Sorex fumeus (smoky shrew): 130041980
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Entry
130041980 CDS
T10594
Symbol
SOS2
Name
(RefSeq) son of sevenless homolog 2 isoform X1
KO
K03099
son of sevenless
Organism
sfum Sorex fumeus (smoky shrew)
Pathway
sfum01521
EGFR tyrosine kinase inhibitor resistance
sfum01522
Endocrine resistance
sfum04010
MAPK signaling pathway
sfum04012
ErbB signaling pathway
sfum04014
Ras signaling pathway
sfum04062
Chemokine signaling pathway
sfum04068
FoxO signaling pathway
sfum04072
Phospholipase D signaling pathway
sfum04150
mTOR signaling pathway
sfum04151
PI3K-Akt signaling pathway
sfum04510
Focal adhesion
sfum04540
Gap junction
sfum04630
JAK-STAT signaling pathway
sfum04650
Natural killer cell mediated cytotoxicity
sfum04660
T cell receptor signaling pathway
sfum04662
B cell receptor signaling pathway
sfum04664
Fc epsilon RI signaling pathway
sfum04714
Thermogenesis
sfum04722
Neurotrophin signaling pathway
sfum04810
Regulation of actin cytoskeleton
sfum04910
Insulin signaling pathway
sfum04912
GnRH signaling pathway
sfum04915
Estrogen signaling pathway
sfum04917
Prolactin signaling pathway
sfum04926
Relaxin signaling pathway
sfum04935
Growth hormone synthesis, secretion and action
sfum05034
Alcoholism
sfum05160
Hepatitis C
sfum05161
Hepatitis B
sfum05163
Human cytomegalovirus infection
sfum05165
Human papillomavirus infection
sfum05200
Pathways in cancer
sfum05205
Proteoglycans in cancer
sfum05206
MicroRNAs in cancer
sfum05207
Chemical carcinogenesis - receptor activation
sfum05208
Chemical carcinogenesis - reactive oxygen species
sfum05210
Colorectal cancer
sfum05211
Renal cell carcinoma
sfum05213
Endometrial cancer
sfum05214
Glioma
sfum05215
Prostate cancer
sfum05220
Chronic myeloid leukemia
sfum05221
Acute myeloid leukemia
sfum05223
Non-small cell lung cancer
sfum05224
Breast cancer
sfum05225
Hepatocellular carcinoma
sfum05226
Gastric cancer
sfum05231
Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:
sfum00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
130041980 (SOS2)
04012 ErbB signaling pathway
130041980 (SOS2)
04014 Ras signaling pathway
130041980 (SOS2)
04630 JAK-STAT signaling pathway
130041980 (SOS2)
04068 FoxO signaling pathway
130041980 (SOS2)
04072 Phospholipase D signaling pathway
130041980 (SOS2)
04151 PI3K-Akt signaling pathway
130041980 (SOS2)
04150 mTOR signaling pathway
130041980 (SOS2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
130041980 (SOS2)
04540 Gap junction
130041980 (SOS2)
09142 Cell motility
04810 Regulation of actin cytoskeleton
130041980 (SOS2)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
130041980 (SOS2)
04660 T cell receptor signaling pathway
130041980 (SOS2)
04662 B cell receptor signaling pathway
130041980 (SOS2)
04664 Fc epsilon RI signaling pathway
130041980 (SOS2)
04062 Chemokine signaling pathway
130041980 (SOS2)
09152 Endocrine system
04910 Insulin signaling pathway
130041980 (SOS2)
04912 GnRH signaling pathway
130041980 (SOS2)
04915 Estrogen signaling pathway
130041980 (SOS2)
04917 Prolactin signaling pathway
130041980 (SOS2)
04926 Relaxin signaling pathway
130041980 (SOS2)
04935 Growth hormone synthesis, secretion and action
130041980 (SOS2)
09156 Nervous system
04722 Neurotrophin signaling pathway
130041980 (SOS2)
09159 Environmental adaptation
04714 Thermogenesis
130041980 (SOS2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
130041980 (SOS2)
05206 MicroRNAs in cancer
130041980 (SOS2)
05205 Proteoglycans in cancer
