Salvelinus fontinalis (brook trout): 129836413 Help Entry 129836413         CDS       T11136                                  Name (RefSeq) ryanodine receptor 2-like   KO K04962   ryanodine receptor 2 Organism sfon  Salvelinus fontinalis (brook trout) Pathway sfon04020   Calcium signaling pathway sfon04260   Cardiac muscle contraction sfon04261   Adrenergic signaling in cardiomyocytes sfon04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:sfon00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     129836413    04020 Calcium signaling pathway     129836413  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     129836413    04261 Adrenergic signaling in cardiomyocytes     129836413  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:sfon04040]     129836413    04990 Domain-containing proteins not elsewhere classified [BR:sfon04990]     129836413 Ion channels [BR:sfon04040]  Voltage-gated cation channels   Ryanodine receptor    129836413 Domain-containing proteins not elsewhere classified [BR:sfon04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    129836413 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_6 EF-hand_7 EF-hand_1 EF-hand_5 EF-hand_8 Motif Other DBs NCBI-GeneID:  129836413 NCBI-ProteinID:  XP_055758508 LinkDB All DBs Position 37:24923678..25013377 Genome browser AA seq 4983 aa AA seqDB search MAESGESEDEIQFLRTNDEVVLQCIFTSQQEHLKLCLAAEGFGCRLCCLESTSNCKNVPP DLSVCSFVLAQCLSVRALQEMLANREDQAAGAGQGGGHRTLLYGHAVLLIHSYSRMYLCC LSTSQSSTDKLAFDVGLQDDKTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSYGSAIDNTSESGSLIVDAAFQQTLWRVAPICSGSGVAQGRLLCVLIVGYLKGGDTLR LLHGHTDECLTVPSTDQGEELRKVVHYEGGAVSSHARSLWRLEILRVGWSSSHTRWGQPF RLRHVTTGRYLSLTEERGLHLVDRERADVKSTSFCFRPSKEKLECGPKKDIDGMGASEIK YGDSMCYVQHVDSGLWLTYQAIDAKCARLGAVQRKAIMHSEGHMDDGLSLSRSQWEESHT ARLIRSTVLLFTGFIRRLDGLSQRANTPSLNLPLETVALSLQDLIGYLQPPGEGLGHEAR QNSVRALKNRQNLFQEEGVIGLVLDCIDRLHLYSSASHFAAAAGKEAGDDWENILNSFYE LLAALIRGNRRNCAQFSGSLDWLVSRLEGLEASTGVLEVLHCVLVESPETLNFIREGHIK SIISLLDKHGRNHKVLDVLCSLCVCHGMAVRSNQHLICDNLLPERDLLLQTRLVNQVTSM RPNIFLALGDDSAQYRRWYYEMTVDQVEPFLTAEPTHLRVGWANTEGYNPYLTGGEAWGG NGVGDDLSSYGFDGLYLWSGCVGRRVSSPYHHLLREDDVVSCCIDLVAPCISFRVNGQPV QGMLENFNTDGLLFPVVSFSAGVKVRFLLGGRHGEFRFLPPPGFAPCSEALLPRVKLRVE PCQDFTQEQYLLGPTVPLTPATFTPSPVDISQVVLPVQLEHIRERLAENTHELWVMDKID LGWTHGAVRDDSKKQDPCLVEFSRLPEQERNHSLQMSQDTLRTLVALGLHIGLADGRADE GVRYLRLSNKYEMPSGYRPAPVDLSHIILSPAQEAVVELLAENDHNVWARDRIRQGWTYS SHQDVKAKRSPHLVPYSLLDERSRQSGRDGVREAVCTLLGYGYSLEPLEQDRAVMPDPCH TAAEKFRVFRADKLYAVTRGKWYFEFEAVTEGDMRVGWARPHCTPNGELGSDMQAFVFDG SKAQWCHQGGEPLGRPWQSGDVVGCMVDIGECTMMVTLNGEVLLNDRGSELAAKDFDINQ GFLPVCSLGVNQKARLNLGRDVASLCYFTECGLQEGYKPFAVNMARDPALWMSWRQPQFI PVQTDHDSIQVTRITGSTESPPCLKVTQRSLGPQSCGSDMGFYRLSMPIECAEAFSRPVG