Sorex fumeus (smoky shrew): 130022802 Help Entry 130022802         CDS       T10594                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism sfum  Sorex fumeus (smoky shrew) Pathway sfum04020   Calcium signaling pathway sfum04024   cAMP signaling pathway sfum04260   Cardiac muscle contraction sfum04261   Adrenergic signaling in cardiomyocytes sfum04371   Apelin signaling pathway sfum04713   Circadian entrainment sfum04911   Insulin secretion sfum04921   Oxytocin signaling pathway sfum04972   Pancreatic secretion sfum05020   Prion disease sfum05022   Pathways of neurodegeneration - multiple diseases sfum05410   Hypertrophic cardiomyopathy sfum05412   Arrhythmogenic right ventricular cardiomyopathy sfum05414   Dilated cardiomyopathy sfum05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:sfum00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     130022802 (RYR2)    04020 Calcium signaling pathway     130022802 (RYR2)    04024 cAMP signaling pathway     130022802 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     130022802 (RYR2)    04921 Oxytocin signaling pathway     130022802 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     130022802 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     130022802 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     130022802 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     130022802 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     130022802 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     130022802 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     130022802 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     130022802 (RYR2)    05414 Dilated cardiomyopathy     130022802 (RYR2)    05415 Diabetic cardiomyopathy     130022802 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:sfum04040]     130022802 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:sfum04990]     130022802 (RYR2) Ion channels [BR:sfum04040]  Voltage-gated cation channels   Ryanodine receptor    130022802 (RYR2) Domain-containing proteins not elsewhere classified [BR:sfum04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    130022802 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  130022802 NCBI-ProteinID:  XP_055969562 LinkDB All DBs Position Unknown AA seq 4970 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTMEKSEGAIDVEKWKFMMKTAQGSGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRSVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV TTGKYLSLLEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGTRKEVDGMGTSEIKYGDSV CYIQHVNTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPDEQLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYKKWYYELMVDHTQPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREY KQERTYTRDLLGPTMPLTQAAFTPVPVDTSQIVLPPHLERIRERLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEER VKKMKLPKNYQLTSGYKPAPMDLSFVKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSS TGERFRIFRAEKTYAVKTGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGSDDRAFAFDGF KAQRWNQGHEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFDVGDG FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPSNHEHIEVTRIDGTIDSSPCLKITQKSFGSQNSSTDIMFYRLSMPIECAEVFSKTGLP GAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKETTKPEFNNHKDYAQEKPSR LKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPANVWV GWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESFAIDSLCGFGIKRSNCYMVCAGES MSPGQGRNNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVF QFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISE RQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVA HALCSHVDEPQLLYAIENKYMPGLLRTGYYDLLIDIHLSSYATARLMMNNEFIVPMTEET KSITLFPDENKKHGLPGIGLSTSLRPRMQFSSPSFVSINNDCYQYSPEFPLDILKTKTIQ MLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKE AATAEEESESLEKDLGTEDSKQEGSVEEEARVGSGPKEGLLQMKLPEPVKLQMCLLLQYL CDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQI NMLLNFKDDKNECPCPEEIRDQLLEFHEDLMAHCGIELDEDGSLDGNSDLTIRGRLLSLV EKVTYLKKKQAEKPVESDSQKSSTLQQLISDTMVRWAQESVIEDPELVRAMFMLLHRQYD GIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNK VFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKA MFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCG LQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGP ALRGEGGNGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLDTEEEEDDTIHMGNAIMTFYA ALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLADLVGVISIAFQMPTIAKDGNVVE PDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMA LALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCL LSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAA SEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQS SMDSEGNFNPQPVDTSNIIIPEKLEYFINKYAEHSHDKWSMDKLATGWIYGEVFSDSSKV QPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQV SVDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVP YDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYV DEAHQYILEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCTG GHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESV KSALRAFLDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIG QHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAYLET HLNKHNIYSIYNTKTSRERAALNLPANVEDVCPNIPSLDKLMEEIVDLAESGIRYTQMPH VMEVILPMLCSYMSRWWEHGPENNLERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEG AWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAEL LILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVAEVFIYWSKSHNFK REEQNFVVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRL LPIGLNICAPGDQELIALAKMRFSMKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKD LPNRTEDTSDPEKTIERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRM APLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGVEPSEEEEGNRRVDPLH QLILLFSRTALTEKCKLDEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQRSKEK EMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKM LDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTC DLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDV IDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMK LSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFF DMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENET LDYEEFVKRFHEPAKDISFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIE IMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTI FEMQLAAQISESDLNERSTNKEESEKEKPEEQGPRMGFFSILTVKSALFALRYNIVTLMR