130041980 (SOS2)
05207 Chemical carcinogenesis - receptor activation
130041980 (SOS2)
05208 Chemical carcinogenesis - reactive oxygen species
130041980 (SOS2)
05231 Choline metabolism in cancer
130041980 (SOS2)
09162 Cancer: specific types
05210 Colorectal cancer
130041980 (SOS2)
05225 Hepatocellular carcinoma
130041980 (SOS2)
05226 Gastric cancer
130041980 (SOS2)
05214 Glioma
130041980 (SOS2)
05221 Acute myeloid leukemia
130041980 (SOS2)
05220 Chronic myeloid leukemia
130041980 (SOS2)
05211 Renal cell carcinoma
130041980 (SOS2)
05215 Prostate cancer
130041980 (SOS2)
05213 Endometrial cancer
130041980 (SOS2)
05224 Breast cancer
130041980 (SOS2)
05223 Non-small cell lung cancer
130041980 (SOS2)
09172 Infectious disease: viral
05161 Hepatitis B
130041980 (SOS2)
05160 Hepatitis C
130041980 (SOS2)
05163 Human cytomegalovirus infection
130041980 (SOS2)
05165 Human papillomavirus infection
130041980 (SOS2)
09165 Substance dependence
05034 Alcoholism
130041980 (SOS2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
130041980 (SOS2)
01522 Endocrine resistance
130041980 (SOS2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
RasGEF
RasGEF_N
RhoGEF
SOS1_NGEF_PH
PH
RHG20_PH
IQ_SEC7_PH
PH_10
Motif
Other DBs
NCBI-GeneID:
130041980
NCBI-ProteinID:
XP_055990268
LinkDB
All DBs
Position
Unknown
AA seq
1334 aa
AA seq
DB search
MQQAPQPYEFFSEENSPKWRGLLVPALRKVQEQVHPNLSANEESLYYIEELIFQLLNKLC
MAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPSLLLPVDKIHPSLKEVLG
YKVDYHVALYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQD
DDIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRELFKPS
DIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQ
DILSPEFNEHFSKLMARPAVTLHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQL
KACSEEQEDRECLNQAITALLNLQGSMDRIYKQYSPRRRPGDPICPFYNRQLRSKHLAIK
KMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKANHSQSRL
PGYSNAEYRLKEKFVMRKIQICDKEDTCECKHAFEIVSKDGNTIIFAAKSSEEKSNWMAA
LISLHYRSTLDRMLDSVLLKEENEQPLRLPSPDVYRFVVKDSEENIVFEDNLQSRSGIPI
IKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTEADK
LAVEKGEQPIIADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISS
VRGKAMKKWVESIAKIIKRKKQAQANGISHNITFESPPPPIEWHLSKPGHFESFELMTLH
PIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV
EAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKKRI
LDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSK
RRKVAEITGEIQQYQNQPYCLRIEPDIRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRN
CRQPTRFPRKSNFPLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKMSFSRITETDIES
TVSAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSRSFFSSCGSLHK
LSEEPLIPPPLPPRKKFDHDASNSKGNIKPDDDPPAIPPRQPPPPKVKPRVPAPTGAFDG
PLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPVGHLHRDPDWFRDTSTCPNS
PNTPPSTPSPRVPRRCYVLSSSHNNLAHPQAPPVPPRQNSSPHLPKLPPKTYKRELSHPP
LYRLPLLENAETPQ
NT seq
4005 nt
NT seq
+upstream
nt +downstream
nt
atgcagcaggcgccgcagccctacgagttcttcagcgaggagaacagtccgaaatggcgc
ggattgttggtgccggccctgaggaaggttcaggagcaagtacatcccaatctttcagca
aatgaagaatctctctactatattgaagagctgatttttcagctgcttaataagttatgc
atggctcaaccaaggactgttcaggatgtggaggaacgagttcaaaagacttttcctcat
ccaattgataaatgggctattgctgatgcacaatctgctatagagaaacgaaaacgaaga
aatccctcccttttactgcctgtggacaaaattcatccctcattgaaggaagttttaggg
tacaaagtggactaccatgtagccttgtacattgtggctgtactggagtatatctcagct
gacatattgaaattggctggtaattatgtttttaatatccgacattatgaaatatctcag
caggacattaaagtttcaatgtgtgcagataaggttttgatggacatgtttgatcaggat
gatgacataggtttggtttctctttgtgaagatgaacctagttcttcaggtgaattaaat
