Entry |
|
Symbol |
PLCB1
|
Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
|
KO |
|
Organism |
shon Sturnira hondurensis
|
Pathway |
shon04070 | Phosphatidylinositol signaling system |
shon04261 | Adrenergic signaling in cardiomyocytes |
shon04613 | Neutrophil extracellular trap formation |
shon04621 | NOD-like receptor signaling pathway |
shon04723 | Retrograde endocannabinoid signaling |
shon04750 | Inflammatory mediator regulation of TRP channels |
shon04925 | Aldosterone synthesis and secretion |
shon04928 | Parathyroid hormone synthesis, secretion and action |
shon04933 | AGE-RAGE signaling pathway in diabetic complications |
shon04935 | Growth hormone synthesis, secretion and action |
shon04961 | Endocrine and other factor-regulated calcium reabsorption |
shon04973 | Carbohydrate digestion and absorption |
shon05022 | Pathways of neurodegeneration - multiple diseases |
|
Module |
shon_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Brite |
KEGG Orthology (KO) [BR:shon00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
118990869 (PLCB1)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
118990869 (PLCB1)
04310 Wnt signaling pathway
118990869 (PLCB1)
04371 Apelin signaling pathway
118990869 (PLCB1)
04020 Calcium signaling pathway
118990869 (PLCB1)
04070 Phosphatidylinositol signaling system
118990869 (PLCB1)
04072 Phospholipase D signaling pathway
118990869 (PLCB1)
04071 Sphingolipid signaling pathway
118990869 (PLCB1)
04022 cGMP-PKG signaling pathway
118990869 (PLCB1)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
118990869 (PLCB1)
04081 Hormone signaling
118990869 (PLCB1)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
118990869 (PLCB1)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
118990869 (PLCB1)
04613 Neutrophil extracellular trap formation
118990869 (PLCB1)
04621 NOD-like receptor signaling pathway
118990869 (PLCB1)
04062 Chemokine signaling pathway
118990869 (PLCB1)
09152 Endocrine system
04911 Insulin secretion
118990869 (PLCB1)
04922 Glucagon signaling pathway
118990869 (PLCB1)
04929 GnRH secretion
118990869 (PLCB1)
04912 GnRH signaling pathway
118990869 (PLCB1)
04915 Estrogen signaling pathway
118990869 (PLCB1)
04921 Oxytocin signaling pathway
118990869 (PLCB1)
04926 Relaxin signaling pathway
118990869 (PLCB1)
04935 Growth hormone synthesis, secretion and action
118990869 (PLCB1)
04918 Thyroid hormone synthesis
118990869 (PLCB1)
04919 Thyroid hormone signaling pathway
118990869 (PLCB1)
04928 Parathyroid hormone synthesis, secretion and action
118990869 (PLCB1)
04916 Melanogenesis
118990869 (PLCB1)
04924 Renin secretion
118990869 (PLCB1)
04925 Aldosterone synthesis and secretion
118990869 (PLCB1)
04927 Cortisol synthesis and secretion
118990869 (PLCB1)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
118990869 (PLCB1)
04270 Vascular smooth muscle contraction
118990869 (PLCB1)
09154 Digestive system
04970 Salivary secretion
118990869 (PLCB1)
04971 Gastric acid secretion
118990869 (PLCB1)
04972 Pancreatic secretion
118990869 (PLCB1)
04973 Carbohydrate digestion and absorption
118990869 (PLCB1)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
