Sturnira hondurensis: 118980680 Help Entry 118980680         CDS       T07222                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism shon  Sturnira hondurensis Pathway shon04020   Calcium signaling pathway shon04024   cAMP signaling pathway shon04260   Cardiac muscle contraction shon04261   Adrenergic signaling in cardiomyocytes shon04371   Apelin signaling pathway shon04713   Circadian entrainment shon04911   Insulin secretion shon04921   Oxytocin signaling pathway shon04972   Pancreatic secretion shon05020   Prion disease shon05022   Pathways of neurodegeneration - multiple diseases shon05410   Hypertrophic cardiomyopathy shon05412   Arrhythmogenic right ventricular cardiomyopathy shon05414   Dilated cardiomyopathy shon05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:shon00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     118980680 (RYR2)    04020 Calcium signaling pathway     118980680 (RYR2)    04024 cAMP signaling pathway     118980680 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     118980680 (RYR2)    04921 Oxytocin signaling pathway     118980680 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     118980680 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     118980680 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     118980680 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     118980680 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     118980680 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     118980680 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     118980680 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     118980680 (RYR2)    05414 Dilated cardiomyopathy     118980680 (RYR2)    05415 Diabetic cardiomyopathy     118980680 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:shon04040]     118980680 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:shon04990]     118980680 (RYR2) Ion channels [BR:shon04040]  Voltage-gated cation channels   Ryanodine receptor    118980680 (RYR2) Domain-containing proteins not elsewhere classified [BR:shon04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    118980680 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  118980680 NCBI-ProteinID:  XP_036893238 LinkDB All DBs Position Unknown AA seq 4935 aa AA seqDB search MAESDDEVVLQCTAAAHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQS LSVRALQEMLANTVEKSEGKFMMKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSS TDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGGS SFHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRT VHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLLEDKTLLLVDK EKADVKSTAFTFRSSKEKLDTGVRKEVDGMGTSEIKYGDSVCYIQHVNTGLWLTYQAVDV KSVRMGATLRKAIMHHEGHMDDGISLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSRK VRAVPGDLPIESVSLSLRDLISYLHPPDEHLDHEDKQNRLRALKNRQNLFQEEGMISLVL