KEGG   Sorex fumeus (smoky shrew): 130037521
Entry
130037521         CDS       T10594                                 
Symbol
RAF1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
sfum  Sorex fumeus (smoky shrew)
Pathway
sfum01521  EGFR tyrosine kinase inhibitor resistance
sfum01522  Endocrine resistance
sfum04010  MAPK signaling pathway
sfum04012  ErbB signaling pathway
sfum04014  Ras signaling pathway
sfum04015  Rap1 signaling pathway
sfum04022  cGMP-PKG signaling pathway
sfum04024  cAMP signaling pathway
sfum04062  Chemokine signaling pathway
sfum04068  FoxO signaling pathway
sfum04071  Sphingolipid signaling pathway
sfum04072  Phospholipase D signaling pathway
sfum04140  Autophagy - animal
sfum04150  mTOR signaling pathway
sfum04151  PI3K-Akt signaling pathway
sfum04210  Apoptosis
sfum04218  Cellular senescence
sfum04270  Vascular smooth muscle contraction
sfum04360  Axon guidance
sfum04370  VEGF signaling pathway
sfum04371  Apelin signaling pathway
sfum04510  Focal adhesion
sfum04540  Gap junction
sfum04550  Signaling pathways regulating pluripotency of stem cells
sfum04613  Neutrophil extracellular trap formation
sfum04625  C-type lectin receptor signaling pathway
sfum04630  JAK-STAT signaling pathway
sfum04650  Natural killer cell mediated cytotoxicity
sfum04660  T cell receptor signaling pathway
sfum04662  B cell receptor signaling pathway
sfum04664  Fc epsilon RI signaling pathway
sfum04666  Fc gamma R-mediated phagocytosis
sfum04720  Long-term potentiation
sfum04722  Neurotrophin signaling pathway
sfum04726  Serotonergic synapse
sfum04730  Long-term depression
sfum04810  Regulation of actin cytoskeleton
sfum04910  Insulin signaling pathway
sfum04912  GnRH signaling pathway
sfum04914  Progesterone-mediated oocyte maturation
sfum04915  Estrogen signaling pathway
sfum04916  Melanogenesis
sfum04917  Prolactin signaling pathway
sfum04919  Thyroid hormone signaling pathway
sfum04921  Oxytocin signaling pathway
sfum04926  Relaxin signaling pathway
sfum04928  Parathyroid hormone synthesis, secretion and action
sfum04929  GnRH secretion
sfum04935  Growth hormone synthesis, secretion and action
sfum05010  Alzheimer disease
sfum05022  Pathways of neurodegeneration - multiple diseases
sfum05034  Alcoholism
sfum05132  Salmonella infection
sfum05152  Tuberculosis
sfum05160  Hepatitis C
sfum05161  Hepatitis B
sfum05163  Human cytomegalovirus infection
sfum05164  Influenza A
sfum05165  Human papillomavirus infection
sfum05167  Kaposi sarcoma-associated herpesvirus infection
sfum05170  Human immunodeficiency virus 1 infection
sfum05200  Pathways in cancer
sfum05205  Proteoglycans in cancer
sfum05206  MicroRNAs in cancer
sfum05207  Chemical carcinogenesis - receptor activation
sfum05208  Chemical carcinogenesis - reactive oxygen species
sfum05210  Colorectal cancer
sfum05211  Renal cell carcinoma
sfum05212  Pancreatic cancer
sfum05213  Endometrial cancer
sfum05214  Glioma
sfum05215  Prostate cancer
sfum05218  Melanoma
sfum05219  Bladder cancer
sfum05220  Chronic myeloid leukemia
sfum05221  Acute myeloid leukemia
sfum05223  Non-small cell lung cancer
sfum05224  Breast cancer
sfum05225  Hepatocellular carcinoma
sfum05226  Gastric cancer
sfum05230  Central carbon metabolism in cancer
sfum05231  Choline metabolism in cancer
sfum05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:sfum00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    130037521 (RAF1)
   04012 ErbB signaling pathway
    130037521 (RAF1)
   04014 Ras signaling pathway
    130037521 (RAF1)
   04015 Rap1 signaling pathway
    130037521 (RAF1)
   04370 VEGF signaling pathway
    130037521 (RAF1)
   04371 Apelin signaling pathway
    130037521 (RAF1)
   04630 JAK-STAT signaling pathway
    130037521 (RAF1)
   04068 FoxO signaling pathway
    130037521 (RAF1)
