KEGG   Suncus etruscus (white-toothed pygmy shrew): 126013417
Entry
126013417         CDS       T09902                                 
Symbol
AKT3
Name
(RefSeq) RAC-gamma serine/threonine-protein kinase isoform X1
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
setr  Suncus etruscus (white-toothed pygmy shrew)
Pathway
setr01521  EGFR tyrosine kinase inhibitor resistance
setr01522  Endocrine resistance
setr01524  Platinum drug resistance
setr04010  MAPK signaling pathway
setr04012  ErbB signaling pathway
setr04014  Ras signaling pathway
setr04015  Rap1 signaling pathway
setr04022  cGMP-PKG signaling pathway
setr04024  cAMP signaling pathway
setr04062  Chemokine signaling pathway
setr04066  HIF-1 signaling pathway
setr04068  FoxO signaling pathway
setr04071  Sphingolipid signaling pathway
setr04072  Phospholipase D signaling pathway
setr04140  Autophagy - animal
setr04150  mTOR signaling pathway
setr04151  PI3K-Akt signaling pathway
setr04152  AMPK signaling pathway
setr04210  Apoptosis
setr04211  Longevity regulating pathway
setr04213  Longevity regulating pathway - multiple species
setr04218  Cellular senescence
setr04261  Adrenergic signaling in cardiomyocytes
setr04370  VEGF signaling pathway
setr04371  Apelin signaling pathway
setr04380  Osteoclast differentiation
setr04510  Focal adhesion
setr04550  Signaling pathways regulating pluripotency of stem cells
setr04611  Platelet activation
setr04613  Neutrophil extracellular trap formation
setr04620  Toll-like receptor signaling pathway
setr04625  C-type lectin receptor signaling pathway
setr04630  JAK-STAT signaling pathway
setr04660  T cell receptor signaling pathway
setr04662  B cell receptor signaling pathway
setr04664  Fc epsilon RI signaling pathway
setr04666  Fc gamma R-mediated phagocytosis
setr04668  TNF signaling pathway
setr04722  Neurotrophin signaling pathway
setr04725  Cholinergic synapse
setr04728  Dopaminergic synapse
setr04810  Regulation of actin cytoskeleton
setr04910  Insulin signaling pathway
setr04914  Progesterone-mediated oocyte maturation
setr04915  Estrogen signaling pathway
setr04917  Prolactin signaling pathway
setr04919  Thyroid hormone signaling pathway
setr04920  Adipocytokine signaling pathway
setr04922  Glucagon signaling pathway
setr04923  Regulation of lipolysis in adipocytes
setr04926  Relaxin signaling pathway
setr04929  GnRH secretion
setr04931  Insulin resistance
setr04932  Non-alcoholic fatty liver disease
setr04933  AGE-RAGE signaling pathway in diabetic complications
setr04935  Growth hormone synthesis, secretion and action
setr04936  Alcoholic liver disease
setr04973  Carbohydrate digestion and absorption
setr05010  Alzheimer disease
setr05017  Spinocerebellar ataxia
setr05132  Salmonella infection
setr05135  Yersinia infection
setr05142  Chagas disease
setr05145  Toxoplasmosis
setr05152  Tuberculosis
setr05160  Hepatitis C
setr05161  Hepatitis B
setr05162  Measles
setr05163  Human cytomegalovirus infection
setr05164  Influenza A
setr05165  Human papillomavirus infection
setr05166  Human T-cell leukemia virus 1 infection
setr05167  Kaposi sarcoma-associated herpesvirus infection
setr05168  Herpes simplex virus 1 infection
setr05169  Epstein-Barr virus infection
setr05170  Human immunodeficiency virus 1 infection
setr05200  Pathways in cancer
setr05205  Proteoglycans in cancer
setr05207  Chemical carcinogenesis - receptor activation
setr05208  Chemical carcinogenesis - reactive oxygen species
setr05210  Colorectal cancer
setr05211  Renal cell carcinoma
setr05212  Pancreatic cancer
setr05213  Endometrial cancer
setr05214  Glioma
setr05215  Prostate cancer
setr05218  Melanoma
setr05220  Chronic myeloid leukemia
setr05221  Acute myeloid leukemia
setr05222  Small cell lung cancer
setr05223  Non-small cell lung cancer
