Salmonella enterica subsp. enterica serovar Typhimurium DT2: STMDT2_00021
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Entry
STMDT2_00021 CDS
T02869
Symbol
thrA
Name
(GenBank) aspartokinase I/homoserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
senr
Salmonella enterica subsp. enterica serovar Typhimurium DT2
Pathway
senr00260
Glycine, serine and threonine metabolism
senr00261
Monobactam biosynthesis
senr00270
Cysteine and methionine metabolism
senr00300
Lysine biosynthesis
senr01100
Metabolic pathways
senr01110
Biosynthesis of secondary metabolites
senr01120
Microbial metabolism in diverse environments
senr01230
Biosynthesis of amino acids
Module
senr_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
senr_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
senr_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
senr00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
STMDT2_00021 (thrA)
00270 Cysteine and methionine metabolism
STMDT2_00021 (thrA)
00300 Lysine biosynthesis
STMDT2_00021 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
STMDT2_00021 (thrA)
Enzymes [BR:
senr01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
STMDT2_00021 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
STMDT2_00021 (thrA)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
ACT_9
NAD_binding_3
ACT_7
ACT
Motif
Other DBs
NCBI-ProteinID:
CDG06159
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All DBs
Position
337..2799
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AA seq
820 aa
AA seq
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MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTIGGQDA
LPNISDAERIFSDLLAGLASAQPGFPLARLKMVVEQEFAQIKHVLHGISLLGQCPDSINA
ALICRGEKMSIAIMAGLLEARGHRVTVIDPVEKLLAVGHYLESTVDIAESTRRIAASQIP
ADHMILMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV
PDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTGNPQAPGTLIGASSD
DDNLPVKGISNLNNMAMFSVSGPGMKGMIGMAARVFAAMSRAGISVVLITQSSSEYSISF
CVPQSDCARARRAMQDEFYLELKEGLLEPLAVTERLAIISVVGDGMRTLRGISAKFFAAL
ARANINIVAIAQGSSERSISVVVNNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGAL
LEQLKRQQTWLKNKHIDLRVCGVANSKALLTNVHGLNLDNWQAELAQANAPFNLGRLIRL
VKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSMDYYHQLRFAAAQSR
RKFLYDTNVGAGLPVIENLQNLLNAGDELQKFSGILSGSLSFIFGKLEEGMSLSQATALA
REMGYTEPDPRDDLSGMDVARKLLILARETGRELELSDIVIEPVLPNEFDASGDVTAFMA
HLPQLDDAFAARVAKARDEGKVLRYVGNIEEDGVCRVKIAEVDGNDPLFKVKNGENALAF
YSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
NT seq
2463 nt
NT seq
+upstream
nt +downstream
nt
atgcgagtgttgaagttcggcggtacatcagtggcaaatgcagaacgttttctgcgtgtt
gccgatattctggaaagcaatgccaggcaagggcaggtagcgaccgtactttccgccccc
gcgaaaattaccaaccatctggtggcaatgattgaaaaaactatcggcggccaggatgct
ttgccgaatatcagcgatgcagaacgtattttttctgacctgctcgcaggacttgccagc
gcgcagccgggattcccgcttgcacggttgaaaatggttgtcgaacaagaattcgctcag
atcaaacatgttctgcatggtatcagcctgctgggtcagtgcccggatagcatcaacgcc
gcgctgatttgccgtggcgaaaaaatgtcgatcgcgattatggcgggacttctggaggcg
cgtgggcatcgcgtcacggtgatcgatccggtagaaaaattgctggcggtgggccattac
cttgaatctaccgtcgatatcgcggaatcgactcgccgtatcgccgccagccagatcccg
gccgatcacatgatcctgatggcgggctttaccgccggtaatgaaaagggtgaactggtg
gtgctgggccgtaatggttccgactattccgccgccgtgctggccgcctgtttacgcgct
gactgctgtgaaatctggactgacgtcgatggcgtgtatacctgtgacccgcgccaggtg
ccggacgccaggctgctgaaatcgatgtcctaccaggaagcgatggaactctcttacttc
ggcgccaaagtccttcaccctcgcaccattacgcccatcgcccagttccagatcccctgt
ctgattaaaaataccggtaatccgcaggcgccaggaacgctgatcggcgcgtccagcgac
gatgataacctgccggttaaagggatctctaaccttaacaacatggcgatgtttagcgtc
tccggcccgggaatgaaagggatgattgggatggcggcgcgtgttttcgccgccatgtct
cgcgccgggatctcggtggtgctcattacccagtcctcctctgagtacagcatcagtttc
tgtgtgccgcagagtgactgcgcgcgtgcccgccgtgcgatgcaggatgagttctatctg
gagctgaaagaggggctgctggagccgctggcggttacggagcggttggcgattatctct
gttgtcggcgacggtatgcgcacgctacgcggcatttcagcgaaattcttcgccgcgctg
gcgcgggctaatatcaatatcgtggcgatcgctcagggatcttctgagcgttctatttct
gtggtggtgaataacgacgatgccaccaccggcgtgcgggtaacgcaccagatgctgttc
aataccgatcaggtgattgaagtgtttgtcattggcgtcggcggcgtcggcggcgcgcta
ctggaacagcttaaacgtcagcaaacctggctgaagaacaagcacatcgatctacgcgtg
tgcggcgtggcgaactcaaaggcgttgctaaccaatgtgcatggcctgaatctggacaac
tggcaggcggaactggcgcaagcgaacgcgccgttcaatctgggacgcttaattcgcctg
gtgaaagaatatcatctactcaatccggtgattgttgattgtacctccagtcaggcggtg
gccgaccagtatgccgacttcctgcgtgaagggttccatgtggtgacgccaaacaagaaa
gcgaacacctcgtcaatggactactaccatcagctacgtttcgccgccgcgcaatcacgg
cgcaaattcttgtatgacaccaacgtcggcgccggtttgccggtaatcgaaaacctgcaa
aacctgctgaatgccggtgatgaactgcaaaaattttccggcattctttccgggtcgctc
tcttttattttcggtaaactggaagaggggatgagtctctcacaggcgaccgccctggcg
cgcgagatgggctataccgaacccgatccgcgcgacgatctttccggtatggatgtggcg
cgtaaactgttgatcctcgcccgcgagacgggccgcgagctggagctttccgatattgtg
attgaaccggtgttgccgaacgagtttgacgcctccggcgatgtgaccgcctttatggca
catctgccgcagcttgacgacgcgtttgccgcccgtgtggcgaaagctcgtgatgaaggt
aaggtattgcgctatgtgggcaatatcgaagaggatggcgtgtgccgcgtgaaaattgcc
gaagttgatggtaacgatccgctcttcaaagtgaaaaacggtgaaaacgcgctggcgttc
tacagccactattatcagcccttgccgttggtgctgcgcggctacggcgcaggcaatgat
gtgacggcggcgggcgtgtttgccgatctgttacggaccctctcatggaagttaggagtt
taa
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