QCVDRLHVYSSAAHFADVAGREAGASWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLI SRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCV CHGVAVRANQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGISEGSAQYKKWYYELMV DHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWAGCIAS TVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIK VRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVPLTQ AAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLV EFSQLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEEKVKKMKLPKNYQLTSGYKPA PMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYTLLD DRTKKSNKDSLREAVRTLLGCGYGLEAPDQDHAARAEVCSSTGERFRIFRAEKTYAVKAG RWYFEFEAVTAGDMRVGWSRPGCQPDQELGADEHAFAFDGFKAQRWHQGNEHYGRSWQAG DVVGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRMNFGK DVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEHIEVTRIDGTVDS SPCLKVTQKSFGAQNSSTDIMFYRLSMPIECAEVFSRPAAGALPGAGLFGPKNDLEDYDV DSDFEVLMKTAHGHLVPDRADKDKDAPKPEFNNHKDYTQEKPSRLKQRFLLRKTKPDYST SHSARLTEDVLADDRDDHEYLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTCFDL DRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESTSPGQGRSNSGLEIGCVVDAASGLLT FTANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHRNPV PQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRVGERQGWLVQCADPLQFMSLHIPEENRSV DILELTEQEELLRFHSHTLRLYSAVCALGNHRVAHALCSHVDEAQLLYAIQSKYMPGLLR TGYYDLLIDIHLSAYATARLMMNNEFIVPMTDETKSITLFPDEHKEHGLPGIGLSTSLRP RMRFSSPSFVSLNHDCYQDSPEFPLDTLKNKTMQMLTEAVREGGLRARDPVGGTTEFLFV PLIKLFYTLLTMGVFQGEDLKHILQLIEPRVFTEAAPGEQQQAPPSEPRKDDSRPEGARG DAAEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHQIEAIVAFSDDFVAKLQDNQRFRYNEV MQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKNECPCPAEIRDQLLDFHEDLMAHC GIELDEDGSPDSNGNLTIRGRLLSLVEKVTYLKKRQAEKPVASDLSKSSTLQQLISETMV RWAQESVIEDPELVRAMFVLLHRQYDGIGGLARALPKTYTISAVSVEDTINLLASLGQIR SLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEI TFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASV MDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSRGYPDIGWNPVEGERYLDFLRFAVF CNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAVEEAIKIAEDPSRDGPSPTSG SSRTPDADEEDDTVHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIP LGDLVGVISIAFPMPTIAKDGNVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLL EVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLRRCAPLFAGTEHHASLIDSL LHTVYRLSKGCSLTRAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLK LLTNHYERCWKYYCLPGGWGSFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPC LSAVAGALPPDYMESSHVSVMEKQSSMDAEGNFNPQPVETSNITIPEKLEYFINKYAEHA HDRWSMDKLANGWIYGETYSDSSKVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWR IERTREGDSMALYSRTRRISQTSQVSVDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENY HNIWAKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFK DLDLDTPSIEKRFAYSFLQQLIHYVDEAHQYILEFDGGSRCKGQHFPYEQEIKFFAKVVL PLIDQYFKNHRLYFLSAASRPLCSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATS IVNCLHILGQTLDARTVMKTGLESVKSALRAFLDSAAEDLEQTLENLKQGQFTHTRHQPR GVTQIINYTTVALLPVLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYV ERQRSSLGECLAAFAGAFPVAFLETHLDKHNSYSIYNTRSSRERAALNLPASVEDVCPNI PSLEKLMEEIVELAESGIRYTQMPHVMEVILPLLCSYMSRWWEHGPENHPGRAEACCTAL DSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKK KAAMVVSEEDHLKAEARGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDNNRAKWLKEP TPEAEDLFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAVSDQE RKKMRRKGDRYSVQTSLIVAALKRLLPIGLNICAPGDQELIALAKNRLSMKDTEDEVRDI IRSNIHLQGKLEDPAIRWQMALYKDLPNRTEDNSDPEKTVERVLDIANVLFHLEQVEHPQ RSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKL IEDLAKPGAEPPEEDEGPKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCH DEEDDDGEEEVKSFEEKEMEKQKLLYQQARLHERGAAEMVLQTISASKGETGPMVAATLK LGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMV TEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLR VQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRL WDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMV DMLVESSNNVEMILKFFNMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTP SETEFLLSCAETDENETLDYEEFVKRFHEPAKDISFNVAVLLTNLSEHMPNDTRLQTFLE LADSVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEG GEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSASKEESEKERPEEQGPGMGFFSILT VQAALLALRYNLLALLRMLSLKSLKKQMKKVKKMTLRDMVAALFSSYWGVLSSLAHFVAS VLRGFSRVVGSLLLGGSLVEGAKKMRVAELLANMPDPTQDEVRDDGEEAERRPLEAALPS EDLTDLKELAEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPLPEVQEKFQ EQEVKEEDKEEKEENKSEPEKADGEDGEKEEKAKDEKGRQKLRSIHTHRYGEPEAPESAF WKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPPRSTSG NTRVGILDSGPDSSLDSSPPGVAAVHYVLEESSGYMEPALRILAVLHTVISFFCIIGYYC LKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRK VMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGV VFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVG LLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIE DPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICG IGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFF PAGDCFRKQYEDQLN NT seq 14808 nt NT seq  +upstreamnt  +downstreamnt atggccgagagtgatgacgaggtggtgctgcagtgcacggcggccgcccacaaggagcag cagaagctctgtttggcagccgaaggatttggcaacaggctctgtttcctggagtccacc tcgaattccaagaatgtgccccccgacctctccatctgcacctttgtgctggagcagtcc ctctccgtccgggccctgcaggagatgctggcgaacacggtggagaaatcagaagggaaa ttcatgatgaagactgctcaaggcggcggtcaccggacgctcctctacggccacgccatc ctgctgcgccactcctacagcggcatgtacctgtgctgcctgtccacctcccggtcttcc actgacaaactggccttcgacgtcggcttgcaagaggacacgacaggtgaggcttgctgg tggaccatccaccccgcctccaagcagcggtccgaaggagagaaggtgcgcgttggtgat gacctcatcctagtgagcgtgtcctctgaaaggtacttgcacctgtcctacggtggcagc agcttccacgtggatgcagctttccagcagacactctggagcgtggccccgatcagctct ggaagtgaagcagcccaagggtatctgatcggtggggacgtcctcaggctgctgcatgga cacatggacgagtgcctcactgtcccctctggagagcacggggaggagcaacggaggacc