Entry |
|
Symbol |
PLCB2
|
Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
|
KO |
|
Organism |
setr Suncus etruscus (white-toothed pygmy shrew)
|
Pathway |
setr04070 | Phosphatidylinositol signaling system |
setr04261 | Adrenergic signaling in cardiomyocytes |
setr04613 | Neutrophil extracellular trap formation |
setr04621 | NOD-like receptor signaling pathway |
setr04723 | Retrograde endocannabinoid signaling |
setr04750 | Inflammatory mediator regulation of TRP channels |
setr04925 | Aldosterone synthesis and secretion |
setr04928 | Parathyroid hormone synthesis, secretion and action |
setr04933 | AGE-RAGE signaling pathway in diabetic complications |
setr04935 | Growth hormone synthesis, secretion and action |
setr04961 | Endocrine and other factor-regulated calcium reabsorption |
setr04973 | Carbohydrate digestion and absorption |
setr05022 | Pathways of neurodegeneration - multiple diseases |
|
Module |
setr_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Brite |
KEGG Orthology (KO) [BR:setr00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
126024570 (PLCB2)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
126024570 (PLCB2)
04310 Wnt signaling pathway
126024570 (PLCB2)
04371 Apelin signaling pathway
126024570 (PLCB2)
04020 Calcium signaling pathway
126024570 (PLCB2)
04070 Phosphatidylinositol signaling system
126024570 (PLCB2)
04072 Phospholipase D signaling pathway
126024570 (PLCB2)
04071 Sphingolipid signaling pathway
126024570 (PLCB2)
04022 cGMP-PKG signaling pathway
126024570 (PLCB2)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
126024570 (PLCB2)
04081 Hormone signaling
126024570 (PLCB2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
126024570 (PLCB2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
126024570 (PLCB2)
04613 Neutrophil extracellular trap formation
126024570 (PLCB2)
04621 NOD-like receptor signaling pathway
126024570 (PLCB2)
04062 Chemokine signaling pathway
126024570 (PLCB2)
09152 Endocrine system
04911 Insulin secretion
126024570 (PLCB2)
04922 Glucagon signaling pathway
126024570 (PLCB2)
04929 GnRH secretion
126024570 (PLCB2)
04912 GnRH signaling pathway
126024570 (PLCB2)
04915 Estrogen signaling pathway
126024570 (PLCB2)
04921 Oxytocin signaling pathway
126024570 (PLCB2)
04926 Relaxin signaling pathway
126024570 (PLCB2)
04935 Growth hormone synthesis, secretion and action
126024570 (PLCB2)
04918 Thyroid hormone synthesis
126024570 (PLCB2)
04919 Thyroid hormone signaling pathway
126024570 (PLCB2)
04928 Parathyroid hormone synthesis, secretion and action
126024570 (PLCB2)
04916 Melanogenesis
126024570 (PLCB2)
04924 Renin secretion
126024570 (PLCB2)
04925 Aldosterone synthesis and secretion
126024570 (PLCB2)
04927 Cortisol synthesis and secretion
126024570 (PLCB2)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
126024570 (PLCB2)
04270 Vascular smooth muscle contraction
126024570 (PLCB2)
09154 Digestive system
04970 Salivary secretion
126024570 (PLCB2)
04971 Gastric acid secretion
126024570 (PLCB2)
04972 Pancreatic secretion
126024570 (PLCB2)
04973 Carbohydrate digestion and absorption
126024570 (PLCB2)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
126024570 (PLCB2)
09156 Nervous system
04724 Glutamatergic synapse
126024570 (PLCB2)
04725 Cholinergic synapse