ATLPISSSVSTARKDLQEFEVDSDFEMLLKSAHVYTGSRDELNHKDYSHDKTSKLKQRFM LKKPKPELNKSHSSARLLQEVHADKDDYDHLAQSTTYYYSVRVLPGQDPSTVWVGWVTSD FHQHQLTFDLEKIRTVTVTLGNDMGKVHESVKRSNCYMVCAGESTGLGQSRRSAGLAIGC LIDTTTGLLTFSSNGMELGTFFQVEPSTRLFPAVFAKANSSNVFQFELGRVKNMLPLSAG LFRSQRRNAMPQCPPRLQVQVLSPILWTRVPDHTLRVQAAHPEDRLGWRVQCLEPLQVMT LLIPEENRCVDILELSELGDLLSFHHHTLLLYSALCALGNTRVGHALCSHLDQSQLLYAI QSPRLPGPLRSAFYHLLGQVHLSTHATARLAMNHEYIVPMTEQTRAITLYPSPRASRSPQ WVPRMGLGTSLRPRMHFTSPCFIRGDGMGVNGDTCGDGVVPSGEGIHIDSPEIPLELLKD LTGNMLTEAVWAVGQGVRDPEGGSIELLLVPLIRLFHTLLVMGLFGDEDLGKVLTLIEPG VFSRPADCSQEEEQEEEEEEQEDENVPDSDRESVMEREGDKRRKIPKLPTKGLLQMKLPE AVKLEICHLFQYLCDCQVRHRVEAVVAFSDTFVGYLQENQRFRYNEVIQALHMSAALTAR KTKEFRSPPQEQINMLLGFREEQGDCPCPEDIREQLLDFHQDLMTHCGIEVDHDTEVVED SNRSIKDRLFSLVGRVISLKRRSADPEEEDRAQNTMTLQQLISDTVVRWAQECVIENPAL VRAMFSLLHRQYEGLGGQMGTPLHKAYTISQVSVEDTMALLASLVQIRSLLSVRMGKEEE RLMIRGLGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGEGESKEITFPKMVAHCCRF LCYFCRISRHNQGSMFEHLSYLLDNSSVGLASPSMRGATPLDVAAASVMDNNELALALRE PDLEKVVQYLAGCGLQSCPMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENAYS VVRLLIRRPECFGPALRGEGGDGLLAAMEEAIRISEDLTMDGPSTTYESNRTLNVLQDEE DDIIHMGHSIMTFYSALIDLLGRCAPEMHLIHAGKGEAIRIRAILRSLIPIQDLEGVIGI PFQIPSLAKDGTIVEPDPSTVFCPDHKAAMVLFLDRVYGIEDQNFLLHLLKVGFLPDLQA VASLDTTDLSATDMALALNRYLCTAVLPLLTKCSSLLSGTEGQGPLVDALLQAVYRLSRA LSLTKAQRDAIEDCMLAICSKLRPSMMQPLLRRLVFDVPLLTNHTKIPLKLLTNHYEQSW KYYCLIGGLGHLCSASEEELHLCRKLFWGVFNALSRKHYDTELSKLALQCLAAAAGALPP DHMDPGCVAWIKRHPSMDAQGHFDPQPVDTSNVSVPERLEFVVNKYAEHTHEKWSMDKFA NGWVHGELCEKTKVHPLLKPYRALAERDKEAYRWSVKETVRSMLAFGWTIERTKEGDGLG LLTCSRRFSQAGQLSFEGASTFTPKPMDMSSVTLSWDQCSVTELLAENYHNTWSRKKKQE VDAKGGGGHSTLVPYDTLPTKEKAKLREKAQDVLKFFQLNGYTVWRDRKAAEMDSPAIAN RFAYTFLQQLLSYTEETQEYMQELELMQTRGQMPIEAPHQQQVDFFSKVALPLLEQYLKN HRLYFLSTAARSRGNGGHASNKEKEMVTSLFCKLGALVRQRISLFGSDAPSIVSCLLILA QSLDVRTLMKTAPESAKVSLRSFFEAAAVDLEMTVENLSMTQSWTQSRGVAHILDYTNTT LLPTLTSIFEHLSHNQYGEDLLVDSVQVSCYKILNSLHSLGISKSFYVEGQRPSAGACLA ALSGAFPVCFLEPALNEDNPYSIYNTMSPKEREDVGVPDEVEEVCPLLPSLQQLLGEVEE LAGAGSGARQAQYSHVTEITLPLLCSYVSRWWQHGPEGQLESPVCTSVTSQHASTLLGNI LRIIHNHLGTGQGDWMKRLAVFSQPIICQAHPQLLRSHFLPLMEKLKKRAESVLQEEEQI KAEGRADASEAELQIQEKFIVLVRDLYAFYPVLIPFVDYNRASWLREPNHEAEKMFGMVA EIFIFWAKSHNFKWEEQNYVVQNEINNMAFLVNNNNHKMSKVSDQERRKMKRKGDRYSTQ TSLIVASLKRLLPVGLSACSPADRGLITLAKSRFTQKDTEDEIRESIHNGLLRLQSKREA PGARWQDVLFRDFPGPTRDTSDPLRTVERVLDIACVLYHLDQVEHPQRKKAVWHKVLSKQ RKRAVVACLRMAPLYNLPRHRAVNLFLQGYDKSWISAEDHSFEEKLVDDLARAGKQERSE REEEGEDDDEQIDPLLQLITLFSRSALTESKLGDDSLYMSYAAIMAKSCCGEEDEEVKSF EEKEMEKQKLLYQQARLHDRGAAQMVLQTISASKGDMGSMVASTLKLGISILNGGNTTVQ QKMLDYLKEKRDVGFFQSVAGLMQSCSVLDLNAFERQNKAEGLGMVIQESSGEKVMPDEK LTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSG KDVIDEHGQRNFSKAINVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHM QMKLSQDSSQIEILKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSSNVEMIL KFFDMFLKLKDLTSSDAFKEYDHDGKGRISKKDFQKAMEAYKRYSQSETQFLLSCTETDE SELLDYEAFVDRFHEPAKDIGFNIAVLLTNLSEHMPHDSRLGTFLQLAECVLSYFQPYLG RIEILGSGKRIERVYFEISESSRTQWDKPQVKESKRQFIFDVVNEGDGKEKMEMFVNFCE DTIFEMQLAAQISGTDTGERTAGKEAEEEEEKDRGKNDEEELERSKMGFFSMSTIWLIVF ALPYGLMMLMSMLSVKNLKNHIKKTTLRNLVMVFASFFQAMIMGLVHFVCSVVRFFLYVL YIVFVSGGLIEGAKKIRVFDLFGGILDPTLDEVTGGSGGYRERRYSTRSSRDELRGLGQS TVSSSDTNVLSDIFGLRVRREGGQYRLMTHDLTASLTDLFNTATGQQSPAEPNGKQQVEG AREEDGNEGEEKESELEKAEREDSEKKEATAKRRVRICSSKPEEPEPQESAFWEMITTHQ KRLLNYFARNFYNMRMLALFVAFSINFILLFYKVSSSSSVSEEEEKVAVLYDSSGDLDEE GTLVNDNTSGITQFVLEESTGYMEPSLRFLSIAHTLISFCCIIGYYCLKVPLVIFKREKD VARKMEFDGLYVTEQPPDEDIKGQWDRLVITTQSFPSNYWDKFVKRKVMDKYGKFYGCDR ISELLGLDKAALDFSSEGQERRRPRREGAWTALLNSIDVKYQVWKLGVVFTDNSFLYLAW YMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILTSVTHNGKQLVLTLGLLAVVVYLYTVV AFNFFRKFYNKSEDGVALDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEFEVVRI IFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYLDNVPHG FETHTLQEHNLANYLFFVMYLINKDETEHTGQESYVWKMYQERCWEFFPVGDCFRKQYED QLC NT seq 14952 nt NT seq  +upstreamnt  +downstreamnt atggctgaatcaggagaaagcgaagatgaaatccaatttctacgtacgaatgatgaggtg gtgctgcagtgcatcttcacatcccaacaggagcatctgaaactgtgcctggctgcagag ggctttggctgcagactctgctgtctggagtccacctccaactgcaagaatgttcctcca gacctgtcggtgtgttcctttgtgctggcccagtgtctgtctgtcagagctctgcaggag atgctggctaacagggaggaccaagcagcaggggctggtcagggaggtggtcatcgcacc ctcctctacggtcatgctgtactgctcatacactcctacagcaggatgtatctttgctgt ttgtccacatcccagtcttcgacagataagctagcgtttgatgttggtctgcaggatgat aaaacaggtgaggcatgctggtggaccattcaccctgcatccaagcagaggtcagagggg gagaaggtccgtgtcggggacgacctcatcctggtcagtgtgtcatctgagagatacctg catttgtcctatgggagtgcgatagacaatacgagtgagagtggcagcctcattgtggac gcagccttccagcagaccctctggagggtcgcccccatctgttctgggagtggagttgct caaggcaggttgctttgtgtgctaatcgtagggtatctgaagggaggggacacgttgagg ctgctgcatggacacacagacgaatgtctgactgtcccatctacagaccagggggaggag ttacgcaaggtggtgcactacgagggtggagcagtctccagtcatgcccgctctctctgg aggctcgagatcctgcgtgttggctggagtagtagccacacacgctggggtcagccattc cggctccgccatgtcaccacagggaggtacctgagtctgaccgaggagagaggccttcac ctggtggacagggagagggctgacgtgaagtccacatccttctgcttccgaccctccaag gagaagctagaatgtggcccaaagaaggacattgatggtatgggtgcctcagagatcaag tatggagactccatgtgctacgtccagcatgtggactctggtctgtggctcacctatcaa gccattgatgccaagtgtgcccgcttgggagcagtgcagcgcaaggccattatgcacagt gagggtcacatggatgacggtctgagcctgtcccgttctcagtgggaggagtcccacacg gccagactcatccgcagcaccgtcctcctcttcacaggcttcatcaggagacttgatggt ctcagtcagcgagcgaacaccccctccttaaacctgccactagagacagtggccctaagt ttgcaggatctgattggctacctccagccacctggggaggggctaggacatgaggctagg cagaacagtgtgcgagctctgaagaacagacagaatctatttcaagaggagggggtcatc ggtttagttcttgactgtattgaccgtttacacctatacagcagtgcctctcattttgct