KEGG   Sorex fumeus (smoky shrew): 130016368
Entry
130016368         CDS       T10594                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
sfum  Sorex fumeus (smoky shrew)
Pathway
sfum01522  Endocrine resistance
sfum04010  MAPK signaling pathway
sfum04015  Rap1 signaling pathway
sfum04068  FoxO signaling pathway
sfum04071  Sphingolipid signaling pathway
sfum04114  Oocyte meiosis
sfum04148  Efferocytosis
sfum04218  Cellular senescence
sfum04261  Adrenergic signaling in cardiomyocytes
sfum04370  VEGF signaling pathway
sfum04380  Osteoclast differentiation
sfum04517  IgSF CAM signaling
sfum04550  Signaling pathways regulating pluripotency of stem cells
sfum04611  Platelet activation
sfum04613  Neutrophil extracellular trap formation
sfum04620  Toll-like receptor signaling pathway
sfum04621  NOD-like receptor signaling pathway
sfum04622  RIG-I-like receptor signaling pathway
sfum04625  C-type lectin receptor signaling pathway
sfum04657  IL-17 signaling pathway
sfum04658  Th1 and Th2 cell differentiation
sfum04659  Th17 cell differentiation
sfum04660  T cell receptor signaling pathway
sfum04664  Fc epsilon RI signaling pathway
sfum04668  TNF signaling pathway
sfum04670  Leukocyte transendothelial migration
sfum04714  Thermogenesis
sfum04722  Neurotrophin signaling pathway
sfum04723  Retrograde endocannabinoid signaling
sfum04728  Dopaminergic synapse
sfum04750  Inflammatory mediator regulation of TRP channels
sfum04912  GnRH signaling pathway
sfum04914  Progesterone-mediated oocyte maturation
sfum04917  Prolactin signaling pathway
sfum04926  Relaxin signaling pathway
sfum04932  Non-alcoholic fatty liver disease
sfum04933  AGE-RAGE signaling pathway in diabetic complications
sfum04935  Growth hormone synthesis, secretion and action
sfum04936  Alcoholic liver disease
sfum05014  Amyotrophic lateral sclerosis
sfum05020  Prion disease
sfum05022  Pathways of neurodegeneration - multiple diseases
sfum05132  Salmonella infection
sfum05133  Pertussis
sfum05135  Yersinia infection
sfum05140  Leishmaniasis
sfum05142  Chagas disease
sfum05145  Toxoplasmosis
sfum05152  Tuberculosis
sfum05161  Hepatitis B
sfum05163  Human cytomegalovirus infection
sfum05167  Kaposi sarcoma-associated herpesvirus infection
sfum05169  Epstein-Barr virus infection
sfum05170  Human immunodeficiency virus 1 infection
sfum05171  Coronavirus disease - COVID-19
sfum05205  Proteoglycans in cancer
sfum05208  Chemical carcinogenesis - reactive oxygen species
sfum05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
sfum05415  Diabetic cardiomyopathy
sfum05417  Lipid and atherosclerosis
sfum05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:sfum00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    130016368 (MAPK12)
   04015 Rap1 signaling pathway
    130016368 (MAPK12)
   04370 VEGF signaling pathway
    130016368 (MAPK12)
   04668 TNF signaling pathway
    130016368 (MAPK12)
   04068 FoxO signaling pathway
    130016368 (MAPK12)
   04071 Sphingolipid signaling pathway
    130016368 (MAPK12)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    130016368 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    130016368 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    130016368 (MAPK12)
   04218 Cellular senescence
    130016368 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    130016368 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    130016368 (MAPK12)
   04613 Neutrophil extracellular trap formation
    130016368 (MAPK12)
   04620 Toll-like receptor signaling pathway
    130016368 (MAPK12)
   04621 NOD-like receptor signaling pathway
    130016368 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    130016368 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    130016368 (MAPK12)
   04660 T cell receptor signaling pathway
    130016368 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    130016368 (MAPK12)
   04659 Th17 cell differentiation
    130016368 (MAPK12)
   04657 IL-17 signaling pathway
    130016368 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    130016368 (MAPK12)
   04670 Leukocyte transendothelial migration
    130016368 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    130016368 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    130016368 (MAPK12)