MLSLKSLKKQMKKVKKMTMKDMVTAFFCSYWSIFLGLLHFVASVFRGFFRIICSLLLGGS LVEGAKKIKVAELLANMPDPTQDEVRGDGEEGERKPLEAPLPSEDLTDLKELTEESDLLS DIFGLDLRREGGQYKLIPHNPNAGLSDLMSNPVPIPEVQEKFQEQKVKEEEKEEKEEIKS EPEKAEGEDGEKEEKVKDDKGKQKLRQLHAHRYGESEVPESAFWKKIIAYQQKLLNYFAR NFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSLSENAKVSTVDSDSNRIIAV HYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYI TEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAAL DFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNF FFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSE DGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVI LLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLAN YLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14913 nt NT seq  +upstreamnt  +downstreamnt atggccgatgggggcgagggcgaggatgagatccagttcctgcgaactgatgatgaagtg gttttgcagtgtaccgcaaccatccacaaagaacaacagaaattatgcttggcagcagaa ggatttggcaacagactttgtttcttggagtccacttcaaattccaagaatgttccccca gacctttccatctgtacctttgtgttggaacagtctctctcagtccgggccctgcaggag atgctggctaacacaatggagaaatcagaaggggcaattgatgtggaaaaatggaaattc atgatgaagacggctcagggtagtggtcatcgaacactcctctatggacatgccatattg ctacgtcattcctacagtggcatgtatctatgctgtttgtccacttctcgatcttcaaca gataagttggcttttgatgttggcttgcaagaggatacaaccggggaggcttgttggtgg actattcatccagcttctaaacaacggtctgaaggagaaaaagtacgagttggagatgat ctcattttagtcagtgtatcctctgagagatacctgcacttgtcttatggcaatggcagt ttgcacgtggatgctgctttccagcagactctctggagtgtggccccaatcagctcagga agtgaagcagcccaagggtatctgattggtggtgatgttctcagattgctgcatggacac atggatgaatgcctcactgtcccttcaggagaacatggtgaagagcagcgaagaagtgtt cattatgaaggtggcgctgtatcagttcatgcccgttccctgtggagactagaaacacta agagttgcgtggagtggaagccacatacgatggggccaacctttccgactacgtcatgtc acaacaggaaaatacttgagtctcctagaagacaaaaatcttctactgatggacaaagaa aaagctgatgtgaagtcaacagcttttaccttccgatcatccaaggaaaaattggatgtc ggcacgagaaaagaagttgatggcatgggaacatcagaaataaaatatggagactcagtg tgctatatccaacatgtaaatacaggcctgtggcttacttaccagtctgtcgatgtgaaa tctgtgagaatgggatccatacaacgtaaggctattatgcatcatgaaggccatatggat gatggcttaaatttatctagatctcagcatgaagaatcacgaacagcacgcgtaatccgg agcacagttttccttttcaatagattcataaggggccttgatgcactcagcaaaaaagca aaggcctccacagtggacttaccaatagagtctgtcagtcttagtctgcaggacctgatt gggtacttccatcccccggatgagcagttagagcatgaagacaagcagaacagattgcga gctctaaagaatcgtcagaatctcttccaggaagagggcatgatcaacctggtgctggag tgcatagacagacttcatgtctatagcagcgcagcgcactttgctgatgtggctggcaga gaagcaggggaatcttggaaatcgattctcaattctctgtatgaattgctagcggctcta attagaggaaatcgtaaaaactgtgctcaattttctggctcccttgactggttgattagc cgattggaaagactggaagcttcttctggtattcttgaagttttacactgtgtattagta gaaagcccagaagctctaaatattattaaagaaggacatattaaatccattatttcactt ttagacaagcatggaagaaatcataaggttctagatgtgttgtgctctctctgcgtttgc catggagtagcagttcgttctaaccagcatctcatctgtgacaatctcctgccaggaaga gacctgttattgcagactcgccttgtgaatcacgtcagcagcatgagacccaatattttt ctgggcgtcagtgaaggttctgctcagtataagaaatggtactatgagttgatggtggac catacacagccatttgtgacagcagaagcaactcatctgcgagtgggctgggcttccact gaaggttattctccgtaccctggcggcggtgaagaatggggtggaaatggtgttggagat gatcttttttcatacggatttgatggtcttcatctttggtcaggttgtattgctcgtact gtaagttcaccaaaccagcatcttttaagaacggatgatgtcatcagctgctgtttagat ctaagtgcccctagtatttcatttcgaattaatggacagcccgttcaaggaatgtttgag aatttcaacattgatggcctcttctttccagtagtgagtttctctgcaggaataaaggta