gcagctgctgggaaggaggcaggagatgactgggagaacatcctcaactccttctatgaa ctactggctgctcttatcaggggaaatcgcaggaactgtgcccagttctcaggctccctg gactggctggtgagcaggctggagggactggaggcctccactggtgtcctggaggtttta cactgtgtccttgttgagagtcctgagactctcaactttataagggaaggacacattaaa tccatcatctctctactggataagcatgggcggaaccataaggtcctggatgtgctatgt tctctctgtgtgtgtcatggtatggcagtgcgttccaaccagcatctgatctgtgataac ctgctaccagagcgagacctgcttctccagactcgtctcgtcaaccaggtcaccagcatg aggcccaacatcttcctggccctgggtgatgactcggcccagtacaggaggtggtactat gagatgactgtagaccaggtggagcccttcctcacggctgagcccactcacctgcgtgtg ggctgggccaacactgagggttacaacccctatctcacgggtggagaggcctgggggggc aacggggtaggagatgatctaagctcctatggctttgacgggctgtacctctggtcaggc tgtgttggccggagagtgagctctccctatcaccaccttctgagggaggacgatgtggtc agctgctgcattgacctcgttgccccctgcatctccttccgggtcaacgggcagccggtc cagggcatgctggaaaacttcaacactgacggactgctcttcccagtggtcagcttctct gctggtgtcaaggtgcgttttctgctgggtgggagacatggagagttccgtttcctgccc cctccaggctttgccccatgttccgaggctctgctccccagggtgaagctgagggtggag ccgtgtcaggacttcacccaggagcaataccttctgggccccactgtacccctcacccca gcaacctttacccctagtccagtagacatcagccaggtggtgttgcctgttcaactggag catattcgtgagagactagcagaaaacacccatgagctgtgggtcatggacaagattgac cttggatggacccatggagctgttagagatgacagtaagaagcaggacccctgtctggtg gagttctccaggctcccagaacaggagcggaaccacagccttcagatgtcccaggacact ctccggactctcgttgcccttggtttgcatattggactggcagatggccgtgctgatgag ggagtgagatacctgaggctctccaacaagtatgagatgcctagtgggtacagaccagcc ccggtagacctgagccacatcatcctgagtcctgcccaggaggcggtggtggagctgctg gctgagaacgatcacaacgtgtgggccagggaccggatcaggcagggctggacctacagc tcacaccaggatgtgaaggcaaagcggagcccccacctggtgccctacagcctgctggat gagaggagcagacaatctggcagagacggtgtgagggaggctgtgtgcaccctgctgggc tacggctacagtctggagcccctggaacaggacagagctgtgatgccagacccatgtcac acagcggctgagaagttcagggtcttcagggcagacaagttgtatgctgtgaccaggggg aagtggtactttgagtttgaggcggtgacggaaggggacatgagggtaggctgggctcgt ccccactgcacaccgaatggggaactaggatcagacatgcaggcttttgtgtttgacggc tccaaggcccagtggtgtcaccagggaggtgagcccctgggtcggccctggcagagtggt gatgtggtgggctgtatggttgacatcggtgaatgcaccatgatggtcactctcaatgga gaggtgcttttgaacgaccgcggatcagagctggctgccaaggactttgacatcaaccag ggcttcctccctgtgtgtagtctcggggtgaaccagaaggccaggctgaatctgggtcgt gacgtggcctcactgtgttacttcacagagtgtggcctacaggaaggttataagccattt gctgtaaacatggccagagacccagccctgtggatgagctggagacaaccacagttcatc cctgtacagacagaccatgatagcatacaggtgacaagaatcactgggtccactgagagc ccaccgtgcctaaaggtaacacagaggtcattggggccccagagttgtggcagtgacatg gggttctacagactcagtatgcctatagagtgtgctgaggccttctccagaccagtaggg gctactttacctatcagcagcagtgtctccacagccaggaaagacctgcaggagtttgag gtggactctgactttgagatgctgctgaaatcagctcatgtttacactggctccagggat gagcttaaccacaaggactacagccatgataaaacatccaaactcaaacaacggttcatg ttgaagaaacccaaaccagagttgaacaaaagccactcatctgcccgtctactgcaggag gttcatgctgacaaagatgactatgaccatctggcccagtccactacgtactattactca