Salmonella enterica subsp. enterica serovar Dublin: SeD_A0002
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Entry
SeD_A0002 CDS
T00757
Symbol
thrA
Name
(GenBank) aspartokinase/homoserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
sed
Salmonella enterica subsp. enterica serovar Dublin
Pathway
sed00260
Glycine, serine and threonine metabolism
sed00261
Monobactam biosynthesis
sed00270
Cysteine and methionine metabolism
sed00300
Lysine biosynthesis
sed01100
Metabolic pathways
sed01110
Biosynthesis of secondary metabolites
sed01120
Microbial metabolism in diverse environments
sed01230
Biosynthesis of amino acids
Module
sed_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
sed_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
sed_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
sed00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
SeD_A0002 (thrA)
00270 Cysteine and methionine metabolism
SeD_A0002 (thrA)
00300 Lysine biosynthesis
SeD_A0002 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
SeD_A0002 (thrA)
Enzymes [BR:
sed01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
SeD_A0002 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
SeD_A0002 (thrA)
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Ortholog
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Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
ACT_9
NAD_binding_3
ACT_7
ACT
Motif
Other DBs
NCBI-ProteinID:
ACH76202
UniProt:
A0A6C6ZZ71
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All DBs
Position
337..2799
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AA seq
820 aa
AA seq
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MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTIGGQDA
LPNISDAERIFSDLLAGLASAQPGFPLARLKMVVEQEFAQIKHVLHGISLLGQCPDSINA
ALICRGEKMSIAIMAGLLEARGHRVTVIDPVEKLLAVGHYLESTVDIAESTRRIAASQIP
ADHMILMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV
PDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTGNPQAPGTLIGASSD
DDNLPVKGISNLNNMAMFSVSGPGMKGMIGMAARVFAAMSRAGISVVLITQSSSEYSISF
CVPQSDCARARRAMQDEFYLELKEGLLEPLAVTERLAIISVVGDGMRTLRGISAKFFAAL
ARANINIVAIAQGSSERSISVVVNNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGAL
LEQLKRQQTRLKNKHIDLRVCGVANSKALLTNVHGLNLDNWQAELAQANAPFNLGRLIRL
VKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSMDYYHQLRFAAAQSR
RKFLYDTNVGAGLPVIENLQNLLNAGDELQKFSGILSGSLSFIFGKLEEGMSLSQATALA
REMGYTEPDPRDDLSGMDVARKLLILARETGRELELSDIVIEPVLPDEFDASGDVTAFMA
HLPQLDDAFAARVAKARDEGKVLRYVGNIEEDGVCRVKIAEVDGNDPLFKVKNGENALAF
YSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
NT seq
2463 nt
NT seq
+upstream
nt +downstream
nt
atgcgagtgttgaagttcggcggtacatcagtggcaaatgcagaacgttttctgcgtgtt
gccgatattctggaaagcaatgccaggcaagggcaggtagcgaccgtactttccgccccc
gcgaaaattaccaaccatctggtggcgatgattgaaaaaactatcggcggccaggatgct
ttgccgaatatcagcgatgccgaacgtattttttctgacctgctcgcaggacttgccagc
gcgcagccgggattcccgcttgcacggttgaaaatggttgtcgaacaagaattcgctcag
atcaaacatgttttgcatggtatcagcctgctgggtcagtgcccggatagcatcaacgcc
gcgctgatttgccgtggcgaaaaaatgtcgatcgcgattatggcgggacttctggaggcg
cgtgggcatcgtgtcacggtgatcgatccggtagaaaaactgttggcggtgggccattac
cttgaatctaccgtcgatatcgcggaatcgactcgccgtatcgccgccagccagatcccg
gccgatcacatgatcctgatggcgggctttaccgccggtaatgaaaagggtgaactggtg
gtgctgggccgtaatggttccgactattccgccgccgtgctggccgcctgtttacgcgct
gactgctgtgaaatctggactgacgtcgatggcgtgtatacctgtgacccgcgccaggtg
ccggacgccaggctgctgaaatcgatgtcctaccaggaagcgatggaactctcttacttc
ggcgccaaagttcttcaccctcgcaccattacgcccatcgcccagttccagatcccctgt
ctgattaaaaataccggtaatccgcaggcgccaggaacgctgatcggcgcgtccagcgac
gatgataatctgccggtcaaagggatctctaaccttaacaatatggcgatgtttagcgtc
tccggcccgggaatgaaagggatgattgggatggcggcgcgtgttttcgccgccatgtct
cgcgccgggatctcggtggtgctcattacccagtcctcctctgagtacagcatcagtttc
tgtgtgccgcagagtgactgcgcgcgtgcccgccgtgcgatgcaggatgagttctatctg
gagctgaaagaggggctgctggagccgctggcggttacggagcggttggcgattatctct
gttgtcggcgacggtatgcgcacgttacgcggcatttcagcgaaattcttcgccgcgctg
gcgcgggccaatatcaatatcgtggcgatcgctcagggatcttctgagcgttccatttct
gtggtggtgaataacgacgatgccaccaccggcgtgcgggtaacgcaccagatgctgttc
aataccgatcaggtgattgaagtgtttgtcattggcgtcggcggcgtcggcggcgcgcta
ctggaacagcttaaacgtcagcaaacccggctgaagaacaagcacatcgatctacgcgtg
tgcggcgtggcgaactcaaaggcgttgctaaccaatgtgcatggcctgaatctggacaac
tggcaggcggaactggcgcaagcgaacgcgccgttcaatctgggacgcttaattcgcctg
gtgaaagaatatcatctactcaatccggtgattgttgattgcacctccagtcaggcggtg
gccgaccagtatgctgacttcctgcgtgaaggattccatgtggtgacgccgaataagaaa
gcgaacacctcgtcgatggactactaccatcagctacgtttcgccgccgcgcaatcacgg
cgcaaattcttgtatgacaccaacgtcggcgccggtttgccggtaatcgaaaacctgcaa
aacctgctgaatgcgggtgatgaactgcaaaaattttccggcattctttccgggtcgctc
tcttttattttcggtaaactggaagaggggatgagtctctcacaggcgaccgccctggcg
cgcgagatgggctataccgaacccgatccgcgcgacgatctttccggtatggatgtggcg
cggaaactgttgatcctcgcccgcgagacgggccgcgagctggagctttccgatattgtg
attgaaccggtgttgccggacgagtttgacgcctccggcgatgtgaccgcctttatggcg
catctgccgcagcttgacgacgcgtttgccgcccgtgtggcgaaagctcgtgatgaaggt
aaggtattgcgctatgtgggcaatatcgaagaggatggcgtgtgccgcgtgaagattgcc
gaagttgatggtaacgatccgctcttcaaagtgaaaaacggtgaaaacgcgctggcgttc
tacagccactattatcagcccttgccgttggtgctgcgcggctacggcgcaggcaatgat
gtgacggcggcgggcgtgtttgccgatctgttacggaccctctcatggaagttaggagtt
taa
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