KEGG   Sorex fumeus (smoky shrew): 130039789
Entry
130039789         CDS       T10594                                 
Symbol
PLCB3
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
sfum  Sorex fumeus (smoky shrew)
Pathway
sfum00562  Inositol phosphate metabolism
sfum01100  Metabolic pathways
sfum04015  Rap1 signaling pathway
sfum04020  Calcium signaling pathway
sfum04022  cGMP-PKG signaling pathway
sfum04062  Chemokine signaling pathway
sfum04070  Phosphatidylinositol signaling system
sfum04071  Sphingolipid signaling pathway
sfum04072  Phospholipase D signaling pathway
sfum04081  Hormone signaling
sfum04082  Neuroactive ligand signaling
sfum04261  Adrenergic signaling in cardiomyocytes
sfum04270  Vascular smooth muscle contraction
sfum04310  Wnt signaling pathway
sfum04371  Apelin signaling pathway
sfum04540  Gap junction
sfum04611  Platelet activation
sfum04613  Neutrophil extracellular trap formation
sfum04621  NOD-like receptor signaling pathway
sfum04713  Circadian entrainment
sfum04720  Long-term potentiation
sfum04723  Retrograde endocannabinoid signaling
sfum04724  Glutamatergic synapse
sfum04725  Cholinergic synapse
sfum04726  Serotonergic synapse
sfum04728  Dopaminergic synapse
sfum04730  Long-term depression
sfum04742  Taste transduction
sfum04750  Inflammatory mediator regulation of TRP channels
sfum04911  Insulin secretion
sfum04912  GnRH signaling pathway
sfum04915  Estrogen signaling pathway
sfum04916  Melanogenesis
sfum04918  Thyroid hormone synthesis
sfum04919  Thyroid hormone signaling pathway
sfum04921  Oxytocin signaling pathway
sfum04922  Glucagon signaling pathway
sfum04924  Renin secretion
sfum04925  Aldosterone synthesis and secretion
sfum04926  Relaxin signaling pathway
sfum04927  Cortisol synthesis and secretion
sfum04928  Parathyroid hormone synthesis, secretion and action
sfum04929  GnRH secretion
sfum04933  AGE-RAGE signaling pathway in diabetic complications
sfum04934  Cushing syndrome
sfum04935  Growth hormone synthesis, secretion and action
sfum04961  Endocrine and other factor-regulated calcium reabsorption
sfum04970  Salivary secretion
sfum04971  Gastric acid secretion
sfum04972  Pancreatic secretion
sfum04973  Carbohydrate digestion and absorption
sfum05010  Alzheimer disease
sfum05016  Huntington disease
sfum05017  Spinocerebellar ataxia
sfum05022  Pathways of neurodegeneration - multiple diseases
sfum05142  Chagas disease
sfum05143  African trypanosomiasis
sfum05146  Amoebiasis
sfum05163  Human cytomegalovirus infection
sfum05200  Pathways in cancer
sfum05415  Diabetic cardiomyopathy
sfum05417  Lipid and atherosclerosis
Module
sfum_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:sfum00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    130039789 (PLCB3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    130039789 (PLCB3)
   04310 Wnt signaling pathway
    130039789 (PLCB3)
   04371 Apelin signaling pathway
    130039789 (PLCB3)
   04020 Calcium signaling pathway
    130039789 (PLCB3)
   04070 Phosphatidylinositol signaling system
    130039789 (PLCB3)
   04072 Phospholipase D signaling pathway
    130039789 (PLCB3)
   04071 Sphingolipid signaling pathway
    130039789 (PLCB3)
   04022 cGMP-PKG signaling pathway
    130039789 (PLCB3)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    130039789 (PLCB3)
   04081 Hormone signaling
    130039789 (PLCB3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    130039789 (PLCB3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    130039789 (PLCB3)
   04613 Neutrophil extracellular trap formation
    130039789 (PLCB3)
   04621 NOD-like receptor signaling pathway
    130039789 (PLCB3)
   04062 Chemokine signaling pathway
    130039789 (PLCB3)
  09152 Endocrine system
   04911 Insulin secretion
    130039789 (PLCB3)
   04922 Glucagon signaling pathway
    130039789 (PLCB3)
   04929 GnRH secretion
    130039789 (PLCB3)
   04912 GnRH signaling pathway
    130039789 (PLCB3)
   04915 Estrogen signaling pathway
