KEGG   Sorex fumeus (smoky shrew): 130045209
Entry
130045209         CDS       T10594                                 
Symbol
EGFR
Name
(RefSeq) epidermal growth factor receptor isoform X1
  KO
K04361  epidermal growth factor receptor [EC:2.7.10.1]
Organism
sfum  Sorex fumeus (smoky shrew)
Pathway
sfum01521  EGFR tyrosine kinase inhibitor resistance
sfum01522  Endocrine resistance
sfum03272  Virion - Hepatitis viruses
sfum04010  MAPK signaling pathway
sfum04012  ErbB signaling pathway
sfum04014  Ras signaling pathway
sfum04015  Rap1 signaling pathway
sfum04020  Calcium signaling pathway
sfum04066  HIF-1 signaling pathway
sfum04068  FoxO signaling pathway
sfum04072  Phospholipase D signaling pathway
sfum04144  Endocytosis
sfum04151  PI3K-Akt signaling pathway
sfum04510  Focal adhesion
sfum04518  Integrin signaling
sfum04519  Cadherin signaling
sfum04520  Adherens junction
sfum04540  Gap junction
sfum04630  JAK-STAT signaling pathway
sfum04810  Regulation of actin cytoskeleton
sfum04912  GnRH signaling pathway
sfum04915  Estrogen signaling pathway
sfum04921  Oxytocin signaling pathway
sfum04926  Relaxin signaling pathway
sfum04928  Parathyroid hormone synthesis, secretion and action
sfum04934  Cushing syndrome
sfum05160  Hepatitis C
sfum05163  Human cytomegalovirus infection
sfum05165  Human papillomavirus infection
sfum05171  Coronavirus disease - COVID-19
sfum05200  Pathways in cancer
sfum05205  Proteoglycans in cancer
sfum05206  MicroRNAs in cancer
sfum05207  Chemical carcinogenesis - receptor activation
sfum05208  Chemical carcinogenesis - reactive oxygen species
sfum05210  Colorectal cancer
sfum05212  Pancreatic cancer
sfum05213  Endometrial cancer
sfum05214  Glioma
sfum05215  Prostate cancer
sfum05218  Melanoma
sfum05219  Bladder cancer
sfum05223  Non-small cell lung cancer
sfum05224  Breast cancer
sfum05225  Hepatocellular carcinoma
sfum05226  Gastric cancer
sfum05230  Central carbon metabolism in cancer
sfum05231  Choline metabolism in cancer
sfum05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:sfum00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03272 Virion - Hepatitis viruses
    130045209 (EGFR)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    130045209 (EGFR)
   04012 ErbB signaling pathway
    130045209 (EGFR)
   04014 Ras signaling pathway
    130045209 (EGFR)
   04015 Rap1 signaling pathway
    130045209 (EGFR)
   04630 JAK-STAT signaling pathway
    130045209 (EGFR)
   04066 HIF-1 signaling pathway
    130045209 (EGFR)
   04068 FoxO signaling pathway
    130045209 (EGFR)
   04020 Calcium signaling pathway
    130045209 (EGFR)
   04072 Phospholipase D signaling pathway
    130045209 (EGFR)
   04151 PI3K-Akt signaling pathway
    130045209 (EGFR)
  09133 Signaling molecules and interaction
   04518 Integrin signaling
    130045209 (EGFR)
   04519 Cadherin signaling
    130045209 (EGFR)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    130045209 (EGFR)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    130045209 (EGFR)
   04520 Adherens junction
    130045209 (EGFR)
   04540 Gap junction
    130045209 (EGFR)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    130045209 (EGFR)
 09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    130045209 (EGFR)
   04915 Estrogen signaling pathway
    130045209 (EGFR)
   04921 Oxytocin signaling pathway
    130045209 (EGFR)
   04926 Relaxin signaling pathway
    130045209 (EGFR)
   04928 Parathyroid hormone synthesis, secretion and action
    130045209 (EGFR)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    130045209 (EGFR)
   05206 MicroRNAs in cancer
    130045209 (EGFR)