cgctttctacttggagggagacatggagaatttaaattccttcctccacctggttatgcg ccatgttatgaagctgttctgccaaaggaaaagttgaaagtggagcacagccgagagtac aagcaagaaagaacgtatacacgggacctcctgggccctacgatgcccttgacgcaagcc gccttcacgccagtccctgtggataccagccagatcgtgttgcctcctcaccttgagagg ataagagaaagactggcagagaatatccatgaactctgggttatgaataaaattgaactt ggctggcagtatggtccggttagagatgacaataagagacagcacccgtgtttggtggaa ttctccaagctgcctgaacaggaacgcaattacaatttacagatgtcccttgagaccctg aagaccttgctggcattaggatgccatgtgggtatatcagatgaacatgctgaagaaaga gtgaaaaaaatgaagctacccaagaattaccagctgacaagtggatacaagcctgcacca atggatcttagttttgtcaaactcactccatctcaggaagcaatggtggacaagttggca gaaaatgctcataatgtatgggcccgggatcgaatacggcagggctggacttatggcatc caacaggatgtaaagaacagaagaaaccctcgtctcgttccctatacccttctggatgac agaacaaagaaatcaaataaggacagcctccgggaggctgtgcggacactgctggggtac ggatacaacctggaggctccagatcaagatcatgctgccagagcggaagtgtgtagcagt actggggaacggttccgaatcttccgtgctgagaaaacttatgctgtgaagactggaagg tggtattttgaatttgaggctgtcactgcaggggacatgagagttggctggagcagacca ggttgtcagcctgaccaggagctggggtcagatgatcgtgcctttgcttttgatggtttc aaggcccagcggtggaaccagggccatgaacactatgggcgctcctggcaagcaggtgac gttgtgggatgtatggtggacatgacagagcatacgatgatgttcacactgaatggagaa atccttcttgatgattcaggttcagaactggctttcaaggactttgatgttggtgatgga tttatacctgtatgtagccttggagtggctcaagttggaaggatgaactttgggaaggat gtcagcacactgaaatattttaccatctgtggtttgcaagagggttatgaaccatttgct gttaatacgaacagggatattaccatgtggctaagcaagaggcttcctcagtttctccag gttccatcaaaccatgaacatattgaggtgaccagaatagatggtaccatagacagttct ccatgtttaaagatcacccagaagtccttcggttctcagaacagcagcactgacatcatg ttttatcgtctgagcatgccaatcgaatgtgcagaggtcttctccaagacgggactcccg ggggcaggtctctttggacccaagaatgatttggaggattatgatgcagattctgacttt gaggttctaatgaagacagcacatggccatttagtgcctgatcgagttgacaaagataaa gaaactacaaaaccagagttcaataaccacaaggattatgctcaggaaaagccctctcgc ctgaaacaaagatttttacttagaagaacaaaacctgattacagcacaagccattctgca agacttactgaagatgtccttgcagatgatcgggatgactatgattacctgatgcaaacg tccacatactattattcagtgagaatctttcctggtcaagagcctgctaatgtatgggta ggctggattacatcagatttccatcagtacgatacaggctttgacttggacagagttcgt acagtaactgttactctaggagatgagaaaggaaaagtgcatgaaagctttgccattgac tcgctgtgtggctttggcatcaaacgcagcaactgctacatggtgtgcgcaggcgagagc atgagccctgggcaaggacggaacaataatggtctggagattggttgtgtggtggatgca gccagcgggctgctcacgtttactgccaatggcaaggaactgagcacatactatcaggtt gaaccaagtacaaaattatttcctgcagtttttgcacaagctaccagtcctaatgttttt cagtttgagttgggaagaataaagaatgtgatgccactttctgcggggttgttcaagagt gaacacaaaaacccagtgccacagtgccccccacgtcttcatgtgcaatttttatcacac gtcttgtggagcagaatgccaaatcagttcttgaaggtggatgtctctcggatcagcgag cgtcaaggctggttggtgcagtgtttggatcccttgcaattcatgtctcttcacatccca gaggagaacaggtctgttgacatattagaattgacagagcaggaagaactgctgaaattc cactatcacactctccgactctattcagctgtctgtgcccttgggaaccaccgggttgcc catgccttgtgcagccatgtagacgaacctcagctcctctatgccatcgagaacaagtac atgcctggtttgctgcggaccggctactatgaccttctgattgacatccaccttagctcc tatgccactgccaggctcatgatgaacaatgaatttattgtccccatgacagaggagaca aagagcatcaccttgttccccgatgagaacaaaaagcatggcctccccgggattggctta agcacctccctgcgacctcgaatgcagttttcctcccccagctttgtaagcattaataat gattgttaccaatacagtccagagttccccctggacatcctaaaaaccaaaactatacag atgctcacagaagctgttaaagagggaagtcttcatgcccgggaccccgtaggaggaacc acggaatttctctttgtacccctcatcaaactgttctatacattgctcatcatgggcatc