setr05224  Breast cancer
setr05225  Hepatocellular carcinoma
setr05226  Gastric cancer
setr05230  Central carbon metabolism in cancer
setr05231  Choline metabolism in cancer
setr05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
setr05415  Diabetic cardiomyopathy
setr05417  Lipid and atherosclerosis
setr05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:setr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    126013417 (AKT3)
   04015 Rap1 signaling pathway
    126013417 (AKT3)
   04630 JAK-STAT signaling pathway
    126013417 (AKT3)
   04668 TNF signaling pathway
    126013417 (AKT3)
   04066 HIF-1 signaling pathway
    126013417 (AKT3)
   04068 FoxO signaling pathway
    126013417 (AKT3)
   04072 Phospholipase D signaling pathway
    126013417 (AKT3)
   04071 Sphingolipid signaling pathway
    126013417 (AKT3)
   04024 cAMP signaling pathway
    126013417 (AKT3)
   04022 cGMP-PKG signaling pathway
    126013417 (AKT3)
   04151 PI3K-Akt signaling pathway
    126013417 (AKT3)
   04152 AMPK signaling pathway
    126013417 (AKT3)
   04150 mTOR signaling pathway
    126013417 (AKT3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    126013417 (AKT3)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    126013417 (AKT3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    126013417 (AKT3)
   04613 Neutrophil extracellular trap formation
    126013417 (AKT3)
   04620 Toll-like receptor signaling pathway
    126013417 (AKT3)
   04660 T cell receptor signaling pathway
    126013417 (AKT3)
   04662 B cell receptor signaling pathway
    126013417 (AKT3)
   04664 Fc epsilon RI signaling pathway
    126013417 (AKT3)
   04666 Fc gamma R-mediated phagocytosis
    126013417 (AKT3)
   04062 Chemokine signaling pathway
    126013417 (AKT3)
  09152 Endocrine system
   04922 Glucagon signaling pathway
    126013417 (AKT3)
   04923 Regulation of lipolysis in adipocytes
    126013417 (AKT3)
   04929 GnRH secretion
    126013417 (AKT3)
   04915 Estrogen signaling pathway
    126013417 (AKT3)
   04917 Prolactin signaling pathway
    126013417 (AKT3)
   04926 Relaxin signaling pathway
    126013417 (AKT3)
   04935 Growth hormone synthesis, secretion and action
    126013417 (AKT3)
   04919 Thyroid hormone signaling pathway
    126013417 (AKT3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    126013417 (AKT3)
  09156 Nervous system
   04725 Cholinergic synapse
    126013417 (AKT3)
   04728 Dopaminergic synapse
    126013417 (AKT3)
   04722 Neurotrophin signaling pathway
    126013417 (AKT3)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    126013417 (AKT3)
  09149 Aging
   04211 Longevity regulating pathway
    126013417 (AKT3)
   04213 Longevity regulating pathway - multiple species
    126013417 (AKT3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    126013417 (AKT3)
   05205 Proteoglycans in cancer
    126013417 (AKT3)
   05207 Chemical carcinogenesis - receptor activation
    126013417 (AKT3)
   05208 Chemical carcinogenesis - reactive oxygen species
    126013417 (AKT3)
   05230 Central carbon metabolism in cancer
    126013417 (AKT3)
   05231 Choline metabolism in cancer
    126013417 (AKT3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    126013417 (AKT3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    126013417 (AKT3)
   05212 Pancreatic cancer
    126013417 (AKT3)
   05225 Hepatocellular carcinoma
    126013417 (AKT3)
   05226 Gastric cancer
    126013417 (AKT3)
   05214 Glioma
    126013417 (AKT3)
   05221 Acute myeloid leukemia
    126013417 (AKT3)
   05220 Chronic myeloid leukemia
    126013417 (AKT3)
   05218 Melanoma
    126013417 (AKT3)
   05211 Renal cell carcinoma
    126013417 (AKT3)
   05215 Prostate cancer
    126013417 (AKT3)
   05213 Endometrial cancer
    126013417 (AKT3)
