Sorex fumeus (smoky shrew): 130035609 Help Entry 130035609         CDS       T10594                                  Symbol TOP2A Name (RefSeq) DNA topoisomerase 2-alpha   KO K03164   DNA topoisomerase II [EC:5.6.2.2] Organism sfum  Sorex fumeus (smoky shrew) Pathway sfum01524   Platinum drug resistance Brite KEGG Orthology (KO) [BR:sfum00001]  09160 Human Diseases   09176 Drug resistance: antineoplastic    01524 Platinum drug resistance     130035609 (TOP2A)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03032 DNA replication proteins [BR:sfum03032]     130035609 (TOP2A)    03036 Chromosome and associated proteins [BR:sfum03036]     130035609 (TOP2A) Enzymes [BR:sfum01000]  5. Isomerases   5.6  Isomerases altering macromolecular conformation    5.6.2  Enzymes altering nucleic acid conformation     5.6.2.2  DNA topoisomerase (ATP-hydrolysing)      130035609 (TOP2A) DNA replication proteins [BR:sfum03032]  Eukaryotic type   DNA Topoisomerases    130035609 (TOP2A) Chromosome and associated proteins [BR:sfum03036]  Eukaryotic type   Chromosome condensation proteins    Other regulators of chromosome condensation     130035609 (TOP2A)   Centrosome formation proteins    Centriole proteins     130035609 (TOP2A) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  DNA_topoisoIV TOPRIM_C DNA_gyraseB DTHCT HATPase_c Toprim Motif Other DBs NCBI-GeneID:  130035609 NCBI-ProteinID:  XP_055983373 LinkDB All DBs Position Unknown AA seq 1537 aa AA seqDB search MEVSPLQPVDENMQISKTKKNDDAKKRLSIERIYQKKTQLEHILLRPDTYIGSVELVTQQ MWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE TASREYKKMFKQTWMNNMGKAGDMELKPFSGEDYTCITFQPDLSKFKMQSLDKDIVALMV RRAYDIAGSTKDVKVFLNGNKLPIKGFRSYVEMYLKDKVDETGNPLKVIHEQVNHRWEVC LTMSEKGFQQISFVNSIATSKGGRHVDYIADQIVTKLIEVVKKKNKGGIAVKTHQVKNHM WIFVNSLIENPTFDSQTKENMTLQVKNFGSTCQLSEKFIKAATGCGIVESILNWVKFKAQ VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTDCTLILTEGDSAKTLAVSGLGVVGRDK YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKSLRYGKIMIMT DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEISFYSLPEFEEWKS SNPNHRKWKVKYYKGLGTSTSKEAKEYFSDMKRHRIQFKYSGPEDDAAISLAFSKKQTDD RKEWLTHFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD GLKPGQRKVLFTCLKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPNDDHTLRFLYDDNQRVEPEW YIPIIPMVLINGAEGIGTGWSCKIPNFDVREVVNNIRRLMDGEEPLPMVPGYKNFKGTIE ELAPNQYVISGEVAILNSTTIEITELPIRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY HTDTTVKFVVKMTEEKLAQAERAGLHKVFKLQSSLTCNSMVLFDHVGCLKKYDTVLDILR DFYELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR GYDSDPVKAWKEAQQKVPDEEENEESDNEKESDKSDSVTDSGPTFNYLLDMPLWYLTKEK