tttcacaatgaggatttgaagcacatcctacagctgattgagcctagtgtgttcaaggaa gctgccactgcagaggaggagagcgaaagtttggagaaagatctgggcactgaagactca aagcaggaaggatctgtggaagaagaagctagagtgggcagtggacccaaggagggcctg ctccaaatgaagctgccagagccagttaaattgcagatgtgtctgctgcttcaatacctc tgtgactgccaagtccggcaccgaatagaagccattgtggctttttcagatgactttgta gcaaagcttcaagataatcagcgattccggtataatgaagttatgcaagcgttaaatatg tcagctgcattgacagccaggaaaacaaaagaatttaggtcaccacctcaagaacagatc aatatgcttctcaattttaaggatgacaaaaatgaatgtccatgtcctgaagaaattcga gaccagctcttggaatttcatgaagatttgatggcccattgcgggattgagctggatgaa gatgggtctctggatggaaacagtgatttaacaattagaggacgcctgctgtccctggta gaaaaggtgacatacctgaagaagaaacaagctgaaaaaccagttgagagtgactcccag aagtcctcaactctacaacagttgatatcagacacgatggtccgatgggctcaagagtct gtcattgaagaccctgagttggtgagggccatgtttatgttgctccatcgacaatatgat ggcatcgggggtctggttcgggctctgccaaagacctacactataaatggtgtttcagtg gaagataccatcaacctgctggcatctcttggacaaatccgttctttgttgagtgtgaga atgggcaaagaagaagagaaacttatgattcgtggattaggggatatcatgaataacaaa gtattttatcaacaccctaatctcatgagggctcttggtatgcatgagacagtgatggag gtcatggtgaatgttttgggaggtggagagtccaaggaaataacttttcctaagatggtg gccaactgttgtcgttttctctgttacttctgtcgtataagtaggcagaatcaaaaagct atgtttgatcatctcagttatttattggaaaacagcagtgttggtcttgcctcgccagct atgaggggttctacaccacttgatgtggcagctgcgtcagtgatggataataatgaattg gccttagctttacgagaaccagatctagaaaaggtagttcgatatttggctggttgcggg ctccagagttgtcagatgctggtgtctaagggatatcctgacattgggtggaatccagtt gaaggagagcgatatcttgattttctcagatttgctgtcttctgtaatggggagagtgtg gaggagaacgcaaatgtggtagtgagactgctcatcaggaggccggaatgctttggccct gcgctgagaggagaaggtgggaatggtcttcttgcagccatggaagaggccataaaaata gctgaggatccctctcgagatggtccgtcaccaactagcggatccagtaaaacacttgat acagaagaagaggaagatgatactatccacatggggaatgccatcatgaccttttatgca gctttgattgaccttttaggtcgttgtgctcctgaaatgcatttgattcatgctgggaaa ggagaggccatcagaattaggtctattctgagatccttaattccattggcagatttggtg ggagtgatcagcatcgcttttcagatgccaacaatagccaaagatggcaatgtggtggag cctgacatgtctgcagggttttgcccagatcacaaggcagccatggttttgttccttgac agggtctatggaattgaagttcaagatttcctcctccatctccttgaagttggctttctg ccagatctccgtgctgctgcttctcttgatacagctgctttgagtgctacagatatggct ttggctctcaatagatacctctgtacagccgtgctgcctttgttaacaagatgtgctcct ctttttgctggcacagagcaccatgcttccctcattgattcattgcttcatactgtctat agactttctaagggctgctcacttaccaaagctcaacgagattccatagaagtttgctta ctctctatctgtggccaattgagaccttccatgatgcaacacttactcagaagattagta tttgatgtcccattattaaacgaacatgcaaagatgcctcttaagctgctgaccaatcat tatgaaagatgctggaaatattactgcttacctggaggatggggaaattttggagcagca tcagaagaagaacttcacttatcaagaaaactgttctggggaatttttgatgccctgtct caaaagaaatatgaacaagaacttttcaaactggcactaccttgcctgagtgcagttgcg ggagctttgcctccagactacatggagtcaaactatgtcagtatgatggaaaaacagtca tcaatggattctgaagggaactttaacccacaacctgttgatacctcaaatattataatt cccgagaagttggaatacttcattaacaaatatgcagaacattcccatgacaagtggtca atggacaagttggctactggatggatttatggggaagtattttcagactcatctaaagtt caaccattaatgaagccatataaactattatctgaaaaagaaaaagaaatttatcgttgg ccaatcaaagaatctttaaaaacaatgctggcttggggttggagaattgaaagaactcgg gagggagacagtatggccctctataatcggactcgacgtatttcccagacaagccaggtg tcagtagatgctgcacatgggtatagccctcgagccattgatatgagtaacgtcacacta tccagagatcttcatgctatggcagaaatgatggctgaaaactatcataacatttgggca aagaaaaagaaaatggaactggaatccaaagggggtggaaatcatccactgctggtaccc tatgatacactgacagccaaagagaaagccaaagacagagaaaaagcacaggacatcctc