KEGG   Sturnira hondurensis: 118992336
Entry
118992336         CDS       T07222                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
shon  Sturnira hondurensis
Pathway
shon01521  EGFR tyrosine kinase inhibitor resistance
shon01522  Endocrine resistance
shon04010  MAPK signaling pathway
shon04012  ErbB signaling pathway
shon04014  Ras signaling pathway
shon04015  Rap1 signaling pathway
shon04022  cGMP-PKG signaling pathway
shon04024  cAMP signaling pathway
shon04062  Chemokine signaling pathway
shon04066  HIF-1 signaling pathway
shon04068  FoxO signaling pathway
shon04071  Sphingolipid signaling pathway
shon04072  Phospholipase D signaling pathway
shon04114  Oocyte meiosis
shon04140  Autophagy - animal
shon04148  Efferocytosis
shon04150  mTOR signaling pathway
shon04151  PI3K-Akt signaling pathway
shon04210  Apoptosis
shon04218  Cellular senescence
shon04270  Vascular smooth muscle contraction
shon04370  VEGF signaling pathway
shon04371  Apelin signaling pathway
shon04380  Osteoclast differentiation
shon04510  Focal adhesion
shon04540  Gap junction
shon04550  Signaling pathways regulating pluripotency of stem cells
shon04613  Neutrophil extracellular trap formation
shon04620  Toll-like receptor signaling pathway
shon04650  Natural killer cell mediated cytotoxicity
shon04660  T cell receptor signaling pathway
shon04662  B cell receptor signaling pathway
shon04664  Fc epsilon RI signaling pathway
shon04666  Fc gamma R-mediated phagocytosis
shon04668  TNF signaling pathway
shon04720  Long-term potentiation
shon04722  Neurotrophin signaling pathway
shon04725  Cholinergic synapse
shon04726  Serotonergic synapse
shon04730  Long-term depression
shon04810  Regulation of actin cytoskeleton
shon04910  Insulin signaling pathway
shon04912  GnRH signaling pathway
shon04914  Progesterone-mediated oocyte maturation
shon04915  Estrogen signaling pathway
shon04916  Melanogenesis
shon04917  Prolactin signaling pathway
shon04919  Thyroid hormone signaling pathway
shon04921  Oxytocin signaling pathway
shon04926  Relaxin signaling pathway
shon04928  Parathyroid hormone synthesis, secretion and action
shon04929  GnRH secretion
shon04934  Cushing syndrome
shon04935  Growth hormone synthesis, secretion and action
shon05010  Alzheimer disease
shon05022  Pathways of neurodegeneration - multiple diseases
shon05034  Alcoholism
shon05132  Salmonella infection
shon05135  Yersinia infection
shon05160  Hepatitis C
shon05161  Hepatitis B
shon05163  Human cytomegalovirus infection
shon05164  Influenza A
shon05165  Human papillomavirus infection
shon05166  Human T-cell leukemia virus 1 infection
shon05167  Kaposi sarcoma-associated herpesvirus infection
shon05170  Human immunodeficiency virus 1 infection
shon05200  Pathways in cancer
shon05205  Proteoglycans in cancer
shon05206  MicroRNAs in cancer
shon05207  Chemical carcinogenesis - receptor activation
shon05208  Chemical carcinogenesis - reactive oxygen species
shon05210  Colorectal cancer
shon05211  Renal cell carcinoma
shon05212  Pancreatic cancer
shon05213  Endometrial cancer
shon05214  Glioma
shon05215  Prostate cancer
shon05216  Thyroid cancer
shon05218  Melanoma
shon05219  Bladder cancer
shon05220  Chronic myeloid leukemia
shon05221  Acute myeloid leukemia
shon05223  Non-small cell lung cancer
shon05224  Breast cancer
shon05225  Hepatocellular carcinoma
shon05226  Gastric cancer
shon05230  Central carbon metabolism in cancer
shon05231  Choline metabolism in cancer
shon05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:shon00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    118992336 (MAP2K1)
   04012 ErbB signaling pathway
    118992336 (MAP2K1)
   04014 Ras signaling pathway
    118992336 (MAP2K1)
   04015 Rap1 signaling pathway
    118992336 (MAP2K1)
   04370 VEGF signaling pathway
    118992336 (MAP2K1)
   04371 Apelin signaling pathway
    118992336 (MAP2K1)
   04668 TNF signaling pathway
    118992336 (MAP2K1)
   04066 HIF-1 signaling pathway
    118992336 (MAP2K1)
   04068 FoxO signaling pathway
    118992336 (MAP2K1)
   04072 Phospholipase D signaling pathway
    118992336 (MAP2K1)
   04071 Sphingolipid signaling pathway
    118992336 (MAP2K1)
   04024 cAMP signaling pathway
    118992336 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    118992336 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    118992336 (MAP2K1)
   04150 mTOR signaling pathway
    118992336 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    118992336 (MAP2K1)
   04148 Efferocytosis
    118992336 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    118992336 (MAP2K1)
   04210 Apoptosis
    118992336 (MAP2K1)
   04218 Cellular senescence
    118992336 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    118992336 (MAP2K1)
   04540 Gap junction
    118992336 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    118992336 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    118992336 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    118992336 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    118992336 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    118992336 (MAP2K1)
   04660 T cell receptor signaling pathway
    118992336 (MAP2K1)
