| Entry |
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| Symbol |
EGFR
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| Name |
(RefSeq) epidermal growth factor receptor isoform X1
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| KO |
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| Organism |
sfum Sorex fumeus (smoky shrew)
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| Pathway |
| sfum01521 | EGFR tyrosine kinase inhibitor resistance |
| sfum04928 | Parathyroid hormone synthesis, secretion and action |
| sfum05207 | Chemical carcinogenesis - receptor activation |
| sfum05208 | Chemical carcinogenesis - reactive oxygen species |
| sfum05230 | Central carbon metabolism in cancer |
| sfum05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
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| Brite |
KEGG Orthology (KO) [BR:sfum00001]
09120 Genetic Information Processing
09125 Information processing in viruses
03272 Virion - Hepatitis viruses
130045209 (EGFR)
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
130045209 (EGFR)
04012 ErbB signaling pathway
130045209 (EGFR)
04014 Ras signaling pathway
130045209 (EGFR)
04015 Rap1 signaling pathway
130045209 (EGFR)
04630 JAK-STAT signaling pathway
130045209 (EGFR)
04066 HIF-1 signaling pathway
130045209 (EGFR)
04068 FoxO signaling pathway
130045209 (EGFR)
04020 Calcium signaling pathway
130045209 (EGFR)
04072 Phospholipase D signaling pathway
130045209 (EGFR)
04151 PI3K-Akt signaling pathway
130045209 (EGFR)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
130045209 (EGFR)
09144 Cellular community - eukaryotes
04510 Focal adhesion
130045209 (EGFR)
04520 Adherens junction
130045209 (EGFR)
04540 Gap junction
130045209 (EGFR)
09142 Cell motility
04810 Regulation of actin cytoskeleton
130045209 (EGFR)
09150 Organismal Systems
09152 Endocrine system
04912 GnRH signaling pathway
130045209 (EGFR)
04915 Estrogen signaling pathway
130045209 (EGFR)
04921 Oxytocin signaling pathway
130045209 (EGFR)
04926 Relaxin signaling pathway
130045209 (EGFR)
04928 Parathyroid hormone synthesis, secretion and action
130045209 (EGFR)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
130045209 (EGFR)
05206 MicroRNAs in cancer
130045209 (EGFR)
05205 Proteoglycans in cancer
130045209 (EGFR)
05207 Chemical carcinogenesis - receptor activation
130045209 (EGFR)
05208 Chemical carcinogenesis - reactive oxygen species
130045209 (EGFR)
05230 Central carbon metabolism in cancer
130045209 (EGFR)
05231 Choline metabolism in cancer
130045209 (EGFR)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
130045209 (EGFR)
09162 Cancer: specific types
05210 Colorectal cancer
130045209 (EGFR)
05212 Pancreatic cancer
130045209 (EGFR)
05225 Hepatocellular carcinoma
130045209 (EGFR)
05226 Gastric cancer
130045209 (EGFR)
05214 Glioma
130045209 (EGFR)
05218 Melanoma
130045209 (EGFR)
05219 Bladder cancer
130045209 (EGFR)
05215 Prostate cancer
130045209 (EGFR)
05213 Endometrial cancer
130045209 (EGFR)
05224 Breast cancer
130045209 (EGFR)
05223 Non-small cell lung cancer
130045209 (EGFR)
09172 Infectious disease: viral