   05205 Proteoglycans in cancer
    130045209 (EGFR)
   05207 Chemical carcinogenesis - receptor activation
    130045209 (EGFR)
   05208 Chemical carcinogenesis - reactive oxygen species
    130045209 (EGFR)
   05230 Central carbon metabolism in cancer
    130045209 (EGFR)
   05231 Choline metabolism in cancer
    130045209 (EGFR)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    130045209 (EGFR)
  09162 Cancer: specific types
   05210 Colorectal cancer
    130045209 (EGFR)
   05212 Pancreatic cancer
    130045209 (EGFR)
   05225 Hepatocellular carcinoma
    130045209 (EGFR)
   05226 Gastric cancer
    130045209 (EGFR)
   05214 Glioma
    130045209 (EGFR)
   05218 Melanoma
    130045209 (EGFR)
   05219 Bladder cancer
    130045209 (EGFR)
   05215 Prostate cancer
    130045209 (EGFR)
   05213 Endometrial cancer
    130045209 (EGFR)
   05224 Breast cancer
    130045209 (EGFR)
   05223 Non-small cell lung cancer
    130045209 (EGFR)
  09172 Infectious disease: viral
   05160 Hepatitis C
    130045209 (EGFR)
   05171 Coronavirus disease - COVID-19
    130045209 (EGFR)
   05163 Human cytomegalovirus infection
    130045209 (EGFR)
   05165 Human papillomavirus infection
    130045209 (EGFR)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    130045209 (EGFR)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    130045209 (EGFR)
   01522 Endocrine resistance
    130045209 (EGFR)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:sfum01001]
    130045209 (EGFR)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:sfum04147]
    130045209 (EGFR)
Enzymes [BR:sfum01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     130045209 (EGFR)
Protein kinases [BR:sfum01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   130045209 (EGFR)
Exosome [BR:sfum04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   130045209 (EGFR)
  Exosomal proteins of pancreatic cancer cells
   130045209 (EGFR)
  Exosomal proteins of bladder cancer cells
   130045209 (EGFR)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 Borrelia_P83 ABC1 Kinase-like
Other DBs
NCBI-GeneID: 130045209
NCBI-ProteinID: XP_055993905
LinkDB
Position
Unknown
AA seq 1213 aa
MRPPAAALAPPLLFLLLQLLAPRVPASPAPDDKRVCQGTSNKLTQLGTFEDHFLSLQRMF
NNCEVVLGNLEITYMQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLKIIRGNVLYEQ
THALSVLSNYYGGNKTGLRELPLRNLQEILQGTVRFSNNPALCNVHSIQWRDIVDDNFLS
NMSLDFQNQLGNCQKCDPSCSNGSCWGPGKENCQKLTKVICAQQCSGRCRGRSPSDCCHN
QCAAGCTGPRESDCLACRRFRDEATCKDTCPQLMLYNPTTYQMDVNPEGKYSFGATCVKK
CPRNYVVTDHGSCVRACSSDNYEVEEDGIRKCKKCEGPCRKVCNGIGIGEFKGTLSINAT
NIKHFKNCTTISGDLHILPVAFKGDSFTHTPPLDPEELNILRTVKEITGFLLIQAWPENR
TDLHIFENLEIIRGRTKQHGRFSLAVVGLNITSLGLRSLKEISDGDVVISENRKLCYAST
VNWKKLFGTSSQKSKVSNNRDLNDCKAMGHVCDPLCSSEGCWGPEPKDCVSCRNVSRGKE
CVEKCNILEGEPREFVENSECIQCHPECLPQTMNITCTGHGPAHCVKCTNYMDGPHCVQT
CPAGVLGENNTLVWKYADANHVCHPCHINCTIGCDGPGLENCIGRTKISFIAIGIVGGLL
LLLVVALAVGLFLRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKL
KILGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVC
RLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQHLLNWCVQIAKGMNYLEDRRLVH
RDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQS
DVWSYGVTVWELMTFGSKPYDGIPASDISTILEKGERLPQPPICTIDVYMIMVKCWMIDA
DSRPKFRELIIEFTKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMEEEDMEDVVDADE
YLVPQQGFFHSPSTSRTPLLSSLSATSNNSTVTCINRNGQSCPLKEDGFLQRYSSDPTGT
VPEENLNDAFLPAPEYVNQCVPKRPAGSVQNPVYHNQPLHAAPGRDPHYQNPSSNAVDNP
EYLNTIYPAHTSSTDAPARWAQTGSHQISLDNPDYQQDFFPKETKSNGIFKGPSAENAEY
LRVAPPSSEFTGA
NT seq 3642 nt   +upstreamnt  +downstreamnt
atgcgacccccggccgccgcgctggccccgccgctgctgtttctgctgctgcagctgctg
gccccgcgagtcccagccagccccgcgcccgacgacaagagagtttgccaaggcacaagt
