Sorex fumeus (smoky shrew): 130041522 Help Entry 130041522         CDS       T10594                                  Symbol ADCY4 Name (RefSeq) adenylate cyclase type 4   KO K08044   adenylate cyclase 4 [EC:4.6.1.1] Organism sfum  Sorex fumeus (smoky shrew) Pathway sfum00230   Purine metabolism sfum01100   Metabolic pathways sfum01522   Endocrine resistance sfum04015   Rap1 signaling pathway sfum04020   Calcium signaling pathway sfum04022   cGMP-PKG signaling pathway sfum04024   cAMP signaling pathway sfum04062   Chemokine signaling pathway sfum04072   Phospholipase D signaling pathway sfum04081   Hormone signaling sfum04082   Neuroactive ligand signaling sfum04114   Oocyte meiosis sfum04211   Longevity regulating pathway sfum04213   Longevity regulating pathway - multiple species sfum04261   Adrenergic signaling in cardiomyocytes sfum04270   Vascular smooth muscle contraction sfum04371   Apelin signaling pathway sfum04540   Gap junction sfum04611   Platelet activation sfum04713   Circadian entrainment sfum04714   Thermogenesis sfum04723   Retrograde endocannabinoid signaling sfum04724   Glutamatergic synapse sfum04725   Cholinergic synapse sfum04727   GABAergic synapse sfum04742   Taste transduction sfum04750   Inflammatory mediator regulation of TRP channels sfum04911   Insulin secretion sfum04912   GnRH signaling pathway sfum04913   Ovarian steroidogenesis sfum04914   Progesterone-mediated oocyte maturation sfum04915   Estrogen signaling pathway sfum04916   Melanogenesis sfum04918   Thyroid hormone synthesis sfum04921   Oxytocin signaling pathway sfum04923   Regulation of lipolysis in adipocytes sfum04925   Aldosterone synthesis and secretion sfum04926   Relaxin signaling pathway sfum04927   Cortisol synthesis and secretion sfum04928   Parathyroid hormone synthesis, secretion and action sfum04934   Cushing syndrome sfum04935   Growth hormone synthesis, secretion and action sfum04970   Salivary secretion sfum04971   Gastric acid secretion sfum04972   Pancreatic secretion sfum04976   Bile secretion sfum05032   Morphine addiction sfum05163   Human cytomegalovirus infection sfum05166   Human T-cell leukemia virus 1 infection sfum05200   Pathways in cancer sfum05207   Chemical carcinogenesis - receptor activation sfum05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:sfum00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     130041522 (ADCY4)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     130041522 (ADCY4)    04371 Apelin signaling pathway     130041522 (ADCY4)    04020 Calcium signaling pathway     130041522 (ADCY4)    04072 Phospholipase D signaling pathway     130041522 (ADCY4)    04024 cAMP signaling pathway     130041522 (ADCY4)    04022 cGMP-PKG signaling pathway     130041522 (ADCY4)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     130041522 (ADCY4)    04081 Hormone signaling     130041522 (ADCY4)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     130041522 (ADCY4)   09144 Cellular community - eukaryotes    04540 Gap junction     130041522 (ADCY4)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     130041522 (ADCY4)    04062 Chemokine signaling pathway     130041522 (ADCY4)   09152 Endocrine system    04911 Insulin secretion     130041522 (ADCY4)    04923 Regulation of lipolysis in adipocytes     130041522 (ADCY4)    04912 GnRH signaling pathway     130041522 (ADCY4)    04913 Ovarian steroidogenesis     130041522 (ADCY4)    04915 Estrogen signaling pathway     130041522 (ADCY4)    04914 