KDELCKLRKEKEEELEILKRKSPTDLWREDLAAFVEELEVLEAKEKKDEQVGLPVKGGKA KGKKPQMTEVLPSPSGKRVIPVVTVEMKAEAERKNKRKVKNENTEGSPQENGEVEGLKKR LEKRLKKEKEPGAKTMKQTTLSFKPVKKGKKRNPWSDSESDMSSDENDFDVPPREIELRK APTKIKTMVDLDSDNDFSDFDEKNQDEDDGDFVPSDDSLPTTKTSQKQTNKEQKPPKSAM SVMDLDADDVKNDVPVSPSPLAADLTAKTETTEPISKKKVTVKKTAAKSQSSTTTAGTKK RGAPKITKKDSGLNSETSKKPDPTKTKIRRKRKPSSSDDSDSNFEEKVSKAAANKKSKGE TNDFHQDLDSALAPRAKSGRAKKPIKYLEESDDDDLF NT seq 4614 nt NT seq  +upstreamnt  +downstreamnt atggaggtgtcacccctgcagcctgtggatgaaaatatgcagatcagcaagaccaagaaa aatgacgatgccaagaaaagattgtccattgaaagaatctatcaaaagaaaacgcaactg gagcatattttgctccggccagacacgtacattggctccgtggagctcgtgacccagcaa atgtgggtttacgatgaagacgttggcatcaactacagggaagtcacttttgttcctggc ttgtacaaaatctttgatgagattctagttaatgctgcagacaacaagcaaagggaccca aaaatgtcttgcattagagtcacaattgacccagaaaacaatttaattagtatatggaat aatggaaaaggtattcctgttgttgaacacaaagttgagaagatgtatgtcccagctctc atcttcggacagctcctaacttctagcaactatgacgatgatgagaagaaagtaacaggt ggccgaaatggctatggagccaagctgtgtaatattttcagtaccaaatttactgtggaa acagccagtagagagtacaagaaaatgttcaaacagacatggatgaataacatggggaaa gctggtgacatggaactcaagccctttagtggagaagattatacatgtattacttttcag cctgatttgtctaagtttaaaatgcaaagcctagacaaagatattgttgcactgatggtt agaagagcatacgatattgctggatccactaaagatgtcaaagtctttctcaatggaaat aagctaccaataaaaggattccgtagctatgtggaaatgtatttgaaggataaggtagat gaaactggcaatccattgaaagttattcacgaacaagtaaatcaccggtgggaagtgtgc ttaacaatgagtgaaaaaggctttcagcaaattagcttcgtcaatagcattgctacttcc aagggtggcagacatgtagactatatagctgatcagattgtgactaaactcattgaagtt gtcaagaagaaaaacaaaggtggtattgcagtaaaaacacatcaggtgaaaaatcacatg tggatttttgtgaattctttaattgaaaatccaacctttgactctcagacaaaagaaaac atgactttacaagtcaagaattttggatcaacatgccaactaagtgaaaaattcatcaaa gctgcaactggctgtggtattgtagaaagcatattaaactgggttaagtttaaggcccag gtccagttaaacaagaagtgttcagctgtaaaacataacagaatcaaaggaattcctaaa ctcgatgatgccaatgatgcagggggtcgaaactccactgactgtacactgatcctgact gaaggagactcggccaaaactttggctgtttcagggcttggtgtggttggaagagacaaa tatggggttttcccacttagaggaaaaatactcaatgttcgagaagcctctcataagcag atcatggaaaatgctgaaattaacaatatcatcaagattgtgggtcttcagtacaagaaa aactatgaagatgaagattcattaaaatctcttcgttatggaaagataatgatcatgaca gatcaggatcaagacggttcccacattaaaggcttattgattaattttatccatcacaat tggccctctcttctacgtcatcgttttctggaagaatttatcacacccattgtaaaggtg tctaaaaacaagcaagaaatatcattttatagcctccctgaatttgaagaatggaaaagt tctaatccaaatcatagaaaatggaaagtcaagtattacaaaggtttgggcaccagtaca tcaaaagaagctaaagaatatttctcagatatgaaaagacatcgcatccaattcaaatat tctggacctgaagatgatgctgccatcagcctggcctttagcaaaaaacaaacagatgat cggaaggaatggttaactcatttcatggaagatagaaggcagcgaaagttacttggtctt cctgaggattacttgtatggacaaactaccacatatctgacatataatgacttcataaac