aacaagctgacccagttgggaacttttgaagaccacttcctgagtctccaaaggatgttc
aacaactgtgaagtggtccttgggaatttggaaatcacctatatgcaaaggaattatgac
ctttccttcttaaagacaatccaggaagtggctggctatgtgctcattgcactcaacact
gtggagaggatccccttggagaacctgaagatcatcagggggaatgtgctatatgaacag
acccacgccctgtcggtcttgtccaactactatggaggcaacaagactgggctgagggag
ctgcctcttcgaaacctccaggaaattctgcagggcactgtgagattcagcaacaaccct
gccttgtgcaacgtgcattctatccagtggcgggacattgttgatgacaacttcctgagc
aacatgtcattggactttcagaaccagctgggtaattgccagaagtgtgatcctagttgt
tccaatggaagctgctggggtcctgggaaggagaactgtcagaaactgaccaaggtcatc
tgtgcccagcagtgttccgggcgctgccgcggccggtcccccagcgactgctgccacaac
cagtgtgccgccggctgcacggggccccgtgaaagcgactgcctggcctgccgcaggttc
cgggatgaagccacatgcaaggacacctgcccacagctcatgctctacaaccccaccaca
taccagatggatgtcaacccagaggggaagtacagctttggtgccacctgtgtgaagaaa
tgcccccggaactacgtggtgacggaccacggctcctgtgtccgagcctgcagctctgac
aactatgaggtggaggaagatggcatccgcaagtgtaagaagtgtgagggaccttgtcgc
aaagtttgtaatggaatagggattggagaatttaaaggcacactttccataaatgccaca
aacattaaacacttcaaaaactgcaccacaatcagtggggatcttcacattctgccagta
gcattcaaaggtgacagcttcacacacactcctcctctggatccagaggaactgaacatc
ctaaggactgtaaaggaaattacagggtttctgcttattcaggcctggccagaaaacagg
acagacctccacatttttgagaacctggaaatcatacgcggtcgaactaagcaacatggt
cgtttttctcttgctgttgtcggcctgaatataacgtccttgggattacgctccctcaag
gagataagtgatggagatgtggtaatttcagaaaaccgaaagttatgctacgcatccaca
gtaaactggaaaaagttatttgggacctcaagtcagaaatcaaaagtttcaaacaataga
gatttaaatgactgtaaggccatgggccatgtgtgtgatcccttatgctcatcggagggc
tgctggggcccagagcccaaagactgtgtgtcctgccgcaacgtcagcaggggaaaggaa
tgtgtggagaaatgcaacatcctagagggggagccacgggagtttgtggagaattctgag
tgtatacagtgccacccagagtgtctgccccagaccatgaacatcacctgcacaggacac
ggaccagcccattgtgtgaagtgcaccaactatatggatggcccccactgtgtccagacc
tgccctgcaggtgtcctgggagaaaacaacaccctggtctggaagtatgccgacgccaac
cacgtgtgccacccttgccacatcaactgtaccatcggctgcgacgggccaggccttgaa
aactgcatcggcaggaccaagatctcgttcatcgccattgggatagtgggagggctcctg
ctgctcctggtggttgcccttgcagttggcctgtttctccgcagacgtcacattgtccgg
aagcgcacactgcggagactgctccaagaaagagagctggttgagcccctgacacccagt
ggagaagcccccaatcaagctctcttgaggatcttaaaggaaactgagttcaaaaagctc
aaaattctgggctctggagcgtttggcacagtgtacaagggactctggatcccagaaggt
gagaaggtgaaaatccctgtggccatcaaggaattaagagaagccacgtctcccaaagcc
aacaaggagattctggatgaagcctatgtcatggccagcgtggacaacccccatgtgtgc
cgtcttctgggcatctgcctgacctccactgtccagctcatcacacagctcatgcctttc
ggctgcctcctagactatgtccgtgagcataaggacaatattggctcccagcacctgctc
aactggtgtgtccagattgcaaagggcatgaattacttggaggatcggcgcttggtgcac
cgtgatttggcagccaggaatgttctggtgaagaccccacagcatgtcaaaatcacagac
tttgggctggccaaactccttggtgccgaagagaaggaataccatgcagaaggaggcaaa
gtgcctatcaagtggatggctttggaatcaattttacaccgaatttacacccaccagagt
gatgtctggagctatggagtcactgtttgggagctgatgacttttggatccaagccttat
gatggtatccctgcgagtgacatctccaccatcctggagaaaggagagcgcctcccgcag
ccccccatctgcaccattgacgtctacatgatcatggtcaagtgctggatgatagatgca
gacagtcgcccaaagttccgtgaactgatcattgaattcaccaaaatggctcgagacccc
cagcgctaccttgtcatccagggggatgagagaatgcacttgccgagccctacggactcc
aacttctaccgagccctgatggaggaggaggacatggaggatgtcgtagatgctgatgag
tacctggttccccagcagggcttcttccacagcccatccacctcccgcacgcccctcctg
agctccctgagtgccaccagcaacaattccaccgtgacttgcattaacagaaatgggcag
agctgccccctcaaggaggatggctttctgcagcgctacagctctgacccgactggcacc
gtgcctgaggagaatctgaatgatgccttcctgcctgcccctgaatatgtcaaccagtgt
gttcccaagaggcctgcaggctctgtccagaacccagtctatcataaccagcctctccat
gcagctcctggcagagacccacactaccagaaccccagcagcaatgcagtggacaacccc
gagtatctcaacaccatctaccctgcccacaccagcagcacggacgctcctgcccgctgg
gcccagacaggcagccaccagatcagcctggacaaccccgactaccagcaggacttcttt
ccaaaggaaaccaagtccaatggcatctttaaggggccttcagctgaaaacgcagagtac
ctgagagtagcaccacccagcagcgagtttactggggcatga

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