KEGG   Streptomyces goshikiensis: PET44_28365
Entry
PET44_28365       CDS       T09307                                 
Name
(GenBank) SDR family NAD(P)-dependent oxidoreductase
  KO
K24559  protomycinolide IV synthase 2
Organism
sgk  Streptomyces goshikiensis
Pathway
sgk00522  Biosynthesis of 12-, 14- and 16-membered macrolides
sgk01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:sgk00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    PET44_28365
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins [BR:sgk01008]
    PET44_28365
Polyketide biosynthesis proteins [BR:sgk01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Protomycinolide IV synthase
     PET44_28365
SSDB
Motif
Pfam: ketoacyl-synt Acyl_transf_1 KR Ketoacyl-synt_C PKS_DH_N PS-DH SpnB_Rossmann KAsynt_C_assoc PP-binding adh_short Docking CurL-like_PKS_C Thiolase_N Epimerase RhiE-like_linker NmrA GDP_Man_Dehyd ACP_syn_III Polysacc_synt_2
Other DBs
NCBI-ProteinID: WBY23216
LinkDB
Position
6440601..6446531
AA seq 1976 aa
MTANDDKIRDYLKRVVAELHSTRQRLNALEDNAREPIAIVGMSCRLPGGVTTPESLWELV
DSGTDAVSPFPDDRGWDLDALHHPESGAVHSREGGFLHDSADFDAEFFGISPREALAMDP
QQRLLLETAWEVFERAGIDPASVRGSRTGVYAGVMYHDYGARLNEIPPGLEGYLVNGSAG
SIASGRVAYTLGLEGPAVTVDTACSSSLVAVHLAAQALRQRECDMALAGGATVLSTPDLF
IDFARLGGLASDGRCKAFSDAADGTSFAEGAGMLLLMRLSDAVDKGHTVLAVIRGSAVNQ
DGASNGLTAPNGLAQQRVIREALANADLGPDQIDAVEAHGTGTRLGDPIEAQALLHTYGK
SRSPERPLLLGSLKSNIGHTQAAAGVAGIIKTVLAMRHGRLPRTLHVTRPSSRVDWSAGA
VELLTQTQDWPGQGDAPRRAGVSSFGASGTNAHLILEGVPDSDDTAAEREPSAGGGAWLL
SGRTEAALRAQARRLHGHLAARPHVSPAAIGRTLARSRTPFEHRAVVIGQDTAALLSGLT
ELASGAAHGPGVITGRAARGRRTALLFTGQGSQRPGAGRRLYERYEVFARALDETAAELD
RHLDRPLREVMFAEPGSATAGLLDRTEYTQPALFALEVALFELVSAWGLRPDALLGHSVG
ELAAAHVAGVFTLPDAARLVTARGRLMGELPAGGAMAAIQAGGPEIEETITALTARRPAR
IAVAALNGPDATVISGDEDAVAELAALWRERGRRAKVLPVSHAFHSPRMDAALEPFARIA
RDVSYAEPRIPVVSNLTGEVASAATLCTPEYWVRHAREAVRFSDGFRTLRDQGIDTFVEL
GPDGVLSALGRDCLRQEEQDAPHQDGSTDRDTAGSPADGQERPVLTVPLLRRDRDETTTC
LGALAAVHTHGVPVDLAAVHGDGPAVDLPTYAFQRTRYWLDVPAPAAGLTTTGLDTADQP
LLPAAIDLPDGEGTVRTGLLSVRTHPWIADHRVQNRTVVPGAALLDIAAWAGTEAGCPRV
AELTFATPLVLPESGEGVRLRVTLSGPDAEGIRTIRIDSRPADAARAADAPSDWTRHASG
TLTPGTEEAGDGADVPADLLGVWPPADATPVALDADAVAAEYRRLADAGVTYGPVFRGLR
AVWRRGEEIFAEVRLPGQAAADASRYGMHPALLDALAHATGFGEQFTEAHGLLPFSWSDV
RIHVRGTDSLRVRIAPAGPDAVTVAAADPAGRPALTARSLTLRPVPAHRFPSPQERSTPL