gtgagggtgttacctggtcaggacccctccactgtctgggtgggctgggtcacctctgac ttccaccagcaccagctgacctttgacctggaaaagatccgcacagtgaccgtcaccctc ggaaatgacatgggcaaggtccatgagagtgtgaaacgtagtaactgctacatggtgtgc gccggagagagcacgggcctggggcagagcaggaggagtgcaggcctggccataggctgt ctgatagacaccaccactggactgctaacattcagctccaacggcatggagctgggaacc ttctttcaggtggagcccagcactaggctgtttcctgcagtctttgccaaggccaacagc tccaatgtgttccagtttgagctagggcgcgtaaagaacatgctgcccctgtcagcgggt ctgttcaggagccagaggaggaatgctatgccccagtgtccccccaggctgcaggtgcag gtgctgtcgcccatcctttggacccgtgtaccagaccacaccctgagggtgcaggctgcc caccctgaagaccgcctcggctggagggtccagtgcttagagcccctgcaggtcatgacc ctgctcatcccagaggagaacaggtgtgtggacatcctggaactctctgagttaggtgac cttctgtctttccatcaccacaccctgctcctctactctgccctctgtgctctgggcaat actcgtgtgggccacgccctctgcagccacctggaccaatcacagctcctctatgccatc cagagcccccgcctccccgggccactgcgctccgccttctaccacctcctgggccaggtg cacctcagcacccacgccacggcccgcctcgctatgaaccacgagtacatcgtccccatg acagagcagaccagggccatcaccctctaccccagccccagggctagtcgaagcccccag tgggttcccagaatgggcctcggcacctccctcagaccccgtatgcacttcacctccccc tgcttcatcagaggagatggcatgggagtcaatggggatacttgtggtgatggcgtggtt ccgtctggggaaggcatccatatagacagcccagagatcccactggaacttctgaaggac ctgacagggaatatgctgactgaggctgtgtgggctgtggggcagggtgtgagggatcct gaagggggcagcattgagctgctgctggtgcccctaattcggctgttccacaccctgctg gtgatggggttgtttggggacgaggatctagggaaagtgctgacactgatcgagcctggg gtcttctcccgacctgcagattgttcccaagaagaggagcaggaggaggaagaggaagag caggaggatgaaaatgtgccagatagtgatagggaaagtgtgatggagagggagggggat aaaaggaggaaaattccaaagcttccaacaaaaggactgcttcagatgaagctaccagaa gctgtcaaacttgagatctgccacctgttccaatacctgtgtgactgtcaggtgcgtcac agggtggaggcggtggtggccttctcagacactttcgtggggtacctgcaggagaaccag cgcttccgctacaacgaggtgatacaggctctccacatgtctgctgccctcaccgcccgc aagaccaaggagttccgctccccgccacaagaacagatcaacatgttactgggcttcaga gaggagcagggggactgtccgtgtccagaggacataagagagcagctgctggacttccac caggacctcatgactcactgtggaattgaagttgaccatgacacagaggttgtggaggat tccaatcgctccatcaaagatcgtctcttcagcttggttgggagagtaatcagcttgaag aggagatctgcagatcctgaagaggaagacagagcacagaataccatgactcttcagcag ctcatctctgacacggtggtgcgctgggcccaggagtgcgtgatagagaacccagctctg gtcagggccatgttctctctgttgcaccggcagtacgagggcttggggggccagatgggc actcccctccacaaggcctacaccatcagccaggtgtcagtggaggacaccatggccttg ctggcctctctggtgcagattcgctctctgctcagcgtccgcatgggcaaggaggaggag agactcatgatccggggactgggaaacataatgaacaataaggtgttctaccagcacccc aacctgatgagggctctggggatgcacgagacggtcatggaggtgatggtgaacgtcctg ggggagggagagtccaaggagatcacctttcctaagatggtggcccattgctgtcgcttc ctttgttacttctgtcgcatcagtaggcacaatcagggatccatgttcgagcacctcagc tacctgttggataatagcagtgttggcctagcatctccgtccatgcgtggagcaacccct ctggacgtggcagctgcctctgtcatggacaacaatgagctggccctggccctgagggaa ccagacctggaaaaagtggtgcagtacttggcaggctgtggtctacagagttgtcccatg ctggtgtctaaaggctaccctgacattggttggaaccctgtggagggggaacgctacctg