   04662 B cell receptor signaling pathway
    118992336 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    118992336 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    118992336 (MAP2K1)
   04062 Chemokine signaling pathway
    118992336 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    118992336 (MAP2K1)
   04929 GnRH secretion
    118992336 (MAP2K1)
   04912 GnRH signaling pathway
    118992336 (MAP2K1)
   04915 Estrogen signaling pathway
    118992336 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    118992336 (MAP2K1)
   04917 Prolactin signaling pathway
    118992336 (MAP2K1)
   04921 Oxytocin signaling pathway
    118992336 (MAP2K1)
   04926 Relaxin signaling pathway
    118992336 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    118992336 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    118992336 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    118992336 (MAP2K1)
   04916 Melanogenesis
    118992336 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    118992336 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    118992336 (MAP2K1)
   04726 Serotonergic synapse
    118992336 (MAP2K1)
   04720 Long-term potentiation
    118992336 (MAP2K1)
   04730 Long-term depression
    118992336 (MAP2K1)
   04722 Neurotrophin signaling pathway
    118992336 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    118992336 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    118992336 (MAP2K1)
   05206 MicroRNAs in cancer
    118992336 (MAP2K1)
   05205 Proteoglycans in cancer
    118992336 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    118992336 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    118992336 (MAP2K1)
   05230 Central carbon metabolism in cancer
    118992336 (MAP2K1)
   05231 Choline metabolism in cancer
    118992336 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    118992336 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    118992336 (MAP2K1)
   05212 Pancreatic cancer
    118992336 (MAP2K1)
   05225 Hepatocellular carcinoma
    118992336 (MAP2K1)
   05226 Gastric cancer
    118992336 (MAP2K1)
   05214 Glioma
    118992336 (MAP2K1)
   05216 Thyroid cancer
    118992336 (MAP2K1)
   05221 Acute myeloid leukemia
    118992336 (MAP2K1)
   05220 Chronic myeloid leukemia
    118992336 (MAP2K1)
   05218 Melanoma
    118992336 (MAP2K1)
   05211 Renal cell carcinoma
    118992336 (MAP2K1)
   05219 Bladder cancer
    118992336 (MAP2K1)
   05215 Prostate cancer
    118992336 (MAP2K1)
   05213 Endometrial cancer
    118992336 (MAP2K1)
   05224 Breast cancer
    118992336 (MAP2K1)
   05223 Non-small cell lung cancer
    118992336 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    118992336 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    118992336 (MAP2K1)
   05161 Hepatitis B
    118992336 (MAP2K1)
   05160 Hepatitis C
    118992336 (MAP2K1)
   05164 Influenza A
    118992336 (MAP2K1)
   05163 Human cytomegalovirus infection
    118992336 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    118992336 (MAP2K1)
   05165 Human papillomavirus infection
    118992336 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    118992336 (MAP2K1)
   05135 Yersinia infection
    118992336 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    118992336 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    118992336 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    118992336 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    118992336 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    118992336 (MAP2K1)
   01522 Endocrine resistance
    118992336 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:shon01001]
    118992336 (MAP2K1)
Enzymes [BR:shon01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     118992336 (MAP2K1)
Protein kinases [BR:shon01001]
 Serine/threonine kinases: STE group
  STE7 family
   118992336 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 118992336
NCBI-ProteinID: XP_036910085
LinkDB
Position
Unknown
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAIGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggccccagacggctccgcggtt
aacgggaccagctcggcagagaccaacctggaggctttgcagaagaagctggaggagctg
gaactcgatgagcagcagcggaagcgccttgaggcctttcttacccagaagcagaaggtg
ggggaactgaaggatgatgactttgagaagatcagcgagctgggtgctggcaatggtggt
gtggtgttcaaggtctcccacaagccatccggcctggttatggccagaaagctaattcac
ctggagatcaaacctgcgatccggaaccagatcataagggagctgcaggttctacatgag
tgtaactccccatacatcgtgggcttctatggtgcattttacagtgatggagagatcagc
atctgcatggagcacatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaatcttgggaaaagttagcattgctgtgataaaaggcctgacatatctg
agggagaagcacaagattatgcatagagatgtcaagccttccaacatcctggtgaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tcagtgcaatcggacatctggagcatggggctctctctggttgagatggcgattgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcggctgagacaccacccaggccaaggacccctgggaggccccttagctcttat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaatgag
cctcctccgaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaattaaaaaccctgcagagagagcagatctgaagcaactcatggttcatgctttc
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccattggc
cttaaccagcccagcacaccaacccacgcagctggtgtctaa

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