   04072 Phospholipase D signaling pathway
    130037521 (RAF1)
   04071 Sphingolipid signaling pathway
    130037521 (RAF1)
   04024 cAMP signaling pathway
    130037521 (RAF1)
   04022 cGMP-PKG signaling pathway
    130037521 (RAF1)
   04151 PI3K-Akt signaling pathway
    130037521 (RAF1)
   04150 mTOR signaling pathway
    130037521 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    130037521 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    130037521 (RAF1)
   04218 Cellular senescence
    130037521 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    130037521 (RAF1)
   04540 Gap junction
    130037521 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    130037521 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    130037521 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    130037521 (RAF1)
   04625 C-type lectin receptor signaling pathway
    130037521 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    130037521 (RAF1)
   04660 T cell receptor signaling pathway
    130037521 (RAF1)
   04662 B cell receptor signaling pathway
    130037521 (RAF1)
   04664 Fc epsilon RI signaling pathway
    130037521 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    130037521 (RAF1)
   04062 Chemokine signaling pathway
    130037521 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    130037521 (RAF1)
   04929 GnRH secretion
    130037521 (RAF1)
   04912 GnRH signaling pathway
    130037521 (RAF1)
   04915 Estrogen signaling pathway
    130037521 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    130037521 (RAF1)
   04917 Prolactin signaling pathway
    130037521 (RAF1)
   04921 Oxytocin signaling pathway
    130037521 (RAF1)
   04926 Relaxin signaling pathway
    130037521 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    130037521 (RAF1)
   04919 Thyroid hormone signaling pathway
    130037521 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    130037521 (RAF1)
   04916 Melanogenesis
    130037521 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    130037521 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    130037521 (RAF1)
   04720 Long-term potentiation
    130037521 (RAF1)
   04730 Long-term depression
    130037521 (RAF1)
   04722 Neurotrophin signaling pathway
    130037521 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    130037521 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    130037521 (RAF1)
   05206 MicroRNAs in cancer
    130037521 (RAF1)
   05205 Proteoglycans in cancer
    130037521 (RAF1)
   05207 Chemical carcinogenesis - receptor activation
    130037521 (RAF1)
   05208 Chemical carcinogenesis - reactive oxygen species
    130037521 (RAF1)
   05230 Central carbon metabolism in cancer
    130037521 (RAF1)
   05231 Choline metabolism in cancer
    130037521 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    130037521 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    130037521 (RAF1)
   05212 Pancreatic cancer
    130037521 (RAF1)
   05225 Hepatocellular carcinoma
    130037521 (RAF1)
   05226 Gastric cancer
    130037521 (RAF1)
   05214 Glioma
    130037521 (RAF1)
   05221 Acute myeloid leukemia
    130037521 (RAF1)
   05220 Chronic myeloid leukemia
    130037521 (RAF1)
   05218 Melanoma
    130037521 (RAF1)
   05211 Renal cell carcinoma
    130037521 (RAF1)
   05219 Bladder cancer
    130037521 (RAF1)
   05215 Prostate cancer
    130037521 (RAF1)
   05213 Endometrial cancer
    130037521 (RAF1)
   05224 Breast cancer
    130037521 (RAF1)
   05223 Non-small cell lung cancer
    130037521 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    130037521 (RAF1)
   05161 Hepatitis B
    130037521 (RAF1)
   05160 Hepatitis C
    130037521 (RAF1)
   05164 Influenza A
    130037521 (RAF1)
   05163 Human cytomegalovirus infection
