Streptomyces griseorubiginosus: DWG14_05661
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Entry
DWG14_05661 CDS
T06099
Symbol
leuA_2
Name
(GenBank) 2-isopropylmalate synthase
KO
K01649
2-isopropylmalate synthase [EC:
2.3.3.13
]
Organism
sge
Streptomyces griseorubiginosus
Pathway
sge00290
Valine, leucine and isoleucine biosynthesis
sge00620
Pyruvate metabolism
sge01100
Metabolic pathways
sge01110
Biosynthesis of secondary metabolites
sge01210
2-Oxocarboxylic acid metabolism
sge01230
Biosynthesis of amino acids
Module
sge_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
sge00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
DWG14_05661 (leuA_2)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
DWG14_05661 (leuA_2)
Enzymes [BR:
sge01000
]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
DWG14_05661 (leuA_2)
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Gene cluster
GFIT
Motif
Pfam:
HMGL-like
IPMS_D2
LeuA_dimer
Motif
Other DBs
NCBI-ProteinID:
AYC41375
UniProt:
A0A124HZ15
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All DBs
Position
6372343..6374064
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AA seq
573 aa
AA seq
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MANRQQPSSMPIHKYGRYEQVDIPDRTWPDNRITVAPRWLSTDLRDGNQSLIDPMSPERK
RRMFDQLVKMGYKEIEVGFPASGQTDFDFVRSIIEEPGVIPDDVTISVLTQAREDLIERT
VESLKGAKRATVHLYNATAPVFRRVVFRGSKDDIKQIAVDGTRLVMEYAEKLLGPETEFG
YQYSPEIFTDTELDFALEVCEAVMDVYQPGPGREIILNLPATVERSTPSTHADRFEWMHR
NLSRREYVCISIHPHNDRGTAVAAAELALMAGADRVEGCLFGQGERTGNVDLVTLGMNLF
SQGVDPQIDFSDIDEIRRTWEYCNQMEVHPRHPYVGDLVYTSFSGSHQDAIKKGFDAMEA
DAAAKGVTVDDIEWAVPYLPIDPKDVGRSYEAVIRVNSQSGKGGIAYVLKNDHKLDLPRR
MQIEFSKIIQAKTDAEGGEVTGSDIWAVFQDEYLPNPENPWGRIQVRNGQSTTDTDGVDT
LKVEATVDGVDTVLTGSGNGPISAFFDALAKVGIDARLLDYQEHTMSEGASAQAASYIEC
AIDGKVLWGIGIDANTTRASLKAVVSAVNRAAR
NT seq
1722 nt
NT seq
+upstream
nt +downstream
nt
atggcgaaccgccagcagcccagttccatgccgatccacaagtacggccggtacgagcag
gtcgacatcccggaccgcacctggccggacaaccggatcaccgtcgccccccgctggctc
tccaccgacctgcgcgacggcaaccagtccctgatcgacccgatgtcgcccgagcgcaag
cgccggatgttcgaccagctggtcaagatgggctacaaggagatcgaggtcggcttcccg
gcgtcgggtcagacggacttcgacttcgtgcggtcgatcatcgaggagccgggcgtgatc
ccggacgacgtgacgatctccgtactgacccaggcccgcgaggacctgatcgagcggacc
gtggagtccctgaagggcgccaagcgggccaccgtccacctgtacaacgccaccgcgccg
gtcttccgccgggtcgtcttccggggctccaaggacgacatcaagcagatcgccgtcgac
ggcacccgcctggtcatggagtacgcggagaagctgctgggcccggagaccgagttcggc
taccagtactccccggagatcttcaccgacaccgagctggacttcgcgctggaggtctgc
gaggcggtgatggacgtctaccagccgggtccgggccgcgagatcatcctcaacctgccc
gccacggtggagcgttcgaccccgtccacgcacgcggaccgcttcgagtggatgcaccgc
aacctgtcccgccgcgagtacgtgtgcatctcgatccacccgcacaacgaccgcggcacc
gccgtcgccgccgccgagctggccctgatggccggcgccgaccgcgtcgagggctgtctg
ttcggacagggcgagcgcaccggcaacgtcgacctggtcaccctgggcatgaacctgttc
tcgcagggcgtcgacccgcagatcgacttctccgacatcgacgagatccgtcgtacgtgg
gagtactgcaaccagatggaggtccacccgcgccacccgtacgtgggcgacctggtctac
acgtccttctccggctcccaccaggacgccatcaagaagggcttcgacgccatggaggcc
gacgcggccgccaagggcgtcaccgtcgacgacatcgagtgggcggtgccctacctgccg
atcgacccgaaggacgtcggccgctcctacgaggccgtgatccgggtcaactcgcagtcc
ggcaagggcgggatcgcgtacgtcctgaagaacgaccacaagctggacctgccgcgccgg
atgcagatcgagttctcgaagatcatccaggcgaagacggacgccgagggcggcgaggtc
accggctcggacatctgggcggtcttccaggacgagtacctgccgaaccccgagaacccc
tggggccgtatccaggtcaggaacggccagtcgaccacggacaccgacggcgtggacacg
ctgaaggtggaggccacggtcgacggcgtcgacaccgtcctgaccggctccggcaacggt
ccgatctccgccttcttcgacgcgctggcgaaggtcggcatcgacgcccggctgctggac
taccaggagcacacgatgagcgagggcgcctccgcgcaggccgcctcctacatcgaatgc
gcgatcgacggcaaggttctgtggggaatcggcatcgacgcgaacacgacgcgtgcgtcg
ctcaaggcggtcgtctcggccgtcaaccgcgccgctcgataa
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