tattatgaccttgtcagaactgaaattgcagaagaaagacagtatctccgggaactaaat
atgatcataaaagtgtttcgagaagcttttctttcagacagagaactgtttaaaccttct
gatattgaaaagattttcagtaacatttcagatatacatgaattgactgtgaaactttta
ggtttaattgaagatacagttgaaatgactgatgaaagcagtcctcatcccttagctggc
agctgtttcgaagatttggcagaagagcaagcatttgatccttatgaaacattatcacaa
gacattctttcaccagagtttaatgaacatttcagtaagttgatggccaggcctgcagta
actctacactttcagtctattgctgatggttttaaagaggcagttcgttatgtccttcca
cgccttatgttggtgccagtatatcattgttggcactattttgaattattaaagcaattg
aaagcatgtagtgaagagcaagaagatagagaatgtttaaaccaagctattactgctctc
ctgaatctccaaggtagtatggatcgaatttacaagcagtattcacctagacgacgaccc
ggggatcctatttgccctttttataatcgccagttaagaagcaaacacctggctattaaa
aaaatgaatgaaattcagaaaaacatagatggatgggaaggcaaagatattggacagtgt
tgtaatgaattcattatggaaggtccattgacaagaattggtgctaaacatgaacggcat
atttttctctttgatggcttaatgatcagctgtaaagccaatcatagccagtctcgactt
cctggttatagtaatgcagaatacagattaaaagaaaaatttgtcatgaggaaaatacag
atatgtgataaagaagatacttgtgaatgcaagcatgcttttgaaatagtatccaaagat
ggaaacactataatttttgctgctaagtcttctgaagagaaaagtaattggatggcagca
cttatttctcttcattatcgtagtactctagatcgaatgctagattcagtattattgaaa
gaagaaaatgagcaaccactgagattaccaagccccgatgtatatcgttttgtagttaaa
gactctgaggaaaacattgtctttgaagacaacttgcaaagtagaagtggaatccccatt
attaaaggaggaactgtggtgaaactaattgaaaggttaacttaccatatgtatgcagat
cccaattttgttcgtacttttcttactacatatcgttcattttgtaaaccacaggaattg
ctaagtttactgattgaacgatttgaaattccagagccagaacctacggaagcagataaa
ttggcagtagagaagggcgagcagccaatcattgcagaccttaaaaggtttcgaaaggaa
tacgttcaaccagtacaacttaggatcttaaatgtgtttcgacactgggttgaacaccat
ttttatgactttgaaagagatttggagttgcttgaaagactagaatccttcatttcaagt
gtaagagggaaagctatgaaaaaatgggtagaatcaattgctaagatcatcaaaaggaag
aaacaagctcaggcaaatggaataagccataatattacctttgaaagtccacctccacca
attgaatggcatctcagcaaaccaggacattttgaatcatttgaacttatgactcttcac
ccaatagaaattgcacgtcagctgacacttttggaatcagatctttacaggaaagtccag
ccatctgagcttgtagggagtgtgtggaccaaagaagataaagaaataaattctccaaac
ttgttaaaaatgattcgtcatacaacaaaccttacactatggtttgagaaatgcattgtg
gaagcagaaaattttgaagaacgggtggcagtactaagtagaattatagaaattctccaa
gtttttcaagatttgaataatttcaacggtgtattggagatagtaagtgcagtaaattca
gtgtcagtgtacagactagatcatacctttgaggcattgcaggaaagaaaaaagagaatt
ttggatgaagctgtggaattaagtcaagatcactttaaaaaatacctagtaaaacttaag
tcaatcaatccaccatgtgtgcctttttttggaatatatttaacaaatattctgaagacc
gaagaagggaataatgattttttaaaaaagaaagggaaagatttaatcaatttcagtaag
aggaggaaagtagctgaaattaccggagaaattcaacagtatcagaatcaaccttactgt
ttacgtatagaaccagatatcaggaggttctttgaaaatcttaaccccatgggaagtgct
tctgaaaaagagtttacagattatttattcaacaagtcactagaaattgaaccccgaaat
tgcagacaaccaactcgatttcctaggaaatcaaatttccctttaaaatctcctggaata
aggcctaatacaggccgacatggctctacctcaggcactttacgaggtcatccaacacca
ttagaaagagaaccatgtaaaatgagctttagtcgtattactgaaactgacattgaatca
acagtgtcagcaccaacttctccaaatacaccttctacgcccccagtttctgcttcttca
gaccttagtgtgtttttggatgtggatctcaacagttcctgtggcagcaatagtatcttt
gcaccagtcctcttgccacattcaaggtctttcttcagctcatgcggtagtttacataaa
ctaagtgaagagccactgatccctccacctcttcctcctcgaaaaaagtttgatcatgat
gcttcaaattctaagggaaacataaaacctgatgatgatccccctgctattccaccaaga
cagcctcctcctccgaaggtgaaacccagagttcctgctccaacaggtgcatttgatggg
cctctgcatagtccacctccaccaccaccaagagatcctcttcctgatactcctcctcca
gttccccttcgacctccagaacactttataaactgtccatttaatcttcagccacctcca
gtgggacatctgcacagagatccagactggttcagagacactagtacatgtcccaattca
ccgaacactcctcctagcacaccctctccgagggtaccacgtcgatgctatgtgctgagt
tctagtcataataatcttgctcatcctcaagctccccctgttccaccaaggcagaattca
agccctcatctaccaaaactgccaccaaagacttataaacgggagctttcgcaccccccc
ttgtacagactgcctttattagaaaatgcagaaactcctcaatga
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