gacttcctacgctttgctgtcttttgcaacggggagagtgtggaggagaatgcctactcg gtagtgaggctgctgattcgccgtccggagtgttttggccccgccctgcgaggtgagggt ggcgatggtctcctggcagccatggaggaagccatcaggatctcagaggacctgactatg gacggaccctccacgacctacgagtccaacagaacactgaacgtgctgcaggatgaggag gatgacataatccacatgggccactccatcatgaccttctactccgccctcatcgacctg ctgggccgctgtgccccggagatgcacctgatccatgctgggaagggcgaggccatccgt atccgggccatcctgcggtccctcatccccatccaggacctggagggagtcatcggcatc cccttccaaatcccctctctagcaaaagatggcaccatagtcgaaccagacccatccact gtgttctgcccggaccacaaggcagccatggtgctgttcctggaccgtgtgtacggcatc gaggaccagaacttcctgctccacctgttgaaagtgggcttcctgccagacctgcaggct gtggcctctttggacacaactgatctgagtgccacagacatggccctggcactgaacagg tacctgtgtacggctgtgctgcccctgctcactaagtgctccagcctgttgtctgggaca gagggccaggggccgctggtggatgctctcctccaggccgtctaccgcctgtccagggcc ctcagcctcaccaaggcccagagagacgccatcgaggactgcatgctggccatatgcagt aagctcaggccgtccatgatgcaacctctactccgacggcttgtttttgatgtgcccctt ctgacaaatcacactaaaataccactcaagctgttgaccaatcactatgagcagagctgg aagtactactgtctgattggaggtttggggcacctgtgctccgcctcagaggaggagctt cacctctgcaggaagctgttctggggagtgttcaatgctctgtccaggaagcactatgac actgagctctccaagctggctctgcagtgtctggcagctgcagctggagccctccctcct gaccacatggaccctggctgtgtagcctggattaagagacacccctccatggacgcacag ggacactttgacccccagcctgtagacacctccaatgtgtcagtaccagagagactggaa tttgtggtgaataaatatgcagaacacacccatgagaagtggtcaatggacaagtttgcc aatggctgggtccatggggagctctgtgaaaagaccaaagtacaccctctcctgaagcct tacagagctctggctgagagggacaaagaggcgtatcgctggtctgtaaaggagaccgtg cgaagtatgttggcctttggctggaccatagagagaactaaagagggagatggccttggc ctactcacctgctcacgccgcttctcccaggctggacagctgtcgtttgaaggagcatca actttcacccccaagccaatggacatgagcagtgtgacactctcatgggaccagtgttct gtgactgaattgctggctgagaactaccataacacctggtccaggaagaagaagcaggaa gtggatgctaaagggggagggggtcattctacgctggtgccctatgataccctccctacc aaggagaaagccaaactgagagagaaagcccaggatgtcctgaagttcttccagctgaac ggctacacagtgtggagggacagaaaggcagcagagatggactcaccagccatagcaaac cgttttgcctacactttcctacagcagctcctctcatacacagaggagacccaagaatac atgcaggagctggagcttatgcagacaagaggtcagatgccaatagaggctccccaccaa cagcaggttgactttttcagcaaggtggcgttaccccttctggagcagtacctgaagaac catcgcctctacttcctttccaccgcagccagatcacgaggcaacggaggtcatgcctcc aataaggagaaggagatggtcaccagcctgttctgcaaattgggagctcttgtcagacaa aggatctctctgtttgggagcgatgcaccttccatcgtcagctgtcttctcatactggcc cagtctcttgatgtcaggactttgatgaagactgctccagaatcagccaaggtctcgcta cggtccttcttcgaggctgcagcggtggacctggagatgaccgtggagaacctctctatg acccagagctggacccagtccagaggggtggcccatatcctggactacaccaataccacc ctgctgccgactctcacctccatttttgaacacctcagccacaatcagtatggagaagac ctcttggtggacagtgtccaggtgtcctgttataagatcctcaacagcctccactcactt ggcatcagcaaaagtttctacgtggaggggcagaggccgtcagcaggagcgtgtctggca gcactgtcaggggctttccctgtgtgtttcctggagccagctctgaatgaggacaacccg tactccatctacaacaccatgagccccaaagagcgagaggatgtgggagttccggacgag