Sorex fumeus (smoky shrew): 130032457
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Entry
130032457 CDS
T10594
Symbol
BRAF
Name
(RefSeq) serine/threonine-protein kinase B-raf isoform X1
KO
K04365
B-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
sfum Sorex fumeus (smoky shrew)
Pathway
sfum01521
EGFR tyrosine kinase inhibitor resistance
sfum01522
Endocrine resistance
sfum04010
MAPK signaling pathway
sfum04012
ErbB signaling pathway
sfum04015
Rap1 signaling pathway
sfum04024
cAMP signaling pathway
sfum04062
Chemokine signaling pathway
sfum04068
FoxO signaling pathway
sfum04150
mTOR signaling pathway
sfum04270
Vascular smooth muscle contraction
sfum04510
Focal adhesion
sfum04650
Natural killer cell mediated cytotoxicity
sfum04720
Long-term potentiation
sfum04722
Neurotrophin signaling pathway
sfum04726
Serotonergic synapse
sfum04730
Long-term depression
sfum04810
Regulation of actin cytoskeleton
sfum04910
Insulin signaling pathway
sfum04914
Progesterone-mediated oocyte maturation
sfum04928
Parathyroid hormone synthesis, secretion and action
sfum04934
Cushing syndrome
sfum05010
Alzheimer disease
sfum05022
Pathways of neurodegeneration - multiple diseases
sfum05034
Alcoholism
sfum05160
Hepatitis C
sfum05161
Hepatitis B
sfum05200
Pathways in cancer
sfum05205
Proteoglycans in cancer
sfum05208
Chemical carcinogenesis - reactive oxygen species
sfum05210
Colorectal cancer
sfum05211
Renal cell carcinoma
sfum05212
Pancreatic cancer
sfum05213
Endometrial cancer
sfum05214
Glioma
sfum05215
Prostate cancer
sfum05216
Thyroid cancer
sfum05218
Melanoma
sfum05219
Bladder cancer
sfum05220
Chronic myeloid leukemia
sfum05221
Acute myeloid leukemia
sfum05223
Non-small cell lung cancer
sfum05224
Breast cancer
sfum05225
Hepatocellular carcinoma
sfum05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
sfum00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
130032457 (BRAF)
04012 ErbB signaling pathway
130032457 (BRAF)
04015 Rap1 signaling pathway
130032457 (BRAF)
04068 FoxO signaling pathway
130032457 (BRAF)
04024 cAMP signaling pathway
130032457 (BRAF)
04150 mTOR signaling pathway
130032457 (BRAF)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
130032457 (BRAF)
09142 Cell motility
04810 Regulation of actin cytoskeleton
130032457 (BRAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
130032457 (BRAF)
04062 Chemokine signaling pathway
130032457 (BRAF)
09152 Endocrine system
04910 Insulin signaling pathway
130032457 (BRAF)
04914 Progesterone-mediated oocyte maturation
130032457 (BRAF)
04928 Parathyroid hormone synthesis, secretion and action
130032457 (BRAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
130032457 (BRAF)
09156 Nervous system
04726 Serotonergic synapse
130032457 (BRAF)
04720 Long-term potentiation
130032457 (BRAF)
04730 Long-term depression
130032457 (BRAF)
04722 Neurotrophin signaling pathway
130032457 (BRAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
130032457 (BRAF)
05205 Proteoglycans in cancer
130032457 (BRAF)
05208 Chemical carcinogenesis - reactive oxygen species
130032457 (BRAF)
09162 Cancer: specific types
05210 Colorectal cancer
130032457 (BRAF)
05212 Pancreatic cancer
130032457 (BRAF)
05225 Hepatocellular carcinoma
130032457 (BRAF)
05226 Gastric cancer
130032457 (BRAF)
05214 Glioma
130032457 (BRAF)
05216 Thyroid cancer
130032457 (BRAF)
05221 Acute myeloid leukemia
130032457 (BRAF)
05220 Chronic myeloid leukemia
130032457 (BRAF)
05218 Melanoma
130032457 (BRAF)
05211 Renal cell carcinoma
130032457 (BRAF)
05219 Bladder cancer
130032457 (BRAF)
05215 Prostate cancer
130032457 (BRAF)
05213 Endometrial cancer
130032457 (BRAF)
05224 Breast cancer
130032457 (BRAF)
05223 Non-small cell lung cancer
130032457 (BRAF)
09172 Infectious disease: viral
05161 Hepatitis B
130032457 (BRAF)
05160 Hepatitis C
130032457 (BRAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
130032457 (BRAF)
05022 Pathways of neurodegeneration - multiple diseases
130032457 (BRAF)