118990869 (PLCB1)
09156 Nervous system
04724 Glutamatergic synapse
118990869 (PLCB1)
04725 Cholinergic synapse
118990869 (PLCB1)
04728 Dopaminergic synapse
118990869 (PLCB1)
04726 Serotonergic synapse
118990869 (PLCB1)
04720 Long-term potentiation
118990869 (PLCB1)
04730 Long-term depression
118990869 (PLCB1)
04723 Retrograde endocannabinoid signaling
118990869 (PLCB1)
09157 Sensory system
04742 Taste transduction
118990869 (PLCB1)
04750 Inflammatory mediator regulation of TRP channels
118990869 (PLCB1)
09159 Environmental adaptation
04713 Circadian entrainment
118990869 (PLCB1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
118990869 (PLCB1)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
118990869 (PLCB1)
09174 Infectious disease: parasitic
05146 Amoebiasis
118990869 (PLCB1)
05142 Chagas disease
118990869 (PLCB1)
05143 African trypanosomiasis
118990869 (PLCB1)
09164 Neurodegenerative disease
05010 Alzheimer disease
118990869 (PLCB1)
05016 Huntington disease
118990869 (PLCB1)
05017 Spinocerebellar ataxia
118990869 (PLCB1)
05022 Pathways of neurodegeneration - multiple diseases
118990869 (PLCB1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
118990869 (PLCB1)
05415 Diabetic cardiomyopathy
118990869 (PLCB1)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
118990869 (PLCB1)
04934 Cushing syndrome
118990869 (PLCB1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:shon04131]
118990869 (PLCB1)
Enzymes [BR:shon01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
118990869 (PLCB1)
Membrane trafficking [BR:shon04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
118990869 (PLCB1)
Endocytosis
Macropinocytosis
Phospholipase C
118990869 (PLCB1)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Position |
Unknown
|
AA seq |
1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRSDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISYLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRMFSA
DRKRVETALEACSLPSSRNDSVPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSLAKKGQISVDGFMRYLS
GEENGVVSPEKLDVNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFESSKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKALKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLTLPALFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETPSEAPSEARTTPAENGVNHTTSLAPKPPSQALHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKTAKKDSKKKSEPSSPEHGSSAIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSAPSSLASDPGKLNHRPPSS
EELGGDHPGKEFDTPL |
NT seq |
3651 nt +upstreamnt +downstreamnt
atggccggggctcagcccggagtgcacgctttgcaactcaagcccgtgtgtgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactccacgattgtcactcct
attattttgaggtctgaccctcagggatttttcttttactggacagatcaaaacaaggag
acggagctgttagatctcagccttgtcaaggatgccagatgtgggaaacacgccaaggct
cccaaggacccgaaattacgtgaacttctggatgtggggaacatcggacgtctggaacat
cgcatgataacggtggtatatggacctgacttggttaacatctcctatttgaaccttgtg
gctttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaac
ctgctggcccagaacatgtccagggatgcatttctggaaaaagcctatactaaacttaag
ctgcaagtcactccagaagggcgcattcctctgaaaaacatataccgtatgttttcagca