   05224 Breast cancer
    126013417 (AKT3)
   05222 Small cell lung cancer
    126013417 (AKT3)
   05223 Non-small cell lung cancer
    126013417 (AKT3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    126013417 (AKT3)
   05170 Human immunodeficiency virus 1 infection
    126013417 (AKT3)
   05161 Hepatitis B
    126013417 (AKT3)
   05160 Hepatitis C
    126013417 (AKT3)
   05164 Influenza A
    126013417 (AKT3)
   05162 Measles
    126013417 (AKT3)
   05163 Human cytomegalovirus infection
    126013417 (AKT3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    126013417 (AKT3)
   05169 Epstein-Barr virus infection
    126013417 (AKT3)
   05165 Human papillomavirus infection
    126013417 (AKT3)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    126013417 (AKT3)
   05152 Tuberculosis
    126013417 (AKT3)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    126013417 (AKT3)
   05142 Chagas disease
    126013417 (AKT3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    126013417 (AKT3)
   05017 Spinocerebellar ataxia
    126013417 (AKT3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    126013417 (AKT3)
   05418 Fluid shear stress and atherosclerosis
    126013417 (AKT3)
   05415 Diabetic cardiomyopathy
    126013417 (AKT3)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    126013417 (AKT3)
   04932 Non-alcoholic fatty liver disease
    126013417 (AKT3)
   04931 Insulin resistance
    126013417 (AKT3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    126013417 (AKT3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    126013417 (AKT3)
   01524 Platinum drug resistance
    126013417 (AKT3)
   01522 Endocrine resistance
    126013417 (AKT3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:setr01001]
    126013417 (AKT3)
Enzymes [BR:setr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     126013417 (AKT3)
Protein kinases [BR:setr01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   126013417 (AKT3)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 ABC1 PH_11
Other DBs
NCBI-GeneID: 126013417
NCBI-ProteinID: XP_049632463
LinkDB
Position
7:48193194..48537801
AA seq 479 aa
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
NT seq 1440 nt   +upstreamnt  +downstreamnt
atgagcgatgttaccattgtgaaagaaggttgggttcagaagaggggggaatatataaaa
aactggaggccaagatatttccttttgaagacagatggctcattcataggatataaagaa
aaacctcaagatgtggatttaccttatccccttaacaacttttcagtggcaaaatgccag
ttaatgaaaacagaacgaccaaagccaaacacatttattatcagatgtctacagtggacc
actgttatagaaagaacatttcatgtagatacaccagaggaaagagaagaatggacagaa
gctattcaagcagtagcagacagactacagaggcaagaagaggagagaatgaattgtagt
ccaacttcacaaattgataatataggggaggaagagatggatgcatctacgacccatcat
aaaagaaagacaatgaatgattttgactatttgaaactactaggtaaaggcacgtttggg
aaagttattttggttcgagaaaaggcaagtgggaaatattatgctatgaagattctgaag
aaagaagttattattgcaaaggatgaagtagcacatactctaacagaaagcagagtatta
aagaacactagacatccttttttaacatccttgaaatattccttccagacaaaagaccgt
ttgtgttttgtgatggaatatgtaaatgggggagagctgtttttccatttgtcgagagag
cgggtgttctctgaggaccgcacacgtttctatggtgcagaaattgtgtctgccttggac
tatctacattctgggaaaattgtgtatcgtgatctcaagttggaaaatctgatgcttgat
aaagatggccatataaaaattactgattttggactttgcaaagaaggaattacagatgca
gcaaccatgaagacattctgtggtacaccagaatatctagcaccagaggtattagaagat
aatgactatggccgagctgtggattggtggggcctaggggttgtcatgtatgaaatgatg
tgtgggaggttacctttctacaaccaggatcatgagaaactttttgaactaatactaatg
gaagacattaaatttcctcgaacactgtcttcagatgcaaaatcattgctttcagggctc
ttgataaaggatccaaataaacgccttggtggaggaccagatgatgcaaaagaaattatg
agacacagtttcttttctggagtaaactggcaagatgtatatgataaaaagcttgtacct
cctttcaagcctcaagtaacatctgagacagataccagatattttgatgaagaatttaca
gctcaaactattacaataacaccacctgaaaaatatgatgaggatggtatggactgcatg
gacaatgagaggcggccacacttccctcagttttcctactctgcaagtggacgagaataa

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