gtggaggaggtgtgtcctctcttgccatctctgcagcagcttctgggggaggtggaggag ctggcaggggcaggctcaggggcacgccaagcccagtacagccatgtcaccgagatcacc ctacccttgctctgcagctacgtgtcccgttggtggcagcacggtcccgagggccagctg gagagcccggtctgcacctcagtcacctcccagcatgcaagcacactgctgggcaacatc ctccgcatcatccacaaccacctgggaacaggccagggagactggatgaagcgcctggca gttttctctcagccaatcatctgccaggcccacccccagttgctgaggagccacttcctg cctctgatggagaaactgaagaagagggcagaatcagtgcttcaggaggaggagcagata aaggctgaggggagggccgatgcgtctgaggcggagctacagattcaggagaaattcatt gtgctggtgcgagacctctacgccttttaccctgtcctcatcccattcgtggactacaat agagcaagttggctacgggaaccgaaccatgaggctgagaagatgttcggcatggtggca gagatcttcatattctgggccaagtctcacaacttcaaatgggaggaacagaactatgtg gtccagaatgagatcaacaacatggctttcttggtcaataataacaatcacaaaatgtcc aaggtgtcagaccaggagaggaggaagatgaagcggaaaggggatcgctactccacacag acctctctcatcgtagcctccctgaagagattgcttcctgtgggactgagtgcgtgttcc ccagcagaccgcggccttatcacactggccaagagccgcttcactcagaaggacacagag gacgagattcgagagagcattcataatggcctgctacgtcttcagagcaaacgggaggcc ccaggggctcggtggcaggatgtcctgttcagggacttcccaggccccacacgggacacc tctgaccctctgaggacagtagaaagggtcctggacattgcttgcgtcctttaccacctg gaccaggtagagcatccccagaggaagaaggcagtgtggcacaaggtgttatccaaacag aggaagagagctgtggtggcctgccttagaatggctcctctctacaacctacccaggcac cgggctgtcaacctttttctacagggctatgacaagtcctggatatctgctgaggatcac tcctttgaggaaaagttggttgacgatttggctagagctggaaagcaggagcgttctgag agagaggaggaaggagaggacgatgacgaacagattgatccgctcctgcagctcatcaca ctgttcagtcggagtgctctgaccgagagtaagcttggcgatgacagtctttacatgtcc tatgctgccataatggcaaagagttgctgtggtgaagaggatgaggaggtgaaaagcttt gaagagaaggagatggagaaacagaagctgttgtatcagcaggccaggctgcatgaccgt ggagctgctcagatggtcctccagactatcagtgctagtaaaggtgacatggggtccatg gtggcctccactctgaagcttggtatttctattctgaatggaggaaataccactgttcag cagaaaatgttggattacctgaaagagaagagggacgtaggtttcttccagagtgtggca ggactcatgcagtcttgtagtgtgctggatttgaatgcgtttgagaggcagaacaaagcc gaaggattagggatggtcatccaggagagctcaggggagaaggttatgcctgatgagaag ttgacctgtgatctttttcgctttctacagctcctctgtgaaggacacaactcagatttt cagaattatttgagaacacaaacaggaaacaacacgactgtgaacatcattatatccact gtggactaccttctcagagtgcaggagtcgataagtgatttctactggtattactctggg aaggatgtgattgacgaacatggccagcgtaacttctccaaggccatcaatgtggccaaa caggtcttcaactctctcacagagtacatccaggggccgtgtactggtaaccagcagagt ctggcccacagtcgtctatgggatgcagtggtgggctttctccatgtctttgctcacatg cagatgaagctgtctcaggattccagccaaattgaaattctgaaagaattgatggatttg caaaaggacatggttgttatgttgttgtccatgttagaaggtaatgtggtaaatggaaca attggcaagcagatggtggacatgttggtggaatcatctagcaatgttgagatgatccta aagttcttcgacatgttcctcaaactcaaagacctgacatcctctgacgcattcaaagag tatgatcacgacggcaaaggtcgcatctccaaaaaggacttccagaaggccatggaggcc tacaagcgctactctcaatccgagacccagttcctcctctcctgcacggagacggatgaa agcgagctcctggattatgaggccttcgtggatcgcttccacgagccagccaaagacatt