aaattcttacagataaatggatatgctgtctccagaggattcaaggacttggagctggac acaccttctattgagaaacgatttgcctatagttttcttcagcagctcattcgctatgtg gatgaagcccatcagtacatccttgagtttgatggtggcagcagaagcaaaggagagcat ttcccttatgagcaagaaatcaagttctttgctaaagttgttcttcctttaattgatcaa tatttcaaaaaccatcgtttatacttcttatctgcagcaagcaggcctctctgtactgga ggacatgcatcaaacaaagagaaagaaatggtgactagcctattctgcaaacttggagtt cttgtcaggcataggatttcactatttggaaatgatgcaacatcaatcgtcaactgtctt cacattttgggtcagactttagatgcaagaactgtgatgaagactggcctagagagtgtc aaaagtgcactgagagcttttctggacaatgctgcagaggatctggagaaaacaatggag aatcttaagcaaggccagttcacccacacgcgaaaccaacccaaaggagttactcagatt atcaattataccaccgtggcattgctgccaatgttgtcatcattatttgaacatattggc cagcatcagttcggagaagatctaatattggaagatgtccaggtatcatgttatagaatt ttaactagcttatatgctttggggaccagcaagagtatttatgtagaaagacaacgttct gctttaggagaatgtctggctgcatttgctggtgcctttcctgtagcatatttggaaact cacctcaacaagcataatatttactcgatctataatactaagacttcacgggagagagca gctctcaatttgccagcgaatgtggaagatgtttgtccaaatataccgtctttagataaa ctgatggaagaaattgtggacttggcagaatctggcattcgctacactcaaatgccacat gtaatggaagtgatactacccatgttgtgtagctacatgtctcgttggtgggagcatgga cctgagaacaatctggaaagggcagaaatgtgctgtaccgctttgaactcagagcacatg aacacacttctggggaatatattgaaaatcatatataataacttgggtattgatgaggga gcctggatgaagaggttagcagtattttcccagcctattataaataaagtgaaacctcag ctcttgaaaactcatttcttgccattaatggaaaaactcaagaaaaaggcagcgatggtg gtatctgaagaagaccatctgaaagccgaggccagaggggatatgtcggaggcagaactt cttattctagatgagtttaccacactggccagagatctctatgccttctaccctctctta attagatttgtggactacaacagggcaaaatggctaaaggagccaaacccagaagcagaa gatctttttcggatggtagcagaagtatttatctactggtccaaatcccataatttcaag agggaagagcagaacttcgtggtacagaatgaaatcaataatatgtctttcctcattact gacaccaagtcaaaaatgtcaaaggcagctgtttctgatcaggaaaggaagaaaatgaag cgcaaaggagatcgctattccatgcagacctctcttattgtagcagctttgaagcgcttg ttgcccattggattaaacatttgtgccccaggagatcaggagctcattgctcttgccaaa atgcgatttagtatgaaagacactgaggatgaagtacgagatataatccgcagcaacatt cacttacaaggcaagttggaagatcctgctattagatggcaaatggctctttacaaagat ttaccaaacagaaccgaagatacttcagatcctgaaaagacaatagagagagtattggat atagcaaatgtgctttttcatcttgaacaggtggaacatcctcagagatctaaaaaggca gtctggcacaaactgctctctaagcagaggaaaagggcagtggtcgcctgcttccgaatg gctcctttatataacctgccaaggcatcgagctgtcaatctctttcttcagggatatgaa aagtcttggattgaaacagaagaacattactttgaagataaactgatagaagatttagcg aaacctggagtggagccttctgaagaagaggaaggcaacagaagagttgatcctcttcat cagctgatccttctgttcagtcgaacagctttaacggagaaatgcaaactggacgaagat tttttatatatggcctatgcagatattatggcaaagagttgtcatgatgaggaagatgat gatggtgaagaggaagtgaagagttttgaagtcacaggatcccaacgcagcaaggaaaaa gaaatggaaaagcaaaagctactctaccagcaagccaggctccatgatcgcggtgctgct gagatggtgttgcagaccataagcgccagcaaaggtgaaactggaccaatggtagctgct actttgaaacttggaattgctatcttaaatggggggaactctacggtgcaacagaaaatg cttgactacctcaaggagaaaaaggatgtgggcttctttcagagtttggctggcctgatg cagtcatgtagcgtccttgacttaaatgcatttgaacggcaaaacaaagctgaaggactg ggaatggtgacagaagaaggatcaggagaaaaggttctacaggatgatgagttcacctgt gacctcttccgcttcctacagctgctttgtgagggacacaattcagattttcaaaattat ctgagaactcagactggcaataatacaactgtcaacattattatttctactgtagactac ctgctaagagttcaggaatccattagtgatttctattggtattattctggaaaagatgtt attgatgaacaaggacaacggaatttctctaaagcaatacaagtggcaaagcaagtcttt aatactctcacagagtatattcagggcccttgcactgggaatcaacagagcttggcacac