gttcattatgaaggtggagctgtatctgtgcacgcacggtccctgtggagactagagact cttcgagttgcgtggagtggaagccacataagatggggccagcctttccgactgcgccac gtcacaacggggaagtacctgagcctcctggaagacaaaaccctcctcctggtggacaaa gagaaagctgatgtgaagtcaacagcgtttaccttccggtcttccaaggaaaagttggac acaggggtgagaaaagaagtcgatggcatggggacctctgagataaagtacggagactcg gtctgctacatccagcacgtgaacacaggcctgtggctgacctaccaggccgtagatgtg aagtctgtgcgaatgggtgccacgctgcgcaaggcgatcatgcaccatgaaggccacatg gatgacggcatcagcctgtcccggtcgcagcacgaggagtcgcggacggcgcgcgtcatc cgcagcaccgtcttcctgttcaaccggttcatcaggggcctggatgctctcagcaggaag gtgagggcggtgcccggggacttgcccatcgagtctgtcagcctgagtctgcgggacctg atcagctacctgcacccgccggacgagcacctggaccatgaggacaagcagaacaggctg agagccctgaagaaccggcagaatctcttccaggaggaggggatgatcagcctcgtgctg cagtgcgtggacaggctgcacgtctacagcagcgccgcccacttcgctgacgtcgctggg agagaagctggcgcatcctggaagtcgatcctgaattctctgtatgagttgctggcggct ctcattagaggaaatcgtaaaaactgtgcccagttttctggttccttggactggctgatc agccgactggaaagactggaagcttcttcaggcattctggaagtcttgcactgcgtgttg gtagaaagtccagaagctctgaacatcatcaaagaagggcacattaaatccatcatttca ctcttagacaagcacggaagaaatcacaaggttctggatgtcctgtgctccctctgcgtc tgccacggagtggccgttcgcgccaaccagcacctcatctgcgacaacctccttccggga cgggatctgctgctgcagacgcgcctggtgaaccacgtcagcagcatgaggcccaatatt ttcctgggcatcagtgaagggtccgctcagtacaagaagtggtactacgagctgatggtg gaccacacggagccctttgtgacagccgaagccactcacctgcgcgtgggctgggcctcc acagaggggtactccccctaccccggtgggggcgaggagtggggcgggaacggcgttgga gacgacctcttttcctacgggtttgatggcctgcatctctgggcaggttgtatcgctagc accgtgagctcgccgaaccagcacctgctgcggacggatgatgtcatcagttgctgttta gatctgagtgcgccgagcatctcattccgaatcaatgggcaacctgttcaaggaatgttt gagaatttcaacatcgacggcctcttctttcctgttgttagtttctctgcaggaataaag gtgcgcttcctgcttggggggaggcacggagagtttaaatttctccctccccctggctat gctccttgctatgaagctgttctgccgaaggagaagttgaaggtggaacacagccgagaa tacaagcaagaaagaacttacacccgggacctgctgggccccacagtgccgctcactcag gctgccttcacgccggtccctgtggacaccagccagattgtgttgcctccccacctggag aggatccgagaaaaactggcagagaatatccatgagctctgggttatgaacaaaattgaa cttggctggcagtatggcccggtcagagatgacaacaagaggcagcacccgtgcctggtg gagttctcccagctgccggagcaggaacgcaattacaacctacagatgtcactcgagacc ctgaagactttgttggcattaggatgtcatgtgggtatatcagatgaacatgctgaagaa aaggtgaaaaagatgaagctacccaaaaattaccagctgacgagtggatacaagcctgcc ccgatggacctgagctttatcaaactcaccccgtctcaggaagcgatggtggacaagttg gcagaaaatgcccacaacgtgtgggcccgggatcggatccggcagggctggacctatggc atccagcaggacgtaaagaacagaagaaacccccgccttgtcccctacacgctgcttgat gacagaaccaagaagtccaacaaggacagcctgcgggaggctgtgcgcacgctgctgggg tgcggctacggcctggaggcgcccgaccaggaccacgcagcccgggccgaagtgtgcagc agcaccggggagcggttccgcatcttccgcgcggagaaaacctacgccgtgaaggccggg aggtggtacttcgagttcgaggcggtcacggcaggagacatgcgggtcggttggagcagg cccggctgccagccagatcaggagctgggcgctgacgagcacgcctttgcttttgacggt ttcaaggcccagcggtggcaccagggcaatgagcactacgggcgctcttggcaagctggt gacgtcgtgggctgtatggtcgacatgacggagcacaccatgatgttcacactgaacggg gagatcctgctcgacgattcaggctcggaactggccttcaaggactttgacgtgggtgac