ggcttcaacattgctgttctcctaaccaacctgtccgagcacatgcctcacgattcacgt cttggtacctttctgcagcttgcagagtgtgttctgagctacttccagccctacctgggc cgtattgagatccttggcagtggcaagcgtatcgagagggtctactttgagatcagcgag tccagccgcacgcagtgggataagcctcaggtcaaagagtccaagagacagttcatattt gacgtggtcaatgagggcgacgggaaagagaagatggagatgtttgtcaacttctgcgaa gacaccatctttgagatgcagctggctgcccagatatcagggacagacactggggagagg accgcaggcaaagaggctgaagaagaggaagaaaaagacagggggaagaatgacgaggag gagttagaaagatccaaaatgggatttttctccatgtccacaatatggctcatcgtcttc gctctaccttatggcttgatgatgctgatgtctatgctctctgtgaaaaacctgaagaac catattaagaagacaactctgaggaatttagtcatggtatttgcttccttcttccaggcc atgatcatgggtctggtccactttgtctgttctgtagttcgcttcttcttatatgtactg tacattgtttttgtaagtggaggactcatagagggggccaagaagataagggtgttcgac ctttttggaggcatccttgaccccacactcgatgaggtcacaggggggtcagggggttac agggagaggagatacagcacaaggtcctcccgggacgagctgagggggctgggccagtca acagtttcctccagtgacaccaatgtcctgtcagacattttcggtctgcgagtgaggaga gaaggaggtcaatacagactaatgactcatgacttaacagccagtctgactgacctgttc aacacagccactggccaacaatcccctgctgagcccaatgggaaacaacaggttgagggt gccagagaagaagatggtaatgaaggagaagagaaagagtctgagttggagaaagcagaa agggaagattctgagaagaaggaggcaacggctaaacggagagttaggatatgctccagc aaacctgaggagccagagcctcaggaatcagccttctgggaaatgataaccactcaccag aagagactgttgaattactttgcgaggaatttctacaacatgcggatgctggctttgttt gttgccttctctatcaacttcattctccttttctacaaggtgtcatcatcctcttctgta agtgaggaagaggagaaggtggcagtgctttacgacagctcaggggacctggatgaagaa ggcaccttggtcaatgacaacacctcaggcattacgcagtttgtcctggaggagagcact ggttacatggagccctctctccgcttcctgtccatcgctcacaccctcatctctttctgc tgtatcattggctactactgcttgaaggtcccgctggttatttttaagcgggagaaagac gtggcgaggaagatggagtttgacggcctctatgtcactgagcagccacctgatgaggac atcaaaggccaatgggacaggcttgtcatcaccacacaatcatttcccagtaattactgg gataaatttgtgaaaaggaaggtgatggacaagtatgggaagttttatggttgtgaccgc atcagtgagctgctggggctggataaggctgctctcgacttcagctccgagggacaggag aggagaaggcccaggagagagggagcctggactgctctattaaactcaattgatgtcaag tatcaggtgtggaaactaggagtagtgttcactgacaactccttcctgtacctggcatgg tatatgaccatgtctgtcctgggccactataataacttcttcttcgctgctcacctgttg gatattgccatgggctttaagacccttagaaccatcctgacctctgttacccacaatggc aaacagttggtcctgactttagggctgctggcagtggtggtgtatctctacaccgttgtg gccttcaacttcttccgcaagttctacaacaagagtgaagatggagtagctctggacatg aaatgtgacgacatgctcacttgctatatgttccacatgtatgtgggcgtgagagcgggg ggtggcatcggtgatgagattgaggacccggccggggacgagtttgaggtggtcaggatc atctttgacatcaccttcttcttcttcgtcatcgtcatcctcctggccatcattcagggt ttgataattgatgcctttggggagctccgtgaccagcaggagcaggtgaaagaggacatg gagaccaagtgtttcatctgtggaatcgggaatgactacttggacaatgtgccccatgga ttcgaaacacacactctgcaggaacacaacctggccaactatctattctttgtgatgtac ctcattaacaaagatgaaacagaacacacgggccaggaatcctacgtatggaaaatgtac caggagcgatgctgggaattctttcctgtcggtgactgtttccgtaaacagtatgaagac cagctctgctga

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