126024570 (PLCB2)
04728 Dopaminergic synapse
126024570 (PLCB2)
04726 Serotonergic synapse
126024570 (PLCB2)
04720 Long-term potentiation
126024570 (PLCB2)
04730 Long-term depression
126024570 (PLCB2)
04723 Retrograde endocannabinoid signaling
126024570 (PLCB2)
09157 Sensory system
04742 Taste transduction
126024570 (PLCB2)
04750 Inflammatory mediator regulation of TRP channels
126024570 (PLCB2)
09159 Environmental adaptation
04713 Circadian entrainment
126024570 (PLCB2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
126024570 (PLCB2)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
126024570 (PLCB2)
09174 Infectious disease: parasitic
05146 Amoebiasis
126024570 (PLCB2)
05142 Chagas disease
126024570 (PLCB2)
05143 African trypanosomiasis
126024570 (PLCB2)
09164 Neurodegenerative disease
05010 Alzheimer disease
126024570 (PLCB2)
05016 Huntington disease
126024570 (PLCB2)
05017 Spinocerebellar ataxia
126024570 (PLCB2)
05022 Pathways of neurodegeneration - multiple diseases
126024570 (PLCB2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
126024570 (PLCB2)
05415 Diabetic cardiomyopathy
126024570 (PLCB2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
126024570 (PLCB2)
04934 Cushing syndrome
126024570 (PLCB2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:setr04131]
126024570 (PLCB2)
Enzymes [BR:setr01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
126024570 (PLCB2)
Membrane trafficking [BR:setr04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
126024570 (PLCB2)
Endocytosis
Macropinocytosis
Phospholipase C
126024570 (PLCB2)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Position |
12:complement(3631300..3651232)
|
AA seq |
1167 aa
MSLLSPILLPPEVKAYLSQGERFIKWDDEATVASPVILRVDPKGYYLYWTYQNKEMEFLD
ITSIRDTRFGKFAKVPKSQKLRDVFNMDFPDNTFLLKALTVVSGPDMVDLTFHNFVSYKE
NVGKDWAEDVLALAKHPLTTNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKR
VEAALSACHLPQNKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSHHAKAKPYMTKEH
LTKFINQKQRDPRLNSLLFPPARPDQVQGLIHKYEPSCINIQRGQLSPEGMVWFLCGPEN
SVLAQDKLLLYQDMTQPLNHYFVNSSHNTYLTAGQFSGVSSAEMYRQVLLAGCRCVELDC
WKGKPPDEEPIITHGFTMTTDIYFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRTMFGDTLLTEPLEKFPLKPGSPLPSPEDLKGKILIKNKKNQFSGKEAGGEPEGSC
PPSTPASEDSGGEEMTELEEKEAADEEDEELGCLDEEEIKKMQSDEGTAGLEVTAYEEMS
SLVNYIQPTKFVSFELSAEKNQSYVISSFTELKAYDLLSKAPVQFVDYNKRQMSRIYPKG
TRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRPDKQ
FNPYSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPSTN
SINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESN
MPLTMPALFVLLEMKDYVPDTLADLTVALANPIKFFNAHDKKSVKLKAAMGEMPLSPFPM
GSPAVAASNGASALRSNGSAAAAGAIATEEASKPVAEPQTASLEELRELKDMVKLQRRHE
KELLEVQRRGEARRQELLERAVAQRAEFESPGCSGSRRAGPDKDSRKKRKEPLETKAGLE
GMDMRLRDLQGRLEQELLQLGQAQHERVRKLRENHLAEQTTKMLELARARQAVELKNLKG
TLQTNTKAMKKKLEAKRLERIQAMVKITSDKMAQERLKREINNSHIQEVVQVLKQMTVNL
ERHQEQLEEKQAACLEQIQELENQFQKEALAEYTARMESLEAEVKESLRTCFPSETDALS
GRPRRTSPELMEQDLAPAEADVQESRF |
NT seq |
3504 nt +upstreamnt +downstreamnt
atgtccctgcttagccccatcctgctgcccccagaggtgaaggcctatctgagccaagga
gaacgcttcatcaaatgggacgacgaagcaaccgtcgcctccccggttattctgcgtgtg
gaccctaagggttattacttgtactggacataccagaataaggagatggaatttctggat
atcaccagcatccgggacacccgctttgggaagtttgccaaggtgcccaagagccagaag
ctccgggatgtgttcaacatggatttccctgacaacaccttcctgctgaaggcactcact