YRLEWTSASASVTGHARPTPAAAEWGVLGDAGQALLKGVRDGAQAPVRTYDDLAALAASD
TPLPDHVLVELGHDGDDLAAGAHDLAERALAVVQGWLAHARFTDARLVVLTHGAVAAGTS
AVRPASAVAWGLLRSAQSEHPGRFVLVDADPSDPAASYRSLSRAVTSGASQLALRGDEIL
VPRLTHGANGQGAAAGPRGDATEPEAAAAMGPAPSGSLSGPWRADGTVLVTGGTGTLGKA
VARHLVTKHGVRHLILAGRRGADAPGAAGLAAELTDLGAVVNIVRCDAADRSALEGVLAA
VPAAHPLTAVVHTAGVLDDGIVTAQTLQRVSAVLRAKADAVTHLHELTRDLDLSAFVLFS
SAAGTLGSPGQSGYAAANSFLDAFAAWRRAQGLPAVSLAWGLWGDGGDGGDGDGGSAGAD
GMGASLAAADLARLRRSGILPLDPAEALELFDEACDPSRTEAVLLPIRLDLAGLRARAAR
GTVHAGVVPEVLHALVPPPAGAGPSSGAGTPDPAAGQEPPTTAAASGTLAEQLAGKPRGE
RLAVLRELVRTEIASVLGHADAQRVQLQFSFKEAGFDSLTAVELRNRLTAVTGTRLPATL
VFDHPTPAALVDHLEQELPKGGQKLPADVPAVLEALDRIRDGLATAVTDDNGRAHVAERL
QELLGTLAPPVAGVRPVNGSNGHDGQGPDELSVGERLAASSDDELFDLFDSDFRSM
NT seq 5931 nt   +upstreamnt  +downstreamnt
atgacggccaacgacgacaagatccgtgactacctgaagcgggttgtcgccgaactgcac
agcacgcgccagcggctgaacgcgctggaggacaacgcccgcgagcccatcgccatcgtg
gggatgagctgccggctgcccggcggggtgaccacccccgagagtctgtgggaactggtc
gactccggcaccgatgccgtctcgccgttccccgacgaccggggctgggacctggacgcg
ctgcaccacccggagtcgggagccgtccactcccgcgagggcggtttcctccatgacagc
gccgacttcgacgcggagttcttcggcatcagcccgcgagaggccctggccatggacccg
cagcagcggctcctgctggagaccgcctgggaggtgttcgagcgggccggtatcgacccg
gcctccgtccgcggctcgcgcacgggggtgtacgcgggtgtcatgtaccacgactacggc
gcccggctgaacgagatcccgccgggtctcgagggctacctggtcaacggcagtgcgggc
agcatcgcctccggccgggtggcctacaccctcgggctggagggtcccgccgtcaccgtc
gacacggcctgctcctcgtcactggtcgccgtgcacctggcggcgcaggcgctgcggcag
cgggagtgcgacatggcgctcgcgggcggcgcgaccgtcctgtccacccccgatctgttc
atcgatttcgcgcgactgggcggcctggcctccgacgggcgctgcaaggcgttctccgac
gcggccgacggcaccagtttcgccgagggtgccggaatgctactcctgatgcgcctgtcg
gacgcggtggacaagggccacaccgtactggcggtcatccgcggctccgccgtcaaccag
gacggtgccagcaacggcctgacggcccccaacggcctcgcccagcagcgggtgatccgc
gaggcgctcgccaacgcggacctgggccccgaccagatcgacgcggtggaggcacacggc
accggaacccggctcggcgaccccatcgaggcacaggccctgctgcacacgtacggcaag
agccgcagccccgaacggcctttgctgctcggctcgctgaagtccaacatcggccacacc
caggccgccgccggcgtggccggaatcatcaagacggtgctggcgatgcgccacggccgg
ctgccccgcaccctgcacgtcacccgtccctccagccgggtggactggtcggcgggcgcg
gtggaactgctcacgcagacacaggactggcccggccagggggacgccccgcgccgcgcc
ggcgtgtcctccttcggcgccagcggcaccaacgcacacctcatcctggagggcgtcccg
gacagcgacgacacggcggcggagcgcgaaccgtccgccggcggtggcgcctggctgctc
tcgggccggaccgaagcggcgctgcgagcccaggcccgcagactccacggccatctcgcc