    130039789 (PLCB3)
   04921 Oxytocin signaling pathway
    130039789 (PLCB3)
   04926 Relaxin signaling pathway
    130039789 (PLCB3)
   04935 Growth hormone synthesis, secretion and action
    130039789 (PLCB3)
   04918 Thyroid hormone synthesis
    130039789 (PLCB3)
   04919 Thyroid hormone signaling pathway
    130039789 (PLCB3)
   04928 Parathyroid hormone synthesis, secretion and action
    130039789 (PLCB3)
   04916 Melanogenesis
    130039789 (PLCB3)
   04924 Renin secretion
    130039789 (PLCB3)
   04925 Aldosterone synthesis and secretion
    130039789 (PLCB3)
   04927 Cortisol synthesis and secretion
    130039789 (PLCB3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    130039789 (PLCB3)
   04270 Vascular smooth muscle contraction
    130039789 (PLCB3)
  09154 Digestive system
   04970 Salivary secretion
    130039789 (PLCB3)
   04971 Gastric acid secretion
    130039789 (PLCB3)
   04972 Pancreatic secretion
    130039789 (PLCB3)
   04973 Carbohydrate digestion and absorption
    130039789 (PLCB3)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    130039789 (PLCB3)
  09156 Nervous system
   04724 Glutamatergic synapse
    130039789 (PLCB3)
   04725 Cholinergic synapse
    130039789 (PLCB3)
   04728 Dopaminergic synapse
    130039789 (PLCB3)
   04726 Serotonergic synapse
    130039789 (PLCB3)
   04720 Long-term potentiation
    130039789 (PLCB3)
   04730 Long-term depression
    130039789 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    130039789 (PLCB3)
  09157 Sensory system
   04742 Taste transduction
    130039789 (PLCB3)
   04750 Inflammatory mediator regulation of TRP channels
    130039789 (PLCB3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    130039789 (PLCB3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    130039789 (PLCB3)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    130039789 (PLCB3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    130039789 (PLCB3)
   05142 Chagas disease
    130039789 (PLCB3)
   05143 African trypanosomiasis
    130039789 (PLCB3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    130039789 (PLCB3)
   05016 Huntington disease
    130039789 (PLCB3)
   05017 Spinocerebellar ataxia
    130039789 (PLCB3)
   05022 Pathways of neurodegeneration - multiple diseases
    130039789 (PLCB3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    130039789 (PLCB3)
   05415 Diabetic cardiomyopathy
    130039789 (PLCB3)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    130039789 (PLCB3)
   04934 Cushing syndrome
    130039789 (PLCB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:sfum04131]
    130039789 (PLCB3)
Enzymes [BR:sfum01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     130039789 (PLCB3)
Membrane trafficking [BR:sfum04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    130039789 (PLCB3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    130039789 (PLCB3)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PI-PLC-Y PH_14 PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 130039789
NCBI-ProteinID: XP_055987670
LinkDB
Position
Unknown
AA seq 1224 aa
MAGARPGVHALQLEPPTVVDTLRRGSKFIKWDEEASSRNLVTLRVDSNGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVAGPDPVNTTFLNF
MAVQEDTAKVWTEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
AGEENGILPLEALDLSADMTQPLSAYFINSSHNTYLTAGQLTGTSSVEMYRQALLWGCRC
VELDVWKGRPPEDEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHQPSSGVPGS
SVRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCTGLSNGEEAALEKPSLELRKSLGE
DGPAPGPEAPGPNDREDEEEDEEEDEQTDLKKPTTDEGTASSEVNATEEMSTLVNYVEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDVPMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLASLRIAAFEEGGRFVGHRILPVSAIRSGYHYICLRNEANQPLCLPALLI
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRATKLAALIGECEAQAGPDTCQETQCPQP
GAQLAANPTHSPLESSPRWPPGPATSPTSPSLSSPGQRDDLIASILSEVAPVPLDELRGH
KSLVKLRSRQERDLRELLKKHQRKAVALTRRLLDGLAQARPRGSGPGGESEKGEEEEMKR
YQEFQRKQVQSLLELREAQADTEAERRQEHLRQAQQRLREIVCDAHLTQLKKLKETNDRE
