Shigella flexneri 2457T (serotype 2a): S2776
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Entry
S2776 CDS
T00128
Symbol
purL
Name
(GenBank) phosphoribosylformyl-glycineamide synthetase, FGAM synthetase
KO
K01952
phosphoribosylformylglycinamidine synthase [EC:
6.3.5.3
]
Organism
sfx
Shigella flexneri 2457T (serotype 2a)
Pathway
sfx00230
Purine metabolism
sfx01100
Metabolic pathways
sfx01110
Biosynthesis of secondary metabolites
Module
sfx_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
sfx00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
S2776 (purL)
Enzymes [BR:
sfx01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor
6.3.5.3 phosphoribosylformylglycinamidine synthase
S2776 (purL)
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Gene cluster
GFIT
Motif
Pfam:
GATase_5
FGAR-AT_PurM_N-like
AIRS_C
FGAR-AT_N
FGAR-AT_linker
AIRS
Motif
Other DBs
NCBI-ProteinID:
AAP17925
UniProt:
A0A9P2IYE6
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Position
complement(2670114..2674001)
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AA seq
1295 aa
AA seq
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MMEILRGSPALSAFRINKLLARFQAARLPVHNIYAEYVHFADLNAPLNDDEHAQLERLLK
YGPALASHAPQGKLLLVTPRPGTISPWSSKATDIAHNCGLQQVNRLERGVAYYIEAGTLT
NEQWQQVTAELHDRMMETVFFDLDDAEQLFAHHQPTPVTSVDLLGQGRQALIDANLRLGL
ALAEDEIDYLQDAFTKLGRNPNDIELYMFAQANSEHCRHKIFNADWIIDGEQQPKSLFRM
IKNTFETTPDHVLSAYKDNAAVMEGSEVGRYFADHETGRYNFHQEPAHILMKVETHNHPT
AISPWPGAATGSGGEIRDEGATGRGAKPKAGLVGFSVSNLRIPGFEQPWEEDFGKPERIV
TALDIMTEGPLGGAAFNNEFGRPALNGYFRTYEEKVNSHNGEELRGYHKPIMLAGGIGNI
RADHVQKGEINVGAKLVVLGGPAMNIGLGGGAASSMASGQSDADLDFASVQRDNPEMERR
CQEVIDRCWQLGDANPILFIHDVGAGGLSNAMPELVSDGGRGGKFELRDILSDEPGMSPL
EIWCNESQERYVLAVAADQLPLFDELCKRERAPYAVIGEATEELHLSLHDRHFDNQPIDL
PLDVLLGKTPKMTRDVQTLKAKGDALVREGITIADAVKRVLHLPTVAEKTFLVTIGDRSV
TGMVARDQMVGPWQVPVANCAVTTASLDSYYGEAMAIGERAPVALLDFAASARLAVGEAL
TNIAATQIGDIKRIKLSANWMAAAGHPGEDAGLYEAVKAVGEELCPALGLTIPVGKDSMS
MKTRWQEGNEEREMTSPLSLVISAFARVEDVRHTITPQLCTEDNALLLIDLGKGNNALGA
TALAQVYRQLGDKPADVRDVVQLKGFYDAIQALVAQRKLLAYHDRSDGGLLVTLAEMAFA
GHCGIDADIASLGDDRLAALFNEELGAVIQVRAADREAVESVLAQHGLADCVHYVGQAVS
GDRFVITANGQTVFSESRTTLRVWWAETTWQMQRLRDNPECADQEHQAKSNDADPGLNVK
LSFDINEDVAAPYIATGARPKVAVLREQGVNSHVEMAAAFQRGGFDAIDVHMSDLLTGRT
GLEDFHALVACGGFSYGDVLGAGEGWAKSILFNDRVRDEFATFFHRPQTLALGVCNGCQM
MSNLRELIPGSELWPRFVRNTSDRFEARFSLVEVTQSPSLLLQGMVGSQMPIAVSHGEGR
VEVRDAAHLAALESKGLVALRYVDNFGKVTETYPANPNGSPNGITAVTTESGRVTIMMPH
PERVFRTVSNSWHPENWGEDGPWMRIFRNARKQLG
NT seq
3888 nt
NT seq
+upstream
nt +downstream
nt
atgatggaaattctgcgtggttcgcctgcactgtcggcattccgaatcaacaaactgctg
gcacgttttcaggctgccaggctcccggttcacaatatttacgccgagtatgtccatttt
gctgacctcaatgcgccgttaaacgatgatgagcacgcacaacttgaacgcctgctgaaa
tatggtccggcactcgccagccacgccccgcaaggcaaactcctgctggtgaccccgcgt
cctggcaccatctctccctggtcttcgaaagcgaccgatattgcccataactgcgggcta
caacaggtaaaccgccttgagcgcggcgttgcttactatatagaagccggtacgctgacc
aatgaacaatggcagcaggttaccgctgaactgcacgaccgcatgatggaaacggtcttt
tttgatttagatgatgcagagcagttgtttgcccaccatcaaccgactccggtcacaagc
gttgatttgctggggcagggccgtcaggcgctgatcgacgctaacctgcgtcttggcttg
gctctggcggaagatgaaattgactatctgcaggatgctttcacaaagcttggtcgtaac
ccgaacgacatcgagctgtatatgttcgctcaggcgaactctgagcactgccgccacaaa
atttttaacgccgactggattatcgacggtgaacaacagccgaaatcgctgttcaggatg
