Sorex fumeus (smoky shrew): 130042645 Help Entry 130042645         CDS       T10594                                  Symbol NOS3 Name (RefSeq) nitric oxide synthase 3   KO K13242   nitric-oxide synthase, endothelial [EC:1.14.13.39] Organism sfum  Sorex fumeus (smoky shrew) Pathway sfum00220   Arginine biosynthesis sfum00330   Arginine and proline metabolism sfum01100   Metabolic pathways sfum04020   Calcium signaling pathway sfum04022   cGMP-PKG signaling pathway sfum04066   HIF-1 signaling pathway sfum04071   Sphingolipid signaling pathway sfum04151   PI3K-Akt signaling pathway sfum04370   VEGF signaling pathway sfum04371   Apelin signaling pathway sfum04611   Platelet activation sfum04915   Estrogen signaling pathway sfum04921   Oxytocin signaling pathway sfum04926   Relaxin signaling pathway sfum04931   Insulin resistance sfum04933   AGE-RAGE signaling pathway in diabetic complications sfum05415   Diabetic cardiomyopathy sfum05417   Lipid and atherosclerosis sfum05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:sfum00001]  09100 Metabolism   09105 Amino acid metabolism    00220 Arginine biosynthesis     130042645 (NOS3)    00330 Arginine and proline metabolism     130042645 (NOS3)  09130 Environmental Information Processing   09132 Signal transduction    04370 VEGF signaling pathway     130042645 (NOS3)    04371 Apelin signaling pathway     130042645 (NOS3)    04066 HIF-1 signaling pathway     130042645 (NOS3)    04020 Calcium signaling pathway     130042645 (NOS3)    04071 Sphingolipid signaling pathway     130042645 (NOS3)    04022 cGMP-PKG signaling pathway     130042645 (NOS3)    04151 PI3K-Akt signaling pathway     130042645 (NOS3)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     130042645 (NOS3)   09152 Endocrine system    04915 Estrogen signaling pathway     130042645 (NOS3)    04921 Oxytocin signaling pathway     130042645 (NOS3)    04926 Relaxin signaling pathway     130042645 (NOS3)  09160 Human Diseases   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     130042645 (NOS3)    05418 Fluid shear stress and atherosclerosis     130042645 (NOS3)    05415 Diabetic cardiomyopathy     130042645 (NOS3)   09167 Endocrine and metabolic disease    04931 Insulin resistance     130042645 (NOS3)    04933 AGE-RAGE signaling pathway in diabetic complications     130042645 (NOS3) Enzymes [BR:sfum01000]  1. Oxidoreductases   1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen    1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor     1.14.13.39  nitric-oxide synthase (NADPH)      130042645 (NOS3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  NO_synthase FAD_binding_1 Flavodoxin_1 NAD_binding_1 Motif Other DBs NCBI-GeneID:  130042645 NCBI-ProteinID:  XP_055990759 LinkDB All DBs Position Unknown AA seq 1203 aa AA seqDB search MGNLSSVGREPGPCGLGLGLGLGLCSKQGPASPAPPEPSRAPAPAPAPAPAPPPAADSPL LSRSLEGPRFPRVKNWEVGSIAYDTLSAQAQQDGPCTPTRCLGSLVLPRKPHSRGAPGPT APELLRQARAFIDQYYSSIKRGGSQAHALRLQEVEAEVAATGTYQLRESELVFGTKQAWR NAPRCVGRIQWGKLQVFDARDCNSAQEMFTYICNHIKYATNKGNLRSAITVFPQRVPGRG DFRIWNGQLIRYAGYRQQDGSVRGDPANVEITELCVQHGWSPGNGRFDVLPLLLQVPDEP PELFTLPPELVLEVPLEHPTLEWFAELGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMS TEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVD HHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYVLSPTFRYQPDP WKGSAAKGAGIARKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLG RLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNS SPRPEQHKSYKTRFNSISCSDQLVSTWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPH FCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQASCETFCVGEDAKAA ARDIFSPKRSWKRQRYRLSAQAQGLQLLPGLVHVHRRKMFQATVLAVENLQSSKSTRATI LVRLDTAGQEGLQYQPGDHVGICPPNRPGLVEALLSRVEDPPPPGEPVAVEQLEKGSPGG PPPGWVRDPRLPPCTLRQALTFFLDITTPPSPRLLQLLSTLAEEPGEQQELETLSQDPRR YEEWKWFRCPSLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSAHPGEIHLTVAV LAYRTQDGLGPLHYGVCSTWLSQLRAGDSVPCFIRGAPSFRLPPDPNLPCILVGPGTGIA