    130037521 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    130037521 (RAF1)
   05165 Human papillomavirus infection
    130037521 (RAF1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    130037521 (RAF1)
   05152 Tuberculosis
    130037521 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    130037521 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    130037521 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    130037521 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    130037521 (RAF1)
   01522 Endocrine resistance
    130037521 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:sfum01001]
    130037521 (RAF1)
Enzymes [BR:sfum01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     130037521 (RAF1)
Protein kinases [BR:sfum01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   130037521 (RAF1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal RA C1_2
Other DBs
NCBI-GeneID: 130037521
NCBI-ProteinID: XP_055985337
LinkDB
Position
Unknown
AA seq 665 aa
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTLVQQFGYQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVSVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTAGDTGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSSSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNSLNASPRPCSRRFCLRGRDA
IRGHSESASPSALSSSPNHLSPTGWSQPRAPAQRERAGPGGQEKNKIRSRGQRDSSYYWE
IEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHV
NILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKN
IIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNN
PFSFQSDVYSYGIVLYELMTGELPYAHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKR
LVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSP
RLPVF
NT seq 1998 nt   +upstreamnt  +downstreamnt
atggagcacatacagggggcctggaagacgatcagcaatggttttgggtttaaagacgcg
gtgtttgatggctccagctgcatttcacctaccttagtccagcagtttggttatcagcgt
cgggcgtcagatgatggcaaacttacggattcttccaagacaagcaacacaatacgtgtt
ttcttgccgaacaagcaaagaacggtggtcagcgtgcgcaatgggatgagcctgcacgac
tgtctcatgaaggcgctcaaggtgaggggcctgcaacccgagtgctgcgccgttttccgg
cttctccacgaacacaagggtaaaaaagcacgtttggattggaatacggatgcagcttca
ttgatcggagaagagcttcaagtagattttctggaccatgttcccctcacaacacacaac
tttgcacggaagaccttcctgaagcttgccttctgtgacatctgtcagaagtttctgcta
aatggatttcggtgtcagacttgcggctacaaatttcacgagcactgtagcaccaaagta
cctaccatgtgtgtggactggagtaacatcaggcagctcctattatttcccaattccact
gctggtgacactggcgtcccagcactgccttctttgaccatgcgtcggatgcgagagtct
gtttcccggatgcctgtcagctctcagcaccgctactccacgccccacgccttcaccttc
aacacctccagctcctcctccgaagggtccctctctcagaggcagaggtccacgtccacg
cccaacgtccacatggtcagcaccactctgcctgtggacagcaggatgattgagaataac
agcctgaatgcttctcccaggccgtgttccagacgattttgtttgaggggaagagacgcc
atccgcgggcacagtgaatcagcctcaccttcagccttgtccagcagccccaaccacctc
agccccacaggctggtcccagcccagagcgccagcgcagagagagcgggcgggccccggg
ggccaggagaagaacaagatcaggtcccgtggccagagagattcaagctactactgggag
atagaggccagtgaggtgatgctgtccacacggatcggctcgggctcctttgggaccgtg
tataagggcaagtggcacggggacgttgcagtgaagatcctgaaggtggtggaccccacg
ccagagcagttccaggccttcaggaacgaggtggctgtgctgcgcaaaactcggcacgtg
aatatcctgctcttcatgggctacatgaccaaggacaacttggccatcgtgacccagtgg
tgcgagggcagcagcctctacaaacacctgcacgtccaggagaccaagttccagatgttc
cagctgatcgacatcgcgcggcagacggcccagggcatggactatttgcacgccaagaac
atcatccacagagacatgaaatccaacaacatatttctccacgaaggcctgacggtgaaa
atcggagattttggcttggcgacagtcaagtcgcgctggagcgggtcccagcaggtggag
cagcccacgggctctgttctgtggatggccccagaggtgatccggatgcaggacaacaac
ccgttcagcttccagtcggacgtctactcctacggcatcgtcctgtacgagctcatgacg
ggcgagctgccctacgcccacatcaacaaccgcgaccagatcatcttcatggtgggccga
gggtacgcctccccggatctcagcaagctctacaagaactgccccaaagccatgaagagg
ctcgtggccgactgcgtgaagaaggtgaaggaggagaggccgctcttcccgcagatcctg
tcttccatcgagctgctccagcactccctccccaaaatcaaccggagcgcctcggagccg
tcattgcaccgggcggcccacaccgaggacatcaacgcctgcacgctgaccacgtcccca
agactgcccgtcttctag

DBGET integrated database retrieval system