Salmonella enterica subsp. enterica serovar Typhimurium ST4/74: STM474_0119
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Entry
STM474_0119 CDS
T01760
Symbol
leuA
Name
(GenBank) 2-isopropylmalate synthase
KO
K01649
2-isopropylmalate synthase [EC:
2.3.3.13
]
Organism
seb
Salmonella enterica subsp. enterica serovar Typhimurium ST4/74
Pathway
seb00290
Valine, leucine and isoleucine biosynthesis
seb00620
Pyruvate metabolism
seb01100
Metabolic pathways
seb01110
Biosynthesis of secondary metabolites
seb01210
2-Oxocarboxylic acid metabolism
seb01230
Biosynthesis of amino acids
Module
seb_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
seb00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
STM474_0119 (leuA)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
STM474_0119 (leuA)
Enzymes [BR:
seb01000
]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
STM474_0119 (leuA)
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Motif
Pfam:
HMGL-like
LeuA_dimer
HCS_D2
IPMS_D2
Trp_syntA
Motif
Other DBs
NCBI-ProteinID:
ADX15863
UniProt:
E8XH24
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Position
complement(132170..133741)
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AA seq
523 aa
AA seq
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MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT
IARTIKNSRVCALARCVEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIE
RAVYMVKRARNYTDDVEFSCEDAGRTPVDDLARVVEAAINAGARTINIPDTVGYTMPFEF
AGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCA
LEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIH
QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNMDHLYDAF
LKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKA
EAANGNGPVDAIYQAINRITGYDVELVKYDLNAKGQGKDALGQVDIVVNHHGRRFHGVGL
ATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV
NT seq
1572 nt
NT seq
+upstream
nt +downstream
nt
atgagccagcaagtcattatttttgatacgaccttacgcgacggcgaacaagcgttacag
gccagcctgagcgcgaaagagaagctgcagattgccctggcccttgagcgcatgggtgtt
gatgtcatggaagtaggcttcccggtctcttctccgggtgattttgaatccgtccaaacc
atcgcccgcaccattaaaaacagccgcgtttgcgccctggcgcgttgtgtagaaaaagac
atcgacgtcgcggcacaggcgctgaaggtcgccgacgcgtttcgcatccatacttttatc
gccacctcgccaatgcacatcgccaccaagctgcgcagcacgctggatgaggttatcgaa
cgcgcggtatacatggttaagcgggcgcgtaattacactgatgacgtagagttctcctgc
gaagatgctggccggacgcctgttgacgatctggcgcgcgtggtggaagccgctataaac
gccggcgcgagaaccattaatattcccgataccgtgggctataccatgccgtttgagttt
gcgggaatcatttccggcctgtatgaacgtgtccccaatatcgacaaagctatcatctcc
gttcatacccacgacgatttagggatagcagtaggcaactcgctggcggcagtacatgcg
ggcgcgcgtcaggttgaaggcgcgatgaacggtatcggagaacgtgccggtaactgcgca
ctggaagaagtgatcatggcgattaaagtgcgcaaagacatcatgaacgtacacaccaac
atcaatcaccacgaaatctggcgcaccagccagaccgtcagccagatctgtaacatgccg
atcccagccaacaaagcgattgtcggcagcggcgctttcgcccactcttccggcatccac
caggatggcgtcctcaagaaccgcgaaaactatgaaatcatgacgccagagtccatcggt
ctgaaccagatacagctgaacctgacctcccgctctggccgtgccgccgtgaaacatcgc
atggaagagatgggttacaaggacacagactacaacatggaccacctgtacgacgcgttc
ctgaagctggcggacaaaaaaggccaggtgttcgactatgacctggaagcgctggcgttt
attaataaacagcaagaagaaccagagcatttccgtctggattacttcagcgtgcagtcc
ggctccagcgatatcgccaccgcttccgtgaagctggcctgtggtgaagagatcaaggcc
gaagcggcgaacggcaacggtccggtcgacgccatctatcaggcgattaaccgcatcact
ggctacgacgttgagttggttaaatacgacctgaacgccaaaggccagggcaaagacgcg
ctgggtcaggtcgatatcgtcgtgaaccatcatggtcgccgcttccacggcgtcgggctg
gcgacggatatcgtcgaatcctccgccaaagcgatggtgcacgtactgaacaatatctgg
cgcgccgccgaagttgaaaaagaattgcaacgcaaagctcaaaataaagagaacaacaag
gaaaccgtgtaa
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