aaggaacttattcttttttcaaattctgataatgagagatctattccatctatggtagat ggtttgaaaccagggcagagaaaggttttgtttacttgtttgaaacgaaatgacaaacga gaggtgaaagttgcccagcttgctgggtcagtggctgagatgtcctcctatcaccatggt gagatgtcactgatgatgaccattatcaacttggcccaaaattttgtggggagcaataat ttaaacctcttgcaacccattggtcagtttggtactaggctacatggtggcaaggattct gctagtcctcgatacatcttcacaatgctcagccctttggctaggttgttattcccacca aacgatgatcataccttaaggttcttatatgatgacaaccaacgtgttgagcctgaatgg tacattcctattatccccatggtgctgataaatggtgctgaaggaattggtacagggtgg tcctgcaaaatccctaattttgatgttcgtgaagttgtaaataacatcaggcgtttgatg gatggagaagaacctttaccaatggttccaggttacaagaacttcaagggaacaatcgaa gagctggctccaaatcagtatgtgattagtggtgaagtggcgattcttaattccacaacc attgaaatcacagagcttcccatcagaacatggacccagacatataaggaacaagttctt gagcccatgttgaatggtactgagaagactcccccgctcatcacagactatcgagaatac cacacagataccaccgtgaagtttgttgtgaagatgacagaagaaaaactggcacaagca gagagagctggacttcacaaagtcttcaaactccaatctagtctcacatgcaactctatg gtgctttttgaccatgtaggctgcttaaagaaatatgataccgtattagatattctaaga gacttctatgaactcaggcttaaatattatggactgagaaaagaatggcttctgggaatg cttggtgctgaatctgctaaactgaataatcaggctcgctttatcttagagaaaatcgat ggcaaaataatcattgaaaataaacctaagaaagaattaattaaggttttgatccagagg ggatatgactcagatcctgtgaaggcttggaaagaagcccagcaaaaggttccagatgaa gaagaaaatgaagagagtgataatgaaaaggaatctgataaaagtgactctgtgacagat tctggaccaaccttcaattaccttcttgatatgcctctttggtatctaactaaggagaag aaggatgaactatgcaaactaagaaaggaaaaagaggaagaattagaaatattaaagagg aagagcccaacagatttatggagagaagacttagctgcttttgttgaagaactggaggtt cttgaagccaaggaaaaaaaagatgaacaagtaggattgcctgtgaaaggtggaaaagca aaggggaaaaaaccccaaatgaccgaagtcttaccttctccaagtggaaaaagagtcatc cctgtagtgactgtagagatgaaagcagaggcagaaaggaaaaataaaaggaaagttaag aatgaaaacactgaaggaagccctcaggagaatggtgaagtagaaggcctcaaaaaaaga ttagaaaagagactgaaaaaagaaaaagaaccaggtgccaagacaatgaaacaaactaca ttatcttttaaaccagtcaaaaaagggaagaagagaaacccctggtctgattcagaatca gatatgagcagtgatgaaaatgattttgatgtccctccacgagaaatagagctacggaaa gcaccaacaaaaattaaaaccatggtagatttggattcagataacgatttctctgatttt gatgaaaagaatcaagatgaagatgatggagattttgttccatcagatgatagtctacct acaaccaaaacttcccaaaaacaaactaacaaagaacagaaaccaccaaaaagtgccatg tcagtaatggaccttgatgctgatgatgtcaagaatgatgtaccagtttccccaagcccc cttgctgccgatttgacagctaaaacggaaactacagagcctatttctaaaaagaaggtg acagtgaagaagacagcagcaaaaagtcaatcttccaccaccactgcaggcaccaaaaaa aggggtgcaccaaaaataaccaaaaaggattcaggtttgaattctgaaacctctaaaaag cctgatcccactaaaacaaagattcgtcgcaaaaggaaaccttcttcttctgatgattct gactctaattttgaggagaaagtttctaaggcagctgcaaataagaaatccaagggggag accaatgacttccatcaggacttagactctgctcttgccccgcgggcaaaatctggacgg gcaaagaagcctataaagtaccttgaagagtcagatgatgatgatctgttttaa

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