ggattcatacctgtatgcagccttggggtggctcaggtgggaaggatgaactttggcaag gacgtgagcaccttgaagtatttcaccatctgtggcttacaggagggctatgaaccattc gctgttaacacgaacagggacatcaccatgtggctaagcaagcgacttcctcagtttctc caggtcccgtcaaaccatgaacacattgaggtgaccaggatcgatggcaccgtggacagc tccccgtgtttaaaggtcacgcagaagtcgttcggtgcccagaacagcagcactgacatc atgttctaccgcctgagcatgcccatcgagtgcgcggaggtcttctccaggccagcagcc ggggcgctgccgggggccggcctctttgggcccaagaacgatttggaggattatgatgtg gactccgacttcgaggttctgatgaagacggcacatggccacctggtgcctgatcgggcc gacaaagacaaagatgctccaaagccagagtttaataaccacaaggattacacacaggag aagccctctcgtctgaaacaaagattcctgctcagaaagacaaagccagattacagcaca agccactcggcgagactcaccgaagacgtcctcgcagatgaccgggacgaccacgaatat ctgatgcagacgtccacgtactattactcagtgagaatattccctggacaagaacccgct aatgtctgggtgggctggatcacatccgatttccatcagtacgatacctgcttcgacttg gacagagttcgcacagtaaccgttactctcggagatgaaaaaggaaaagtacacgaaagc atcaaacgcagcaactgctacatggtgtgtgcgggcgagagcacgagccctgggcaggga cgcagcaacagcgggctggagatcggctgcgtggtggatgccgccagtgggctgctcacc ttcacggccaacggcaaggagctgagcacatactaccaggtggagccaagtaccaaattg tttcctgcggtttttgcgcaagctacaagtcccaatgtcttccagtttgagctgggaaga ataaagaatgtgatgcctctctccgcgggcctcttcaagagtgagcaccgaaaccctgtg cctcagtgccccccgcggctgcatgtgcagttcctgtcacatgtgttgtggagcaggatg cccaaccagttcctgaaggtggacgtgtcccgggtcggcgagcgccagggctggctggtg cagtgcgcggaccccctgcagttcatgtccctgcacatccccgaggagaacaggtccgtg gacatcctggagctgaccgagcaggaggagctgctgcgcttccactcgcacaccctgcgg ctctactcggccgtgtgcgccctgggcaaccaccgcgtggcgcatgcgctctgcagccac gtggacgaggcgcagctgctctacgccatccagagcaagtacatgcccggcctgctgcgc accggctactatgacctgctcattgacatccacctgagcgcctacgccactgcccggctc atgatgaacaatgagttcatcgtgcccatgacggacgagaccaagagcatcacgctcttt ccggacgagcacaaggagcatgggctgcccggcatcggcctcagcacctccctgcgccca cgcatgcgattctcctcacctagctttgtgagcctcaaccacgactgctaccaggacagc ccggagttccccctggacacgctcaagaacaagaccatgcagatgctgactgaggccgtg cgggagggtggactgcgggcgcgggaccctgtagggggcaccactgagttcctcttcgtg ccgctcatcaagctcttctacacgctgctcaccatgggcgtcttccaaggtgaggacctg aagcacatcctgcagctgattgagccccgggtgttcacagaggctgccccaggggagcag cagcaggctccgccctcggagccccgcaaggatgactcccgacccgagggtgcacgtggg gatgcagccgaggggctgctgcagatgaagcttcctgagcccgtgaagctgcagatgtgc ctgctccttcagtacctctgtgactgccaggtccgacaccagatagaagccatagtggcc ttttcagacgacttcgttgccaagctgcaagacaaccagcgcttccgctacaatgaggtc atgcaggccttgaacatgtcagccgcactcacggccaggaagacaaaggagttcaggtcc ccgcctcaagaacagatcaacatgcttctcaacttcaaggatgacaaaaacgaatgtcca tgtcctgcagaaatccgcgaccagctcctggactttcatgaagacctcatggcgcattgc ggaattgagctggatgaagatggctctccagatagcaatggcaacttaacaatcagaggc cgcctgctgtccctggtggaaaaggtgacatacctgaagaagaggcaagcagaaaagcca gtggcgagcgacctcagcaagtcctccaccctgcagcagctgatctcggagaccatggtc cggtgggctcaggagtccgtcatcgaggaccccgagctggtgcgggccatgtttgttttg ctgcatcggcagtatgatggcatcggcgggctggcgcgggctctgcccaagacctacacg atcagcgccgtgtccgtggaggacaccatcaacctgctggcctcgctcgggcagatccgc tcgctgctgagcgtgaggatgggcagagaagaggagaagctcatgattcgaggacttggg