Streptomyces globosus: C0216_06545
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Entry
C0216_06545 CDS
T06864
Symbol
leuC
Name
(GenBank) 3-isopropylmalate dehydratase large subunit
KO
K01703
3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:
4.2.1.33
4.2.1.35
]
Organism
sgz
Streptomyces globosus
Pathway
sgz00290
Valine, leucine and isoleucine biosynthesis
sgz00660
C5-Branched dibasic acid metabolism
sgz01100
Metabolic pathways
sgz01110
Biosynthesis of secondary metabolites
sgz01210
2-Oxocarboxylic acid metabolism
sgz01230
Biosynthesis of amino acids
Module
sgz_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
sgz00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00660 C5-Branched dibasic acid metabolism
C0216_06545 (leuC)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
C0216_06545 (leuC)
Enzymes [BR:
sgz01000
]
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.33 3-isopropylmalate dehydratase
C0216_06545 (leuC)
4.2.1.35 (R)-2-methylmalate dehydratase
C0216_06545 (leuC)
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Motif
Pfam:
Aconitase
DUF4946
AcnX
Motif
Other DBs
NCBI-ProteinID:
AXE23153
UniProt:
A0A344TWY2
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Position
1386489..1387913
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AA seq
474 aa
AA seq
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MGRTLAEKVWDDHVVRRAEGEPDLLFIDLHLLHEVTSPQAFEGLRQAGRKVRRLDLTIAT
EDHNTPTLDIDKPIADPVSRAQLETLRRNCAEFGVRLHPLGDVEQGVVHVVGPQLGLTQP
GTTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPLARPKTMAITVTGELAEGVTA
KDLILAIIARIGTGGGQGYVIEYRGEAVEKLSMEARMTVCNMSIEAGARAGMIAPDQTTF
DYLKGRDHAPTGEDWDAAVAYWKTLRTDDDAVFDAEVVIDGSSLSPFVTWGTNPGQGAPL
SANVPDPASYEDASERLAAEKALEYMGLTAGQPLRDIRVDTVFVGSCTNGRIEDLRAVAD
VIKGRKVADGVRMLVVPGSVRVALQAVEEGLDKVFKDAGAEWRHAGCSMCLGMNPDQLAP
GERSASTSNRNFEGRQGKGGRTHLVSPQVAAATAVLGHLASPADLSDVHATAGV
NT seq
1425 nt
NT seq
+upstream
nt +downstream
nt
atgggtaggacactcgcggagaaggtctgggacgaccacgtcgtccggcgcgccgagggc
gagcccgacctcctcttcatcgatctgcacctgctgcacgaggtgaccagcccccaggcg
ttcgaaggcctgcggcaggccggccgcaaggtccgccgtctcgacctcaccatcgcgacc
gaggaccacaacacccccaccctcgacatcgacaagccgatcgcggacccggtctcccgg
gcccagctggagacgctgcgcaggaactgcgccgagttcggggtgcgcctgcacccgctg
ggcgacgtcgagcagggcgtcgtccacgtcgtgggaccgcagctgggcctgacccagccg
ggcaccaccgtcgtctgcggcgactcccacacctcgacgcacggcgccttcggcgccctc
gccttcggcatcggcaccagccaggtcgagcacgtcctggccacccagacgctgcccctg
gcccgccccaagaccatggcgatcaccgtcaccggcgagctggccgagggcgtcaccgcc
aaggacctgatcctggcgatcatcgccaggatcggcaccggcggcggccagggctacgtc
atcgagtaccgcggcgaggccgtcgagaagctgtcgatggaagcccgcatgaccgtctgc
aacatgtcgatcgaggccggcgcccgcgccggcatgatcgcccccgaccagacgaccttc
gactacctgaagggccgcgaccacgcccccaccggcgaggactgggacgccgcggtcgcc
tactggaagaccctgcgcaccgacgacgacgccgtcttcgacgcggaggtcgtcatcgac
ggctcctcgctgtccccgttcgtcacctggggcaccaacccgggacagggcgcgccgctg
tcggcgaacgtccccgacccggcttcgtacgaggacgcctcggagcgcctcgcggccgaa
aaggccctggagtacatggggttgaccgccgggcagccgctgcgcgacatccgtgtcgac
accgtcttcgtaggctcctgcaccaacggccggatcgaggacctccgcgccgtcgccgac
gtcatcaagggccgcaaagtcgccgacggcgtacggatgctggtcgtccccggctccgtc
cgcgtcgccctgcaggcggtcgaggagggcctggacaaggtcttcaaggacgcgggcgcc
gaatggcggcacgccggctgctccatgtgcctgggcatgaaccccgaccaactggcgccc
ggcgagcgctccgcctccacctcgaaccgcaacttcgagggccggcagggcaagggcggc
cgcacccacctggtctccccgcaggtcgccgccgccaccgcggtcctgggccacctggcc
tcgcccgccgacctgtccgacgtccacgccaccgccggagtctga
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