgtgctgcggccgggcgacaagacggactccgtgctcccgatcgggcgcgcgctg
ccccgccggcggaccttcgtcctggacgcggcgctgcggccgctgcccgccggcacggtg
ggggagctgtacgtggcggggccgagcctggcgcgcggctactggaacagccccggtccg
actgcggaccggttcgtggcgtgcccgtacgcgtccggcgagcggatgtaccgcaccggc
gacctggtgcgcgagaccgaggacggagagctgctcttcgtcggccgcgcggacagccag
gtcaaagtgcgtggcttccgcgtggagttgggtgaggtggaggcggctctggcggcccac
cccgccgtggcccaggccgtggtcgtcgcccgcgaggaccggcacggggagcgccgcctg
gccggctacgtcgtcccgcaggagccggaaggccttgacccccggctcgtccgcgatgcc
gtcgcaaggacactgcccgagtacatggtccccaccgcggtactggccctcgcgtccctc
cccgtgacccgcaacggcaaggtcgaccgcgacgccctgcccgcccccgacttcgccgcg
aaggtcacgggccacgcgccgcgcaccgaggacgaggcggtcctgtgcgccctgatggcg
gagctgctcggcctggaacgcgtcggcgtcgaggacagcttcttcgagctcggcggcgac
tcgatcatgtcgatgcaactggccgcccgcgcccggcgcgcgcacctgttcttcagggcg
gaggacgttttcgagcacgcgacaccggcggcccttgccgcggtcgcccgatcagggcag
ggggccggggagcggtccggagtgccgggcgggcccggggagcggcaggagacgaccgga
cgcgaccgctccgccgcttcgctcatggacgacctccgcgaggacgagaccgaccggctg
cgggccgcggtgcccggcctggtggacgtatggccgctgtcgccgctccaggaagggatg
ctcttccacgccaccttcgacgacgaagggccggacgtgtacgcgagccagcggacgctg
gcactggacggcccccttgacgtcgcccggctgcggacgtcgtggcacacgctgctcgcc
cggcacgccgtgctgcgcgcgagcttccaccagcgcgactccgggcagacggtgcaagtc
atcacgaccgacgccgagttgccctggcgcgaggccgatctctcggagctgccggaaggt
gacgtgcccgccgaggtggcacgcctcgccgcggccgaacgtgccgagaagctcgacctc
cgcgcggcaccgttgctgaggctgctcctgatacgcctcggcgccggccggcatcgccag
atcgtcaccgtccaccactccctggtggacggctggtccaccgacgtcgtcttcgcggag
ctctccgagctgtacgcggcgggcggcgacggccggacactgcccacgacgacgtcctac
gggacatacctggcctggatcgacaggcaggacaaggaagcggcgcgcgacgcctggcgc
gccgagttcgccggggcggacgagccgacgctgctggtgcccgacgagccggtcgggccg
caggtcgtgccggaaccggtgccgttcgagctgaccgaggaactcacccgcggtgtggcc
gagttggcccgctcccaaggggtgaccgtcaacacggtcgtgcagggcgcgtgggcccag
gtgctcgcccggctggtggggcgcacggacgtggtgttcggcactccggtggcaggccgt
cccgcggagctgccgggggtcgagtcggcggtcggcctgttcctcaacaccttgcccgta
cgggtgagcctggcggcggaccagtcggtcgccgggctgctcgccgacctgcgggagcgc
caggtcgggctgatgtcccggcagcacctgggactccgcgagatccaccgaatcgccggg
cccggcgcggtgttcgacacgctcgtggtgttcgagaaccttccccggacgcccgacggg
accggtgccgcagcagagctggccatccgtcccgtaggggagccggaggacaggggccac
tacccgctggcgctgatcgtggtccctgacacccggctgcgggggctcgtcgtgcaccgc
ccggacgtggtgggacgcgaccgggcccaggccgtgatctcctcgctggtccgcgtgatc
gagcagatggtggcggatccgtcgtcgccggtgggacggctcgacatcctcaccgagacc
gaacgcgcgctcgtggcgcgggagcaggaacggcagcggggggagcgaaacgcgtcggcg
cgggcagccgtgcccgacgtgacggcaccggacctcttcgccgagcaggccgcggccacg
cccgccgcggtggcggtggtcgacggccggcgttcgctgacgtacggcgaactggccgcc
cgcgccggacggctggcgcgctgcctgacggacaggggagtgggtccggagacacgggtg
gccgtcatggcggaccgctcggcggaactggtgacggccctcctcgcggtggcggcggcc
ggaggtgtctatgtccccgtggacccggggcttcccccggcgcggctgcgcctgctcctc
gacgacgtggccccgccggtcctggtgtgcgcggagcagactcgcgacgcggtaccgcag
gaattcaccggccaactgatgctcctggacgaccagttgactaccggcggagtggccgaa
caggccggattcgcggacggcctgatgaaggacgcggagcggcgcacaccgctcaccgcc
tccaacgcggcgtacgtgatctacacatccgggtcgaccggcacccccaagggtgcggtc
