KEGG   Sorex fumeus (smoky shrew): 130040054
Entry
130040054         CDS       T10594                                 
Symbol
RPS6KB2
Name
(RefSeq) ribosomal protein S6 kinase beta-2 isoform X1
  KO
K04688  ribosomal protein S6 kinase beta [EC:2.7.11.1]
Organism
sfum  Sorex fumeus (smoky shrew)
Pathway
sfum01521  EGFR tyrosine kinase inhibitor resistance
sfum01522  Endocrine resistance
sfum04012  ErbB signaling pathway
sfum04066  HIF-1 signaling pathway
sfum04140  Autophagy - animal
sfum04150  mTOR signaling pathway
sfum04151  PI3K-Akt signaling pathway
sfum04152  AMPK signaling pathway
sfum04211  Longevity regulating pathway
sfum04213  Longevity regulating pathway - multiple species
sfum04350  TGF-beta signaling pathway
sfum04371  Apelin signaling pathway
sfum04666  Fc gamma R-mediated phagocytosis
sfum04714  Thermogenesis
sfum04910  Insulin signaling pathway
sfum04931  Insulin resistance
sfum05163  Human cytomegalovirus infection
sfum05165  Human papillomavirus infection
sfum05170  Human immunodeficiency virus 1 infection
sfum05200  Pathways in cancer
sfum05205  Proteoglycans in cancer
sfum05207  Chemical carcinogenesis - receptor activation
sfum05210  Colorectal cancer
sfum05212  Pancreatic cancer
sfum05221  Acute myeloid leukemia
sfum05224  Breast cancer
sfum05225  Hepatocellular carcinoma
sfum05226  Gastric cancer
sfum05231  Choline metabolism in cancer
sfum05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:sfum00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    130040054 (RPS6KB2)
   04350 TGF-beta signaling pathway
    130040054 (RPS6KB2)
   04371 Apelin signaling pathway
    130040054 (RPS6KB2)
   04066 HIF-1 signaling pathway
    130040054 (RPS6KB2)
   04151 PI3K-Akt signaling pathway
    130040054 (RPS6KB2)
   04152 AMPK signaling pathway
    130040054 (RPS6KB2)
   04150 mTOR signaling pathway
    130040054 (RPS6KB2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    130040054 (RPS6KB2)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    130040054 (RPS6KB2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    130040054 (RPS6KB2)
  09149 Aging
   04211 Longevity regulating pathway
    130040054 (RPS6KB2)
   04213 Longevity regulating pathway - multiple species
    130040054 (RPS6KB2)
  09159 Environmental adaptation
   04714 Thermogenesis
    130040054 (RPS6KB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    130040054 (RPS6KB2)
   05205 Proteoglycans in cancer
    130040054 (RPS6KB2)
   05207 Chemical carcinogenesis - receptor activation
    130040054 (RPS6KB2)
   05231 Choline metabolism in cancer
    130040054 (RPS6KB2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    130040054 (RPS6KB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    130040054 (RPS6KB2)
   05212 Pancreatic cancer
    130040054 (RPS6KB2)
   05225 Hepatocellular carcinoma
    130040054 (RPS6KB2)
   05226 Gastric cancer
    130040054 (RPS6KB2)
   05221 Acute myeloid leukemia
    130040054 (RPS6KB2)
   05224 Breast cancer
