KEGG   Streptomyces graminofaciens: SGFS_077610
Entry
SGFS_077610       CDS       T09325                                 
Name
(GenBank) 2-isopropylmalate synthase
  KO
K01649  2-isopropylmalate synthase [EC:2.3.3.13]
Organism
sgrf  Streptomyces graminofaciens
Pathway
sgrf00290  Valine, leucine and isoleucine biosynthesis
sgrf00620  Pyruvate metabolism
sgrf01100  Metabolic pathways
sgrf01110  Biosynthesis of secondary metabolites
sgrf01210  2-Oxocarboxylic acid metabolism
sgrf01230  Biosynthesis of amino acids
Module
sgrf_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:sgrf00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    SGFS_077610
  09105 Amino acid metabolism
   00290 Valine, leucine and isoleucine biosynthesis
    SGFS_077610
Enzymes [BR:sgrf01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.13  2-isopropylmalate synthase
     SGFS_077610
SSDB
Motif
Pfam: HMGL-like IPMS_D2 LeuA_dimer
Other DBs
NCBI-ProteinID: BBC36467
LinkDB
Position
8640519..8642240
AA seq 573 aa
MANRQQPTSMPVHKYGQYEQVDIPDRTWPNNRITAAPRWLSTDLRDGNQSLIDPMSPERK
RRMFDQLVKMGYKEIEVGFPASGQTDFDFVRSIIEEPGAIPDDVTISVLTQAREDLIERT
VESLKGAKRATVHLYNATAPVFRRVVFRGSKDDIKQIAVDGTRLVMEYAEKLLGPETEFG
YQYSPEIFTDTELDFALEVCEAVMDVYQPGPGREIILNLPATVERSTPSTHADRFEWMGR
NISRREHVVISVHPHNDRGTAVAAAELALMAGADRVEGCLFGQGERTGNVDLVTLGMNLF
SQGVDPQIDFSDIDEIRRTWEYCNQMEVHPRHPYVGDLVYTSFSGSHQDAIKKGFDAMEA
SAAEQGKTVDDIEWAVPYLPIDPKDVGRSYEAVIRVNSQSGKGGIAYVLKNDHKLDLPRR
MQIEFSKLIQAKTDAEGGEVTGGDIWAVFQDEYLPNPENPWGRIQVLSGQSTTDKDGVDT
LTVEAEVDGAETTLVGTGNGPISAFFHALQGIGIDARLLDYTEHTMSEGASAQAASYIEV
AIEDKVLWGIGIDANTTRASLKAVVSAVNRAAR
NT seq 1722 nt   +upstreamnt  +downstreamnt
atggcgaaccgccagcagcccacgtccatgccggtccacaagtacgggcagtacgagcag
gtcgacatccccgaccgcacgtggccgaacaaccggatcaccgccgccccccgctggctc
tccaccgacctgcgcgacggcaaccagtccctgatcgacccgatgtcgcccgagcgcaag
cgccggatgttcgaccaactggtcaagatgggctacaaggagatcgaggtcggcttcccg
gcctccggccagaccgacttcgacttcgtacggtcgatcatcgaagagcccggcgccatc
cccgacgacgtcaccatctccgtactgacccaggcccgtgaggacctgatcgagcggacc
gtggagtcgctgaagggcgccaagcgggcgaccgtccacctgtacaacgccaccgccccc
gtcttccgccgcgtcgtcttccgcggctccaaggacgacatcaagcagatcgccgtcgac
ggcacccgcctggtgatggagtacgcggagaagctgctgggcccggagaccgagttcggc
taccagtacagcccggagatcttcaccgacaccgagctggacttcgccctggaggtctgc
gaggcggtgatggacgtctaccagcccggcccgggccgcgagatcatcctcaacctgccc
gccacggtggagcgatcgacgccctcgacgcacgcggaccgcttcgagtggatgggccgc
aacatctcccgccgcgagcacgtcgtcatctccgtccacccgcacaacgaccgcggtacg
gccgtcgcggcggccgagctggcgctgatggccggcgccgaccgcgtcgagggctgcctg
ttcgggcagggcgagcgcaccggcaacgtcgacctggtcaccctgggcatgaacctgttc
tcccagggagtcgacccgcagatcgacttctccgacatcgacgagatccgtcgtacgtgg
gagtactgcaaccagatggaggtccacccgcgccacccgtacgtgggcgacctggtctac
acgtccttctccggctcccaccaggacgccatcaagaagggcttcgacgccatggaggcg
tccgccgcggagcagggcaagacggtcgacgacatcgagtgggccgtgccgtacctgccg
atcgaccccaaggacgtaggccgctcctacgaggccgtcatccgcgtcaactcgcagtcc
ggcaagggcggtatcgcgtacgtcctgaagaacgaccacaagctggacctgccgcgccgg
atgcagatcgagttctcgaagctcatccaggcgaagacggacgccgagggcggcgaggtc
accggcggtgacatctgggcggtcttccaggacgagtacctgccgaaccccgagaacccg
tggggccgtatccaggtcctgagcggccagtcgaccaccgacaaggacggcgtggacacg
ctgaccgtcgaagccgaggtcgacggcgccgagaccactctggtcggcaccggcaacggc
ccgatctcggccttcttccacgcgctgcagggcatcggtattgacgcccgcctgctggac
tacaccgagcacacgatgagcgagggcgcctccgcacaggccgcctcctacatcgaggtc
gccatcgaggacaaggtcctgtggggcatcggcatcgacgccaacacgacgcgtgcctcg
ctgaaggcggtcgtctcggcggtgaaccgggcggcgcgctag

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