Salmonella enterica subsp. enterica serovar Heidelberg SL476: SeHA_C0002
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Entry
SeHA_C0002 CDS
T00738
Symbol
thrA
Name
(GenBank) aspartokinase/homoserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
seh
Salmonella enterica subsp. enterica serovar Heidelberg SL476
Pathway
seh00260
Glycine, serine and threonine metabolism
seh00261
Monobactam biosynthesis
seh00270
Cysteine and methionine metabolism
seh00300
Lysine biosynthesis
seh01100
Metabolic pathways
seh01110
Biosynthesis of secondary metabolites
seh01120
Microbial metabolism in diverse environments
seh01230
Biosynthesis of amino acids
Module
seh_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
seh_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
seh_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
seh00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
SeHA_C0002 (thrA)
00270 Cysteine and methionine metabolism
SeHA_C0002 (thrA)
00300 Lysine biosynthesis
SeHA_C0002 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
SeHA_C0002 (thrA)
Enzymes [BR:
seh01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
SeHA_C0002 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
SeHA_C0002 (thrA)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
ACT_9
NAD_binding_3
ACT_7
ACT
Motif
Other DBs
NCBI-ProteinID:
ACF69432
UniProt:
A0A6C6ZRT3
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All DBs
Position
337..2799
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AA seq
820 aa
AA seq
DB search
MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTIGGQDA
LPNISDAERIFSDLLAGLASAQPGFPLARLKMVVEQEFAQIKHVLHGISLLGQCPDSINA
ALICRGEKMSIAIMAGLLEARGHRVTVIDPVEKLLAVGHYLESTVDIAESTRRIAASQIP
ADHMILMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV
PDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTGNPQAPGTLIGASSD
DDNLPVKGISNLNNMAMFSVSGPGMKGMIGMAARVFAAMSRAGISVVLITQSSSEYSISF
CVPQSDCARARRAMQDEFYLELKEGLLEPLAVTERLAIISVVGDGMRTLRGISAKFFAAL
ARANINIVAIAQGSSERSISVVVNNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGAL
LEQLKRQQTWLKNKHIDLRVCGVANSKALLTNVHGLNLDNWQAELAQANAPFNLGRLIRL
VKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSMDYYHQLRFAAAQSR
RKFLYDTNVGAGLPVIENLQNLLNAGDELQKFSGILSGSLSFIFGKLEEGMSLSQATALA
REMGYTEPDPRDDLSGMDVARKLLILARETGRELELSDIVIEPVLPDEFDASGDVTAFMA
HLPQLDDAFAARVAKARDEGKVLRYVGNIEEDGVCRVKIAEVDGNDPLFKVKNGENALAF
YSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
NT seq
2463 nt
NT seq
+upstream
nt +downstream
nt
atgcgagtgttgaagttcggcggtacatcagtggcaaatgcagaacgttttctgcgtgtt
gccgatattctggaaagcaatgccaggcaagggcaggtagcgaccgtactttccgccccc
gcgaaaattaccaaccatctggtggcgatgattgaaaaaactatcggcggccaggatgct
ttgccgaatatcagcgatgccgaacgtattttttctgacctgctcgcaggacttgccagc
gcgcagccgggattcccgcttgcacggttgaaaatggttgtcgaacaagaattcgctcag
atcaaacatgttttgcatggtatcagcctgctgggtcagtgcccggacagcatcaacgcc
gcgctgatttgccgtggcgaaaaaatgtctatcgcgattatggcgggacttctggaggcg
cgtgggcatcgcgtcacggtgatcgatccggtagaaaaactgctggcggtgggtcattat
cttgaatctaccgtcgatatcgcggaatcgactcgccgtatcgccgccagccagatcccg
gccgatcacatgatcctgatggcgggctttaccgccggtaatgaaaagggtgaactggtg
gtgctggggcgtaatggctctgactactctgccgccgtgctggccgcctgtttacgcgct
gactgctgtgaaatctggactgacgtcgatggcgtgtatacctgtgacccgcgccaggtg
ccggacgccagactgctgaaatcgatgtcctaccaggaagcgatggaactctcttacttc
ggcgccaaagtccttcaccctcgcaccataacgcctatcgcccagttccagatcccctgt
ctgattaaaaataccggtaatccgcaggcgccaggaacgctgatcggcgcgtccagcgac
gatgataatctgccggtgaaagggatctctaaccttaacaacatggcgatgtttagcgtc
tccggcccgggaatgaaagggatgattgggatggcggcgcgtgttttcgccgccatgtct
cgtgccgggatctcggtggtgctcattacccagtcctcctctgagtacagcatcagcttc
tgtgtgccgcagagtgactgcgcgcgtgcccgccgtgcgatgcaggatgagttctatctg
gagctgaaagaggggctgctggagccgctggcggttactgagcggttggcgattatctct
gttgtcggcgacggtatgcgcacgctacgcggcatttcagcgaaattcttcgccgcgctg
gcgcgggccaatatcaatatcgtggcgatcgctcagggatcttctgagcgttccatttct
gtggtggtgaataacgacgatgccaccaccggcgtgcgggtaacgcaccagatgctgttc
aataccgatcaggtgattgaagtgtttgtcattggcgtcggcggcgtcggcggcgcgcta
ctggaacagcttaaacgtcagcaaacctggctgaagaacaagcacatcgatctacgcgtg
tgcggcgtggcgaactcaaaggcgttgctaaccaatgtgcatggcctgaatctggacaac
tggcaggcggaactggcgcaagcgaacgcgccgttcaatctgggacgcttaattcgcctg
gtgaaagaatatcatctactcaatccggtgattgttgattgtacctccagtcaggcggtg
gccgaccaatatgccgacttcctgcgtgaagggttccatgtggtgacgccaaacaagaaa
gcgaacacctcgtcgatggactactaccatcagctacgtttcgccgccgcgcaatcacgg
cgcaaattcttgtatgacaccaacgtcggcgccggtttgccggtaatcgaaaacctgcaa
aacctgctgaatgccggtgatgaactgcaaaaattttccggcattctttccgggtcgctc
tcttttattttcggtaaactggaagaggggatgagtctctcacaggcgaccgcgctggcg
cgcgagatgggctataccgaacccgatccgcgcgacgatctttccggtatggatgtggcg
cgtaaactgttgatcctcgcccgcgagacgggccgcgagctggagctttccgatattgtg
attgaaccggtgttgccggacgagtttgacgcctccggcgatgtgaccgcctttatggcg
catctgccgcagcttgacgacgcgtttgccgcccgtgtggcgaaagctcgtgatgaaggt
aaggtattgcgctatgtgggcaatatcgaagaggatggcgtgtgccgcgtgaaaattgcc
gaagttgatggtaacgatccgctcttcaaagtgaaaaacggtgaaaacgcgctggcgttc
tacagccactattatcagcccttgccgttggtgctgcgcggctacggcgcaggcaatgat
gtgacggcggcgggcgtgtttgccgatctgttacggaccctctcatggaagttaggagtt
taa
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