gtcccccaccggggcctgcgcaacctcgtcgccgaccgcatcgcgcgctaccggatcgac
gcggacagcgcggtgctccaactcgtctcgccgagcttcgacgtctccatgtcggacatc
tggccggtgctctgcgcgggtggccggctggtcctcgcaccgcccgcgcgtcggcacgcg
accggcgaggagctggtccacctgatgcgcacgcagcgggtgacgcacgtcgcgatgaca
ccgaccctcctggcgcagcttccgccggaggaactgcccgcgttgcgtgtcctggtcatc
ggcggcgagcccgtctccgacgagctgcgccgtcagtggtcggtgaaccgcgagatctac
agcgagtacggggtcaccgaggcgacggtcgcctcgacggtgagccgccctctcgacgcc
cacgacgagccgtcgatcggccgcccggtcgccaacacctccgcccacgtccttgacgcg
ttcctgcggccggtgcccgcggacacggtgggcgagctgtacgtggcgggcgcgggcctg
gcacgcggctacctgcggcggacgaggctgacggcgcggcgcttcgtggcgagcccgttc
gcgcacggcgagcggatgtacaggaccggggacctggtgcgccgcaccggcaccggcgac
ctcgtctacgcgggtcgtgccgacgcgcaggtgaaggtgcgcggattccgggtggagctc
ggcgagatcgaggcggccctcacggggcatcccgccgtcgaccgggccgtggtgatcctc
aggcaggaccggcagggggaacgccgcctggtcggctatgtggtgggcaccgacgcccga
gccgaagcccaggcccaggccggggccggggccggggcccgagccgagcaccggatggcc
ccacgacccctggacatgcaatcagtgcgcgagtacgccgccgaggcgctgccggagtac
atggtgcccgcggccgtcctcgccctcgacgcactgcccgtcaccccgaacggcaaggtc
gacgtccccgcgctccccgcgcccgacttcgccgaccatgtgtcgggccgggcgccggag
ggcgaggcggagaagatcctctgcgccctgttcgccgaggtcctcggccttgagcgggtc
ggcgccgacgacaacttcttccggctcggcggggattcgatcagctcgatgcagctggtg
agccgcgcccgccgggagggtgccctcttcagcgcccaggacgtgttcgagcacgggtcg
ccggaaggcctcgcgcgcgtggtcaggctcggtgccggacgcgtggcgggaccggacgtg
ggcgagggcgaggtcgcctggacacccgtgatgcgggccctgggcgagcgggcactcggc
ggcggattcacccagtgggtggtgatgggcacccccgcgggtctcggcggcgaagtcctg
gcggcgggcctgggcgccgtactcgacacgcacgacatgctgcgcgcccacgcggtggcc
actgacgcggtggccactgacgcggtggccgacggcgataccgggccccgcctggtggtc
ggcgagcgcggatccgtcgatgccgcccgcctgatcacccggctcgacacggcggaggtc
ccgacggagggcctggacgagctggcgggccgtgccgcgcgcgatgcggtcctgcgcctg
gatcccttcgccggtgcgatggtccaggcggtgtggctggacgcggggccggggcgggtc
gggcgactggccttggtggtgcaccacttggcggtggacggggtctcgtggcggatcctg
gccccggacctgcgcgccgcgtgcgaggcggcggccgccgggcgggagccggggctcgac
cctgtcggcacgtccttcaggcgctggtccaggctcctcgtcgaggaggcaaccggcagc
gaccgcgtcgcggaactcgacgcctggaccacgctgctcggcgacagggcgacggcggaa
ccacccctcggtcaccgggccctcgacccggcacgggacacagcggcagggatgcaccac
cggtcctggaccgtcccgccccagcaggcggccacgctcgcgggatccacaccggccctc
ttccactgcggagtgcacgaggtgctcctcgccacgctggccggagccgtcgtccaaggg
cggcgcggcactcacggaacggtcctgatcgacgtcgagggacatggacgcaagccggtc
caggacgccgatctgctgcgcaccgtcgggtggttcaccagcgtgcaccccatccgcctt
gacctgtccggcatcgacacgacgagggcggcagccggtggaccggacgtcggctcgctc
ctgaaggcggtcaaggaacaggcacgggcggtgccgggcgacggactcggacacggcctg
cttcgccacctgaaccccgagacgggcccggtgctcgccgcgctgcccggcccgcaggtc
ggcttcaactacatgggccgcttccccgcggtcggcggaagcgccgatgtccggccctgg
cagatggcaggcgaagaggcgataggaagctccaccgcggcggccatgcccgcgacgcac
acccttgaggccggtgcgaccatccgcgacgccgccgaagggcccgagctgaccctctcg
ctgagctggcacggcgcggtcctcgacgagtccgtggcggaacgcgtcggccgccactgg
ctcgacctgctcgcgggcctggcagcccacaccaccgacccgacggcgggcggccacacc
ccgtccgacttccctctcgtcgagctcgcccaggacgaggtcgagcagttcgaagcgatg
gcagcagagctcgaaggagggcgttcgctgtga

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