gcccgcccccacgtgtcacccgccgcgatcggacggacgctggcccgctcccgtacaccg
ttcgagcaccgggccgtcgtcatcggacaggacaccgccgcactcctgagcggcctcacg
gagctggcgtccggcgccgcgcacggacccggggtgatcaccggccgggccgcacgcgga
cgccgtaccgcactgctcttcaccgggcagggcagccagcggccgggcgccgggcgccgg
ctctacgagcggtacgaggtcttcgcccgggccctggacgagacggccgcggaactcgac
cggcacctggaccgcccgctgcgcgaggtgatgttcgcggaaccgggcagcgcgacggcc
ggtctcctcgaccgaaccgagtacacccagcccgcgctgttcgccctggaagtcgccctc
ttcgagctggtgagcgcctggggcctgcgccccgacgcactcctggggcactcggtcggc
gaactggccgccgcccacgttgccggagtgttcaccctgcccgacgccgcccgcctggtg
acggcgcgggggcggctgatgggcgagctgccggccggtggcgccatggcggcgatccag
gcaggcggcccggagatcgaggagacgatcacggcgctcacggctcgtaggccggcgcgc
atcgccgtcgccgcactcaacgggcccgacgccaccgtgatctcgggcgacgaggacgcg
gtcgccgagctcgccgcactgtggcgggagcggggccgccgtgccaaggtgctgcccgtc
agccacgctttccactcgccgcgcatggacgccgcactggaaccgttcgcccggatcgcg
cgcgacgtctcctacgccgagccgcgcatcccggtggtctccaacctgaccggcgaggtc
gcgtcggccgcgacgctgtgcaccccggagtactgggtgcggcacgcgcgcgaggccgtg
cgcttcagcgacggcttccgcaccctgcgcgaccaggggatcgacaccttcgtcgaactg
ggaccggacggcgtgctgtccgccctgggacgtgactgcctgcgccaagaggaacaggac
gccccgcaccaggacggctcgacggaccgtgacacggccggttcccccgccgacgggcag
gagcgtcccgtgctgacggtgccgctgctgcgccgggaccgcgacgagacgaccacctgc
ctcggcgccctggccgccgtccacacccacggtgtccccgtcgacctcgcggccgtgcac
ggtgacgggcccgccgtcgacctccccacctacgccttccagcgcacgcgctactggctg
gacgtcccggcccccgccgccggcctcaccaccaccggtctggacacagcggaccagccc
ctgctcccggccgccatcgacctgcccgacggggaaggcaccgtacggaccgggctgctc
tccgtccgcacccacccgtggatcgccgaccaccgcgtccagaaccgcaccgtggtaccc
ggagcggccctcctggacatcgccgcctgggcgggcaccgaagcgggctgcccccgggtc
gccgagctgaccttcgccacgcccctcgtgctgcccgagagcggggagggggtccggctg
cgcgtgacgctgagcggtcccgacgcggaaggcatccgtacgatacgcatcgactcccgg
cccgccgacgccgctcgggcagccgacgccccctccgactggacccggcacgcgtccggc
accctcacccccggaaccgaggaggccggtgacggcgccgatgtgccggcggacctgctc
ggcgtctggccccctgccgacgcgaccccggtggccctcgacgcggacgccgtcgcggct
gagtaccggcgcctcgcggacgcgggcgtgacctacggccccgtgttccggggactgcgc
gccgtctggcggcgcggcgaagagatcttcgccgaggtccggctccccggccaggcggcc
gccgacgcctcgcggtacggcatgcacccggccctgctggacgctctggcgcacgccacc
ggattcggcgaacagttcaccgaggcccacggcctgctgccgttctcctggagcgacgtc
cggatccacgtccgcggcaccgactccctgcgcgtacggatcgccccggcgggacccgac
gccgtgaccgtcgcggcggccgacccggcgggccgcccggccctcaccgcccgctcactc
