Streptomyces pratensis: Sfla_4732
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Entry
Sfla_4732 CDS
T01647
Name
(GenBank) UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate/D-alanyl-D-alanyl ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
sfa
Streptomyces pratensis
Pathway
sfa00300
Lysine biosynthesis
sfa00550
Peptidoglycan biosynthesis
sfa01100
Metabolic pathways
sfa01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
sfa00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
Sfla_4732
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
Sfla_4732
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
Sfla_4732
Enzymes [BR:
sfa01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
Sfla_4732
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
Motif
Other DBs
NCBI-ProteinID:
ADW06133
UniProt:
A0A8D3WJA2
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Position
5452065..5453483
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AA seq
472 aa
AA seq
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MIALSLAEIAGIVGGQPHDVPDLSATVTGPVVIDSREVRQGSLFAAFAGERVDGHDYAER
AVEAGAVAVLAARPVGVPAIVVDDVVAALGALARAAVERLGTTVVALTGSAGKTSTKDLI
AQILERKAPTVWTPGSLNNEIGLPLTALRATAETRHLVLEMGARGIGHIEYLAGLTPPRI
GLVLNVGSAHIGEFGSREAIAQAKGELVEVLPEDGAAVLNADDPLVRAMASRTKARVILF
GEAPDADVRGENVRLTDDGRPAFALHTPTGCSDVTLRLYGEHHVSNALAAAAVAHELGMS
VTEIADALSGAGTLSRWRMEVTERPDGVTVVNDAYNANPESMKAALRALAAMGKARQAAG
GRTWAVLGQMAELGDASLAEHDAVGRLAVRLNVSKLVAVGGQEASWLQLGAYNEGSWGEE
SVHVSDAQAAVDLLRSELRPGDVVLVKASRSVGLEKVALALLETTEGEVAVR
NT seq
1419 nt
NT seq
+upstream
nt +downstream
nt
gtgatcgccctctccctcgccgagatcgccggaatcgtcggcgggcagccgcacgacgtg
ccggacctgtccgccaccgtcacgggccccgtcgtcatcgactcccgggaggtgcggcag
ggctccctgttcgccgcgttcgcgggtgagcgcgtcgacggccacgactacgcggagcgc
gccgtcgaggcgggtgccgtggccgtgctcgcggcccgccccgtcggcgtcccggcgatc
gtcgtcgacgacgtcgtggccgccctcggcgccctcgcccgtgcggccgtcgagcgtctc
ggcaccaccgtcgtcgcgctgaccggatcggcgggcaagacgtccacgaaggacctcatc
gcccagatcctggaacgcaaggcgcccacggtctggacgcccggctccctcaacaacgag
atcggactcccgctcaccgcgctgcgcgccacggcggaaacccgccatctcgtgctcgag
atgggcgcccggggcatcggccacatcgagtacctcgccggcctgacgccccctcggatc
ggcctggtcctcaacgtgggcagcgcccacatcggggagttcggcagccgcgaggcgatc
gcgcaggccaagggcgaactcgtcgaggtcctgcccgaggacggcgcggcggtcctgaac
gccgacgacccgctcgtgcgggcgatggcgtcccgcacaaaggcccgggtgatcctcttc
ggggaggccccggatgcggacgtacggggagagaacgtgcggctcacggacgacgggcgg
cccgctttcgcccttcacacacccaccgggtgcagcgacgtgaccttgcgcctgtacggt
gagcaccacgtgtcgaacgcgctcgccgcggccgccgtcgcccatgagttgggcatgtcc
gtgaccgagatcgccgatgcgctctccggggcgggcaccctctcccgctggcgcatggag
gtcaccgagcgtccggacggtgtgacggtcgtcaacgacgcctacaacgcgaaccccgaa
tccatgaaggccgcactccgtgcgctggccgccatgggcaaggcccgacaggcagccggg
gggcgcacgtgggcggtgctcggtcagatggccgagctcggtgacgcgtcgctcgccgag
cacgacgcggtcggacggctcgccgtccggctcaacgtcagcaagctcgtcgctgtcgga
ggacaagaagcctcctggctgcaactgggcgcatataacgagggttcgtggggtgaggag
tcggtgcacgtgtccgacgcacaggcggccgtcgacctgttgcgcagtgaactgcgcccg
ggagacgtcgtgctggtgaaggcgtcccggtcggtcggcctggagaaggtcgccctggca
ctgctggagacgaccgagggcgaggtcgccgtccgatga
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