Progesterone-mediated oocyte maturation     130041522 (ADCY4)    04921 Oxytocin signaling pathway     130041522 (ADCY4)    04926 Relaxin signaling pathway     130041522 (ADCY4)    04935 Growth hormone synthesis, secretion and action     130041522 (ADCY4)    04918 Thyroid hormone synthesis     130041522 (ADCY4)    04928 Parathyroid hormone synthesis, secretion and action     130041522 (ADCY4)    04916 Melanogenesis     130041522 (ADCY4)    04925 Aldosterone synthesis and secretion     130041522 (ADCY4)    04927 Cortisol synthesis and secretion     130041522 (ADCY4)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     130041522 (ADCY4)    04270 Vascular smooth muscle contraction     130041522 (ADCY4)   09154 Digestive system    04970 Salivary secretion     130041522 (ADCY4)    04971 Gastric acid secretion     130041522 (ADCY4)    04972 Pancreatic secretion     130041522 (ADCY4)    04976 Bile secretion     130041522 (ADCY4)   09156 Nervous system    04724 Glutamatergic synapse     130041522 (ADCY4)    04727 GABAergic synapse     130041522 (ADCY4)    04725 Cholinergic synapse     130041522 (ADCY4)    04723 Retrograde endocannabinoid signaling     130041522 (ADCY4)   09157 Sensory system    04742 Taste transduction     130041522 (ADCY4)    04750 Inflammatory mediator regulation of TRP channels     130041522 (ADCY4)   09149 Aging    04211 Longevity regulating pathway     130041522 (ADCY4)    04213 Longevity regulating pathway - multiple species     130041522 (ADCY4)   09159 Environmental adaptation    04713 Circadian entrainment     130041522 (ADCY4)    04714 Thermogenesis     130041522 (ADCY4)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     130041522 (ADCY4)    05207 Chemical carcinogenesis - receptor activation     130041522 (ADCY4)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     130041522 (ADCY4)    05163 Human cytomegalovirus infection     130041522 (ADCY4)   09165 Substance dependence    05032 Morphine addiction     130041522 (ADCY4)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     130041522 (ADCY4)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     130041522 (ADCY4)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     130041522 (ADCY4) Enzymes [BR:sfum01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      130041522 (ADCY4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom AC_N CD52 Motif Other DBs NCBI-GeneID:  130041522 NCBI-ProteinID:  XP_055989724 LinkDB All DBs Position Unknown AA seq 1074 aa AA seqDB search MARLFSPRPPPSEDLFYETYYSLSQQYPLVLLLLLIVLGALLALLAVAWATGRELISDPG FLTIVLCALGGFSLLLGLASREQWLQRWTRPLSGFVWVALLALGHSFLFTGGVVSAWDQV SFFLFVIFTVYAMLPLGMWDAVAAGLTSSLSHLLALGFYLGPQPDSRPALLPQLAANAVL FLCGNVAGAYHKALMERALRATFREALTSLHSRRRLDTEKKHQEHLLLSILPAYLAREMK AEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNE LFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATG VDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAG AYAVEAAAMEHRDPYLRDLGEPTYLVIDPRAEEDEKGTAGGLLSSLEGPKMRPSLLMTRY LESWGAAKPFAHLSHVDSPVSTSTPLPEKALASFSPQWSLDRSRTPRGLDDELDTGDAKF FQVIEQLNSQNQWKQSKDFSPLTLFFREEKMEKEYRLSTLPAFKYYAACTFLVFLSNFII QMLVTNRPPALTITYSVTFLLFLLLLFVCFSEHLTRCVLKGPKMLHWLPALSGLVATRPG LRVALGTATILLVFTMAIIILFFLPATASCPFHTHNISSVTANLSWELPGSLPLISIPYS MHCCVLAFFSCSVYLHMSFELKLLLLLLGLAASCSFFLHSHAWLSDCLIARLYLGPSRPG VLKEPKLMGAISFFIFFFTLLFLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLE NVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLN EIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFA MALGAKLEVINKHSFNNFHLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVL GKIQVTEETAEALQSLGYTCYSRGVIKVKGKGQLCTYFLNTDFTRAGPPSATLG NT seq 3225 nt NT seq  +upstreamnt  +downstreamnt atggcgcgcctgttcagcccccggccgccccccagcgaggacctcttctacgagacctac tacagcctgagccagcagtacccgctggtgctgctgctgctgctcatcgtgctcggcgcg ctgctggcgctgctggcggtcgcctgggccaccggcagggagctgatctcagacccaggc ttcctgaccattgtgctgtgtgctctgggcggtttctccctgctgctgggactggcttcc cgggaacagtggctgcagcgctggacacgacccctctcaggcttcgtgtgggtggcactg ctcgcccttggtcatagcttcctgttcactggaggcgtagtgagcgcctgggaccaggtg tccttcttcctctttgtcatcttcactgtgtacgctatgctgcccttgggtatgtgggac gcagttgctgcgggcctcacctcatcactctcacacctgctggcccttggattctatctt ggaccccaaccggactcaaggcccgcactgctgccacagctggcggctaacgcggtgctg ttcctgtgcgggaacgtggcgggggcgtaccacaaggcgctgatggagcgcgcgctgcgc gccaccttccgggaggcgctgacctcgctgcactcgcgccgccgactggacaccgagaag aagcaccaggaacaccttctcttgtccatccttccggcctacctggcccgcgagatgaag gcagagatcatggcccggctgcaggctggacagggctcccgaccagagagtaccaacaac ttccacagcctctatgtcaagagacaccagggagtgagtgtgctgtatgcagacatcgtg ggcttcacgcgactggccagtgagtgctcgccaaaggagttggtgctcatgctcaacgag ctcttcggcaagtttgaccagatcgccaaggagcacgaatgcatgcggatcaagatcctg ggagactgttactactgcgtctcgggcctaccactttcgctgccagaccacgccatcaac tgcgtgcgcatggggctggacatgtgtcgggccatcaggaagctgcgggcagccacgggt gtggatatcaacatgcgtgtgggcgtgcactctggcagtgtgctctgcggagtcattggg ctgcagaagtggcagtatgacgtgtggtcccatgatgtcacgctggccaaccacatggag gcgggcggcgtgccagggcgggtgcacatcacaggggctaccctggccctgctggcaggt gcttatgcagtggaggctgcagctatggaacaccgggacccttaccttcgggatctgggg gagcctacctacctggtcatcgatccccgggctgaggaggatgaaaagggcaccgctgga ggcttgctgtcttctcttgagggccccaaaatgcgtccttccctgctgatgacccgctac ctggagtcctggggtgcagccaagccttttgctcacctgagccatgtggatagccccgtg tccacctccaccccgctcccggagaaggctctggcttccttcagcccccagtggagcctg gaccggagccgcaccccccgaggacttgatgatgaactggacacaggggatgccaagttc ttccaggtcatcgaacagctcaattcacaaaaccagtggaagcagtcgaaggacttcagc ccactgacactgttcttccgagaagagaagatggaaaaagagtatcggctctccacactc cccgccttcaagtactacgcagcctgcaccttcctggtcttcctctccaacttcatcatt cagatgctggtgaccaacaggcccccagctctgaccatcacctacagtgtcaccttcctc ctcttcctcctcctcctcttcgtttgcttctcagagcacctgacgaggtgcgtcttgaaa ggtcccaagatgctgcattggctgcccgccctctctggcctggtggccaccaggcccgga ctgcgagtcgccctgggcacggccaccatcctcctggtcttcaccatggccatcatcatc ctgttcttcttaccggcaaccgctagctgtcctttccacactcacaacatatcctcggtg accgccaacctctcctgggagctccccggctccttgcctctcatcagcatcccgtactcc atgcactgctgcgtgctggctttcttctcctgctccgtctacctgcacatgagcttcgag ctgaagctgctgctgctgctgctcgggctggcagcctcctgctccttcttcctgcactcc cacgcctggctgtccgactgcctcatcgcccgcctctatctgggcccctccaggccaggc gtactgaaggaacccaaactgatgggcgctatctccttcttcatcttcttcttcaccctc ctgttcctggcccgccagaatgagtattactgccgcctggacttcctgtggaagaaaaag ctgcggcaggagcgggaggagactgagacaatggagaacctgactcggctgcttttggag aatgtgctcccggcacacgtggccccccagttcatcggccagaaccggcgcaacgaggac ctctaccaccagtcctacgagtgcgtctgtgtgctcttcgcctcagtccctgactttaag gagttctactctgaatccaacatcaaccatgaggggctcgagtgtctgcggctgctcaat gagatcattgctgatttcgatgagctactctccaagcccaagttcagtggtgtggagaag atcaaaaccattggcagcacctacatggcagctacaggcttaaatgccacctcggggcag gacgcccagcaggatgctgagcgcagctgtagccacctgggcaccatggtggaattcgcg atggccctgggggctaagctggaggttatcaacaagcattccttcaacaacttccatctg cgtgtggggctgaatcatggacctgtagtggccggagtgattggagcccagaagccacaa tatgacatctggggcaacacagtgaacgtggccagccgcatggagagtacaggagtgttg ggcaagatccaagtgactgaagagacagctgaggcgctgcagtccttaggctacacctgc tacagccggggtgtcatcaaggtcaagggcaagggacagctctgcacctacttcctaaac acagacttcactcgagctggtcctccctcggccaccctgggctga

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