| Entry |
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| Symbol |
ARAF
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| Name |
(RefSeq) serine/threonine-protein kinase A-Raf
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| KO |
| K08845 | A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] |
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| Organism |
sfum Sorex fumeus (smoky shrew)
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| Pathway |
| sfum01521 | EGFR tyrosine kinase inhibitor resistance |
| sfum04650 | Natural killer cell mediated cytotoxicity |
| sfum04914 | Progesterone-mediated oocyte maturation |
| sfum04928 | Parathyroid hormone synthesis, secretion and action |
| sfum05022 | Pathways of neurodegeneration - multiple diseases |
| sfum05208 | Chemical carcinogenesis - reactive oxygen species |
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| Brite |
KEGG Orthology (KO) [BR:sfum00001]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
130036768 (ARAF)
04012 ErbB signaling pathway
130036768 (ARAF)
04068 FoxO signaling pathway
130036768 (ARAF)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
130036768 (ARAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
130036768 (ARAF)
09152 Endocrine system
04910 Insulin signaling pathway
130036768 (ARAF)
04914 Progesterone-mediated oocyte maturation
130036768 (ARAF)
04928 Parathyroid hormone synthesis, secretion and action
130036768 (ARAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
130036768 (ARAF)
09156 Nervous system
04726 Serotonergic synapse
130036768 (ARAF)
04720 Long-term potentiation
130036768 (ARAF)
04730 Long-term depression
130036768 (ARAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
130036768 (ARAF)
05205 Proteoglycans in cancer
130036768 (ARAF)
05208 Chemical carcinogenesis - reactive oxygen species
130036768 (ARAF)
09162 Cancer: specific types
05210 Colorectal cancer
130036768 (ARAF)
05212 Pancreatic cancer
130036768 (ARAF)
05225 Hepatocellular carcinoma
130036768 (ARAF)
05226 Gastric cancer
130036768 (ARAF)
05214 Glioma
130036768 (ARAF)
05221 Acute myeloid leukemia
130036768 (ARAF)
05220 Chronic myeloid leukemia
130036768 (ARAF)
05218 Melanoma
130036768 (ARAF)
05211 Renal cell carcinoma
130036768 (ARAF)
05219 Bladder cancer
130036768 (ARAF)
05215 Prostate cancer
130036768 (ARAF)
05213 Endometrial cancer
130036768 (ARAF)
05224 Breast cancer
130036768 (ARAF)
05223 Non-small cell lung cancer
130036768 (ARAF)
09172 Infectious disease: viral
05161 Hepatitis B
130036768 (ARAF)
05160 Hepatitis C
130036768 (ARAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
130036768 (ARAF)
05022 Pathways of neurodegeneration - multiple diseases
130036768 (ARAF)
09165 Substance dependence
05034 Alcoholism
130036768 (ARAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
130036768 (ARAF)
01522 Endocrine resistance
130036768 (ARAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:sfum01001]
130036768 (ARAF)
Enzymes [BR:sfum01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
130036768 (ARAF)
Protein kinases [BR:sfum01001]
Serine/threonine kinases: TKL group
RAF family [OT]
130036768 (ARAF)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
Unknown
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| AA seq |
643 aa
MRRLAQDGGNRGRCSVTGTSWHQPGLTSAHLDKVLGSMEPPRGLPANGAEPSRTVGTVKV
YLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDG
EELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTV
CVDMSTNRQQFYNSVHDLSGGSRHHEAPLNLPLNEPLSPQGPSSCTQNCSPEHFPFPAPA
NAPLQRIRSTSTPNVHMVSTTAPMDSSLLQFTAQNFSTDAVGGKGGGDGAPRVSPNLANV
SSGRKSPHSKSPSEQRERKSLADEKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGT
VFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQ
WCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTV
KIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELM
TGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFKREERPLFPQI
LATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP |
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| NT seq |
1932 nt +upstreamnt +downstreamnt
atgagaagactggcccaagatggaggcaaccgcggccgctgcagcgtgacaggaacctca
tggcaccagcctggtctcacctcagcccatcttgacaaagtcttaggctccatggagcct
ccacggggcctccctgccaatggggctgaaccgtcccggacagtgggcactgtcaaagta
tacttacccaacaagcaacgcacggtggtaactgtccgggatggcatgagtgtctacgac
tctctagacaaggccctgaaggtgagaggtctcaatcaggattgctgtgtggtttaccgg
ctcatcaaggggagaaagacagtcactgcctgggacacagccattgcccctttggatggt
gaagagctcattgtggaggttctcgaagatgtcccactgaccatgcataattttgtacgg
aagaccttcttcagcctggcattctgtgacttctgccttaagtttctgttccatggtttc
cgctgccaaacctgtggctacaagttccaccagcattgttcctccaaggtgcccacagtc
tgtgtcgacatgagcaccaaccgccaacagttctacaacagtgtccatgatttgtctgga
ggctccagacaccacgaggctcccctgaatctccccttgaatgagccactaagtcctcag
ggtcccagctcctgcactcagaactgcagccctgagcacttccccttccctgctccagcc
aatgctcccctccagcgcatccggtccacatccacccccaatgtccatatggtcagcacc
acagcccccatggactctagcctcctccagttcactgcccagaatttcagcactgatgct
gttggtggtaaaggtggtggtgatggagccccgcgtgtgagccccaacctagccaatgtg
tcctcggggaggaagtctccacattccaagtccccatcagaacagcgggagcggaaatcc
ttggctgatgagaaaaagaaagtgaagaatctggggtaccgggactcgggctattactgg
gaggtgccacccagtgaggtgcagctgctgaagaggatcgggacaggctcgtttggcact
gtgtttcgcgggcggtggcatggtgatgtggccgtgaaggttctcaaggtcgcccaaccc
acagccgagcaggctcaggccttcaagaacgagatgcaggtgctcaggaaaactcgacat
gtcaacatcttgctgttcatgggcttcatgacccgaccgggatttgccatcatcacacag
tggtgtgaaggctccagcctctaccaccacctgcatgtggccgacacacgcttcgacatg
gtccagctcattgatgtagcccggcagactgcccagggcatggactacctccatgccaag
aacatcatccaccgagatctcaagtctaacaatatcttcctacacgaggggctcaccgtg
aagattggtgatttcggcctggccacagtgaagacacgctggagtggggcccaaccattg
gagcagccttcaggctctgtgctatggatggcggcagaggtgattcgaatgcaggacccg
aacccgtacagcttccagtcagatgtctatgcctacggggttgtgctgtacgagctgatg
accggttcactgccttatagccacatcggtagccgtgaccagattatctttatggttggc
cgtggctatctgtccccggacctcagcaaaatctccagcaactgccccaaagccatgcgg
cgcctgctgtctgactgcctcaagttcaagagggaggagcggcctctcttcccccagatc
ctggccacgattgagctgctgcagcggtcactccccaagattgagcggagtgcctccgaa
ccctccttgcaccgcacccaggctgatgagttgcctgcctgcttactcagcgcagcccgc
ctagtgccttag |
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