gacatcatgaataataaagtgttctaccagcaccctaacctcatgagggcgctggggatg cacgaaacggtgatggaggtcatggtgaacgtcctgggcggtggggagtccaaggagatc acttttcccaagatggtggccaactgttgccgttttctctgttacttctgtcgtataagt cggcagaatcagaaagctatgtttgatcacctcagttatttattggaaaacagcagcgtt ggtctagcctcaccagcaatgcgggggtcgactccactggatgtggccgcagcctcggtg atggataacaacgagctggccttggcgctgcgtgagccagatctggagaaggtcgtgcga tatctggccggctgtggactgcagagctgccagatgctggtgtcgagggggtacccggac atcggttggaacccagtcgaaggggagcggtacctcgactttctgcggttcgccgtcttc tgtaatggggagagcgtggaggagaatgccaatgtagtggtgaggctgctcatcaggagg cccgagtgcttcggccccgccctgcggggggagggcgggaacggtcttctggcggctgtg gaagaggccatcaagatagctgaggacccctctcgagacggtccctcaccaaccagcggg tccagcagaacccctgatgcagacgaggaggatgacaccgtgcacatggggaacgccatc atgaccttctacgctgctctgatcgacctgctgggacgctgcgcccctgaaatgcatttg attcatgccggcaagggagaagccatcaggatcagatccattctgagatccctcattccg ctgggagacttggtgggagtgatcagcatcgctttcccgatgcccacgatcgccaaggat gggaatgtggtggagcccgacatgtctgcggggttttgcccagatcacaaggcagccatg gttttgttccttgacagggtctatggaattgaggttcaagattttctcctccaccttcta gaggtcggctttctgccagatctccgggctgctgcttctttagatacggcggccttgagt gctacagacatggccttggccctcaaccggtacctctgcacagccgtgctgcctctgctg aggaggtgtgccccgctcttcgctggcaccgagcaccacgcatccctcatcgactcactg ctccacactgtgtacaggctgtcgaagggctgctcgctgaccagggcccagcgggactcc atagaagtttgcttgctgtccatttgcggccaactgagaccttccatgatgcagcactta ctcagaagattagtgtttgatgtcccgctgttaaatgaacacgcaaagatgcctcttaag ctgctgacaaaccattatgaacggtgctggaaatattactgtctgcctggagggtgggga agcttcggagcggcctcagaagaagaacttcatttatcaagaaaattgttctggggaatt tttgatgccttgtctcaaaagaaatacgaacaagaacttttcaaactggccctgccctgc ctgagtgccgtggctggagctttgcctccagactacatggagtccagtcacgtcagtgtg atggagaagcagtcctccatggatgccgaaggcaacttcaacccacagcctgttgaaacc tcgaacatcacaattcctgagaagctggaatacttcattaacaagtacgccgagcacgcc catgacagatggtccatggacaagttggccaatggatggatttatggggaaacatattca gactcatctaaagttcaaccattaatgaaaccatataaactattatctgaaaaggaaaaa gaaatttatcgctggccaatcaaagaatccttaaaaacgatgctggcatggggctggaga atcgagcgcactcgggagggggacagcatggcgctctacagccggacaaggcgcatctcg cagaccagccaggtttccgtagatgccgcccatgggtatagcccccgggccatcgacatg agcaacgtcacactgtccagagacctgcatgctatggcagaaatgatggctgaaaactac cacaatatatgggcaaagaaaaagaaaatggagctggagtccaaaggagggggaaaccac cccctgctggtgccttatgacacactgacagccaaggagaaagccaaagacagggagaaa gctcaggacatcctcaagttcctgcagatcaacgggtatgctgtgtccaggggcttcaag gacctggacttggacacgccgtccatcgagaagcggttcgcctacagtttccttcagcag ctcatccactacgtggacgaggcccatcagtacatcctggagttcgatggcggcagcaga tgcaaaggacagcatttcccttacgaacaagaaatcaagttctttgctaaagttgttctg cctttaattgatcagtatttcaaaaaccaccgtttgtacttcttgtctgcagcgagcaga ccactctgctctgggggacatgcctcaaacaaggagaaagaaatggtgacaagcctgttc tgcaaactcggagttcttgtcaggcataggatttcactgtttggaaatgatgcaacatca attgtcaactgcctgcacattctgggccagacgctggatgcgaggacggtcatgaagacg ggcctggagagcgtgaagagtgcgctcagggcattcctggacagcgctgctgaggacctg gagcagacgctggagaacctgaagcagggccagttcacccacacccgccaccagcccagg ggcgtcacccagatcatcaactacaccacggtggccctgctgcccgtgctgtcctcgctg