acgctgcgccccgtcccggcgcaccggttcccgagtccgcaggagcggagcacaccgttg
taccgactggagtggacgtcggcctccgcttcggtgaccggacacgcccgtcccacgccg
gcggcagcggagtggggcgtcctcggcgatgcgggccaggccctcctcaagggcgtacgc
gacggagcgcaggcaccggtacggacctacgacgatctggccgcgctcgcggcctccgac
acgcccctgcccgaccacgtcctggtggagctcggccacgacggggacgaccttgccgca
ggcgcccacgacctggccgaacgtgcgttggccgtggtgcagggctggctggcccacgcc
cgcttcaccgacgcacgactggtcgtgctgacacacggggcggtggcggccggcaccagc
gcggtccgcccggcctcggccgtcgcctggggactgctgcgcagcgcacagtccgagcac
ccgggccgcttcgtactggtcgacgcggacccgtccgacccggctgcctcgtaccgctcc
ctgtcgcgggccgtcacctcgggagcctcccaactcgccctgcgcggcgacgagatcctc
gtaccccgactcacccatggagcgaacgggcagggcgctgccgccggtccccgcggcgac
gccaccgagccggaagcggccgcggccatggggcccgccccgtcggggagcctttccggc
ccctggcgcgcggacggcaccgtgctcgtcacgggcggaaccggaacgctcggcaaggcc
gtggcccggcatctcgtgaccaagcacggcgtccggcacctgatactggccggccggcgc
ggtgcggacgccccgggcgcggccggactggccgccgaactgaccgacctgggcgccgtc
gtgaacatcgtccgctgtgacgccgccgaccgctcggcgctcgaaggggtgctggccgcc
gtccccgccgcgcacccgctcaccgctgtcgtgcacaccgccggtgtgctggacgacggc
atcgtcacggcacagaccctccaacgggtctcggcagttctgcgggccaaggcggacgcc
gtcacacacctgcacgaactgacccgtgacctggacctgtccgccttcgtcctcttctcg
tcggctgcgggcaccctcggcagtcccggccagtccggctacgcggccgccaacagcttc
ctcgacgcgttcgccgcctggcggcgcgcgcagggcctgcccgccgtgtccctggcctgg
ggcctgtggggtgacggcggtgacggcggtgacggcgacggcggtagcgcaggggccgac
ggcatgggagcgagcctggccgccgccgacctggcacggctgcgccgttccggaatcctg
cccctcgaccccgccgaggcattggaactgttcgacgaggcctgcgacccctccaggacc
gaggcagtgttgctgccgatccgcctcgacctggccggcctgcgtgctcgtgccgcccgc
ggcaccgtacacgcaggcgtggtacccgaagtgctgcacgccctggtgcccccgcccgcc
ggtgccggaccttcgtccggtgcgggcacgccggaccctgcggcgggccaggagcccccg
accacggccgcggcatccggcaccctggccgaacagctcgccgggaagccgcgcggcgag
cggctcgccgtcctcagggagctcgtgcgcaccgaaatcgcctcggtgctcgggcacgcg
gacgcccaacgcgtccaactccagttctccttcaaggaagccggattcgactcgctcacc
gccgtcgaactccgcaacaggctcaccgccgtcaccggaacgaggcttcccgccacactg
gtcttcgaccatccgacgccggcggcactcgtcgaccacctggaacaggaactgccgaag
ggcggtcagaaacttcccgcggacgtcccggccgttctggaggcactcgatcggatccgg
gacggactggccaccgctgtcaccgacgacaacggccgcgcccacgtcgcggaacgcctt
caggaactgctcggcacgctcgccccgccggtggcgggcgtccgcccggtcaacggctcg
aacggtcacgacgggcagggccccgatgaactgtcggtcggcgaacgcctcgccgccagc
tccgacgacgagctcttcgacctcttcgacagcgacttccgatcgatgtag

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