agtcggctatgggatgcggtggtgggatttcttcatgtttttgctcacatgcaaatgaag ctgtctcaggactccagtcaaattgaactcttaaaagagttaatggatctccagaaggat atggtggtcatgttgttatccatgttagaaggtaatgttgtaaatggaaccattggcaaa cagatggttgatatgcttgtggaatcttccaacaacgtggaaatgattctcaaatttttc gacatgttcctaaagctgaaggatttgacttcttctgatacatttaaagaatatgaccct gacggcaagggagttatttccaagagggacttccataaagccatggagagccacaagcac tacacacaatcagaaaccgagtttctcctgtcctgcgcagagacagatgaaaatgaaact ctggactatgaagaatttgtcaagcgcttccatgaacccgccaaggacatcagcttcaat gtggctgtccttctgacaaatctttccgaacacatgcccaatgatacccgcctccagacc tttctcgaattagcagaaagtgtgctgaattacttccagcccttccttggccgaattgag atcatgggcagtgccaaacgcattgagagggtttactttgaaatcagtgaatccagccga actcagtgggagaagccgcaggtcaaggagtccaagagacagttcatatttgatgtggtt aatgaagggggagagaaagagaagatggaactttttgtgaacttctgtgaggataccata ttcgagatgcagctggcggctcagatctctgaatcggatttgaatgagaggtccaccaac aaagaagagagtgagaaggagaagccagaggagcaggggccgaggatgggtttcttttcc attctgactgtcaagtcagccttgtttgcactcaggtataatatcgtgactcttatgcgc atgctcagtctaaagagcctaaagaaacagatgaaaaaagtgaagaagatgaccatgaag gacatggtcacagccttcttttgctcctattggagtatttttctgggtctcttgcacttt gtggccagcgtgttcagaggctttttccgtattatctgcagcctgctactgggaggaagc ctagtagaaggtgctaaaaagatcaaagttgctgagctcttggccaacatgccagacccc actcaggatgaggtacgaggagatggagaggagggtgagaggaaacccttggaggcccct ttgccctctgaagatctaacagacctaaaggagctgacagaggaaagtgaccttctctcc gacatatttggtttggatctgaggcgagaaggaggacagtacaaattgattcctcacaat ccaaatgctggtctcagtgacctcatgagcaacccagtccccatcccagaggtgcaagaa aaatttcaggaacagaaggtaaaagaagaagaaaaggaagaaaaagaagaaataaaatct gaaccagaaaaggctgaaggagaagatggagaaaaggaagaaaaagtcaaagatgacaag ggtaaacaaaaattaaggcagctccatgcacacagatatggcgaatcagaggttcctgag tcagcattctggaagaaaattatagcctaccaacagaaacttctaaactattttgctcgc aacttttacaacatgagaatgttagccttatttgtcgcatttgcgatcaatttcatcttg cttttttataaggtttccacttcttctgtggttgaaggaaaagaactccccactcgtagt ttaagtgaaaatgccaaagtcagcaccgtggacagcgattcaaatagaatcattgccgtt cattatgtcctggaggagagcagtggctacatggagccgacgttgcgtatcctcgctatt ctccacactgtcatttctttcttctgcatcattggatactactgcttgaaagtcccctta gttatttttaagcgagaaaaggaagtagcacggaaattggaatttgatggactttatatt acagaacagccctcggaagatgatattaaaggccagtgggatagacttgtgatcaacaca cagtcttttcccaacaactactgggacaaatttgttaaaagaaaggttatggataagtat ggagaattctatggccgagatagaatcagtgaattacttggtatggataaagctgctctg gatttcagtgatgcccgagaaaagaagaagccaaagaaagacagctccctgtcagccgta ctgaattctattgatgtgaagtatcagatgtggaaactcggagttgtttttactgacaat tccttcctctacttagcctggtacatgactatgtccgttcttggacactataacaacttt tttttcgctgctcatcttcttgacatagctatgggattcaagaccttaagaactatcttg tcatcagtaactcacaatggcaaacagcttgtattaactgtcggtttattagctgttgtt gtatacctctatactgttgtggcatttaactttttccgaaaattctacaacaaaagcgaa gatggtgatacaccagatatgaaatgtgatgatatgctaacatgttatatgttccacatg tatgttggagtacgtgctggaggaggtattggtgatgaaattgaagacccagctggtgat gagtatgagatttatagaatcatctttgacatcaccttcttcttctttgtaattgtcatt cttttggccataatacaaggtttaattattgatgcttttggagaattacgagaccaacag gaacaagtcaaagaagacatggagaccaagtgcttcatctgtgggataggcaatgattac tttgacacagtacctcatggctttgaaacccacactttacaggagcacaacttggccaat tacctgttttttctgatgtaccttataaataaagatgaaacagaacacacaggacaggaa tcttatgtctggaaaatgtatcaagaacggtgttgggaatttttcccagcaggggattgc ttcaggaagcagtacgaagaccagctaaattag

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