gatcggaaacgagttgagactgcattagaggcttgtagtcttccatcttcaaggaatgat
tcagtacctcaagaagatttcactccagaagtgtacagagttttcctgaacaacctttgc
cctcgacctgaaattgataacatcttttctgaatttggtgccaaaagcaaaccatacctt
accgttgatcagatgatggattttatcaatcttaagcagcgagatccccggctaaatgaa
atactttacccacctttaaagcaagagcaagtccaagtattgattgagaagtatgaaccc
aacagtagcctcgccaaaaaaggacagatatcagtggatggatttatgcgctacctgagt
ggagaagaaaatggggtcgtttcacctgagaaactggatgtgaacgaagatatgtctcag
ccactttctcactatttcattaattcctcgcacaacacctacctcacagctggccagctg
gctggaaactcctccgttgagatgtatcgtcaagtactcctgtctggttgtcgctgtgtg
gagctggactgctggaaaggacggaccgcagaggaggaaccagtcatcacccatgggttc
accatgacaaccgaaatatcctttaaggaagtgatagaagcaatcgctgagtgtgcattt
aagacttcaccttttccgattctcctttcgtttgagaatcacgtggattccccgaagcag
caagccaagatggcggagtactgccgactgatcttcggagatgcccttctcatggagcca
ctggaaaaataccctctggaatctggagttcctcttccaagccctatggatttaatgtac
aaaattttggtgaaaaataagaagaaatcacacaagtcgtcagaaggaagtggcaaaaag
aagctctcagaacaagcttccaacacatacagcgactcctccagcgtgttcgaaccctcg
tcacctggagccggagaagctgatacggagagtgatgacgacgatgatgatgatgactgt
aaaaagtcttcaatggacgaggggacagcagggagcgaggccatggccacggaagagatg
tctaacctggtgaactacattcagccagtcaagtttgagtcatttgaaagttcaaaaaaa
agaaatagaagttttgaaatgtcttccttcgtggaaaccaaaggacttgagcagctgacg
aagtccccggtggaattcgtggaatataacaaaatgcagcttagcaggatctatccaaaa
ggaacccgtgtcgactcatccaactacatgccgcagcttttctggaacgcaggctgtcag
atggttgccctgaatttccaaacagtggacctggctatgcagataaatatggggatgtat
gagtacaatgggaagagcggctaccgactaaagccagagttcatgaggagacccgacaag
cattttgatccattcacggaaggcatcgtcgatggcatagtggccaacactttatccgtt
aagattatttcaggccagtttctttctgataagaaagtcggcacctacgtggaagtggat
atgtttggcctgcctgtggacacaaggaggaaagcattgaagaccaagacatcgcaagga
aatgctgtaaaccctgtgtgggaagaagagcccattgtgttcaaaaaggtggttcttcct
tccctggcctgcctgaggatagcagtttatgaagaaggaggtaaatttattggccacagg
atcttgccagtgcaagcgattcggccaggctaccactacatctgtctgaggaatgagagg
aaccaaccgctgacgctccccgctctcttcgtctacatcgaggtgaaagactatgtccca
gacacatatgcagatgtgattgaagctttgtcaaatccaattcgatatgtgaatctgatg
gagcagagagctaagcaactggctgctttgacactggaagatgaagaagaagtaaagaaa
gaggctgatcctggggaaacgccatcagaagcgccgagtgaagccaggacgactcccgca
gaaaatggagtgaaccacactacatccctggcacccaaaccaccctcccaggctctccac
agccagcctgctccaggttctgtaaaggcacctgccaaaacagaagatcttattcaaagc
gttttaacagaagtggaggcgcagactattgaagagctgaagcaacagaaatcatttgta
aaacttcaaaagaagcactacaaagaaatgaaagacctagttaagagacaccacaagaaa
accactgaccttatcaaagaacacactacaaagtataatgaaattcagaacgactactta
agaaggagggcagctttggaaaagacagccaaaaaggatagtaagaaaaaatcagagccc
agcagccctgagcacggctcatcagccattgagcaggacctcgctgccctggatgctgaa
atgacccaaaagttaatagacttgaaggataaacaacaacagcagctgcttaatcttcga
caagaacagtattatagtgaaaaataccagaagcgagaacatatcaaactgcttattcag
aaattgacggatgtcgctgaagaatgtcagaacaatcagttaaagaagctcaaagagatc
tgtgagaaagaaaagaaggaattaaagaagaaaatggataaaaagaggcaggagaagata
acagaagcgaaatctaaagacaaaagccagatggaagaggaaaagacagagatgatccgg
tcatacattcaggaagtggtgcagtacatcaagaggttagaagaggcacaaagtaaacgg
caagaaaaactcgtagagaaacacaaggagatacgtcagcagatcctggacgaaaagccc
aagctgcaggtggagctggagcaagagtaccaagacaagttcaaaagactgcccctggag
attttggagttcgtacaggaagccatgaaagggaagatcagtgaggacagcaatcacagt
tctgccccttcctcactggcctcggaccctgggaaactgaaccacaggcccccttccagt
gaggagctgggaggagaccacccaggaaaagagtttgatactcctctgtga |