Shigella flexneri NCTC1 (serotype 2a): NCTC1_00072
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Entry
NCTC1_00072 CDS
T03751
Symbol
leuA
Name
(GenBank) 2-isopropylmalate synthase,2-isopropylmalate synthase,2-isopropylmalate synthase,Isopropylmalate/homocitrate/citramalate synthases,2-isopropylmalate synthase,HMGL-like
KO
K01649
2-isopropylmalate synthase [EC:
2.3.3.13
]
Organism
sft
Shigella flexneri NCTC1 (serotype 2a)
Pathway
sft00290
Valine, leucine and isoleucine biosynthesis
sft00620
Pyruvate metabolism
sft01100
Metabolic pathways
sft01110
Biosynthesis of secondary metabolites
sft01210
2-Oxocarboxylic acid metabolism
sft01230
Biosynthesis of amino acids
Module
sft_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
sft00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
NCTC1_00072 (leuA)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
NCTC1_00072 (leuA)
Enzymes [BR:
sft01000
]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
NCTC1_00072 (leuA)
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GFIT
Motif
Pfam:
HMGL-like
LeuA_dimer
HCS_D2
IPMS_D2
Motif
Other DBs
NCBI-ProteinID:
CDX05368
UniProt:
A0AB33S9D6
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Position
1:complement(79286..80857)
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AA seq
523 aa
AA seq
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MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT
IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE
RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF
AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS
LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH
QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF
LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA
EAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVTNYNGRRFHGVGL
ATDIVESSAKAMVHVLNNIWRAAEVEKELQRKTQHNENNKETV
NT seq
1572 nt
NT seq
+upstream
nt +downstream
nt
atgagccagcaagtcattattttcgataccacattgcgcgacggtgaacaggcgttacag
gcaagcttgagtgtgaaagaaaaactgcaaattgcgctggcccttgagcgtatgggtgtt
gacgtgatggaagtcggtttccccgtctcttcgccgggcgattttgaatcggtgcaaacc
atcgcccgccaggttaaaaacagccgcgtatgtgcgttagctcgctgcgtggaaaaagat
atcgacgtggcggccgaatccctgaaagtcgccgaagccttccgtattcatacctttatt
gctacctccccaatgcacatcgccaccaagctgcgcagcaccctagacgaggtgatcgaa
cgcgctatctatatggtgaaacgcgcccgtaattacaccgatgatgttgaattttcttgc
gaagatgccgggcgtacacccattgccgatctggcgcgagtggtcgaagcggcgattaat
gccggtgccaccaccatcaacattccggacaccgtgggctacaccatgccgtttgagttc
gccggaatcatcagcggcctgtatgaacgcgtacctaacatcgacaaagccattatttcc
gtacatacccacgacgatttaggcctggcggtcggcaactcactggcggcggtacatgcc
ggtgcacgccaggtggaaggtgcaatgaacgggatcggcgagcgtgccggtaactgttcg
ctggaagaagtcatcatggcgattaaagttcgtaaggatattctcaacgtccacaccgcc
attaatcaccaagagatatggcgcaccagccagttagttagccagatttgtaatatgccg
atcccggcaaacaaagccattgttggcagcggcgcattcgctcactcctccggtatccac
caggatggcgtgctgaaaaaccgcgaaaactacgaaatcatgacaccagaatctattggt
ctgaaccaaatccagctgaatctgacctctcgttcggggcgtgcggcggtgaaacatcgc
atggatgagatggggtataaagaaagtgaatataatttagacaatttgtacgatgctttc
ctgaagctggcggacaaaaaaggtcaggtgtttgattacgatctggaggcgctggccttc
atcggtaagcagcaagaagagccggagcatttccgtctggattacttcagcgtgcagtct
ggctctaacgatatcgccaccgccgccgtcaaactggcctgtggcgaagaagtcaaagca
gaagccgccaacggtaacggtccggtcgatgccgtctatcaggcaattaaccgcatcact
gactataacgtcgaactggtgaaatacagcctgaccgccaaaggtcacggtaaagatgcg
ctgggtcaggtggatattgtcaccaactacaacggtcgccgcttccacggcgtcggcctg
gccaccgatattgtcgagtcctccgccaaagccatggtgcacgtactgaacaatatctgg
cgtgccgcagaagtcgaaaaagagttgcaacgcaaaactcaacacaacgaaaacaacaag
gaaaccgtgtga
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