atcaaaaatactttcgaaaccacgccagatcacgttctctctgcttataaagataacgcc
gccgtaatggaaggttctgaagtgggccgctactttgctgaccacgaaacgggccgctac
aatttccatcaggaaccggcgcacatcctgatgaaagtcgaaactcacaaccacccgacg
gcgatttctccgtggccgggcgcggcgaccggttccggcggtgaaatccgcgatgaaggt
gccaccgggcgcggcgcgaagccgaaagctggtttggttggtttctccgtatccaacctg
cgaattcctggcttcgaacagccgtgggaagaagatttcggtaagcctgagcgcattgtt
accgcgctggacatcatgaccgaaggcccgctgggcggtgcggcgtttaacaacgaattt
ggtcgtccggcactgaacggctacttccgtacttatgaagaaaaagtgaacagccacaat
ggcgaagagctgcgcggttatcacaaaccgatcatgctggcgggcgggatcggcaacatt
cgcgccgatcacgtacaaaaaggcgagatcaacgtcggtgcgaagctggtcgttctcggc
ggcccggcaatgaacatcggtcttggcggcggcgcggcgtcttccatggcgtctggtcag
tctgatgccgacctcgactttgcttccgtacagcgcgacaacccggagatggagcgtcgt
tgccaggaagtgatcgaccgttgctggcagcttggtgatgctaacccaattctgtttatc
cacgacgtcggtgcgggcggtctttctaacgcgatgccggagctggtgagcgacggcgga
cgcggcggtaaatttgaactgcgcgatattctaagcgacgaaccgggcatgagcccgctg
gaaatctggtgtaacgaatcccaggaacgctacgtgctggcggttgctgccgatcaatta
ccgctgtttgacgaactgtgtaagcgtgagcgcgcaccctacgcggtgattggtgaagcg
accgaagaactgcatctttctctgcacgatcgtcattttgataatcagccgatcgatctg
ccgctggacgtcctgcttggtaaaacgccgaagatgacccgcgatgtacaaacgctgaaa
gcgaagggcgatgcgctggtccgtgaagggatcaccattgcagacgcggtgaaacgcgta
ctgcatctgccgaccgtggcggagaaaactttcctggtgaccatcggtgaccgcagcgta
accggcatggtggcgcgcgatcagatggtggggccgtggcaggtgccggtcgctaactgc
gcggtcactaccgccagcctcgacagctactacggtgaagcgatggcgattggcgagcgt
gcgccggttgcgctgctggatttcgccgcctctgcccgtctggcggtcggtgaagcgtta
accaatattgccgcaacacagattggcgatatcaaacgcattaaactttccgccaactgg
atggcggcggcaggccaccctggtgaagatgcgggcctgtatgaagccgttaaagccgtg
ggtgaagaactttgtccggcgctgggcctgacgatcccggtgggtaaagactctatgtcg
atgaaaacccgctggcaggaaggtaacgaagagcgcgaaatgacgtcgccgctgtcgctg
gtgatttctgcatttgcccgcgtggaagatgtacgtcacaccatcacgccgcagctttgt
accgaagataacgcactgctgctgattgatttgggcaaaggcaataacgcgctgggcgca
acggcgctggcgcaggtttatcgtcagcttggcgacaaaccggcagatgtacgcgatgtt
gtccaactgaaaggcttctatgacgcgattcaggcgctggttgcacagcgtaagctgctg
gcgtatcacgaccgctctgatggaggcctgctggtaacgctggcggaaatggcctttgca
ggtcattgtggcattgacgcggatatcgcctctctgggtgacgatcgcctggcggcgttg
tttaacgaagaactgggtgcggtgattcaggttcgtgccgctgaccgtgaagcggtcgag
tccgtactggcacagcatgggcttgcggattgcgtccattatgttgggcaggcggtttcc
ggtgaccgttttgtgattaccgccaacgggcagactgtattcagcgaaagccgcactacg
ttgcgtgtctggtgggcagaaactacctggcagatgcagcgcctgcgtgacaacccggag
tgtgccgatcaggagcatcaggcgaaatctaacgacgccgatccgggcctgaatgtaaaa
ctgtcgttcgatatcaacgaagatgtggcagcaccgtatattgccactggcgcacgtccg
aaagttgccgtactgcgtgagcagggcgtgaactcgcatgttgaaatggcggcagctttc
caacgtgggggctttgatgctatcgacgtgcatatgagcgacctgctgactggacgtacg
ggactggaggattttcacgccctggtcgcgtgcggaggtttctcctacggtgatgtgctg
ggtgccggtgaaggttgggcgaagtctatcctgttcaatgaccgtgtacgcgatgagttt
gcaaccttcttccatcgtccgcaaacgctggccctgggggtatgtaacggttgccagatg
atgtctaacctgcgtgaactgatcccggggagtgagttgtggccacgttttgtgcgtaac
acctccgatcgctttgaagcgcgtttcagcctggttgaagtaacccaaagcccgtctctg
ctgttgcaggggatggtgggctcgcaaatgccgattgctgtctctcatggtgaagggcgc
gtggaagtgcgtgatgcggcgcatctggcggcactggaaagcaaagggctggtggcactg
cgctatgtcgataacttcggcaaagtcactgaaacctacccggctaacccgaacggttca
ccgaacggtattacggcggttacgactgaaagtggtcgagtcaccattatgatgccgcac
ccggaacgtgttttccgtactgtcagcaactcctggcatccggaaaactggggcgaggat
ggcccatggatgcgcattttccgcaatgcgcgtaagcagttggggtaa
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