    130040054 (RPS6KB2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    130040054 (RPS6KB2)
   05163 Human cytomegalovirus infection
    130040054 (RPS6KB2)
   05165 Human papillomavirus infection
    130040054 (RPS6KB2)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    130040054 (RPS6KB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    130040054 (RPS6KB2)
   01522 Endocrine resistance
    130040054 (RPS6KB2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:sfum01001]
    130040054 (RPS6KB2)
Enzymes [BR:sfum01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     130040054 (RPS6KB2)
Protein kinases [BR:sfum01001]
 Serine/threonine kinases: AGC group
  RSK family [OT]
   130040054 (RPS6KB2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Pkinase_C Pkinase_fungal Kinase-like ABC1
Other DBs
NCBI-GeneID: 130040054
NCBI-ProteinID: XP_055988068
LinkDB
Position
Unknown
AA seq 497 aa
MTPEPGPDCQSERRRGRAQGPAGPAWPWRLCLTWTWRRRRAARARPRPIPAPRVPGRYEE
VELTEDSVNPGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGANSGKIYAMKVLRKAKIV
RNAKDTAHTRAERNILESVRHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFL
EDTACFYLGEITLALGHLHAQGIIYRDLKPENIMLNSQGHIKLTDFGLCKESIHEGAVTH
TFCGTIEYMAPEILVRSGHNRAVDWWSLGALMHDMLTGSPPFTAENRKKTMDKIVKGKLV
LPPYLTADARDLIKKFLKRNPAQRMGGGPGDAADVQRHPFFRHINWDDLLARHVDPPFRP
SLQSEEDVSQFDVRFTRQTPVDSPDDSALSESADQAFLGFTYVAPSVLDSIKEGFSFQPK
LRSPRRLNSSPRTPISPLKFSPFEGFRPSPGPQEPMETPPPPLLPPPSPPPARTPPLPIR
PPSGGKRSKRGRGRPGR
NT seq 1494 nt   +upstreamnt  +downstreamnt
atgacgccagagcccggtccggactgtcagtcggagcggcgccgcggacgggcccagggg
cccgcggggccggcttggccatggcggctgtgtttgacctggacctggagacggaggagg
gcagcgagggcgaggccgaggccgattccagccccgcgggtcccgggcaggtacgaggag
gtggagctgacggaggacagcgtgaacccgggccccgagcgcatcggcccgcactgcttt
gagcttctgcgggtgctgggcaaaggcggctacggcaaggtattccaggttcgcaaggtg
cagggcgccaactcgggcaaaatatacgccatgaaagtgctgaggaaggccaaaatcgtg
cgcaacgccaaggacacagcgcacacgcgcgccgagcggaacattctggagtcggtgagg
cacccgttcatcgtggagctggcctacgccttccagaccgggggcaaactctacctcatc
ctcgagtgtctcagtggaggcgagctcttcacgcacctggagcgggagggcatcttcctg
gaggacacggcctgcttctacctgggagagatcacgctggccctgggccacctccacgcc
caaggcatcatctacagggacctcaagcccgagaacatcatgctcaacagccagggacac
atcaaactcaccgacttcgggctctgcaaagaatccatccacgagggcgccgtcacccac
accttctgtggcaccatcgagtacatggcccccgagattctggtgcggagcggccacaac
cgagcggtggactggtggagcctgggggccctcatgcacgacatgctcaccggctcgccc
cccttcactgccgagaaccggaagaagaccatggacaagatcgtcaaagggaagctggtg
ctgcccccgtacctcaccgccgacgcccgggacctcatcaagaagtttctgaagcggaat
cctgcccagcggatggggggtggcccgggggatgctgccgatgtgcagaggcaccccttc
ttccggcacatcaattgggacgacctcctggcccgccacgtggaccctccgttcaggccc
tctctgcaatccgaggaggacgtgagccagtttgacgtgcgattcacccgccagacgccc
gtggacagccctgacgactcggccctcagtgagagcgctgaccaggccttcctgggcttc
acctacgtggccccgtcggtgctggacagcatcaaggagggcttctccttccagcccaag
ctgcgctccccccgccgcctcaacagcagcccccggaccccgatcagccccctgaagttc
tcaccctttgaggggttccggcccagccctggcccccaggagcccatggagacccccccg
cctcccctgctgccgccgccttcgccgccacccgccaggacgccccccctccccatccgg
cccccctcggggggcaagaggtccaagaggggccgtgggcgccccggtcgctag

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