   04917 Prolactin signaling pathway
    130016368 (MAPK12)
   04926 Relaxin signaling pathway
    130016368 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    130016368 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    130016368 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    130016368 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    130016368 (MAPK12)
   04722 Neurotrophin signaling pathway
    130016368 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    130016368 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    130016368 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    130016368 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    130016368 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    130016368 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    130016368 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    130016368 (MAPK12)
   05161 Hepatitis B
    130016368 (MAPK12)
   05171 Coronavirus disease - COVID-19
    130016368 (MAPK12)
   05163 Human cytomegalovirus infection
    130016368 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    130016368 (MAPK12)
   05169 Epstein-Barr virus infection
    130016368 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    130016368 (MAPK12)
   05135 Yersinia infection
    130016368 (MAPK12)
   05133 Pertussis
    130016368 (MAPK12)
   05152 Tuberculosis
    130016368 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    130016368 (MAPK12)
   05140 Leishmaniasis
    130016368 (MAPK12)
   05142 Chagas disease
    130016368 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    130016368 (MAPK12)
   05020 Prion disease
    130016368 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    130016368 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    130016368 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    130016368 (MAPK12)
   05415 Diabetic cardiomyopathy
    130016368 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    130016368 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    130016368 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    130016368 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    130016368 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:sfum01001]
    130016368 (MAPK12)
Enzymes [BR:sfum01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     130016368 (MAPK12)
Protein kinases [BR:sfum01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   130016368 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kdo Haspin_kinase Kinase-like
Other DBs
NCBI-GeneID: 130016368
NCBI-ProteinID: XP_055963026
LinkDB
Position
Unknown
AA seq 367 aa
MGSPPPARRGFYRQEVTKTDWEVRAVYQDLQPVGSGAYGAVCSAVDSRTGLKVAIKKLYR
PFQSELYAKRAYRELRLLKHMRHDNVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLSEDRIQFLVYQMLKGLKYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK
VTGTPPEEFVQRLQSAEAKNYMKGLPELEKKDFASILTDASPLAVNLLEKMLVLDAEQRV
TAAEALTHPYFESLHDTEDEPKAQKYDESFDDVDRTLEEWKRVTYKEVLSFKPPRHLGVK
SSKETAL
NT seq 1104 nt   +upstreamnt  +downstreamnt
atggggtcgccgccgcccgcccgccggggcttctaccgccaggaggtgaccaagacggac
tgggaggtccgcgccgtgtaccaggacctgcagcccgtgggctcgggcgcgtacggcgcc
gtgtgctcggccgtggacagccgcaccggcctcaaggtggccatcaagaagctgtaccgg
cccttccagtcggagctgtacgccaagcgcgcctaccgggagctgcgtctgctcaaacac
atgcgccacgacaacgtgatcgggctgctggatgtcttcacccctgatgagaccttggac
gacttcacggacttctacctggtgatgccgttcatgggcacggacctgggcaagctcatg
aagcacgagaagctgagcgaggaccgaatccagttcctggtttaccagatgctgaagggg
ctgaagtacatccacgccgccggcatcatccacagggacctgaagcccggcaacctggcg
gtgaatgaggactgtgagctgaagatcctggactttggtctggccagacaggcggacagc
gagatgaccggctacgtggtgactcggtggtaccgggcacccgaggtcatcctgaactgg
atgcggtacacgcagacagtcgacatctggtcggtgggctgcatcatggcggagatgatc
acgggaaaaacgctgttcaagggcagtgaccacctggaccagctgaaggagatcatgaag
gtgacgggcacccctccagaggagtttgtccagaggctgcagagtgcagaggccaagaac
tatatgaaggggctcccggagctggagaagaaggatttcgcttccatcctgacggacgcc
agcccgctggccgtgaacctcctggagaagatgctggtgctggatgccgagcagcgggtg
accgcggccgaggcgctcacgcacccctactttgagtccctgcatgacacggaggacgag
cccaaggcccagaagtatgatgagtcgtttgatgacgtggaccggaccctggaggagtgg
aagcgtgtcacctacaaagaggtgctcagctttaagcctccccggcacctgggagttaag
agttccaaggagacggccttgtga

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