Salmonella enterica subsp. enterica serovar Gallinarum 287/91: SG0002
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Entry
SG0002 CDS
T00770
Symbol
thrA
Name
(GenBank) aspartokinase I/homoserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
seg
Salmonella enterica subsp. enterica serovar Gallinarum 287/91
Pathway
seg00260
Glycine, serine and threonine metabolism
seg00261
Monobactam biosynthesis
seg00270
Cysteine and methionine metabolism
seg00300
Lysine biosynthesis
seg01100
Metabolic pathways
seg01110
Biosynthesis of secondary metabolites
seg01120
Microbial metabolism in diverse environments
seg01230
Biosynthesis of amino acids
Module
seg_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
seg_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
seg_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
seg00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
SG0002 (thrA)
00270 Cysteine and methionine metabolism
SG0002 (thrA)
00300 Lysine biosynthesis
SG0002 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
SG0002 (thrA)
Enzymes [BR:
seg01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
SG0002 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
SG0002 (thrA)
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Gene cluster
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Motif
Pfam:
Homoserine_dh
AA_kinase
ACT_9
NAD_binding_3
ACT_7
ACT
Motif
Other DBs
NCBI-ProteinID:
CAR35912
UniProt:
B5REZ8
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All DBs
Position
227..2689
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AA seq
820 aa
AA seq
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MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTIGGQDA
LPNISDAERIFSDLLAGLASAQPGFPLARLKMVVEQEFAQIKHVLHGISLLGQCPDSINA
ALICRGEKMSIAIMAGLLEARGHRVTVIDPVEKLLAVGHYLESTVDIAESTRRIAASQIP
ADHMILMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV
PDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTGNPQAPGTLIGASSD
DDNLPVKGISNLNNMAMFSVSGPGMKGMIGMAARVFAAMSRAGISVVLITQSSSEYSISF
CVPQSDCARARRAMQDEFYLELKEGLLEPLAVTERLAIISVVGDGMRTLRGISAKFFAAL
ARANINIVAIAQGSSERSISVVVNNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGAL
LEQLKRQQTWLKNKHIDLRVCGVANSKALLTNVHGLNLDNWQAELAQANAPFNLGRLIRL
VKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSMDYYHQLRFAAVQSR
RKFLYDTNVGAGLPVIENLQNLLNAGDELQKFSGILSGSLSFIFGKLEEGMSLSQATALA
REMGYTEPDPRDDLSGMDVARKLLILARETGRELELSDIVIEPVLPDEFDASGDVTAFMA
HLPQLDDAFAARVAKARDEGKVLRYVGNIEEDGVCRVKIAEVDGNDPLFKVKNGENALAF
YSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
NT seq
2463 nt
NT seq
+upstream
nt +downstream
nt
atgcgagtgttgaagttcggcggtacatcagtggcaaatgcagaacgttttctgcgtgtt
gccgatattctggaaagcaatgccaggcaagggcaggtagcgaccgtactttccgccccc
gcgaaaattaccaaccatctggtggcgatgattgaaaaaactatcggcggccaggatgct
ttgccgaatatcagcgatgccgaacgtattttttctgacctgctcgcaggacttgccagc
gcgcagccgggattcccgcttgcacggttgaaaatggttgtcgaacaagaattcgctcag
atcaaacatgttttgcatggtatcagcctgctgggtcagtgcccggatagcatcaacgcc
gcgctgatttgccgtggcgaaaaaatgtcgatcgcgattatggcgggacttctggaggcg
cgtgggcatcgcgtcacggtgatcgatccggtagaaaaactgttggcggtgggccattac
cttgaatctaccgtcgatatcgcggaatcgactcgccgtatcgccgccagccagatcccg
gccgatcacatgatcctgatggcgggctttaccgccggtaatgaaaagggtgaactggtg
gtgctgggccgtaatggttccgactattccgccgccgtgctggccgcctgtttacgcgct
gactgctgtgaaatctggactgacgtcgatggcgtgtatacctgtgacccgcgccaggtg
ccggacgccaggctgctgaaatcgatgtcctaccaggaagcgatggaactctcttacttc
ggcgccaaagttcttcaccctcgcaccattacgcccatcgcccagttccagatcccctgt
ctgattaaaaataccggtaatccgcaggcgccaggaacgctgatcggcgcgtccagcgac
gatgataacctgccggttaaagggatctctaaccttaacaacatggcgatgtttagcgtc
tccggcccgggaatgaaagggatgattgggatggcggcgcgtgttttcgccgccatgtct
cgcgccgggatctcggtggtgctcattacccagtcctcctctgagtacagcatcagcttc
tgtgtgccgcagagtgactgcgcgcgtgcccgccgtgcgatgcaggatgagttctatctg
gagctgaaagaagggctgctggagccgctggcggttacggagcggttggcgattatctct
gttgtcggcgacggtatgcgcacgctacgcggcatttcagcgaaattcttcgccgcgctg
gcgcgggctaatatcaatatcgtggcgatcgctcagggatcttctgagcgttccatttct
gtggtggtgaataacgacgatgccaccaccggcgtgcgggtaacgcaccagatgctgttc
aataccgatcaggtgattgaagtatttgtcattggcgtcggcggcgtcggcggcgcgcta
ctggaacagcttaaacgtcagcaaacctggttgaagaacaagcacatcgatctacgcgtg
tgcggcgtggcgaactcaaaggcgttgctaaccaatgtgcatggcctgaatctggacaac
tggcaggcggaactggcgcaagcgaacgcgccgttcaatctgggacgcttaattcgcctg
gtgaaagaatatcatctactcaatccggtgattgttgattgtacctccagtcaggcggtg
gccgaccagtatgccgacttcctgcgtgaaggattccatgtggtgacgccaaacaagaaa
gcgaacacctcgtcgatggactactaccatcagctacgtttcgccgccgtgcaatcacgg
cgcaaattcttgtatgacaccaacgtcggcgccggtttgccggtaatcgaaaacctgcaa
aacctgctgaatgcgggtgatgaactgcaaaaattttccggcattctttccgggtcgctc
tcttttattttcggtaaactggaagaggggatgagtctctcacaggcgaccgccctggcg
cgcgagatgggctataccgaacccgatccgcgcgacgatctttccggtatggatgtggcg
cggaaactgttgatcctcgcccgcgagacgggccgcgagctggagctttccgatattgtg
attgaaccggtgttgccggacgagtttgacgcctccggcgatgtgaccgcctttatggcg
catctgccgcagcttgacgacgcgtttgccgcccgtgtggcgaaagctcgtgatgaaggt
aaggtattgcgctatgtgggcaatatcgaagaggatggcgtgtgccgcgtgaagattgcc
gaagttgatggtaacgatccgctcttcaaagtgaaaaacggtgaaaacgcgctggcgttc
tacagccactattatcagcccttgccgttggtgctgcgcggctacggcgcaggcaatgat
gtgacggcggcgggcgtgtttgccgatctgttacggaccctctcatggaagttaggagtt
taa
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