PFRGFWQERLHDIDSKGLQPFPMTLVFGCRCSQLDHLYRDEVQDAQRRGVFGRVLTAFSR EPNSPKTYVQDILRTELAEEVHRVLCLEGGHMFVCGDVTMATSVLQTVQRILATEGNMEL DEAGDLIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERRRGAVPWAFDPPGLDT AGS NT seq 3612 nt NT seq  +upstreamnt  +downstreamnt atgggcaacctcagcagcgtgggccgggagccggggccctgcggcctggggctggggctg ggcctggggctctgcagcaagcagggtccggcctcgcccgcgccccccgagcccagccgg gcccccgcgcccgcgcccgcgcccgcgcccgccccgccgcctgcagccgacagccccctg ctctcccggtccctggagggacccaggttcccccgagtgaagaactgggaggtggggagc atcgcctatgacacgctgagcgcccaggcccagcaggacgggccctgcacccccacgcgc tgcctgggctccctggtgctcccgcggaagccgcacagccggggcgcccctgggcccacc gcccccgagctgctgcgccaggccagggccttcatcgaccagtactacagctccatcaag agaggtggctcccaggcccacgcgctgcgactgcaggaggtggaggccgaagtggcggcc acgggcacgtaccagctgcgggagagcgagctggtgttcgggaccaagcaggcctggcgc aacgccccccgctgcgtgggccgcatccagtggggcaaactacaggtgtttgacgcgcgg gactgcaactcggcccaggagatgttcacctacatctgtaaccacatcaagtatgccacc aacaagggcaacctccgctcggccatcaccgtcttcccccagcgtgtccccggccgcggg gacttccggatctggaacgggcagctgatccgctacgctgggtaccggcagcaggacggg tcggtgcggggggaccctgccaacgtggagatcaccgagctctgcgtccagcacggctgg agccccgggaacggccgcttcgacgtgctgccgctgctgcttcaggtgcctgacgagccc ccggagctcttcaccctgccccccgagctggtcctcgaggtgcctctggaacaccccacg ctggagtggttcgccgagctgggcctgcgctggtacgccctcccggccgtgtccaacatg ctgctggagatcgggggcctggagttccccgcggcccccttcagcggctggtacatgagc acggagatcggcacgcggaacctgtgcgacccccaccgctacaacatcctggaggacgtg gccgtgtgcatggacctggacacccggacgacctcatccctgtggaaggacaaggcggcc gtggagatcaacgtcgccgtgctacacagctaccagctggccaaggtcaccatcgtggac caccacgcggccacggcgtccttcatgaagcacctggagaacgagcagaaggcgcgcggg ggctgcccggccgactgggcctggatcgtgccccccatctcgggcagcctcacgcccgtc ttccaccaggagatggtcaactacgtgctgtccccgaccttccgctaccagccggacccc tggaagggcagcgcggccaagggggccggcatcgccaggaagaagaccttcaaggaggtg gccaacgcagtcaagatctccgcgtccctcatgggcaccgtgatggccaagcgcgtgaag gcgaccatcctgtacggctcggagacgggccgcgcgcagagctacgcacagcagcttggg agactcttccggaaggccttcgacccccgggtgctgtgcatggacgagtacgatgtggtg tccctggagcacgagacgctggtgctggtggtgaccagcacattcgggaacggggacccc ccggagaacggagagagttttgccgctgccctcatggagatgtcggggccctacaacagt tccccaaggccggagcagcacaagagctacaaaacccgcttcaacagcatctcctgctcc gaccagctggtgtccacgtggcgtcggaagcggaaggaatcgagtaacacggacagcgct ggggcgctgggcaccctcaggttctgtgtgttcgggctgggctcccgagcgtacccccac ttctgcgcctttgcccgcgcggtggacacgcggctggaggagctgggcggagagcggctg ctgcagctgggccagggggacgagctgtgtggccaggaggaggccttccgcggctgggcg caggccgccttccaggcctcctgcgagaccttctgcgtgggagaggacgccaaggcggcc gcccgcgacatcttcagccccaagcgcagctggaaacgccagaggtaccggctgagcgcc caggcccagggcctccagctgctgccaggtctggtccacgtgcacaggcggaagatgttc caggcgaccgtgctggcggtggagaacctgcagagcagcaagtccacccgcgccaccatc ctggtgcgcctggacacggccggccaggaggggctccagtaccagcccggggaccacgtg ggcatctgcccgcccaaccggcccggcctggtggaggcgctgctgagccgcgtggaggac ccgccgccgcccggggagcccgtggccgtggagcagctggagaagggcagcccgggtggc cctcccccaggctgggtgcgggacccccgcctgcccccctgcacgctgcgccaggccctc accttcttcctggacatcaccaccccgcccagcccgcggctgctgcagctgctcagcacg ttggccgaggagcccggggagcagcaggagctggagaccctcagccaggacccccggcgc tacgaggagtggaagtggttccgctgcccgtcgctgctggaggtgctggagcagttcccg tccgtggcgctgcccgcgcccctgctcctcacgcagctgcccctgctgcagccgcgctac tactcggtcagctccgcgcccagtgctcaccccggcgagatccacctcacggtggccgtg ctggcctaccgcacgcaggacggcctgggtcccctgcactacggagtctgctccacgtgg ctgagccagctcagggccggagacagcgtcccctgcttcatcaggggggctccctccttc cggctaccccctgaccccaatttgccctgcatcctggtgggcccgggcactggcatcgcc cccttccgggggttttggcaagagcggcttcatgacattgacagcaaagggttgcagccc ttcccgatgaccttggtgttcggctgccgatgctcccagctcgaccatctctaccgcgac gaggtgcaggatgcccagcggcgcggggtgttcggccgcgtcctcacggccttctcccgg gaacccaacagccctaagacgtatgtgcaggacatcctcagaacggagctggccgaggag gtgcaccgcgtgctgtgcctagagggaggccacatgttcgtctgcggggacgtcaccatg gcaaccagtgtcctgcagacggtgcagcgcatcctggccaccgagggcaacatggagctg gacgaggccggcgacctcattggcgtgctgcgggatcagcaacgctatcacgaggacatt ttcgggctcaccctacgcacccaggaggtgacaagccgcattcgcacccagagcttctcc ctgcaggagcgacgccggggagcagtgccctgggcttttgaccccccgggtctagacact gcaggctcctga

DBGET integrated database retrieval system