KKELQKILDRKRHNSISEAKNREKNKKEAELTEINRRHITESVNSIRRLEEAQKQRHERL
LSGQQQVLQQLTEEEPKLQAQLAQECQELRARLPQEIRRSLLGEPPEGLGAGQRVACASN
GHAPGSSGHLSGADSESQEENTQL
NT seq 3675 nt   +upstreamnt  +downstreamnt
atggcgggcgccaggcccggcgtccacgcgctgcagctggagccgcccaccgtggtggac
accctgcggcgcgggagtaagttcatcaagtgggacgaggaggcctccagtcggaacctg
gtgacccttcgtgtggacagcaatggcttcttcctgtactggacagggcccaacatggag
gtggacacgctggacatcagctccatcagggacacgcgcacaggacgctacgcccgcctg
cccaaggaccccaagattcgggaggtgctgggctttgggggccctgacgcccggctcgag
gagaagctgatgaccgtggtggccgggcctgacccggtgaacaccacgttcctgaacttc
atggccgtgcaggaagacaccgccaaggtctggactgaggagctcttcaagctggcgatg
aacatcctggcccagaacgcctcccggaacaccttcctgcgcaaggcatacacaaagttg
aagctgcaagtgaaccaggacgggcggattccggtcaagaacattctgaagatgttctca
gcagacaagaagcgtgtggagacggcgctggagtcctgtggcctcaaattcaaccggagc
gagtccattcggccagacgagttttccctggagatcttcgagcggttcctgaacaagctg
tgcctgaggccagacatagacaagatcctgttggagataggggccaagggcaagccgtac
ctgacgctggagcagctgatggatttcatcaaccagaagcagcgggacccgaggctcaac
gaggtgctgtacccgccgctgcggccctcgcaggcccggctgctcatcgagaagtacgag
cccaaccagcagttcctggagcgggaccagatgtccatggagggcttcagccgctacctg
gcaggggaggagaacggcatcctgcccctggaggcgctggacctgagcgccgacatgacc
cagccgctgagcgcctacttcatcaactcctcgcacaacacctacctcacggcggggcag
ctgaccgggacgtcgtcggtggagatgtaccggcaggcgctgctgtggggctgccgctgc
gtagagctggacgtgtggaaggggcggccgcccgaggacgagcccttcatcacccacggc
ttcaccatgaccaccgaggtgcccctgcgggacgtgctggaggccatcgccgagacggct
ttcaagacctcgccctaccccgtcatcctgtccttcgagaaccacgtggactcggccaag
cagcaggctaagatggccgagtactgccgctccatcttcggggacgccctgctcatcgac
ccgctggacaagtacccgctggccccgggcgtgcccctgcccagcccccaggacctgatg
ggccgcatcctggtgaagaacaagaaacggcaccagcccagcagcggcgtccccggaagc
tccgtgcgcaaacggccgctggaacagagcaactcggccctgagcgagagctccgccgcc
accgagccctcctcgccccagctcgggtctcccagctccgacagctgcacaggcctgagc
aacggcgaggaggccgccctggagaagcccagcctggagctgcggaagtctctgggcgag
gacgggccagcgccgggccccgaagctcccggacccaatgaccgggaggatgaggaggaa
gatgaggaagaggacgagcagacggacctcaaaaagccaaccacagatgagggcaccgcc
agcagcgaggtcaatgccacagaagagatgtccacgctggtcaactacgtcgagcccgtc
aagttcaagtccttcgaggctgctcggaagaggaacaagtgcttcgagatgtcgtccttc
gtggagaccaaggccatggagcagctgaccaagagccccatggagtttgtggaatacaac
aagcagcagctgagccgcatctaccccaagggcacccgcgtggactcctccaactacatg
ccgcagctcttctggaacgtgggctgccagctggtggcactcaacttccagactctggat
gtgccaatgcagctcaacgccggcgtgttcgagtacaacgggcgcagcggctacctgctg
aagcccgagttcatgcggcggcccgacaagtccttcgaccccttcactgaggtcatcgtg
gatggcatcgtggccaatgccttgcgggtcaaggtgatttcggggcagttcctgtccgac
cgcaaggtgggcatctacgtggaggtggacatgttcgggctccccgtggacacccggcgc
aagtaccgtacccggacctcccagggcaactccttcaaccctgtgtgggacgaggagccc
ttcgacttccccaaggtggtattgcccacgctggcctcactgcgcattgcggcctttgag
gagggcggccggtttgtcgggcaccgcatcctgcccgtgtctgccatccgctcagggtac
cactacatctgcctgcggaacgaggccaaccagccgctctgcctgcccgccctgctcatc
tacaccgaagcctccgactacatccccgacgaccaccaggactacgccgaggccttgatc
aaccccatcaagcacgtgagcctgatggaccagagggccacgaaactggccgccctcatc
ggggagtgtgaggcccaggctggtcccgatacctgccaggagacccagtgtccgcagcct
ggggcccagctggctgccaaccccacacacagccccctggagtcctccccgcgctggccc
ccgggccctgccacctcccccaccagcccgtccctcagcagcccagggcagcgagatgac
ctcatcgccagcatcctctcagaggtggccccggtcccgctggatgagctccgtggccac
aagagtctggtgaaactgcggagccggcaggagcgagacctgcgggagctgctgaagaag
caccagcggaaggcggtggcgctcacgcggcggctgctagatggcctggcccaggcccgg
ccccgggggagcggaccagggggcgagtcggagaagggggaggaggaagagatgaagcgg
taccaggagttccagaggaaacaggttcagagcctcctggagctgcgcgaggcgcaggcg
gacacggaggccgagcggaggcaggagcacctgagacaggcgcagcagcggctccgggag
atcgtctgtgacgcgcacctcacccagctcaagaagctcaaggagaccaacgacagggag
aagaaggaactgcagaagattctggataggaaacgccacaacagcatctccgaggccaag
aatagggagaagaacaagaaggaggcggagttgaccgagatcaaccgccgacacatcacc
gagtcggtcaactccatccgcaggctggaggaggcccagaagcagcgtcacgagcgactc
ctgtccggccagcagcaagtgctccagcagctaacagaggaggagcccaagctgcaggcc
cagctggcccaggagtgccaggagcttcgggcacggctgccccaggagatccgccggagc
ctgctgggcgaaccgcccgaggggctgggggccgggcagcgggtggcctgtgccagcaat
ggtcacgcgcccgggagcagcgggcacctgtccggcgccgactcggagagccaggaggag
aacacgcagctctga

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