Streptomyces griseoviridis: ELQ87_26725
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Entry
ELQ87_26725 CDS
T06660
Symbol
leuA
Name
(GenBank) 2-isopropylmalate synthase
KO
K01649
2-isopropylmalate synthase [EC:
2.3.3.13
]
Organism
sgd
Streptomyces griseoviridis
Pathway
sgd00290
Valine, leucine and isoleucine biosynthesis
sgd00620
Pyruvate metabolism
sgd01100
Metabolic pathways
sgd01110
Biosynthesis of secondary metabolites
sgd01210
2-Oxocarboxylic acid metabolism
sgd01230
Biosynthesis of amino acids
Module
sgd_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
sgd00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
ELQ87_26725 (leuA)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
ELQ87_26725 (leuA)
Enzymes [BR:
sgd01000
]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
ELQ87_26725 (leuA)
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Gene cluster
GFIT
Motif
Pfam:
HMGL-like
IPMS_D2
LeuA_dimer
Motif
Other DBs
NCBI-ProteinID:
AZS87420
UniProt:
A0A3S9ZHY3
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All DBs
Position
5965751..5967472
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AA seq
573 aa
AA seq
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MANRQQPSTMPIHKYGRYEQVDLPDRTWPDNRITVAPRWLSTDLRDGNQALIDPMSPERK
RRMFDQLVAMGYKEIEVGFPASGQTDFDFVRSIIEEEGAIPDDVTISVLTQAREDLIERT
VESLKGARRATVHLYNATAPVFRRVVFRGSKDDIKQIAVDGTRLVVEYAEKLLGPETEFG
YQYSPEIFTDTELDFALEVCEAVMDVWQPGPGREIILNLPATVERSTPSTYADRFEWMHR
NLTRREHVVLSVHPHNDRGTAVAAAELALMAGADRVEGCLFGQGERTGNVDLVTLGMNLF
SQGVDPQIDFSDIDEIRRVGEYCNQMEVHPRHPYAGDLVYTSFSGSHQDAIKKGFDAMEA
QAAERGVTVDDIEWAVPYLPIDPKDVGRSYEAVIRVNSQSGKGGIAYVLKNDHKLDLPRR
MQIEFSKIIQAKTDAEGGEITGADIWAVFQDEYLPRAQNPWGRVQVRNGQSTTDTDGVDT
LTVEATVDGVDTVLSGSGNGPISAFFDALQTIGIDVRLLDYQEHTMSEGASAQAASYIEC
AIDGKILWGIGIDANTTRASLKAVVSAVNRATR
NT seq
1722 nt
NT seq
+upstream
nt +downstream
nt
atggcgaaccgccagcagcccagcaccatgccgatccacaagtacggccgctacgagcag
gtcgacctccccgaccgcacctggcccgacaaccggatcaccgtcgctccgcgctggctc
tccaccgatctgcgcgacggcaaccaggccctgatcgacccgatgtcgcccgagcgcaag
cgccggatgttcgaccagctggtcgcgatgggctacaaggagatcgaggtcggcttcccg
gcctccggccagaccgacttcgacttcgtgcgctccatcatcgaggaagagggcgcgatc
cccgacgacgtcacgatctccgtactgacccaggcccgcgaggacctgatcgagcggacc
gtggagtccctgaagggcgcgcggcgggccaccgtccacctctacaacgcgaccgcgccg
gtcttccgccgggtcgtcttccgcggctccaaggacgacatcaagcagatcgccgtcgac
ggcacccggctggtcgtcgagtacgccgagaagctgctgggcccggagacggagttcggc
taccagtactcgcccgagatcttcaccgacaccgagctggacttcgcgctggaggtctgc
gaggcggtgatggacgtctggcagcccggccccggccgcgagatcatcctcaacctgccc
gccacggtggagcgttcgacgccgtcgacgtacgcggaccgcttcgagtggatgcaccgc
aacctgacccgccgcgagcacgtcgtgctctccgtccacccgcacaacgaccgcggtacg
gcggtggcggcggccgagctggcgctgatggcgggcgccgaccgcgtcgagggctgcctc
ttcgggcagggcgagcgcaccggcaacgtcgacctggtcaccctcggcatgaacctgttc
tcgcagggcgtcgacccgcagatcgacttctccgacatcgacgagatccgccgcgtcggc
gagtactgcaaccagatggaggtccacccgcgccacccgtacgcgggcgacctggtctac
acgtccttctccggctcccaccaggacgccatcaagaagggcttcgacgccatggaggcc
caggccgccgagcggggcgtcaccgtcgacgacatcgagtgggcggtgccctacctgccg
atcgacccgaaggacgtcggccgctcctacgaggcggtcatccgggtcaactcgcagtcg
ggcaagggcgggatcgcctacgtcctgaagaacgaccacaagctggacctgccgcgccgg
atgcagatcgagttctcgaagatcatccaggccaagacggacgccgagggcggcgagatc
accggcgccgacatctgggccgtcttccaggacgagtacctgccccgcgcgcagaacccg
tggggccgcgtccaggtccgcaacggccagtcgaccaccgacaccgacggcgtggacacc
ctcaccgtcgaggccaccgtcgacggcgtggacaccgtcctgtccggctcgggcaacggt
ccgatctcggccttcttcgacgccctgcagaccatcggcatcgacgtacggctgctggac
taccaggagcacacgatgagcgagggcgcctccgcgcaggccgcctcctacatcgaatgc
gcgatcgacggcaagattctgtggggcatcggcatcgacgcgaacacgacgcgtgcgtcg
ctgaaggcggtcgtctccgcggtcaaccgcgcgacccgctga
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