tttgagcacatcggccagcaccagtttggagaagacctgatattggaagatgtgcaggta tcctgttacagaattctaaccagcttatatgctttgggaacaagcaagagtatttatgtg gaaaggcagcgctcctcgctgggggagtgtctggcagccttcgccggtgcctttcctgtg gcgtttctcgaaactcatcttgacaaacacaacagctactccatctacaacaccaggtct tcccgagagcgagcagctctcaatttgccagcgagtgtagaagatgtctgtccaaacata ccatctttggagaagctcatggaggagattgtggaactagccgagtctggtatccgctac acgcagatgccacacgtgatggaagtcattctgcctttgctgtgcagttacatgtcccga tggtgggagcatgggcccgagaaccacccgggccgggcagaggcctgctgcacggccctg gactcagagcacatgaacaccctgctggggaacatactgaagatcatctacaacaacctg gggattgatgagggggcctggatgaagaggctagcagtgttttcccagcctataataaat aaagtgaagccgcagctcttgaaaactcatttcttgccactgatggagaaactgaagaaa aaggcagccatggtggtttctgaggaagaccatctgaaagccgaggcccggggggacatg tccgaggccgaacttctcatcctggacgagttcaccacgctggccagggacctgtatgcc ttctaccccctcctgattcgatttgtggacaataacagggcgaagtggctcaaagagcct accccggaggccgaggaccttttccgcatggtggccgaagtgttcatctactggtcgaag tcccacaatttcaagagagaagagcagaacttcgttgtgcagaacgaaatcaacaacatg tctttcctgatcactgacaccaagtcaaagatgtcaaaggcggctgtttccgaccaggag cggaagaagatgaggcggaagggcgaccgctactctgtgcagacctcgctcatcgtggcc gccctgaagcggctgctgcccatcgggctgaacatctgtgctcccggagaccaggagctc atcgccctggccaagaatcggctgagtatgaaagacactgaggatgaagtccgagatata atccgcagtaatattcatttacaaggcaagctggaggaccctgctattaggtggcaaatg gccctttacaaggacttacctaataggactgaagacaattcagatcctgagaagacagtg gagagagtcctggacatagccaacgtgctcttccacctcgaacaggtggagcaccctcag aggtctaagaaggccgtctggcacaagctgctctccaagcagaggaagagagcggtggtg gcctgcttccggatggcccctctctacaacctgcccaggcaccgggctgtcaatctcttc cttcagggatatgaaaagtcctggatcgaaacggaagaacattactttgaagataagcta atagaagatttagcaaaacctggagcagagcctccagaggaagacgaaggcccgaagaga gtggaccctctgcatcagttgatcctcctgttcagtcgcacggccctaacggagaaatgc aaactggaggaagattttttatacatggcttatgcagatattatggcaaagagttgtcat gatgaagaagatgatgatggtgaagaggaagtgaagagttttgaagagaaggagatggag aagcagaagcttctgtaccagcaggcccggctgcacgagcgtggcgctgccgagatggta ctgcagacgatcagcgccagcaaaggggagaccggaccgatggtggccgctactctgaaa ctcggcattgctatcctgaacggcggcaactccacagtacagcagaaaatgctcgactac ctcaaggagaagaaggacgtgggcttcttccagagcctcgcgggcctgatgcagtcctgc agtgtccttgacctgaatgcatttgagcggcagaacaaagctgaaggacttggaatggtg accgaggaaggatcaggagagaaggttcttcaggatgacgagttcacctgtgacctcttc cgcttcctgcaactgctgtgcgagggacacaactcagattttcagaactatctgaggacc cagactggcaacaacaccactgtcaacatcattatctccaccgtggactacctgctgagg gttcaggaatccatcagtgatttctattggtactactccgggaaagatgtcattgacgag caagggcagcggaacttctccaaggccattcaagtagcaaaacaagtcttcaacacactc acggagtacattcagggcccctgcaccggcaaccagcagagcctggcccacagccggctc tgggacgccgtcgtgggcttcctccacgtgttcgcccacatgcagatgaagctgtcgcag gactccagtcagatcgagctgttgaaagagctcatggacctccagaaggacatggtggtc atgctgctgtccatgcttgaaggtaatgttgtcaacgggaccatcggcaagcagatggtc gacatgctcgtggagtcttccaacaacgtggagatgattctcaagttcttcaacatgttc ttaaaactgaaggacttgacgtcttctgacacatttaaggaatatgaccctgatggcaag ggggtcatttccaagagggacttccacaaagccatggaaagccataagcactacacaccg