gtggtgtctggccctgacatggtggacctcaccttccacaactttgtctcctacaaggag
aatgtgggcaaggactgggctgaagatgtgttggccctggccaagcatccgctgactact
aacgcccctcgaagcaccttcctggataaaatcctggtgaagctcaagatgcagctcaac
cctgaagggaagattcctgttaagaattttttccagatgtttcctgctgaccgcaagcgg
gtagaagctgccctcagtgcctgccacctcccccagaacaagaatgatgccatcaatcca
gaggacttcccagaatctgtctacaagagtttcctcatgagtctttgccctcggccagaa
atagatgagatcttcacctcccaccacgccaaggcaaaaccctatatgaccaaagagcac
ctgaccaaattcatcaaccagaagcagcgggacccccggctcaactccttgctgttccca
ccagcccggccagaccaggttcagggtctcatccacaagtatgagcccagttgcatcaac
atccaaaggggccagctgtcccccgagggtatggtgtggtttctgtgcggccctgagaac
agtgtgctggcccaggacaagctgctgctctaccaagacatgacacagcccctcaaccat
tacttcgttaactcctcacacaacacctacctcacagcgggccagttctcaggagtctcc
tcggctgagatgtaccgccaggtgctgctggcaggctgccgctgtgtggagctggactgc
tggaaggggaagccgcccgacgaggagcctattatcacccatggcttcaccatgaccact
gacatctacttcaaggaagccattgaagccattgcagaaagtgccttcaagacctccccg
taccccgtcatcctgtcgttcgaaaaccacgtggactcaccccgacaacaggccaagatg
gctgagtactgccggacgatgtttggggacacactgctcacagagcccctggaaaaattc
ccgctgaaacccggcagccccctgcccagccctgaggatctcaaaggcaagattctcatc
aagaacaagaagaaccaattttctggcaaggaggcgggtggggagccagagggcagctgc
ccacccagcaccccagcgagtgaggattcaggtggtgaagagatgactgagctggaggag
aaggaggcagcagatgaagaagacgaagagttgggatgtctggatgaagaggaaataaag
aagatgcagtcagatgagggcacagcaggcctagaggtgacagcatatgaggaaatgtcc
agcctggtcaactacatccagcccaccaagttcgtctccttcgaactctcggctgagaag
aaccagagctacgtcatctcctccttcacagagctcaaggcctatgacctgctgtccaag
gcccccgtgcagtttgtggactacaacaagcgccagatgagccgcatctaccccaagggc
actcgcatggactcctccaactatatgccccagatgttctggaatgccggctgccagatg
gtggctcttaactttcagacgatggacttgcccatgcagcagaacatggctctgtttgag
ttcaatggccagagtggctacctcctcaagcacgagttcatgcggcggccagacaagcag
ttcaacccctactctgtggaccgcatcgatgtggtggtcgccaccaccctgtccatcacg
gtaatctcggggcagttcctgtcagaacgtagtgtgcgcacctacgtggaagtagagctg
tttggccttcctggggaccccaagaggcgctatcgcaccaagctgtcacccagcaccaac
tccatcaaccctgtctggaaggaggaaccatttgtcttcgagaagatcctgatgcctgag
ctggcctccctcagggtggctgtgatggaggaaggcaacaagttccttgggcatcgcatc
atccccatcaacgccctgaactctggataccaccacttgtgcctgcacagtgagagcaac
atgcccctcaccatgccagcactctttgtcctcctggagatgaaggactatgtgccagac
accctggcagatctcacggtggccctcgccaaccccatcaagttcttcaatgcccatgat
aagaagtctgtgaagctcaaggctgccatgggagaaatgcctctttcgccttttccgatg
ggcagcccagcagtggctgcaagcaatggggcttctgccttgagaagcaacgggtcagca
gcggcagcgggagctattgccacggaggaggccagcaagccagttgcagagccgcagaca
gctagcctggaggaattgcgtgagttgaaggacatggtgaagctgcagcgcaggcatgag
aaggagctgctggaggtgcagcggcgtggagaggcgcgcaggcaggagctgctggagagg
gccgtggcacaacgcgccgagttcgagtccccgggttgcagtgggagtcgcagggctggc
ccggacaaggactcgcgaaagaagaggaaggagcccttggagaccaaggcgggcctggaa
ggcatggacatgcgccttcgagatctgcagggccggctggagcaggagctgctgcagcta
ggccaggcccagcatgagcgtgtgcgcaagcttcgcgagaaccacctggcagagcaaacc
accaagatgctggagctggcacgagcaaggcaggccgtggagctgaaaaatctcaagggg
acactacagaccaacaccaaagccatgaagaaaaagctggaggccaagaggctggagagg
atccaagccatggtcaagatcacttcagacaagatggcccaggagaggttgaagagagag
attaacaactcacacatccaggaggttgtgcaggtactcaagcagatgacggtgaaccta
gaacgtcaccaagagcagctagaagagaagcaggcagcctgcctggagcagatacaggag
ttggaaaaccagttccagaaggaggcactggctgagtatacagctaggatggagagcctg
gaagctgaggtgaaggagtccctgaggacctgcttcccctcagagactgatgccctttcc
ggaagacccaggaggacctcccctgagttaatggagcaggatctggctcctgcagaggca
gatgtccaggagagccgtttctga |