05160 Hepatitis C
130045209 (EGFR)
05171 Coronavirus disease - COVID-19
130045209 (EGFR)
05163 Human cytomegalovirus infection
130045209 (EGFR)
05165 Human papillomavirus infection
130045209 (EGFR)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
130045209 (EGFR)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
130045209 (EGFR)
01522 Endocrine resistance
130045209 (EGFR)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:sfum01001]
130045209 (EGFR)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:sfum04147]
130045209 (EGFR)
Enzymes [BR:sfum01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
130045209 (EGFR)
Protein kinases [BR:sfum01001]
Receptor tyrosine kinases (RTK)
EGFR family [OT]
130045209 (EGFR)
Exosome [BR:sfum04147]
Exosomal proteins
Exosomal proteins of colorectal cancer cells
130045209 (EGFR)
Exosomal proteins of pancreatic cancer cells
130045209 (EGFR)
Exosomal proteins of bladder cancer cells
130045209 (EGFR)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
Unknown
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| AA seq |
1213 aa
MRPPAAALAPPLLFLLLQLLAPRVPASPAPDDKRVCQGTSNKLTQLGTFEDHFLSLQRMF
NNCEVVLGNLEITYMQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLKIIRGNVLYEQ
THALSVLSNYYGGNKTGLRELPLRNLQEILQGTVRFSNNPALCNVHSIQWRDIVDDNFLS
NMSLDFQNQLGNCQKCDPSCSNGSCWGPGKENCQKLTKVICAQQCSGRCRGRSPSDCCHN
QCAAGCTGPRESDCLACRRFRDEATCKDTCPQLMLYNPTTYQMDVNPEGKYSFGATCVKK
CPRNYVVTDHGSCVRACSSDNYEVEEDGIRKCKKCEGPCRKVCNGIGIGEFKGTLSINAT
NIKHFKNCTTISGDLHILPVAFKGDSFTHTPPLDPEELNILRTVKEITGFLLIQAWPENR
TDLHIFENLEIIRGRTKQHGRFSLAVVGLNITSLGLRSLKEISDGDVVISENRKLCYAST
VNWKKLFGTSSQKSKVSNNRDLNDCKAMGHVCDPLCSSEGCWGPEPKDCVSCRNVSRGKE
CVEKCNILEGEPREFVENSECIQCHPECLPQTMNITCTGHGPAHCVKCTNYMDGPHCVQT
CPAGVLGENNTLVWKYADANHVCHPCHINCTIGCDGPGLENCIGRTKISFIAIGIVGGLL
LLLVVALAVGLFLRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKL
KILGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVC
RLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQHLLNWCVQIAKGMNYLEDRRLVH
RDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQS
DVWSYGVTVWELMTFGSKPYDGIPASDISTILEKGERLPQPPICTIDVYMIMVKCWMIDA
DSRPKFRELIIEFTKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMEEEDMEDVVDADE
YLVPQQGFFHSPSTSRTPLLSSLSATSNNSTVTCINRNGQSCPLKEDGFLQRYSSDPTGT
VPEENLNDAFLPAPEYVNQCVPKRPAGSVQNPVYHNQPLHAAPGRDPHYQNPSSNAVDNP
EYLNTIYPAHTSSTDAPARWAQTGSHQISLDNPDYQQDFFPKETKSNGIFKGPSAENAEY
LRVAPPSSEFTGA |
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| NT seq |
3642 nt +upstreamnt +downstreamnt
atgcgacccccggccgccgcgctggccccgccgctgctgtttctgctgctgcagctgctg
gccccgcgagtcccagccagccccgcgcccgacgacaagagagtttgccaaggcacaagt
aacaagctgacccagttgggaacttttgaagaccacttcctgagtctccaaaggatgttc
aacaactgtgaagtggtccttgggaatttggaaatcacctatatgcaaaggaattatgac
ctttccttcttaaagacaatccaggaagtggctggctatgtgctcattgcactcaacact
gtggagaggatccccttggagaacctgaagatcatcagggggaatgtgctatatgaacag
acccacgccctgtcggtcttgtccaactactatggaggcaacaagactgggctgagggag
ctgcctcttcgaaacctccaggaaattctgcagggcactgtgagattcagcaacaaccct
gccttgtgcaacgtgcattctatccagtggcgggacattgttgatgacaacttcctgagc
aacatgtcattggactttcagaaccagctgggtaattgccagaagtgtgatcctagttgt