tcggagactgagttccttctgtcctgcgcagagacagatgaaaatgagaccctggactac gaggaatttgtcaagcggttccacgaacctgcgaaggacatcagcttcaacgtcgccgtc cttctgaccaacctctcggagcacatgcccaacgacacgcggctgcagaccttcctggag ctggcggacagcgtgctcaactacttccagcccttcctgggccgcattgagatcatgggc agtgccaagcgcatcgagagggtctacttcgagatcagcgagtccagccggacgcagtgg gagaagccccaggtcaaggagtccaagaggcagttcatctttgatgtggtcaacgagggc ggcgagaaggagaagatggagctctttgtgaacttctgcgaggacaccatattcgagatg cagctggcagcccagatctcagagtcggacctgaacgagaggtcggccagcaaggaagag agcgagaaggagcggccggaggagcagggcccggggatgggcttcttctccatcctgact gtgcaggcggccctgctggccctcaggtacaacctcctggccctcctgcgcatgctcagc ctgaagagcctgaagaagcagatgaagaaggtgaagaagatgacgctgagggacatggtt gcggcgctcttctcctcctactggggagtcctgagcagcctcgcgcactttgtggccagc gtcctccgtggcttctcccgtgtggtgggcagcctcctcttggggggcagcctggtggaa ggcgccaagaagatgagagtggcagagctcctggcgaacatgccggaccccacgcaggac gaggtgagggacgatggggaagaggccgagaggaggcccctggaggctgccctgccctcg gaggacctcacggacctgaaggagctggcggaggaaagtgacctcctctcggacatattt ggcttggacctgaagagagaaggagggcagtacaaactcatccctcacaacccgaatgca ggccttagcgacctcatgagcaaccctgtgccccttcccgaggtgcaggaaaagtttcag gaacaggaggtgaaagaggaggacaaggaagaaaaggaagaaaacaaatcggaacctgaa aaggctgatggagaagacggagagaaagaggagaaagccaaggacgagaaaggcaggcag aagctccggtcgatccacacacacagatatggagagccagaggcccccgagtctgcgttc tggaagaaaatcatagcgtatcagcagaagctgctaaactattttgctcgcaacttttac aacatgagaatgttagccttatttgtcgccttcgcaatcaatttcatcctgctcttctat aaggtgtccacttcttctgtggttgaaggaaaggagctcccccctcgcagcacaagtgga aacaccagagtgggcatcctggacagcggccccgacagcagcctggacagcagcccacca ggcgtggcggccgtgcactacgtgctggaggagagcagcggctacatggagcccgccctg cgcatcctggccgtgctgcacaccgtcatctccttcttctgcatcatcggctactactgc ttgaaagtcccgctggttatttttaagcgcgaaaaggaagtagctcgaaaattggagttt gatgggctttatattacagaacagccttcggaagatgatattaaaggccagtgggataga ctcgtgatcaacacacagtcatttcccaacaactactgggacaaatttgttaaaagaaag gttatggataaatatggggagttttatggcagggacagaattagtgagctgctcggcatg gacaaagcggctctggacttcagcgatgcccgggagaagaagaagccgaagaaagacagc tccctctcagccgtgctgaactccattgacgtgaagtatcagatgtggaagctcggagtg gtcttcacagacaactccttcctctacctcgcctggtacatgaccatgtccgttcttgga cactacaacaacttcttctttgctgctcaccttctcgacattgctatggggttcaagacg ctgagaaccatcttgtcatcggtaactcacaatggcaagcagcttgtgttaaccgtcggc ttgttagctgttgtcgtgtacctctacactgttgtggcattcaacttcttccggaaattt tacaataaaagtgaagacggcgacaccccggacatgaagtgtgacgatatgctcacgtgc tacatgttccacatgtacgtcggcgtgcgggctggagggggcatcggtgacgagatcgaa gacccggcgggcgatgagtacgagatctaccgcatcatcttcgacatcaccttctttttc ttcgtcattgtcatcctcctggccataatacaaggtttaattatcgatgcgtttggagaa ctgagagaccagcaggaacaagtgaaggaagacatggagaccaagtgcttcatctgtgga ataggcaatgattactttgacacggtgccacacggctttgaaacgcacaccttacaggag cacaacttggccaattacctgttctttctgatgtatctcataaacaaggacgagacggag cacacaggacaggagtcttatgtctggaagatgtatcaagaaagatgctgggagtttttc cccgcaggggactgtttccggaaacagtacgaagaccagctgaattaa

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