09165 Substance dependence
05034 Alcoholism
130032457 (BRAF)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
130032457 (BRAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
130032457 (BRAF)
01522 Endocrine resistance
130032457 (BRAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
sfum01001
]
130032457 (BRAF)
Enzymes [BR:
sfum01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
130032457 (BRAF)
Protein kinases [BR:
sfum01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
130032457 (BRAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
ABC1
C1_2
Pkinase_fungal
Kdo
Motif
Other DBs
NCBI-GeneID:
130032457
NCBI-ProteinID:
XP_055979989
LinkDB
All DBs
Position
Unknown
AA seq
755 aa
AA seq
DB search
MIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVS
SSASTDTVTSSSSSSLSVLPSSLSVFQNPTDVSRSNPKSPQKPIVRVFLPNKQRTVVPAR
CGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPL
TTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVS
KFFEHHPISQEEASLAETALTSGPSPSAPPSDALGPQILTSPSPSKSIPIPQPFRPADED
HRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRSDGAPLNQLMRCLRKYQSRTPSP
LLHSVPSEIVFDFEPGPVFRGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSS
EDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVFKGKWHGDVAVKMLNVTAPTP
QQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIK
LIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQ
LSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRG
YLSPDLSKVRSNCPKAMKRLMAECLKKKREERPLFPQILASIELLARSLPKIHRSASEPS
LNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
NT seq
2268 nt
NT seq
+upstream
nt +downstream
nt
atgattaagttgacacaggaacatatagaggccctattggacaaatttggtggggaacat
aatccaccatcgatctatctggaggcctacgaagaatacaccagcaagctagatgccctc
caacaaagagaacaacagttgttggaatccctggggaatggaactgatttttctgtttct
agttcagcatcaacagatactgttacatcttcttcctcctctagcctttcagtgctacct
tcatctctttcagtttttcaaaatcccacagatgtgtcccggagcaaccccaagtcacca
cagaaacctattgttagagtcttcctgcccaacaaacagaggacagtggtaccagcaagg
tgtggagtgacagtccgggacagtctaaagaaagcactaatgatgagaggtctgattcca
gagtgctgtgctgtttacagaattcaggatggagagaagaaaccaattggctgggataca
gatatttcctggcttactggagaagaattacatgtagaagtattggaaaacgttccactt
acaacacacaactttgtacggaaaacttttttcaccttagcattttgtgacttttgtcga
aagctgcttttccagggtttccgctgtcaaacatgtggttataaatttcaccagcgttgt
agtacagaggtgccactgatgtgtgttaattatgaccaacttgatttgctgtttgtctcc
aagttctttgaacaccacccaatatcacaggaggaggcctccttagcagagaccgccctt
acgtcgggaccctccccgtccgcgcccccctccgatgctctggggccccaaattctcacc
agtccatctccttcaaaatccattccaatcccacagcctttccgaccagcagatgaagat
catcggaaccagtttggacagcgagaccggtcctcgtcagctccaaatgtgcacatcaac
acaatcgagcctgtcaatatcgatgacttgattagagaccaagggtttcgtagtgatgga
gcccctttgaaccagctgatgcgctgtcttcggaaataccaatcccggactcccagcccc
ctcctccattctgtccccagtgaaatagtgtttgattttgagcctggcccagtgttcaga
ggatcgacgacaggattgtcagccaccccccctgcctccttacctggctcgctcactaat
gtgaaagctttgcagaaatctccaggacctcagcgggagaggaaatcatcctcatcctcg
gaagacaggaatcgaatgaaaacacttggaaggagggattcaagtgatgattgggagatt
cctgatgggcagatcactgtgggacaaagaattggatcgggatcatttgggactgtcttc
aagggaaagtggcatggtgacgtggcagtgaagatgttaaatgtgacagcacccacacct
cagcagttacaggccttcaaaaacgaagtaggagtactcaggaaaactcgccatgtgaat
atcctcctcttcatgggctactccaccaagccgcagctggccatcgtcacccagtggtgc
gagggctccagcttgtaccaccacctccacatcattgagaccaaatttgagatgatcaag
ctcatagatatcgccaggcagaccgcacaaggcatggattatttacacgccaagtcaatc
atccacagagacctcaagagtaataatatttttcttcatgaagacctcacagtgaaaata
ggtgattttggcctcgccacagtgaaatctcggtggagtggctcccatcagtttgaacag
ttatctggatccattttgtggatggcaccagaagtgatcagaatgcaagataaaaaccca
tatagttttcagtcagatgtatatgcttttggaattgttctgtatgaactgatgactggg
cagttaccttactcaaacatcaacaacagagatcagatcatctttatggtgggtcgaggc
tatctgtcgccagatctcagtaaggtacggagtaactgtccgaaagccatgaagaggttg
atggccgagtgcctgaagaagaagagagaggagaggccactcttcccccagattctcgcc
tctatcgagctgctggcccgctcattgccaaaaattcaccgcagtgcatcagaaccctcc
ttgaatcgggctggcttccagacggaggatttcagtctctatgcttgtgcttctccaaaa
acacccatccaggcagggggatatggagaatttgcagccttcaagtag
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