tccaatggaagctgctggggtcctgggaaggagaactgtcagaaactgaccaaggtcatc
tgtgcccagcagtgttccgggcgctgccgcggccggtcccccagcgactgctgccacaac
cagtgtgccgccggctgcacggggccccgtgaaagcgactgcctggcctgccgcaggttc
cgggatgaagccacatgcaaggacacctgcccacagctcatgctctacaaccccaccaca
taccagatggatgtcaacccagaggggaagtacagctttggtgccacctgtgtgaagaaa
tgcccccggaactacgtggtgacggaccacggctcctgtgtccgagcctgcagctctgac
aactatgaggtggaggaagatggcatccgcaagtgtaagaagtgtgagggaccttgtcgc
aaagtttgtaatggaatagggattggagaatttaaaggcacactttccataaatgccaca
aacattaaacacttcaaaaactgcaccacaatcagtggggatcttcacattctgccagta
gcattcaaaggtgacagcttcacacacactcctcctctggatccagaggaactgaacatc
ctaaggactgtaaaggaaattacagggtttctgcttattcaggcctggccagaaaacagg
acagacctccacatttttgagaacctggaaatcatacgcggtcgaactaagcaacatggt
cgtttttctcttgctgttgtcggcctgaatataacgtccttgggattacgctccctcaag
gagataagtgatggagatgtggtaatttcagaaaaccgaaagttatgctacgcatccaca
gtaaactggaaaaagttatttgggacctcaagtcagaaatcaaaagtttcaaacaataga
gatttaaatgactgtaaggccatgggccatgtgtgtgatcccttatgctcatcggagggc
tgctggggcccagagcccaaagactgtgtgtcctgccgcaacgtcagcaggggaaaggaa
tgtgtggagaaatgcaacatcctagagggggagccacgggagtttgtggagaattctgag
tgtatacagtgccacccagagtgtctgccccagaccatgaacatcacctgcacaggacac
ggaccagcccattgtgtgaagtgcaccaactatatggatggcccccactgtgtccagacc
tgccctgcaggtgtcctgggagaaaacaacaccctggtctggaagtatgccgacgccaac
cacgtgtgccacccttgccacatcaactgtaccatcggctgcgacgggccaggccttgaa
aactgcatcggcaggaccaagatctcgttcatcgccattgggatagtgggagggctcctg
ctgctcctggtggttgcccttgcagttggcctgtttctccgcagacgtcacattgtccgg
aagcgcacactgcggagactgctccaagaaagagagctggttgagcccctgacacccagt
ggagaagcccccaatcaagctctcttgaggatcttaaaggaaactgagttcaaaaagctc
aaaattctgggctctggagcgtttggcacagtgtacaagggactctggatcccagaaggt
gagaaggtgaaaatccctgtggccatcaaggaattaagagaagccacgtctcccaaagcc
aacaaggagattctggatgaagcctatgtcatggccagcgtggacaacccccatgtgtgc
cgtcttctgggcatctgcctgacctccactgtccagctcatcacacagctcatgcctttc
ggctgcctcctagactatgtccgtgagcataaggacaatattggctcccagcacctgctc
aactggtgtgtccagattgcaaagggcatgaattacttggaggatcggcgcttggtgcac
cgtgatttggcagccaggaatgttctggtgaagaccccacagcatgtcaaaatcacagac
tttgggctggccaaactccttggtgccgaagagaaggaataccatgcagaaggaggcaaa
gtgcctatcaagtggatggctttggaatcaattttacaccgaatttacacccaccagagt
gatgtctggagctatggagtcactgtttgggagctgatgacttttggatccaagccttat
gatggtatccctgcgagtgacatctccaccatcctggagaaaggagagcgcctcccgcag
ccccccatctgcaccattgacgtctacatgatcatggtcaagtgctggatgatagatgca
gacagtcgcccaaagttccgtgaactgatcattgaattcaccaaaatggctcgagacccc
cagcgctaccttgtcatccagggggatgagagaatgcacttgccgagccctacggactcc
aacttctaccgagccctgatggaggaggaggacatggaggatgtcgtagatgctgatgag
tacctggttccccagcagggcttcttccacagcccatccacctcccgcacgcccctcctg
agctccctgagtgccaccagcaacaattccaccgtgacttgcattaacagaaatgggcag
agctgccccctcaaggaggatggctttctgcagcgctacagctctgacccgactggcacc
gtgcctgaggagaatctgaatgatgccttcctgcctgcccctgaatatgtcaaccagtgt
gttcccaagaggcctgcaggctctgtccagaacccagtctatcataaccagcctctccat
gcagctcctggcagagacccacactaccagaaccccagcagcaatgcagtggacaacccc
gagtatctcaacaccatctaccctgcccacaccagcagcacggacgctcctgcccgctgg
gcccagacaggcagccaccagatcagcctggacaaccccgactaccagcaggacttcttt
ccaaaggaaaccaagtccaatggcatctttaaggggccttcagctgaaaacgcagagtac
ctgagagtagcaccacccagcagcgagtttactggggcatga |
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